Database Query Results : , , SVCT-2

SVCT-2, Sodium-dependent Vitamin C Transporter 2: Click to Expand ⟱
Source:
Type:
SVCT-2 is a protein that plays a role in the transport of vitamin C (ascorbic acid) into cells.
SVCT-2 is expressed in: 70% breast, 60% lung, 80% CRC, 50% Prostate, 70% ovarian, 60% Pancreatic, 50% liver, 60% stomach, 50% esophageal, 60% Head and Neck, 50% Melanoma, 70% GBM, 60% Medulloblastoma.
SVCT-2 was involved in the transport of vitamin C into lung cancer cells and that its inhibition reduced cancer cell growth and survival.
Scientific Papers found: Click to Expand⟱
636- VitC,    Acute Effects of Vitamin C Exposure On Colonic Crypts: Direct Modulation of pH Regulation
- in-vivo, NA, NA
pH↓, SVCT-2∅,
632- VitC,    High-Dose Vitamin C: Preclinical Evidence for Tailoring Treatment in Cancer Patients
- Review, NA, NA
SVCT-2∅, ROS↑, Hif1a↓, PARP∅, TET2↑,
631- VitC,    Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2
- vitro+vivo, Liver, NA
SVCT-2∅, ROS↑, DNAdam↑, ATP↓, TumCCA↑, Apoptosis↑, OS↑, CD133↓, EpCAM↓, OV6↓, γH2AX↑,
628- VitC,  Mg,    Enhanced Anticancer Effect of Adding Magnesium to Vitamin C Therapy: Inhibition of Hormetic Response by SVCT-2 Activation
- in-vivo, Colon, CT26 - in-vitro, NA, MCF-7 - in-vitro, NA, SkBr3
AntiCan↑, SVCT-2↝, TumCD↑, ROS↑, P21↑, proCasp3↑, TumVol↓, DNAdam↑, NAD↓,
3133- VitC,    Vitamin C supplementation had no side effect in non-cancer, but had anticancer properties in ovarian cancer cells
- in-vitro, Ovarian, NA
*SVCT-2↑, *GLUT1↓, SVCT-2↓, GLUT1↑, TumCP↓, CDK2↓, PARP↓, selectivity↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 3,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis ⓘ

NAD↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   proCasp3↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

OV6↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   PARP↓, 1,   PARP∅, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   EpCAM↓, 1,  

Migration ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Barriers & Transport ⓘ

GLUT1↑, 1,   SVCT-2↓, 1,   SVCT-2↝, 1,   SVCT-2∅, 3,  

Cellular Microenvironment ⓘ

pH↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,   TET2↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   OS↑, 1,   TumVol↓, 1,  
Total Targets: 28

Pathway results for Effect on Normal Cells:


Barriers & Transport ⓘ

GLUT1↓, 1,   SVCT-2↑, 1,  
Total Targets: 2

Scientific Paper Hit Count for: SVCT-2, Sodium-dependent Vitamin C Transporter 2
5 Vitamin C (Ascorbic Acid)
1 Magnesium
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:814  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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