RUNX2 Cancer Research Results
RUNX2, Runt-related transcription factor 2: Click to Expand ⟱
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RUNX2 (Runt-related transcription factor 2) is a transcription factor that plays a crucial role in the regulation of bone development and osteoblast differentiation.
RUNX2 is overexpressed in: breast, prostate, lung, osteosarcoma.
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Scientific Papers found: Click to Expand⟱
*NRF2↑, *NOX↓, *TAC↑, *ROS↓, *NQO1↑, *p‑PTEN↑, RUNX2↓, SOX9↓,
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓,
*miR-34b-5p↓, *ALP↑, *RUNX2↑, *BMP2↑, *OCN↑, *OPN↑, *β-catenin/ZEB1↑, *STAC2↑, *Diff↑, *BMD↑,
*PPARγ↓, *p‑JNK↑, *Wnt↑, *ALP∅, *COL1∅, *RUNX2∅, *OCN∅, *FABP4↓, *p‑JNK↑, *Diff↓,
Showing Research Papers: 1 to 4 of 4
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
Catalase↓, 1, ROS↑, 1,
Mitochondria & Bioenergetics(tgid=3) ⓘ
MMP↓, 1,
Cell Death(tgid=5) ⓘ
Akt↓, 2, Apoptosis↑, 1, Casp3↑, 1, Casp8↑, 1, Casp9↑, 1, TumCD↑, 1,
Kinase & Signal Transduction(tgid=6) ⓘ
SOX9↓, 1,
Transcription & Epigenetics(tgid=7) ⓘ
tumCV↓, 1,
DNA Damage & Repair(tgid=10) ⓘ
DNAdam↑, 1,
Cell Cycle & Senescence(tgid=11) ⓘ
TumCCA↑, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
CTSB↓, 1, CTSD↓, 1, EMT↓, 1, PI3K↓, 1, RUNX2↓, 1,
Migration(tgid=13) ⓘ
i-Ca+2↑, 1, E-cadherin↓, 1, MMP2↓, 1, MMP9↓, 1, N-cadherin↓, 1, Slug?, 1, Snail?, 1, TIMP2↓, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
FOXP3↑, 1,
Total Targets: 27
Pathway results for Effect on Normal Cells:
NA, unassigned(tgid=0) ⓘ
antiAll↑, 1,
Redox & Oxidative Stress(tgid=1) ⓘ
Catalase↑, 1, CYP2E1↓, 1, GPx↑, 1, GSTs↑, 1, MDA↓, 1, NQO1↑, 1, NRF2↑, 2, ROS↓, 3, SOD↑, 1, TAC↑, 1,
Mitochondria & Bioenergetics(tgid=3) ⓘ
MMP↑, 1,
Core Metabolism/Glycolysis(tgid=4) ⓘ
ALAT↓, 1, DGAT1↓, 1, FABP4↓, 1, FASN↓, 1, PPARγ↓, 1,
Cell Death(tgid=5) ⓘ
BAX↓, 1, BMP2↑, 2, Casp3↓, 1, Cyt‑c↓, 1, p‑JNK↑, 2,
Kinase & Signal Transduction(tgid=6) ⓘ
OCN↑, 1, OCN∅, 1,
Autophagy & Lysosomes(tgid=9) ⓘ
p62↑, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
Diff↓, 1, Diff↑, 1, p‑PTEN↑, 1, RUNX2↑, 2, RUNX2∅, 1, Wnt↑, 1,
Migration(tgid=13) ⓘ
COL1↑, 1, COL1∅, 1, OPN↑, 1, STAC2↑, 1, β-catenin/ZEB1↑, 1,
Angiogenesis & Vasculature(tgid=14) ⓘ
miR-34b-5p↓, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
COX2/PTGS2↓, 1, IL6↓, 1, NF-kB↓, 1, PGE2↓, 1, TNF-α↓, 1,
Cellular Microenvironment(tgid=17) ⓘ
NOX↓, 1,
Protein Aggregation(tgid=19) ⓘ
AGEs↓, 1,
Clinical Biomarkers(tgid=22) ⓘ
ALAT↓, 1, ALP↑, 1, ALP∅, 1, AST↓, 1, BMD↑, 1, IL6↓, 1,
Total Targets: 50
Scientific Paper Hit Count for: RUNX2, Runt-related transcription factor 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:776 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid
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