Database Query Results : , , LGR5

LGR5, Leucine-rich repeat-containing G-protein coupled receptor 5: Click to Expand ⟱
Source:
Type:
LGR5 (Leucine-rich repeat-containing G-protein coupled receptor 5) is a protein that plays a crucial role in the development and maintenance of stem cells in various tissues, including the intestine, stomach, and hair follicles.
LGR5 is overexpressed in various types of cancer, including colorectal, breast, and ovarian cancer. In these cancers, LGR5 has been found to promote the self-renewal and proliferation of cancer stem cells, leading to tumor growth and metastasis.
Inhibiting LGR5 activity has been shown to reduce the growth and self-renewal of cancer stem cells, leading to tumor regression and improved survival in preclinical models.
Scientific Papers found: Click to Expand⟱
437- CUR,    Anti-cancer activity of amorphous curcumin preparation in patient-derived colorectal cancer organoids
- vitro+vivo, CRC, TCO1 - vitro+vivo, CRC, TCO2
cycD1/CCND1↓, cMyc↓, p‑ERK↓, CD44↓, CD133↓, LGR5↓, TumCCA↑, TumVol↓, CSCs↓,
439- CUR,    Curcumin suppresses LGR5(+) colorectal cancer stem cells by inducing autophagy and via repressing TFAP2A-mediated ECM pathway
- in-vitro, CRC, LGR5
Apoptosis↑, TumAuto↑, GP1BB↓, COL9A3↓, COMP↓, AGRN↓, ITGB4↓, LAMA5↓, COL2A1↓, ITGB6↓, LGR5↓, TFAP2A↓, ECM/TCF↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics ⓘ

COMP↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   TFAP2A↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   CD44↓, 1,   CSCs↓, 1,   p‑ERK↓, 1,   LGR5↓, 2,  

Migration ⓘ

AGRN↓, 1,   COL2A1↓, 1,   COL9A3↓, 1,   GP1BB↓, 1,   ITGB4↓, 1,   ITGB6↓, 1,   LAMA5↓, 1,  

Angiogenesis & Vasculature ⓘ

ECM/TCF↓, 1,  

Functional Outcomes ⓘ

TumVol↓, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: LGR5, Leucine-rich repeat-containing G-protein coupled receptor 5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:688  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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