Database Query Results : , , PRC2

PRC2, Polycomb repressive complex 2: Click to Expand ⟱
Source:
Type:
Polycomb repressive complex 2 (PRC2) is a key epigenetic regulator that plays a crucial role in maintaining cellular identity and suppressing tumor formation.
PRC2 is a histone methyltransferase complex that catalyzes the trimethylation of histone H3 lysine 27 (H3K27me3), a repressive epigenetic mark that silences gene expression. PRC2 is composed of four core subunits: EZH2 (enhancer of zeste homolog 2), SUZ12, EED, and RbAp46/48.
PRC2 is often overexpressed or mutated, leading to aberrant epigenetic regulation and contributing to tumorigenesis.
EZH2, the catalytic subunit of PRC2, is often overexpressed in various types of cancer.
Scientific Papers found: Click to Expand⟱
672- EGCG,    Molecular Targets of Epigallocatechin—Gallate (EGCG): A Special Focus on Signal Transduction and Cancer
- Review, NA, NA
DNMT1↓, HDAC↓, G9a↓, PRC2↓, DNMT3A↓, 67LR↓, Apoptosis↑, TumCCA↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics ⓘ

PRC2↓, 1,  

DNA Damage & Repair ⓘ

DNMT1↓, 1,   DNMT3A↓, 1,   G9a↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,  

Migration ⓘ

67LR↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PRC2, Polycomb repressive complex 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:833  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page