Database Query Results : , , H3

H3, Histone 3: Click to Expand ⟱
Source:
Type:
Histone 3 (H3) is a protein that is a component of chromatin, the complex of DNA and proteins that makes up the chromosomes in the nucleus of eukaryotic cells. H3 is one of the five main histone proteins, and it plays a crucial role in the regulation of gene expression and the maintenance of chromatin structure.
H3 has been found to be overexpressed in various types of cancer, including breast, prostate, lung, and colon cancer.
Scientific Papers found: Click to Expand⟱
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
4981- ATV,    Crosstalk between Statins and Cancer Prevention and Therapy: An Update
Apoptosis↑, selectivity↑, eff↑, HMG-CoA↓, *cardioP↑, OS↑, IL1β↓, IL6↓, IL8↓, TNF-α↓, TumAuto↑, Histones↝, ac‑H3↑, ac‑H4↑, HDAC↓,
2699- BBR,    Plant Isoquinoline Alkaloid Berberine Exhibits Chromatin Remodeling by Modulation of Histone Deacetylase To Induce Growth Arrest and Apoptosis in the A549 Cell Line
- in-vitro, Lung, A549
HDAC↓, TumCCA↑, TNF-α↓, COX2↓, MMP2↓, MMP9↓, P21↑, P53↑, Casp↑, ac‑H3↑, ac‑H4↑, ROS↑, MMP↓,
3236- EGCG,  BA,    Molecular mechanisms for inhibition of colon cancer cells by combined epigenetic-modulating epigallocatechin gallate and sodium butyrate
- in-vitro, Colon, RKO - in-vitro, Colon, HCT116 - in-vitro, Colon, HT29
Apoptosis↑, TumCCA?, HDAC1↓, DNMT1↓, survivin↓, HDAC↓, P21↑, NF-kB↑, γH2AX↑, ac‑H3↑, DNAdam↑,
1516- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*Dose∅, Half-Life∅, BioAv∅, BBB↑, toxicity∅, eff↓, Apoptosis↑, Casp3↑, Cyt‑c↑, cl‑PARP↑, DNMTs↓, Telomerase↓, angioG↓, Hif1a↓, NF-kB↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, IGF-1↓, H3↓, HDAC1↓, *LDH↓, *ROS↓,
1503- EGCG,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, NA, NA
selectivity↑, DNMT1↓, RECK↑, MMPs↓, TumCI↓, angioG↓, TumMeta↓, HATs↓, IκB↑, NF-kB↓, IL6↓, COX2↓, NOS2↓, ac‑H3↑, ac‑H4↑, eff↑,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2↓, IAP2↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
798- GAR,    Garcinol, an acetyltransferase inhibitor, suppresses proliferation of breast cancer cell line MCF-7 promoted by 17β-estradiol
- in-vitro, BC, MCF-7
TumCP↓, TumCCA↑, Apoptosis↑, ac‑H3↑, ac‑H4∅, NF-kB↓, ac‑p65↑, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓,
1504- GEN,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, NA, NA
DNMTs↓, P21↑, p16↑, ac‑H3↑, ac‑H4↑, TumCCA↑, Casp↑, Apoptosis↑, hTERT/TERT↓, BTG3↑,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp↓, Half-Life↓, Half-Life↝, eff↑, BioAv↓,
2875- HNK,    Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo
- in-vitro, Lung, A549 - in-vitro, Lung, H1299 - in-vitro, Lung, H460 - in-vitro, SCC, H226
HDAC↓, tumCV↓, TumCCA↑, cycD1/CCND1↓, ac‑H3↑, ac‑H4↑, selectivity↑, CDK2↓, CDK4↓,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
2927- LT,    Luteolin Causes 5′CpG Demethylation of the Promoters of TSGs and Modulates the Aberrant Histone Modifications, Restoring the Expression of TSGs in Human Cancer Cells
- in-vitro, Cerv, HeLa
TumCMig↓, DNMTs↓, HDAC↓, HATs↓, ac‑H3↓, ac‑H4↓, MMP2↓, MMP9↓, HO-1↓, E-cadherin↑, EZH2↓, HER2/EBBR2↓, IL18↓, IL8↓, IL2↓,
2049- PB,    Modifying histones to tame cancer: clinical development of sodium phenylbutyrate and other histone deacetylase inhibitors
- Review, Var, NA
HDAC↓, ac‑H3↑, ac‑H4↑, ac‑H3↑, eff↝, toxicity↓,
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27↑, CDK1↓, p‑CDK1↓, cycA1/CCNA1↓, CycB/CCNB1↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1/CCND1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
3357- QC,    The polyphenol quercetin induces cell death in leukemia by targeting epigenetic regulators of pro-apoptotic genes
- in-vitro, AML, HL-60 - NA, NA, U937
DNMT1↓, DNMT3A↓, HDAC↓, ac‑H3↑, ac‑H4↑, BAX↑, APAF1↑, BNIP3↑, STAT3↑,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, eff↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, eff↑, eff↑, eff↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
4198- SFN,    Sulforaphane epigenetically enhances neuronal BDNF expression and TrkB signaling pathways
- vitro+vivo, AD, NA
*TrkB↑, *CREB↑, CaMKII ↑, *ERK↑, *ac‑H3↑, *ac‑H4↑, *HDAC↓, *HDAC2↓, *BDNF↑,
3661- SFN,    Beneficial Effects of Sulforaphane Treatment in Alzheimer's Disease May Be Mediated through Reduced HDAC1/3 and Increased P75NTR Expression
- in-vitro, AD, NA
*cognitive↑, *HDAC1↓, *HDAC2↓, *HDAC3↓, *H3↑, *H4↑, *Aβ↓, *BioAv↑, *BBB↑, *neuroP↑,
1725- SFN,    Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway
- Review, Var, NA
*toxicity∅, AntiCan↑, antiOx↑, NRF2↑, DNMTs↓, HDAC↓, Hif1a↓, VEGF↓, P21↑, TumCCA↑, ac‑H3↑, ac‑H4↑, DNAdam↑, Dose↝,
1453- SFN,    Sulforaphane Reduces Prostate Cancer Cell Growth and Proliferation In Vitro by Modulating the Cdk-Cyclin Axis and Expression of the CD44 Variants 4, 5, and 7
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCG↓, TumCP↓, TumCCA↑, H3↑, H4↑, HDAC↓, CDK1↑, CDK2↑, p19↑, *BioAv↑,
1434- SFN,  GEM,    Sulforaphane Potentiates Gemcitabine-Mediated Anti-Cancer Effects against Intrahepatic Cholangiocarcinoma by Inhibiting HDAC Activity
- in-vitro, CCA, HuCCT1 - in-vitro, CCA, HuH28 - in-vivo, NA, NA
HDAC↓, ac‑H3↑, ChemoSen↑, tumCV↓, TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, TumCI↓, VEGF↓, VEGFR2↓, Hif1a↓, eNOS↓, EMT?, TumCG↓, Ki-67↓, TUNEL↑, P21↑, p‑Chk2↑, CDC25↓, BAX↑, *ROS↓, NQO1?,
1497- SFN,    Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells
- in-vitro, Nor, PrEC - in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
HDAC↓, selectivity↑, TumCCA↑, Apoptosis↑, selectivity↑, H3↑, P21↑, selectivity↑,
1471- SFN,    ROS-mediated activation of AMPK plays a critical role in sulforaphane-induced apoptosis and mitotic arrest in AGS human gastric cancer cells
- in-vitro, GC, AGS
TumCP↓, Apoptosis↑, TumCCA↑, CycB/CCNB1↑, P21↑, p‑H3↑, p‑AMPK↑, eff↓, MMP↓, Cyt‑c↑, ROS↑, eff↓,
2164- SFN,  dietP,    Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in HDAC3 Protein Expression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice
- in-vitro, Pca, NA
HDAC↓, Dose↝, Risk↓, TumCP↓, H3↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 25

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   ATF3↑, 1,   Catalase↓, 1,   CYP1A1↓, 1,   GPx↓, 1,   GSH↓, 2,   GSR↓, 1,   GSR↑, 1,   GSTs↓, 1,   HO-1↓, 2,   HO-1↑, 1,   lipid-P↑, 2,   NQO1?, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 4,   ROS↓, 1,   ROS↑, 9,   mt-ROS↑, 1,   SIRT3↑, 2,   SOD↓, 1,   SOD2↓, 1,   VitC↓, 1,   VitE↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   CDC2↓, 2,   CDC25↓, 2,   mitResp↓, 1,   MMP↓, 8,   c-Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   p‑AMPK↑, 1,   ATG7↑, 1,   cMyc↓, 2,   Histones↝, 1,   HK2↓, 1,   HMG-CoA↓, 1,   LDHA↓, 2,   NADPH↑, 1,   PCK1↓, 1,   PFK↓, 1,   PKM2↓, 1,   SIRT1↓, 1,  

Cell Death ⓘ

Akt↓, 3,   p‑Akt↓, 2,   APAF1↑, 1,   Apoptosis↑, 9,   Bak↑, 1,   BAX↑, 6,   Bcl-2↓, 5,   Bcl-xL↓, 2,   BTG3↑, 1,   Casp↑, 3,   Casp1↓, 1,   Casp3↓, 1,   Casp3↑, 4,   cl‑Casp3↑, 3,   Casp8↑, 1,   cl‑Casp8↑, 2,   Casp9↑, 2,   cl‑Casp9↑, 1,   cFLIP↓, 1,   Chk2↓, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   Cyt‑c↑, 7,   Diablo↑, 2,   DR5↑, 3,   Fas↑, 2,   FasL↑, 1,   HEY1↓, 1,   HGF/c-Met↓, 1,   hTERT/TERT↓, 1,   IAP2↓, 1,   iNOS↓, 1,   JNK↑, 1,   p‑JNK↑, 1,   MAPK↓, 3,   MAPK↑, 1,   Mcl-1↓, 1,   Mcl-1↑, 1,   p‑MDM2↓, 1,   p27↑, 1,   p38↑, 1,   p‑p38↓, 1,   p‑p38↑, 1,   PUMA↑, 1,   survivin↓, 3,   Telomerase↓, 1,   TumCD↑, 1,   TUNEL↑, 1,  

Kinase & Signal Transduction ⓘ

CaMKII ↑, 1,   EF-1α↓, 1,   HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

cJun↑, 1,   EZH2↓, 1,   H3↓, 4,   H3↑, 4,   p‑H3↓, 1,   p‑H3↑, 1,   ac‑H3↓, 1,   ac‑H3↑, 13,   H4↓, 1,   H4↑, 2,   ac‑H4↓, 1,   ac‑H4↑, 9,   ac‑H4∅, 1,   HATs↓, 2,   HATs↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

CHOP↑, 2,   cl‑CHOP↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 4,   GRP78/BiP↑, 2,   HSP90↓, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 2,   Beclin-1↑, 1,   BNIP3↑, 1,   LC3II↑, 2,   LC3s↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

ATM↑, 1,   CHK1↓, 1,   CHK1↑, 1,   DNAdam↑, 2,   DNMT1↓, 3,   DNMT3A↓, 1,   DNMTs↓, 5,   p16↑, 1,   P53↑, 5,   PARP↑, 2,   cl‑PARP↑, 4,   PARP1↑, 1,   PCNA↓, 4,   γH2AX↑, 2,  

Cell Cycle & Senescence ⓘ

CDK1↓, 2,   CDK1↑, 1,   p‑CDK1↓, 1,   CDK2↓, 4,   CDK2↑, 1,   CDK4↓, 5,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 2,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 6,   cycE/CCNE↓, 1,   p19↑, 1,   P21?, 1,   P21↑, 9,   p‑RB1↓, 2,   TumCCA?, 1,   TumCCA↑, 14,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   CD34↓, 1,   cFos↑, 1,   CSCs↓, 2,   EMT?, 1,   EMT↓, 4,   p‑ERK↓, 1,   FOXO3↓, 1,   FOXO3↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   HDAC↓, 15,   HDAC1↓, 2,   IGF-1↓, 1,   mTOR↓, 1,   p‑mTOR↓, 1,   mTORC1↓, 2,   mTORC2↓, 1,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   NOTCH1↓, 2,   NOTCH3↓, 1,   OCT4↓, 1,   P70S6K↓, 1,   PI3K↓, 2,   p‑PI3K↓, 1,   PTEN↓, 1,   PTEN↑, 2,   RAS↓, 1,   SOX2↓, 1,   p‑Src↓, 1,   STAT3↓, 5,   STAT3↑, 1,   p‑STAT6↓, 1,   TumCG↓, 2,  

Migration ⓘ

AntiAg↓, 1,   AP-1↓, 1,   AXL↓, 1,   Ca+2↑, 1,   i-Ca+2↑, 1,   Cdc42↓, 1,   CEA↓, 1,   CLDN1↓, 1,   CLDN2↓, 2,   CXCL12↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 3,   ER-α36↓, 1,   FAK↓, 1,   ITGB1↓, 1,   Ki-67↓, 3,   MET↓, 1,   p‑MET↓, 1,   MMP13↓, 1,   MMP2↓, 5,   MMP7↓, 1,   MMP9↓, 4,   MMPs↓, 6,   N-cadherin↓, 3,   PKCδ↓, 1,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 2,   Slug↓, 1,   Snail↓, 3,   SOX4↓, 1,   TGF-β↓, 1,   TSP-1↑, 1,   TumCI↓, 3,   TumCMig↓, 3,   TumCP↓, 6,   TumMeta↓, 3,   Tyro3↓, 1,   uPA↓, 3,   Vim↓, 2,   Vim↑, 1,   Zeb1↓, 1,   ZO-1↑, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 3,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 4,   ATF4↑, 1,   EGFR↓, 1,   EGFR↑, 1,   eNOS↓, 1,   Hif1a↓, 5,   NO↓, 1,   PDGFR-BB↓, 1,   VEGF↓, 6,   VEGFR2↓, 4,  

Barriers & Transport ⓘ

BBB↑, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

ASC↓, 1,   COX2↓, 5,   CXCR4↓, 1,   ICAM-1↓, 1,   IKKα↓, 2,   IL10↓, 1,   IL18↓, 1,   IL1β↓, 1,   IL2↓, 1,   IL2↑, 1,   IL6↓, 4,   IL8↓, 2,   IκB↑, 1,   JAK1↓, 1,   NF-kB↓, 8,   NF-kB↑, 1,   p65↓, 1,   p‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 1,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 3,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv∅, 1,   ChemoSen↑, 5,   Dose↝, 4,   eff↓, 3,   eff↑, 13,   eff↝, 1,   Half-Life↓, 2,   Half-Life↝, 1,   Half-Life∅, 1,   RadioS↑, 2,   selectivity↑, 7,  

Clinical Biomarkers ⓘ

AR↓, 1,   CEA↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 1,   EGFR↑, 1,   EZH2↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 4,   Ki-67↓, 3,   NOS2↓, 1,   NSE↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cachexia↓, 1,   chemoP↑, 2,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 2,   RenoP↑, 2,   Risk↓, 1,   toxicity↓, 1,   toxicity∅, 1,  
Total Targets: 314

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   GSTs↑, 1,   lipid-P↓, 1,   Prx↑, 1,   ROS↓, 3,   SOD↑, 1,   SOD2↑, 1,  

Core Metabolism/Glycolysis ⓘ

CREB↑, 1,   LDH↓, 1,  

Cell Death ⓘ

Casp3?, 1,   Casp3↓, 1,  

Transcription & Epigenetics ⓘ

H3↑, 1,   ac‑H3↑, 1,   H4↑, 1,   ac‑H4↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,   HDAC↓, 1,   HDAC1↓, 1,   HDAC2↓, 2,   HDAC3↓, 1,  

Barriers & Transport ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling ⓘ

IL10↑, 1,   IL1β↓, 1,   Inflam↓, 3,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,   TrkB↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 2,   Dose∅, 1,   eff↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

LDH↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cardioP↑, 1,   cognitive↑, 1,   neuroP↑, 2,   toxicity↓, 1,   toxicity∅, 1,  
Total Targets: 42

Scientific Paper Hit Count for: H3, Histone 3
8 Sulforaphane (mainly Broccoli)
3 EGCG (Epigallocatechin Gallate)
2 Honokiol
2 Luteolin
2 Quercetin
1 Ashwagandha(Withaferin A)
1 Atorvastatin
1 Berberine
1 Butyrate
1 Fisetin
1 Garcinol
1 Genistein (soy isoflavone)
1 Phenylbutyrate
1 Propolis -bee glue
1 Gemcitabine (Gemzar)
1 diet Plant based
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:890  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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