Database Query Results : , , STAT2

STAT2, Signal Transducer and Activator of Transcription 2: Click to Expand ⟱
Source:
Type: protein
STAT2 (Signal Transducer and Activator of Transcription 2) is a protein that plays a crucial role in the regulation of immune responses, particularly in the context of viral infections and cancer.
STAT2 has been shown to have both tumor-suppressive and tumor-promoting functions, depending on the type of cancer and the cellular context.

High STAT2 expression has been associated with better prognosis and improved response to therapy.
Low STAT2 expression has been linked to poor prognosis and reduced survival.

Expression varies depending on Cancer.
Scientific Papers found: Click to Expand⟱
464- CUR,    Curcumin inhibits the viability, migration and invasion of papillary thyroid cancer cells by regulating the miR-301a-3p/STAT3 axis
- in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, TPC-1
TumCI↓, TumCI↓, MMP2↓, MMP9↓, EMT↓, STAT3↓, miR-301a-3p↓, STAT↓, N-cadherin↓, Vim↓, Fibronectin↓, p‑JAK↓, p‑JAK2↓, p‑JAK3↓, p‑STAT1↓, p‑STAT2↓, E-cadherin↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   STAT↓, 1,   p‑STAT1↓, 1,   p‑STAT2↓, 1,   STAT3↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   Fibronectin↓, 1,   miR-301a-3p↓, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   TumCI↓, 2,   Vim↓, 1,  

Immune & Inflammatory Signaling ⓘ

p‑JAK↓, 1,   p‑JAK2↓, 1,   p‑JAK3↓, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: STAT2, Signal Transducer and Activator of Transcription 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:738  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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