Database Query Results : , , Sharpin

Sharpin, SHANK-associated RH domain interactor: Click to Expand ⟱
Source:
Type:
SHARPIN (SHANK-associated RH domain interactor) is a protein that plays a crucial role in the regulation of cell growth, survival, and migration.
SHARPIN is involved in the regulation of cell growth and survival, and its overexpression has been linked to the development of cancer.
Scientific Papers found: Click to Expand⟱
581- Api,  Cisplatin,    The natural flavonoid apigenin sensitizes human CD44+ prostate cancer stem cells to cisplatin therapy
- in-vitro, Pca, CD44+
Bcl-2↓, survivin↓, Casp8↑, P53↑, Sharpin↓, APAF1↑, p‑Akt↓, NF-kB↓, P21↑, Cyc↓, CDK2↓, CDK4/6↓, Snail↓, ChemoSen↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

p‑Akt↓, 1,   APAF1↑, 1,   Bcl-2↓, 1,   Casp8↑, 1,   survivin↓, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   Cyc↓, 1,   P21↑, 1,  

Migration ⓘ

CDK4/6↓, 1,   Sharpin↓, 1,   Snail↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Sharpin, SHANK-associated RH domain interactor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:805  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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