Database Query Results : , , CDX2

CDX2, Caudal-type homeobox 2: Click to Expand ⟱
Source:
Type: transcription factor
CDX2 (Caudal-type homeobox 2) is a transcription factor that plays a crucial role in the development and differentiation of the intestinal epithelium. In the context of cancer, CDX2 is often used as a diagnostic marker to help identify the primary site of origin for metastatic carcinomas.
Expressed in: CRC GI, Pancreatic, intestine, appendiceal, biliary, esophageal, ovarian, endometrial
Scientific Papers found: Click to Expand⟱
443- CUR,    Reduced Caudal Type Homeobox 2 (CDX2) Promoter Methylation Is Associated with Curcumin’s Suppressive Effects on Epithelial-Mesenchymal Transition in Colorectal Cancer Cells
- in-vitro, CRC, SW480
DNMT1↓, DNMT3A↓, N-cadherin↓, Vim↓, Wnt↓, Snail↓, Twist↓, β-catenin/ZEB1↓, E-cadherin↑, EMT↓, CDX2↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


DNA Damage & Repair ⓘ

DNMT1↓, 1,   DNMT3A↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

CDX2↓, 1,   EMT↓, 1,   Wnt↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   N-cadherin↓, 1,   Snail↓, 1,   Twist↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CDX2, Caudal-type homeobox 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:700  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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