RUNX2 Cancer Research Results

RUNX2, Runt-related transcription factor 2: Click to Expand ⟱
Source:
Type:
RUNX2 (Runt-related transcription factor 2) is a transcription factor that plays a crucial role in the regulation of bone development and osteoblast differentiation.
RUNX2 is overexpressed in: breast, prostate, lung, osteosarcoma.
Scientific Papers found: Click to Expand⟱
5873- CA,    Carnosic acid serves as a dual Nrf2 activator and PTEN/AKT suppressor to inhibit traumatic heterotopic ossification
- vitro+vivo, Nor, NA
*NRF2↑, *NOX↓, *TAC↑, *ROS↓, *NQO1↑, *p‑PTEN↑, RUNX2↓, SOX9↓,
530- MF,    Low frequency sinusoidal electromagnetic fields promote the osteogenic differentiation of rat bone marrow mesenchymal stem cells by modulating miR-34b-5p/STAC2
- in-vivo, Nor, NA
*miR-34b-5p↓, *ALP↑, *RUNX2↑, *BMP2↑, *OCN↑, *OPN↑, *β-catenin/ZEB1↑, *STAC2↑, *Diff↑, *BMD↑,
218- MFrot,  MF,    Extremely low frequency magnetic fields inhibit adipogenesis of human mesenchymal stem cells
- in-vitro, Nor, NA
*PPARγ↓, *p‑JNK↑, *Wnt↑, *ALP∅, *COL1∅, *RUNX2∅, *OCN∅, *FABP4↓, *p‑JNK↑, *Diff↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Kinase & Signal Transduction ⓘ

SOX9↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

RUNX2↓, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

NQO1↑, 1,   NRF2↑, 1,   ROS↓, 1,   TAC↑, 1,  

Core Metabolism/Glycolysis ⓘ

FABP4↓, 1,   PPARγ↓, 1,  

Cell Death ⓘ

BMP2↑, 1,   p‑JNK↑, 2,  

Kinase & Signal Transduction ⓘ

OCN↑, 1,   OCN∅, 1,  

Proliferation, Differentiation & Cell State ⓘ

Diff↓, 1,   Diff↑, 1,   p‑PTEN↑, 1,   RUNX2↑, 1,   RUNX2∅, 1,   Wnt↑, 1,  

Migration ⓘ

COL1∅, 1,   OPN↑, 1,   STAC2↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

miR-34b-5p↓, 1,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Clinical Biomarkers ⓘ

ALP↑, 1,   ALP∅, 1,   BMD↑, 1,  
Total Targets: 25

Scientific Paper Hit Count for: RUNX2, Runt-related transcription factor 2
2 Magnetic Fields
1 Carnosic acid
1 Magnetic Field Rotating
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:776  State#:%  Dir#:%
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