Database Query Results : , , miR-200c

miR-200c, miR-200c: Click to Expand ⟱
Source:
Type: tumour-suppressor miRNA
miR-200c studied particularly in the regulation of epithelial-to-mesenchymal transition (EMT) and cancer metastasis.
miR-200c is a member of the miR-200 family, which includes miR-200a, miR-200b, and miR-200c. These miRNAs are known to play a crucial role in maintaining epithelial cell identity and suppressing EMT, a process by which epithelial cells acquire a mesenchymal phenotype and become more migratory and invasive.

miR-200c has been shown to target several genes involved in EMT and cancer progression, including:

     ZEB1 and ZEB2, transcription factors that promote EMT and cancer metastasis.
     TGF-β, a cytokine that promotes EMT and cancer progression.
     Vimentin, a protein that is highly expressed in mesenchymal cells and is associated with cancer metastasis.

The overexpression of miR-200c has been shown to inhibit EMT and cancer metastasis in various types of cancer, including breast, lung, and ovarian cancer. Conversely, the downregulation of miR-200c has been associated with cancer progression and poor prognosis.

Downregulated in: lung, CRC, GC, pancreatic, HCC (associated with poor prognosis).
Scientific Papers found: Click to Expand⟱
4707- CUR,    The Potential Role of Curcumin as a Regulator of microRNA in Colorectal Cancer: A Systematic Review
- Review, Var, NA
miR-497↑, miR-200c↑, miR-409-3p↑, miR-34a↑, miR-126↑, miR-145↑, miR-206↑, miR-491↑, miR-141↑, miR-429↑, miR-101↑, miR-15↑, miR-21↓, miR-155↓, miR-221↓, miR‐222↓, miR-17↓, miR-130a↓, miR-27a-3p↓, miR-20↓,
679- EGCG,  5-FU,    Epigallocatechin-3-gallate targets cancer stem-like cells and enhances 5-fluorouracil chemosensitivity in colorectal cancer
- in-vitro, CRC, NA
NOTCH1↓, BMI1↓, SUZ12↓, EZH2↓, miR-34a↑, miR-200c↑, miR-145↑, CSCs↓,
816- GAR,    Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells
- in-vitro, PC, PANC1
Mcl-1↓, EZH2↓, ABCG2↓, Gli1↓, NOTCH1↓, miR-200c↑,
800- GAR,    Garcinol Regulates EMT and Wnt Signaling Pathways In Vitro and In Vivo, Leading to Anticancer Activity against Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, NA, NA
EMT↓, MET↑, E-cadherin↑, Vim↓, Zeb1↓, ZEB2↑, miR-200c↑, Let-7↑, p‑β-catenin/ZEB1↓, NF-kB↓,
522- MF,    Low Magnetic Field Exposure Alters Prostate Cancer Cell Properties
- in-vitro, Pca, PC3
MMP2↑, MMP9↑, miR-21↑, miR-155↑, miR-210↑, miR-200c↓, miR-126↓,
1437- SFN,    Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition
- Review, NA, NA
HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, HDAC8↓, eff↑, ac‑HSP90↑, DNMT1↓, DNMT3A↓, hTERT/TERT↓, NRF2↑, HO-1↑, NQO1↑, miR-155↓, miR-200c↑, SOX9↓, *toxicity↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

HO-1↑, 1,   NQO1↑, 1,   NRF2↑, 1,  

Cell Death ⓘ

hTERT/TERT↓, 1,   Mcl-1↓, 1,   miR-497↑, 1,  

Kinase & Signal Transduction ⓘ

SOX9↓, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 2,   miR-145↑, 2,   miR-21↓, 1,   miR-21↑, 1,   miR-27a-3p↓, 1,   miR-409-3p↑, 1,  

Protein Folding & ER Stress ⓘ

ac‑HSP90↑, 1,  

DNA Damage & Repair ⓘ

DNMT1↓, 1,   DNMT3A↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

BMI1↓, 1,   CSCs↓, 1,   EMT↓, 1,   Gli1↓, 1,   HDAC↓, 1,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC8↓, 1,   Let-7↑, 1,   miR-101↑, 1,   miR-34a↑, 2,   miR-429↑, 1,   NOTCH1↓, 2,   SUZ12↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   MET↑, 1,   miR-130a↓, 1,   miR-141↑, 1,   miR-155↓, 2,   miR-155↑, 1,   miR-20↓, 1,   miR-200c↓, 1,   miR-200c↑, 5,   miR-206↑, 1,   miR-221↓, 1,   miR-491↑, 1,   miR‐222↓, 1,   MMP2↑, 1,   MMP9↑, 1,   Vim↓, 1,   Zeb1↓, 1,   ZEB2↑, 1,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

miR-126↓, 1,   miR-126↑, 1,   miR-15↑, 1,   miR-17↓, 1,   miR-210↑, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ABCG2↓, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

EZH2↓, 2,   hTERT/TERT↓, 1,   SUZ12↓, 1,  
Total Targets: 61

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: miR-200c, miR-200c
2 Garcinol
1 Curcumin
1 EGCG (Epigallocatechin Gallate)
1 5-fluorouracil
1 Magnetic Fields
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:765  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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