Database Query Results : , , MEG3

MEG3, Maternally Expressed Gene 3: Click to Expand ⟱

Source:

Type:

Long non-coding RNA (lncRNA) MEG3 (Maternally Expressed Gene 3) is a tumor suppressor gene that has been implicated in various types of cancer. MEG3 is a large, non-coding RNA molecule that is normally expressed in many tissues, but its expression is often reduced or lost in cancer cells.

Studies have shown that MEG3 plays a crucial role in regulating cell growth, apoptosis (programmed cell death), and angiogenesis (the formation of new blood vessels). MEG3 has been shown to inhibit the expression of oncogenes (genes that promote cancer) and to induce the expression of tumor suppressor genes.

In cancer, the downregulation of MEG3 has been associated with increased cell proliferation, invasion, and metastasis.
Loss of expression: Breast, lung, liver, CRC, prostate, ovarian, gastric, esophageal, pancreatic, thyroid, cervical, bladder, RCC.

Scientific Papers found: Click to Expand⟱

430-

CUR,

Curcumin suppresses tumor growth of gemcitabine-resistant non-small cell lung cancer by regulating lncRNA-MEG3 and PTEN signaling

vitro+vivo,

Lung,

A549

50, 100 and 150 μM, 48 h; 100 mg/kg, 3 weeks

mice

PTEN↑, MEG3↑,

2369-

VitD3,

Long Non-coding RNA MEG3 Activated by Vitamin D Suppresses Glycolysis in Colorectal Cancer via Promoting c-Myc Degradation

in-vitro,

CRC,

DLD1

in-vitro,

CRC,

RKO

MEG3↑, Glycolysis↓, lactateProd↓, LDHA↓, PKM2↓, HK2↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 1, HK2↓, 1, lactateProd↓, 1, LDHA↓, 1, PKM2↓, 1,

Cell Death ⓘ

MEG3↑, 2,

Proliferation, Differentiation & Cell State ⓘ

PTEN↑, 1,
Total Targets: 7

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: MEG3, Maternally Expressed Gene 3

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells