Database Query Results : , , SMG1

SMG1, Suppressor of Morphogenetic Defects in Genitalia 1: Click to Expand ⟱
Source:
Type: gene
SMG1 (Suppressor of Morphogenetic Defects in Genitalia 1) is a gene that plays a crucial role in the regulation of DNA damage response and cell cycle progression.
SMG1 is a phosphatidylinositol 3-kinase-related kinase (PIKK) that is activated in response to DNA damage. It phosphorylates and activates downstream targets, including p53, a tumor suppressor protein that plays a key role in preventing cancer. SMG1 also regulates the cell cycle by phosphorylating and inhibiting the activity of cyclin-dependent kinases (CDKs), which are essential for cell cycle progression.

Studies have shown that SMG1 is frequently downregulated or mutated in various types of cancer, including breast, lung, and colon cancer.
Scientific Papers found: Click to Expand⟱
472- CUR,    Curcumin inhibits ovarian cancer progression by regulating circ-PLEKHM3/miR-320a/SMG1 axis
- vitro+vivo, Ovarian, SKOV3 - vitro+vivo, Ovarian, A2780S
TumCP↓, Apoptosis↑, PCNA↓, miR-320a↓, BAX↑, cl‑Casp3↑, circ‑PLEKHM3↑, SMG1↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   cl‑Casp3↑, 1,  

DNA Damage & Repair ⓘ

PCNA↓, 1,   SMG1↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

circ‑PLEKHM3↑, 1,  

Migration ⓘ

miR-320a↓, 1,   TumCP↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SMG1, Suppressor of Morphogenetic Defects in Genitalia 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:748  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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