Database Query Results : , , RNR

RNR, Ribonucleotide Reductase: Click to Expand ⟱

Source:

Type: enzyme

RNR (Ribonucleotide Reductase) is an enzyme that plays a crucial role in the synthesis of DNA. It is responsible for converting ribonucleotides into deoxyribonucleotides, which are the building blocks of DNA.
In cancer, RNR is often overexpressed, which can contribute to the rapid growth and proliferation of cancer cells. This is because cancer cells require a constant supply of DNA building blocks to support their rapid division.

Research has shown that inhibiting RNR can be an effective way to slow down or stop the growth of cancer cells.

Scientific Papers found: Click to Expand⟱

635-

VitC,

VitK3,

The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress

in-vitro,

NA,

RNR↓, GSH↓, Trx1↓, GPx↓, lipid-P↑, AIF↑, ROS↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

GPx↓, 1, GSH↓, 1, lipid-P↑, 1, ROS↑, 1, Trx1↓, 1,

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,

Core Metabolism/Glycolysis ⓘ

RNR↓, 1,
Total Targets: 7

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: RNR, Ribonucleotide Reductase

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells