Database Query Results : , , CTNNB1

CTNNB1, catenin (cadherin-associated protein), beta 1, 88kDa: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
CTNNB1, which encodes the protein beta-catenin, plays a significant role in the Wnt signaling pathway, which is crucial for cell proliferation, differentiation, and adhesion. Mutations in the CTNNB1 gene can lead to the stabilization and accumulation of beta-catenin in the cytoplasm and nucleus, resulting in the activation of Wnt target genes that promote oncogenesis.
CTNNB1 mutations are commonly associated with several types of cancer.
CTNNB1 (which encodes beta-catenin) is considered an oncogene when it is mutated or dysregulated. Overall, CTNNB1 expression and its mutations are often associated with poor prognosis across various cancer types.
Scientific Papers found: Click to Expand⟱
4027- FulvicA,    Mummy Induces Apoptosis Through Inhibiting of Epithelial-Mesenchymal Transition (EMT) in Human Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10
tumCV↓, selectivity↑, TGF-β↓, Twist↓, NOTCH1↓, CTNNB1↓, Src↓, E-cadherin↑, EMT↓, TumMeta↓, BioAv↑,
5017- UA,    Ursolic acid disturbs ROS homeostasis and regulates survival-associated gene expression to induce apoptosis in intestinal cancer cells
- in-vitro, Cerv, INT-407 - in-vitro, CRC, HCT116
AntiCan↑, TumCG↓, ROS↑, Apoptosis↑, TumCMig↓, CTNNB1↓, Twist↓, Bcl-2↓, survivin↓, NF-kB↓, Sp1/3/4↓, BAX↑, P21↑, P53↑, eff↓, TumCMig↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CTNNB1↓, 2,   EMT↓, 1,   NOTCH1↓, 1,   Src↓, 1,   TumCG↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   TGF-β↓, 1,   TumCMig↓, 2,   TumMeta↓, 1,   Twist↓, 2,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   eff↓, 1,   selectivity↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 24

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CTNNB1, catenin (cadherin-associated protein), beta 1, 88kDa
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:70  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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