Database Query Results : , , miR-130a

miR-130a, miR-130a microRNA: Click to Expand ⟱
Source:
Type: microRNA
MicroRNAs (miRNAs) are small non-coding RNAs that play a crucial role in regulating gene expression by binding to the 3' untranslated region (3' UTR) of target mRNAs, leading to their degradation or inhibition of translation.
miR-130a is overexpressed in several types of cancer: breast, lung, CRC, ovarian.
key targets of miR-130a: Tp53, PTEN, SMAD4, RUNX3.

miR-130a is generally considered protumorigenic in many contexts. Its ability to target and downregulate tumor suppressor genes can facilitate tumor growth, invasion, and metastasis.
Scientific Papers found: Click to Expand⟱
722- Bor,    Boric acid as a promising agent in the treatment of ovarian cancer: Molecular mechanisms
- in-vitro, Ovarian, MDAH-2774
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, ROS↑, miR-21↓, miR-130a↓, Casp8∅, Casp10∅, cycD1/CCND1∅, CDK6∅, CDK4∅, FADD∅, DR4∅, DR5∅,
4707- CUR,    The Potential Role of Curcumin as a Regulator of microRNA in Colorectal Cancer: A Systematic Review
- Review, Var, NA
miR-497↑, miR-200c↑, miR-409-3p↑, miR-34a↑, miR-126↑, miR-145↑, miR-206↑, miR-491↑, miR-141↑, miR-429↑, miR-101↑, miR-15↑, miR-21↓, miR-155↓, miR-221↓, miR‐222↓, miR-17↓, miR-130a↓, miR-27a-3p↓, miR-20↓,
4709- CUR,    Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways
- Review, Var, NA
miR-21↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, miR-99↑, JAK↓, STAT↓, cycD1/CCND1↓, P21↑, ChemoSen↑, miR-192-5p↑, cMyc↓, Wnt↓, β-catenin/ZEB1↓, miR-130a↓,
449- CUR,    Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/β-Catenin Pathways via miR-130a
- vitro+vivo, CRC, SW480
TumCP↓, β-catenin/ZEB1↓, TCF↓, miR-21↓, NKD2↑, miR-130a↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,  

Cell Death ⓘ

Apoptosis↑, 2,   Casp10∅, 1,   Casp8∅, 1,   DR4∅, 1,   DR5∅, 1,   FADD∅, 1,   miR-497↑, 1,  

Transcription & Epigenetics ⓘ

miR-145↑, 1,   miR-192-5p↑, 1,   miR-21↓, 4,   miR-27a-3p↓, 1,   miR-409-3p↑, 1,  

Cell Cycle & Senescence ⓘ

CDK4∅, 1,   cycD1/CCND1↓, 1,   cycD1/CCND1∅, 1,   P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

miR-101↑, 1,   miR-34a↑, 1,   miR-429↑, 1,   miR-99↑, 1,   NKD2↑, 1,   STAT↓, 1,   TCF↓, 1,   Wnt↓, 1,  

Migration ⓘ

miR-130a↓, 4,   miR-141↑, 1,   miR-155↓, 1,   miR-20↓, 1,   miR-200c↑, 1,   miR-206↑, 1,   miR-221↓, 1,   miR-491↑, 1,   miR‐222↓, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 3,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

miR-126↑, 1,   miR-15↑, 1,   miR-17↓, 1,  

Immune & Inflammatory Signaling ⓘ

JAK↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6∅, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  
Total Targets: 45

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-130a, miR-130a microRNA
3 Curcumin
1 Boron
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:705  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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