Database Query Results : , , PCLAF

PCLAF, Proliferating Cell Nuclear Antigen-Associated Factor: Click to Expand ⟱
Source:
Type: protein, transcriptional coactivator
PCLAF (Proliferating Cell Nuclear Antigen-Associated Factor) is a protein that has been associated with cancer. It is a transcriptional coactivator that plays a role in the regulation of cell proliferation and DNA replication.

Research has shown that PCLAF is overexpressed in various types of cancer, including breast, lung, and colon cancer. This overexpression has been linked to increased cell proliferation, tumor growth, and poor prognosis.
Scientific Papers found: Click to Expand⟱
461- CUR,    Curcumin inhibits prostate cancer progression by regulating the miR-30a-5p/PCLAF axis
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, miR-30a-5p↑, PCLAF↓, Bcl-2↓, Casp3↓, BAX↑, cl‑Casp3↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↓, 1,   cl‑Casp3↑, 1,  

Transcription & Epigenetics ⓘ

miR-30a-5p↑, 1,  

DNA Damage & Repair ⓘ

PCLAF↓, 1,  

Migration ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PCLAF, Proliferating Cell Nuclear Antigen-Associated Factor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:729  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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