Database Query Results : , , SFRP5

SFRP5, Secreted Frizzled-Related Protein 5: Click to Expand ⟱
Source:
Type: tumor suppressor protein
SFRP5 (Secreted Frizzled-Related Protein 5) is a member of the SFRP family of proteins, which are known to play a role in regulating the Wnt signaling pathway.
SFRP5 has been found to act as a tumor suppressor. It inhibits the Wnt/β-catenin signaling pathway, which is often aberrantly activated in various types of cancer, including colorectal, breast, and lung cancers.
SFRP5 expression is frequently downregulated or lost in cancer cells.
Scientific Papers found: Click to Expand⟱
470- CUR,    Regulation of carcinogenesis and modulation through Wnt/β-catenin signaling by curcumin in an ovarian cancer cell line
- in-vitro, Ovarian, SKOV3
Wnt/(β-catenin)↓, EMT↓, DNMT3A↓, cycD1/CCND1↓, cMyc↓, Fibronectin↓, Vim↓, E-cadherin↑, SFRP5↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,  

DNA Damage & Repair ⓘ

DNMT3A↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   SFRP5↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   Fibronectin↓, 1,   Vim↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SFRP5, Secreted Frizzled-Related Protein 5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:745  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page