Database Query Results : , , GADD45A

GADD45A, Growth Arrest and DNA Damage-inducible 45 alpha: Click to Expand ⟱
Source:
Type: TSG/protein
GADD45A (Growth Arrest and DNA Damage-inducible 45 alpha) is a protein that plays a crucial role in various cellular processes, including cell cycle regulation, DNA repair, and apoptosis.
GADD45A is a tumor suppressor gene that is often downregulated in various types of cancer, including breast, lung, and colon cancer.
Scientific Papers found: Click to Expand⟱
454- CUR,    Curcumin-Induced DNA Demethylation in Human Gastric Cancer Cells Is Mediated by the DNA-Damage Response Pathway
- in-vitro, GC, MGC803
TumCMig↓, TumCP↓, ROS↑, mtDam↑, DNAdam↑, Apoptosis↑, ATR↑, P21↑, p‑P53↑, GADD45A↑, p‑γH2AX↑,
1942- PL,    Piperlongumine inhibits antioxidant enzymes, increases ROS levels, induces DNA damage and G2/M cell cycle arrest in breast cell lines
- in-vitro, BC, MCF-7
ROS↑, SOD1↑, Trx1↓, Catalase↓, PrxII↓, ROS↑, GADD45A↑, P21↑, DNAdam↑, TumCCA↑,
1747- RosA,    Molecular Pathways of Rosmarinic Acid Anticancer Activity in Triple-Negative Breast Cancer Cells: A Literature Review
- Review, BC, MDA-MB-231 - Review, BC, MDA-MB-468
TumCCA↑, TNF-α↑, GADD45A↑, BNIP3↑, survivin↓, Bcl-2↓, BAX↑, HH↓, eff↑, ChemoSen↑, RadioS↑, TumCP↓, TumCMig↓, Apoptosis↑, RenoP↑, CardioT↓,
1688- Se,    Potential Role of Selenium in the Treatment of Cancer and Viral Infections
- Review, Var, NA
IL2↑, INF-γ↑, Th1 response↑, Th2↑, Dose↑, AntiCan∅, Risk↑, chemoP↑, Hif1a↓, VEGF↓, selectivity↑, *GADD45A↑, NRF2↓, *NRF2↑, ChemoSen↑, angioG↓, PrxI↓, ChemoSideEff↓, eff↑,
2119- TQ,    Dual properties of Nigella Sativa: anti-oxidant and pro-oxidant
- Review, Var, NA
*ROS↓, ROS↑, chemoP↑, RenoP↑, hepatoP↑, NLRP3↓, neuroP↑, NF-kB↓, P21↑, HDAC↓, Apoptosis↑, TumCP↓, GSH↓, GADD45A↑, GSK‐3β↑,
2100- TQ,    Dual properties of Nigella Sative: Anti-oxidant and Pro-oxidant
- Review, NA, NA
ROS⇅, *antiOx↑, *SOD↑, *MPO↑, *neuroP↑, *chemoP↑, *radioP↑, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, Bcl-xL↓, survivin↓, COX2↓, MMP9↓, VEGF↓, ROS↑, P21↑, HDAC↓, GSH↓, GADD45A↑, AIF↑, STAT3↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   GSH↓, 2,   NRF2↓, 1,   PrxI↓, 1,   PrxII↓, 1,   ROS↑, 5,   ROS⇅, 1,   SOD1↑, 1,   Trx1↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   mtDam↑, 1,   XIAP↓, 1,  

Cell Death ⓘ

Apoptosis↑, 3,   BAX↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   IAP1↓, 1,   IAP2↓, 1,   survivin↓, 2,  

Autophagy & Lysosomes ⓘ

BNIP3↑, 1,  

DNA Damage & Repair ⓘ

ATR↑, 1,   DNAdam↑, 2,   GADD45A↑, 5,   p‑P53↑, 1,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 4,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↑, 1,   HDAC↓, 2,   HH↓, 1,   STAT3↓, 1,  

Migration ⓘ

MMP9↓, 1,   TumCMig↓, 2,   TumCP↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL2↑, 1,   INF-γ↑, 1,   NF-kB↓, 2,   Th1 response↑, 1,   Th2↑, 1,   TNF-α↑, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 2,   Dose↑, 1,   eff↑, 2,   RadioS↑, 1,   selectivity↑, 1,  

Functional Outcomes ⓘ

AntiCan∅, 1,   CardioT↓, 1,   chemoP↑, 2,   ChemoSideEff↓, 1,   hepatoP↑, 1,   neuroP↑, 1,   RenoP↑, 2,   Risk↑, 1,  
Total Targets: 58

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   MPO↑, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

DNA Damage & Repair ⓘ

GADD45A↑, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,   neuroP↑, 1,   radioP↑, 1,  
Total Targets: 9

Scientific Paper Hit Count for: GADD45A, Growth Arrest and DNA Damage-inducible 45 alpha
2 Thymoquinone
1 Curcumin
1 Piperlongumine
1 Rosmarinic acid
1 Selenium
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:718  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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