Database Query Results : , , RSK

RSK, Ribosomal S6 Kinase: Click to Expand ⟱
Source:
Type:
RSK (Ribosomal S6 Kinase) is a family of serine/threonine kinases that play a crucial role in various cellular processes, including cell growth, differentiation, and survival.
RSK is overexpressed in various types of cancer, including breast, lung, colon, and prostate cancer.
RSK phosphorylates and activates downstream targets, such as:
     ERK1/2: promotes cell growth and survival.
     AKT: promotes cell survival and inhibits apoptosis.
     NF-κB: promotes cell survival and inflammation.
RSK proteins are activated by phosphorylation, which allows them to bind to and phosphorylate downstream targets.
Scientific Papers found: Click to Expand⟱
573- ART/DHA,    Artesunate suppresses tumor growth and induces apoptosis through the modulation of multiple oncogenic cascades in a chronic myeloid leukemia xenograft mouse model
- vitro+vivo, NA, NA
p‑p38↓, p‑ERK↓, p‑CREB↓, p‑Chk2↓, p‑STAT5↓, p‑RSK↓, SOCS1↑, Apoptosis↑, Casp3↑,
2001- Ash,    Withania somnifera: from prevention to treatment of cancer
- Review, Var, NA
toxicity↓, TumW↓, Dose?, eff↝, Ki-67↓, survivin↓, XIAP↓, PERK↑, p‑RSK↑, CHOP↑, DR5↑, Dose↝, BG↓, DNMTs↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

p‑CREB↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Casp3↑, 1,   p‑Chk2↓, 1,   DR5↑, 1,   p‑p38↓, 1,   p‑RSK↓, 1,   p‑RSK↑, 1,   survivin↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   PERK↑, 1,  

DNA Damage & Repair ⓘ

DNMTs↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,   p‑STAT5↓, 1,  

Migration ⓘ

Ki-67↓, 1,  

Immune & Inflammatory Signaling ⓘ

SOCS1↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose?, 1,   Dose↝, 1,   eff↝, 1,  

Clinical Biomarkers ⓘ

BG↓, 1,   Ki-67↓, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,   TumW↓, 1,  
Total Targets: 24

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: RSK, Ribosomal S6 Kinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:799  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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