Database Query Results : , , PFKL

PFKL, Phosphofructokinase, Liver: Click to Expand ⟱
Source:
Type: enzyme
PFKL (Phosphofructokinase, Liver) is an enzyme that plays a crucial role in glycolysis, the process by which cells convert glucose into energy. PFKL is a key regulatory enzyme in the glycolytic pathway, and it is primarily expressed in the liver.
PFKL has been shown to be overexpressed in certain types of tumors, including liver cancer. This overexpression may contribute to the development and progression of cancer by promoting glycolysis and energy production in cancer cells.
PFKL is a key regulatory enzyme in the glycolytic pathway.
PFKL plays a role in the regulation of glucose metabolism in diabetes.
Scientific Papers found: Click to Expand⟱
2249- MF,    Pulsed electromagnetic fields modulate energy metabolism during wound healing process: an in vitro model study
- in-vitro, Nor, L929
*TumCMig↑, *tumCV↑, *Glycolysis↑, *ROS↓, *mitResp↓, *other↝, *OXPHOS↓, *pH↑, *antiOx↑, *PFKM↑, *PFKL↑, *PKM2↑, *HK2↑, *GLUT1↑, *GPx1↑, *GPx4↑, *SOD1↑,
525- MF,    Pulsed electromagnetic fields regulate metabolic reprogramming and mitochondrial fission in endothelial cells for angiogenesis
- in-vitro, Nor, HUVECs
*angioG↑, *GPx1↑, *GPx4↑, *SOD↑, *PFKM↑, *PFKL↑, *PKM2↑, *PFKP↑, *HK2↑, *GLUT1↑, *GLUT4↑, *ROS↓, *MMP↝, *Glycolysis↑, *OXPHOS↓,
2431- QC,    The Protective Effect of Quercetin against the Cytotoxicity Induced by Fumonisin B1 in Sertoli Cells
- in-vitro, Nor, TM4
*Apoptosis↓, *ROS↓, *antiOx↓, *MMP↑, *GPI↑, *HK2↑, *ALDOA↑, *PKM1↑, *LDHA↑, *PFKL↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 1,   GPx1↑, 2,   GPx4↑, 2,   OXPHOS↓, 2,   ROS↓, 3,   SOD↑, 1,   SOD1↑, 1,  

Mitochondria & Bioenergetics ⓘ

mitResp↓, 1,   MMP↑, 1,   MMP↝, 1,  

Core Metabolism/Glycolysis ⓘ

ALDOA↑, 1,   Glycolysis↑, 2,   GPI↑, 1,   HK2↑, 3,   LDHA↑, 1,   PFKL↑, 3,   PFKM↑, 2,   PFKP↑, 1,   PKM1↑, 1,   PKM2↑, 2,  

Cell Death ⓘ

Apoptosis↓, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,   tumCV↑, 1,  

Migration ⓘ

TumCMig↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,  

Barriers & Transport ⓘ

GLUT1↑, 2,   GLUT4↑, 1,  

Cellular Microenvironment ⓘ

pH↑, 1,  
Total Targets: 29

Scientific Paper Hit Count for: PFKL, Phosphofructokinase, Liver
2 Magnetic Fields
1 Quercetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:770  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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