Database Query Results : , , 14-3-3 proteins

14-3-3 proteins, 14-3-3 proteins: Click to Expand ⟱
Source:
Type:
14-3-3 proteins are a family of conserved regulatory molecules that play a crucial role in various cellular processes, including cell cycle regulation, apoptosis, and signal transduction. 14-3-3 proteins bind to a wide range of proteins, including kinases, phosphatases, and transcription factors, and modulate their activity, localization, and stability.
14-3-3 proteins can bind to and inhibit pro-apoptotic proteins, such as BAD and BAX, and promote cell cycle progression by binding to and activating cyclin-dependent kinases.
Overexpression: breast, lung, ovarian, pancreatic
Altered: colon, prostate, liver brain
Scientific Papers found: Click to Expand⟱
434- CUR,    Curcumin induces apoptosis in lung cancer cells by 14-3-3 protein-mediated activation of Bad
- in-vitro, Lung, A549
14-3-3 proteins↓, p‑BAD↓, p‑Akt↓, Akt↓, cl‑Casp9↑, cl‑PARP↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

14-3-3 proteins↓, 1,   Akt↓, 1,   p‑Akt↓, 1,   p‑BAD↓, 1,   cl‑Casp9↑, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: 14-3-3 proteins, 14-3-3 proteins
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:684  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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