Database Query Results : , , CSCsMark

CSCsMark, Cancer Stem Cell Markers: Click to Expand ⟱
Source:
Type:
CSC markers include nanog, sox2, and oct3/4
CSC markers: CD55, CD133, ALDH1, SOX2, OCT4, NANOG, BMI1, ABCG2, CD24, EpCAM
Scientific Papers found: Click to Expand⟱
10- CUR,    Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog Pathways
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
HH↓, Wnt/(β-catenin)↓, Shh↓, Smo↓, Gli1↝, GLI2↝, CSCs↓, CD133↓, CSCsMark↓,
1168- IVM,  SRF,    Ivermectin synergizes sorafenib in hepatocellular carcinoma via targeting multiple oncogenic pathways
- in-vitro, HCC, NA
TumMeta↓, mTOR↓, EMT↓, CSCsMark↓, STAT3↓,
4959- PEITC,    Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment
- in-vitro, Ovarian, NA
CSCs↓, ALDH↓, CSCsMark↓, eff↑,
4961- PEITC,    Phenethyl isothiocyanate suppresses cancer stem cell properties in vitro and in a xenograft model
- vitro+vivo, CRC, HCT116
CSCs↓, TumCG↓, CSCsMark↓,
4898- Sal,    Salinomycin as a potent anticancer stem cell agent: State of the art and future directions
- Review, Var, NA
CSCs↓, AntiCan↑, ChemoSen↑, RadioS↑, Wnt↓, MAPK↓, TumAuto↑, ATP↓, ROS↑, DNAdam↑, ER Stress↑, CSCsMark↓, Iron↑, *toxicity↝,
5000- Sal,    Salinomycin kills cancer stem cells by sequestering iron in lysosomes
- vitro+vivo, BC, NA
CSCsMark↓, eff↑, Ferroptosis↑, ROS↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   Iron↑, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Cell Death ⓘ

Ferroptosis↑, 1,   MAPK↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   CD133↓, 1,   CSCs↓, 4,   CSCsMark↓, 6,   EMT↓, 1,   Gli1↝, 1,   HH↓, 1,   mTOR↓, 1,   Shh↓, 1,   Smo↓, 1,   STAT3↓, 1,   TumCG↓, 1,   Wnt↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

GLI2↝, 1,   TumMeta↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↑, 2,   RadioS↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 29

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity↝, 1,  
Total Targets: 1

Scientific Paper Hit Count for: CSCsMark, Cancer Stem Cell Markers
2 Phenethyl isothiocyanate
2 salinomycin
1 Curcumin
1 Ivermectin
1 Sorafenib (brand name Nexavar)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:796  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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