Database Query Results : , , ERCC1

ERCC1, Excision Repair Cross Complementation group 1: Click to Expand ⟱
Source:
Type: protein
ERCC1 (Excision Repair Cross Complementation group 1) is a protein that plays a crucial role in the repair of DNA damage caused by environmental factors, such as ultraviolet light and chemicals. It is involved in the nucleotide excision repair (NER) pathway, which is responsible for removing damaged DNA segments and repairing them.

In the context of cancer, ERCC1 has been found to be overexpressed in various types of tumors, including lung, colon, and ovarian cancers.
Scientific Papers found: Click to Expand⟱
441- CUR,    Curcumin Regulates ERCC1 Expression and Enhances Oxaliplatin Sensitivity in Resistant Colorectal Cancer Cells through Its Effects on miR-409-3p
- in-vitro, CRC, HCT116
ERCC1↓, Bcl-2↓, GSTP1/GSTπ↓, MRP↓, P-gp↓, miR-409-3p↑, survivin↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSTP1/GSTπ↓, 1,  

Core Metabolism/Glycolysis ⓘ

ERCC1↓, 1,  

Cell Death ⓘ

Bcl-2↓, 1,   survivin↓, 1,  

Transcription & Epigenetics ⓘ

miR-409-3p↑, 1,  

Barriers & Transport ⓘ

MRP↓, 1,   P-gp↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ERCC1, Excision Repair Cross Complementation group 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:696  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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