Database Query Results : , , miR-34b-5p

miR-34b-5p, miR-34b-5p: Click to Expand ⟱
Source:
Type: tumor suppressor miRNA
miR-34b-5p is downregulated in several types of cancer: CRC, breast, lung, prostate. The tumor suppressor function of miR-34b-5p is thought to be mediated by its ability to target and downregulate genes involved in cell proliferation, survival, and metastasis. Some of the target genes of miR-34b-5p include:

• BCL-2: an anti-apoptotic protein that promotes cell survival.
• CCND1: a cyclin-dependent kinase that promotes cell cycle progression.
• VEGF: a vascular endothelial growth factor that promotes angiogenesis (the formation of new blood vessels).
Scientific Papers found: Click to Expand⟱
530- MF,    Low frequency sinusoidal electromagnetic fields promote the osteogenic differentiation of rat bone marrow mesenchymal stem cells by modulating miR-34b-5p/STAC2
- in-vivo, Nor, NA
*miR-34b-5p↓, *ALP↑, *RUNX2↑, *BMP2↑, *OCN↑, *OPN↑, *β-catenin/ZEB1↑, *STAC2↑, *Diff↑, *BMD↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

BMP2↑, 1,  

Kinase & Signal Transduction ⓘ

OCN↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1,   RUNX2↑, 1,  

Migration ⓘ

OPN↑, 1,   STAC2↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

miR-34b-5p↓, 1,  

Clinical Biomarkers ⓘ

ALP↑, 1,   BMD↑, 1,  
Total Targets: 10

Scientific Paper Hit Count for: miR-34b-5p, miR-34b-5p
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:775  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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