Database Query Results : , , tumCV

tumCV, Cell Viability: Click to Expand ⟱

Source:

Type:

Cell Viability

Scientific Papers found: Click to Expand⟱

239-

AL,

Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways

in-vitro,

GC,

SGC-7901

 30ug/ml

Apoptosis↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, Fas↑, tumCV↓, DNAdam↑, ROS↑, Telomerase↓,

246-

AL,

Allicin induces apoptosis of the MGC-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway

in-vitro,

GC,

MGC803

 0-10ug/ml

Apoptosis↑, cl‑Casp3↑, p38↑, tumCV↓, BAX↑, Bcl-2↑,

250-

AL,

Allicin Induces p53-Mediated Autophagy in Hep G2 Human Liver Cancer Cells

in-vitro,

Liver,

HepG2

 35uM

P53↓, PI3K↓, mTOR↓, Bcl-2↓, AMPK↑, TSC2↑, Beclin-1↑, TumAuto↑, tumCV↓, ATG7↑, MMP↓,

2646-

AL,

Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress

in-vitro,

Pca,

DU145

in-vitro,

Melanoma,

RPMI-8226

AntiCan↑, eff↓, ChemoSen↑, ER Stress↑, tumCV↓, DNAdam↑, GSH∅, HSP70/HSPA5↓, UPR↑, β-catenin/ZEB1↓, ROS↑, HO-2↑, SIRT1↑, GlucoseCon∅, lactateProd∅, chemoP↑,

3434-

ALA,

Alpha lipoic acid modulates metabolic reprogramming in breast cancer stem cells enriched 3D spheroids by targeting phosphoinositide 3-kinase: In silico and in vitro insights

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

tumCV↓, PI3K↓, p‑Akt↓, p‑P70S6K↓, mTOR↓, ATP↓, GlucoseCon↓, ROS↑, PKM2↓, LDHA↓, Glycolysis↓, ChemoSen↑,

3442-

ALA,

α‑lipoic acid modulates prostate cancer cell growth and bone cell differentiation

in-vitro,

Pca,

22Rv1

in-vitro,

Pca,

C4-2B

in-vitro,

Nor,

3T3

tumCV↓, TumCMig↓, TumCI↓, ROS↑, Hif1a↑, JNK↑, Casp↑, TumCCA↑, Apoptosis↑, selectivity↑,

1007-

And,

In vitro and in silico evaluation of Andrographis paniculata ethanolic crude extracts on fatty acid synthase expression on breast cancer cells

in-vitro,

BC,

MCF-7

mice

in-vitro,

BC,

EMT6

tumCV↓, i-FASN↓,

1024-

Api,

CUR,

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects

vitro+vivo,

Melanoma,

A375

 (30 μM) for 24 h

in-vitro,

Melanoma,

A2058

in-vitro,

Melanoma,

RPMI-7951

TumCG↓, Apoptosis↑, PD-L1↓, STAT1↓, tumCV↓, T-Cell↑,

1008-

Api,

Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling

in-vitro,

CRC,

HCT116

0-50uM

38.15 ± 1.32 μM

in-vitro,

CRC,

SW480

Wnt/(β-catenin)↓, β-catenin/ZEB1↓, TumAuto↑, Akt↓, mTOR↓, tumCV↓, TumCCA↑, TumAuto↑, p‑Akt↓, p‑p70S6↓, p‑4E-BP1↓,

1536-

Api,

Apigenin causes necroptosis by inducing ROS accumulation, mitochondrial dysfunction, and ATP depletion in malignant mesothelioma cells

in-vitro,

MM,

MSTO-211H

0, 10, 30, and 50 µM) of apigenin for 48 h and 72 h

in-vitro,

MM,

H2452

tumCV↓, ROS↑, MMP↓, ATP↓, Apoptosis↑, Necroptosis↑, DNAdam↑, TumCCA↑, Casp3↑, cl‑PARP↑, MLKL↑, p‑RIP3↑, Bax:Bcl2↑, eff↓, eff↓,

1563-

Api,

MET,

Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells

in-vitro,

Nor,

HDFa

metformin (5 mM), apigenin (1 or 20 µM),

in-vitro,

PC,

AsPC-1

in-vitro,

PC,

MIA PaCa-2

in-vitro,

Pca,

DU145

in-vitro,

Pca,

LNCaP

in-vivo,

NA,

mice

selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,

2576-

ART/DHA,

AL,

The Synergistic Anticancer Effect of Artesunate Combined with Allicin in Osteosarcoma Cell Line in Vitro and in Vivo

in-vitro,

OS,

MG63

in-vivo,

NA,

0 mg/kg per
day, i.p.), allicin (5 mg/kg per day, i.p.)

mice

eff↑, tumCV↓, Casp3↑, Casp9↑, Apoptosis↑, TumCG↓,

1368-

Ash,

Cisplatin,

Withania somnifera Root Extract Enhances Chemotherapy through ‘Priming’

in-vitro,

Colon,

HT-29

1 μg/mL, 5 μg/mL and 10 μg/mL W. somnifera for 48 h

in-vitro,

BC,

MDA-MB-231

tumCV↓, *toxicity↓, ROS↑, mitResp↓, ChemoSen↑,

1369-

Ash,

Withaferin A inhibits cell proliferation of U266B1 and IM-9 human myeloma cells by inducing intrinsic apoptosis

in-vitro,

Melanoma,

U266

9 μM

tumCV↓, Apoptosis↑, BAX↑, Cyt‑c↑, Bcl-2↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, ROS↑, eff↓,

1433-

Ash,

SFN,

A Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer Cells

in-vitro,

BC,

MCF-7

1.0 µM WA and 5.0 µM SFN

in-vitro,

BC,

MDA-MB-231

eff↑, Bcl-2↓, BAX↑, tumCV↓, DNMT1↓, DNMT3A↓, HDAC↓,

4809-

ASTX,

Astaxanthin Inhibits Proliferation of Human Gastric Cancer Cell Lines by Interrupting Cell Cycle Progression

in-vitro,

GC,

AGS

50 and 100 μM significantly suppressed cell proliferation

could not reach IC50 even under 100 μM.

in-vitro,

GC,

MKN45

tumCV↓, TumCP↓, TumCCA↑, p‑ERK↓, p27↑, cycD1/CCND1↓, CDK4↓,

4818-

ASTX,

MEL,

Effect of astaxanthin and melatonin on cell viability and DNA damage in human breast cancer cell lines

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

T47D

in-vitro,

Nor,

MCF10

TumCD↑, DNAdam↑, *antiOx↑, *AntiTum↑, Inflam↓, tumCV↓, Bcl-2↓, Apoptosis↓, selectivity↑, eff↑, Dose↓,

4822-

ASTX,

Rad,

Astaxanthin Synergizes with Ionizing Radiation (IR) in Oral Squamous Cell Carcinoma (OSCC)

tumCV↓, selectivity↑, RadioS↑, GPx4↓, Ferroptosis↑,

1533-

Ba,

Baicalein, as a Prooxidant, Triggers Mitochondrial Apoptosis in MCF-7 Human Breast Cancer Cells Through Mobilization of Intracellular Copper and Reactive Oxygen Species Generation

in-vitro,

BrCC,

MCF-7

85μM for 24 h

in-vitro,

Nor,

MCF10

557uM

tumCV↓, i-ROS↑, MMP↓, Bcl-2↓, BAX↑, Cyt‑c↑, Casp9↑, Casp3↑, eff↓, selectivity↑, *toxicity∅, Apoptosis↑, Fenton↑,

1529-

Ba,

Studies on the Inhibitory Mechanisms of Baicalein in B16F10 Melanoma Cell Proliferation

in-vitro,

Melanoma,

B16-F10

ROS↑, eff↓, tumCV↓, Casp3↑, necrosis↑,

2475-

Ba,

Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis

in-vitro,

CRC,

HCT116

in-vitro,

CRC,

DLD1

in-vivo,

NA,

(10, 20 mg/kg, i.g., every two days for two weeks)

CRC xenograft mouse model,

tumCV↓, GPx4↓, STAT3↓, Ferroptosis↑,

1396-

BBR,

Berberine induced down-regulation of matrix metalloproteinase-1, -2 and -9 in human gastric cancer cells (SNU-5) in vitro

in-vitro,

GC,

SNU1041

in-vitro,

GC,

SNU5

tumCV↓, ROS↑, MMP1↓, MMP2↓, MMP9↓, MMP7∅,

1402-

BBR,

Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction

in-vitro,

GBM,

T98G

tumCV↓, ROS↑, Ca+2↑, ER Stress↑, eff↓, Bax:Bcl2↑, MMP↓, Casp9↑, Casp3↑, cl‑PARP↑,

1386-

BBR,

Berberine-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species generation and mitochondrial-related apoptotic pathway

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

tumCV↓, ROS↑, JNK↑, MMP↓, Bcl-2↓, BAX↑, Cyt‑c↑, AIF↝,

2715-

BBR,

Rad,

Berberine Can Amplify Cytotoxic Effect of Radiotherapy by Targeting Cancer Stem Cells

in-vitro,

BC,

MCF-7

tumCV↓, OCT4↓, SOX2↓, RadioS↑, CSCs↓,

2691-

BBR,

Berberine induces FasL-related apoptosis through p38 activation in KB human oral cancer cells

in-vitro,

Oral,

tumCV↓, DNAdam↑, Casp3↑, Casp7↑, FasL↑, Casp8↑, Casp9↑, PARP↑, BAX↑, BAD↑, APAF1↑, MMP2↓, MMP9↓, p‑p38↑, ERK↑, MAPK↑,

2751-

BetA,

Betulinic acid inhibits proliferation and triggers apoptosis in human breast cancer cells by modulating ER (α/β) and p53

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

MCF-7

tumCV↓, ER-α36↓,

2750-

BetA,

GEM,

Betulinic acid, a major therapeutic triterpene of Celastrus orbiculatus Thunb., acts as a chemosensitizer of gemcitabine by promoting Chk1 degradation

in-vitro,

PC,

Bxpc-3

in-vitro,

Lung,

H1299

CHK1↓, ChemoSen↑, tumCV↓, Apoptosis↑, DNAdam↑,

2742-

BetA,

Betulinic acid impairs metastasis and reduces immunosuppressive cells in breast cancer models

in-vitro,

BC,

MDA-MB-231

in-vivo,

BC,

4T1

intraperitoneal administration of 10 mg/kg/day BA

in-vitro,

BC,

MCF-7

tumCV↓, TumCMig↓, TumCI↓, STAT3↑, FAK↓, MMPs↓, MMP2↓, MMP9↓, TIMP2↑,

2757-

BetA,

Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO-1 Pathways

in-vitro,

GBM,

U251

tumCV↓, TumCMig↓, TumCI↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, Ferroptosis↑, HO-1↑, NRF2↑,

2723-

BetA,

Betulinic acid and oleanolic acid modulate CD81 expression and induce apoptosis in triple-negative breast cancer cells through ROS generation

in-vitro,

BC,

MDA-MB-231

Apoptosis↑, tumCV↓, ROS↑,

2726-

BetA,

Betulinic acid induces DNA damage and apoptosis in SiHa cells

in-vitro,

Cerv,

SiHa

39.83 μg/ml

tumCV↓, DNAdam↑, MMP↓, ROS↑, TumCCA↑, TOP1↓,

2734-

BetA,

Betulinic Acid Modulates the Expression of HSPA and Activates Apoptosis in Two Cell Lines of Human Colorectal Cancer

in-vitro,

CRC,

HCT116

6.441 µg/mL (14.15 µM)

in-vitro,

CRC,

SW480

1.67 µg/mL (3.670 µM)

tumCV↓, HSP70/HSPA5⇅, ROS↑, cl‑Casp3↑, mt-Apoptosis↑, Dose↝,

2730-

BetA,

Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells

in-vitro,

Bladder,

T24

tumCV↓, TumCP↓, TumCMig↓, Casp↑, TumAuto↑, LC3B-II↑, p‑AMPK↑, mTOR↓, BMI1↓, ROS↑, eff↓,

725-

Bor,

Boric acid exert anti-cancer effect in poorly differentiated hepatocellular carcinoma cells via inhibition of AKT signaling pathway

in-vitro,

HCC,

tumCV↓, Apoptosis↑, TumAuto↑, p‑Akt↓,

1424-

Bos,

Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells

in-vitro,

BC,

T47D

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

tumCV↓, Apoptosis↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑,

1447-

Bos,

Boswellia carterii n-hexane extract suppresses breast cancer growth via induction of ferroptosis by downregulated GPX4 and upregulated transferrin

in-vitro,

BC,

MDA-MB-231

1-100uM BCHE

in-vitro,

BC,

MCF-7

in-vivo,

BC,

4T1

400-800 mg/kg

mouse BC 4T1

in-vitro,

Nor,

MCF10

tumCV↓, AntiCan↑, *toxicity↓, Ferroptosis↑, i-Iron↑, GPx4↓, ROS↑, lipid-P↑, Tf↑, TumCG↓,

1104-

CAR,

Carvacrol Ameliorates Transforming Growth Factor-β1-Induced Extracellular Matrix Deposition and Reduces Epithelial-Mesenchymal Transition by Regulating The Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway In Hk-2 Cells

in-vitro,

Kidney,

HK-2

tumCV↓, COL4↓, COL1↓, Fibronectin↓, E-cadherin↑, Snail↑, Vim↑, α-SMA↑, PI3K↓, Akt↓,

939-

Catechins,

5-FU,

Targeting Lactate Dehydrogenase A with Catechin Resensitizes SNU620/5FU Gastric Cancer Cells to 5-Fluorouracil

vitro+vivo,

GC,

SNU620

lactateProd↓, ROS↑, tumCV↓, LDHA↓, mt-ROS↑, proApCas↑,

4493-

Chit,

Selenate,

Se,

A novel synthetic chitosan selenate (CS) induces apoptosis in A549 lung cancer cells via the Fas/FasL pathway

in-vitro,

Lung,

A549

tumCV↓, Apoptosis↑, TumCCA↑, Fas↑, FasL↑, FADD↑, Casp↑,

1145-

CHr,

Chrysin inhibits propagation of HeLa cells by attenuating cell survival and inducing apoptotic pathways

in-vitro,

Cerv,

HeLa

tumCV↓, BAX↑, BID↑, BOK↑, APAF1↑, TNF-α↑, FasL↑, Fas↑, FADD↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Mcl-1↓, NAIP↓, Bcl-2↓, CDK4↓, CycB/CCNB1↓, cycD1/CCND1↓, cycE1↓, TRAIL↑, p‑Akt↓, Akt↓, mTOR↓, PDK1↓, BAD↓, GSK‐3β↑, AMPK↑, p27↑, P53↑,

2797-

CHr,

A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells

in-vivo,

BC,

40-100 uM

metastasis mouse model of breast cancer

in-vitro,

BC,

4T1

100 and 250 mg/kg daily

tumCV↓, p‑STAT3↓, VEGF↓, Weight∅, angioG↓,

2787-

CHr,

Network pharmacology unveils the intricate molecular landscape of Chrysin in breast cancer therapeutics

Analysis,

Var,

MCF-7

22.55 µM

TumCP↓, angioG↓, TumCI↓, TumMeta↓, TP53↑, Akt↓, Casp3↑, tumCV↓, TNF-α↓, BioAv↑, BioAv↑, AKT1↓,

1584-

Citrate,

Anticancer effects of high-dose extracellular citrate treatment in pancreatic cancer cells under different glucose concentrations

in-vitro,

PC,

MIA PaCa-2

in-vitro,

PC,

PANC1

tumCV↓, i-Ca+2↓, TumCMig↓, CD133↓, pH↑, eff↑, Ki-67↓, eff↑,

1592-

Citrate,

Inhibition of Mcl-1 expression by citrate enhances the effect of Bcl-xL inhibitors on human ovarian carcinoma cells

in-vitro,

Ovarian,

SKOV3

5mM,10mM

in-vitro,

Ovarian,

IGROV1

eff↑, tumCV↓, Mcl-1↓, eff↑,

1593-

Citrate,

Citrate Induces Apoptotic Cell Death: A Promising Way to Treat Gastric Carcinoma?

in-vitro,

GC,

BGC-823

10mM

in-vitro,

GC,

SGC-7901

PFK↓, Glycolysis↓, tumCV↓, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, ATP↓, ChemoSen↑, Mcl-1↓, glucoNG↑, FBPase↑, OXPHOS↓, TCA↓, β-oxidation↓, HK2↓, PDH↓, ROS↑,

4776-

CoQ10,

Antitumor properties of Coenzyme Q0 against human ovarian carcinoma cells via induction of ROS-mediated apoptosis and cytoprotective autophagy

vitro+vivo,

Ovarian,

SKOV3

(SKOV-3) cells and xenografted nude mice

ROS↑, eff↓, AntiCan↑, Apoptosis↑, tumCV↓, TumCG↓, TumCCA↑, LC3s↑, ERStress↑, Beclin-1↑, Bax:Bcl2↑, HER2/EBBR2↓, Akt↓, mTOR↓,

4764-

CoQ10,

VitE,

Auxiliary effect of trolox on coenzyme Q10 restricts angiogenesis and proliferation of retinoblastoma cells via the ERK/Akt pathway

in-vitro,

RPE,

Y79

in-vitro,

Nor,

ARPE-19

in-vivo,

NA,

tumCV↓, Apoptosis↑, ROS↑, MMP↓, TumCCA↑, VEGF↓, ERK↓, Akt↓, ChemoSen↑, chemoP↑, toxicity↓, angioG↓,

1642-

Cu,

HCAs,

Copper-assisted anticancer activity of hydroxycinnamic acid terpyridine conjugates on triple-negative breast cancer

in-vitro,

BC,

4T1

(IC50 ∼ 3.5 ± 2.5 μM

in-vitro,

Nor,

L929

IC50 ∼ 15 ± 5 μM

tumCV↓, selectivity↑,

1639-

Cu,

HCAs,

Green synthesis of copper oxide nanoparticles using sinapic acid: an underpinning step towards antiangiogenic therapy for breast cancer

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

angioG↓, tumCV↓, Dose↓, ROS↑,

1410-

CUR,

Curcumin induces ferroptosis and apoptosis in osteosarcoma cells by regulating Nrf2/GPX4 signaling pathway

vitro+vivo,

OS,

MG63

tumCV↓, Apoptosis↑, TumCG↓, NRF2↓, GPx4↓, HO-1↓, xCT↓, ROS↑, MDA↑, GSH↓,

2304-

CUR,

Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition

in-vitro,

Lung,

H1299

0–20 μM curcumin for 24

in-vitro,

BC,

MCF-7

in-vitro,

Cerv,

HeLa

in-vitro,

Pca,

PC3

in-vitro,

Nor,

HEK293

Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, mTOR↓, Hif1a↓, selectivity↑, Dose↝, tumCV↓,

2976-

CUR,

Curcumin suppresses the proliferation of oral squamous cell carcinoma through a specificity protein 1/nuclear factor‑κB‑dependent pathway

in-vitro,

Oral,

HSC3

in-vitro,

HNSCC,

CAL33

tumCV↓, Sp1/3/4↓, p65↓, HSF1↓, NF-kB↓,

2820-

CUR,

Hepatoprotective Effect of Curcumin on Hepatocellular Carcinoma Through Autophagic and Apoptic Pathways

in-vitro,

HCC,

HepG2

50 μM

*hepatoP↑, *ROS↓, tumCV↓,

872-

CUR,

RES,

New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects

in-vitro,

BC,

TUBO

15uM, 15uM

in-vitro,

BC,

SALTO

TumCP↓, tumCV↓, p62↓, p62↑, TumAuto↑, TumAuto↓, ROS↑, ROS↓, CHOP↑,

1878-

DCA,

5-FU,

Synergistic Antitumor Effect of Dichloroacetate in Combination with 5-Fluorouracil in Colorectal Cancer

in-vitro,

CRC,

LS174T

57mM

in-vitro,

CRC,

LoVo

29mM

in-vitro,

CRC,

SW-620

38mM

in-vitro,

CRC,

HT-29

47mM

tumCV↓, eff↑, PDKs↓, lactateProd↓, Glycolysis↓, mitResp↑, TumCCA↑, Bcl-2↓, BAX↑, Casp3↑,

4913-

DSF,

Anticancer effects of disulfiram: a systematic review of in vitro, animal, and human studies

Review,

Var,

Apoptosis↑, tumCV↑, eff↑, toxicity↓, antiNeop↑, ChemoSen↑, RadioS↑, OS↑, ROS↑, SOD↓, MMP1↓, eff↑, Half-Life↓,

1605-

EA,

Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence

Review,

Var,

*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,

3241-

EGCG,

Epigallocatechin gallate triggers apoptosis by suppressing de novo lipogenesis in colorectal carcinoma cells

in-vitro,

CRC,

HCT116

0.5 ± 0.05 mm

in-vitro,

CRC,

HT29

0.8 ± 0.06 mm

in-vitro,

Liver,

HepG2

 > 1 mm

in-vitro,

Liver,

HUH7

 > 1 mm

tumCV↓, mtDam↑, Apoptosis↑, ATP↓, lipoGen↓, eff↑,

1321-

EMD,

Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: roles of apoptotic cell death and LS1034 tumor xenografts model

in-vitro,

CRC,

LS1034

in-vivo,

NA,

mice

tumCV↓, TumCCA↑, ROS↑, Ca+2↑, MMP↓, Apoptosis↑, Cyt‑c↑, Casp9↑, Bax:Bcl2↑,

1332-

EMD,

Induction of Apoptosis in HepaRG Cell Line by Aloe-Emodin through Generation of Reactive Oxygen Species and the Mitochondrial Pathway

in-vivo,

Nor,

HepaRG

rata

*tumCV↓, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↑, *Bax:Bcl2↑, *Casp3↑, *Casp8↑, *Casp9↑, *cl‑PARP↑, *TumCCA↑, *P21↑, *cycE/CCNE↑, *cycA1/CCNA1↓, *CDK2↓,

1330-

EMD,

Aloe emodin-induced apoptosis in t-HSC/Cl-6 cells involves a mitochondria-mediated pathway

in-vitro,

NA,

12.5, 25, or 50 microM

tumCV↓, Casp3↑, Casp9↑, MMP↓, Cyt‑c↑, BAX↑, Bax:Bcl2↑,

3460-

EP,

Picosecond pulsed electric fields induce apoptosis in HeLa cells via the endoplasmic reticulum stress and caspase-dependent signaling pathways

in-vitro,

Cerv,

HeLa

tumCV↓, Apoptosis↑, TumCCA↑, GRP78/BiP↑, GRP94↑, CEBPA↑, CHOP↑, Ca+2↑, Casp12↑, Casp9↑, Casp3↑, Cyt‑c↑, BAX↑, Bcl-2↓, ER Stress↑, MMP↓,

975-

Est,

Estrogen inhibits autophagy and promotes growth of endometrial cancer by promoting glutamine metabolism

vitro+vivo,

UEC,

GLS↑, cMyc↑, GlutMet↑, tumCV↑, TumAuto↓,

1114-

The Potential Effect of Fucoidan on Inhibiting Epithelial-to-Mesenchymal Transition, Proliferation, and Increase in Apoptosis for Endometriosis Treatment: In Vivo and In Vitro Study

vitro+vivo,

NA,

tumCV↓, TumCMig↓, VEGF↓, EMT↓, Apoptosis↑,

1112-

FA,

Ferulic acid exerts antitumor activity and inhibits metastasis in breast cancer cells by regulating epithelial to mesenchymal transition

in-vitro,

BC,

MDA-MB-231

in-vivo,

BC,

mouse

tumCV↓, Apoptosis↑, AntiTum↑, TumMeta↓, EMT↓, TumVol↓, TumW↓,

2844-

FIS,

Fisetin, a dietary flavonoid induces apoptosis via modulating the MAPK and PI3K/Akt signalling pathways in human osteosarcoma (U-2 OS) cells

in-vitro,

OS,

U2OS

tumCV↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, BAD↑, Bcl-2↓, Bcl-xL↓, PI3K↓, Akt↓, ERK↓, p‑JNK↑, p‑cJun↑, p‑p38↑, ROS↑, MMP↓, mTORC1↓, PTEN↑, p‑GSK‐3β↓, GSK‐3β↑, NF-kB↓, IKKα↑, Cyt‑c↑,

2847-

FIS,

Fisetin-induced cell death, apoptosis, and antimigratory effects in cholangiocarcinoma cells

in-vitro,

CCA,

tumCV↓, ChemoSen↑, TumCMig↓, ROS↑, TumCI↓, angioG↓, CDK2↓, PI3K↓, Akt↓, mTOR↓, EGFR↓, Casp↑, mTORC1↓, mTORC2↑, cycD1/CCND1↓, cycE/CCNE↓, MMP2↓, MMP9↓, ER Stress↑, Ca+2↑, eff↓,

2851-

FIS,

Apoptosis induction in breast cancer cell lines by the dietary flavonoid fisetin

in-vitro,

BC,

MDA-MB-468

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

MCF-7

in-vitro,

BC,

T47D

in-vitro,

BC,

SkBr3

in-vitro,

Nor,

tumCV↓, selectivity↑, TumCCA↑, Apoptosis↑, ROS∅,

2856-

FIS,

N -acetyl- L -cysteine enhances fisetin-induced cytotoxicity via induction of ROS-independent apoptosis in human colonic cancer cells

in-vitro,

Colon,

COLO205

eff↑, ROS↑, tumCV↓, Casp3↑, Bcl-2↓, MMP↓, eff↑,

2841-

FIS,

Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer

in-vitro,

Nor,

RAW264.7

LPS-induced Raw264.7 cells

in-vitro,

Liver,

HepG2

10, 25, 100, and 200 μM, 24 h

in-vitro,

Liver,

Hep3B

in-vitro,

Liver,

HUH7

*Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, Apoptosis↓, ER Stress↑, Ca+2↑, PERK↑, ATF4↑, CHOP↑, GRP78/BiP↑, tumCV↓, LDH↑, Casp3↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, p‑eIF2α↑, RadioS↑,

2843-

FIS,

Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential

Review,

Var,

NRF2↑, Keap1↓, ChemoSen↑, BioAv↓, Cyt‑c↑, Casp3↑, Casp9↑, BAX↑, tumCV↓, Mcl-1↓, cl‑PARP↑, IGF-1↓, Akt↓, CDK6↓, TumCCA↑, P53?, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, MMP2↓, MMP9↓, MMP1↓, MMP7↓, MMP3↓, VEGF↓, PI3K↓, mTOR↓, COX2↓, Wnt↓, EGFR↓, NF-kB↓, ERK↓, ROS↑, angioG↓, TNF-α↓, PGE2↓, iNOS↓, NO↓, IL6↓, HSP70/HSPA5↝, HSP27↝,

4027-

FulvicA,

Mummy Induces Apoptosis Through Inhibiting of Epithelial-Mesenchymal Transition (EMT) in Human Breast Cancer Cells

in-vitro,

BC,

MDA-MB-231

31.3±0.4 µg/ml

in-vitro,

BC,

MCF-7

 40±0.8µg/ml

in-vitro,

Nor,

MCF10

89.66±1.2 µg/ml

tumCV↓, selectivity↑, TGF-β↓, Twist↓, NOTCH1↓, CTNNB1↓, Src↓, E-cadherin↑, EMT↓, TumMeta↓, BioAv↑,

4025-

FulvicA,

Mumio (Shilajit) as a potential chemotherapeutic for the urinary bladder cancer treatment

in-vitro,

Bladder,

T24

Review,

AD,

tumCV↓, selectivity↑, TumCCA↑, other↝, *neuroP↑, *memory↑, *tau↓, *other↝, *lipid-P↓, *VitC↑, *antiOx↑,

4024-

FulvicA,

ANTI-CARCINOGENIC ACTIVITY OF SHILAJIT REGARDING TO APOPTOSIS ASSAY IN CANCER CELLS: A SYSTEMATIC REVIEW OF IN-VITRO STUDIES

Review,

Var,

*Inflam↓, *antiOx↑, TumCG↓, tumCV↓, ROS↑, ChemoSen↑, toxicity↝,

4023-

FulvicA,

Shilajit (Mumio) Elicits Apoptosis and Suppresses Cell Migration in Oral Cancer Cells through Targeting Urokinase-type Plasminogen Activator and Its Receptor and Chemokine Signaling Pathways

in-vitro,

Oral,

tumCV↓, selectivity↑, Apoptosis↑, uPA↓, TumCMig↓, Dose↝, CXCc↓,

1065-

GA,

Gallic acid, a phenolic acid, hinders the progression of prostate cancer by inhibition of histone deacetylase 1 and 2 expression

vitro+vivo,

Pca,

mice

tumCV↓, MMP↓, DNAdam↑, HDAC1↓, HDAC2↓, PCNA↓, cycD1/CCND1↓, cycE1↓, P21↑, TumVol↓,

1086-

GA,

Anti-leukemic effects of gallic acid on human leukemia K562 cells: downregulation of COX-2, inhibition of BCR/ABL kinase and NF-κB inactivation

in-vitro,

AML,

K562

tumCV↓, TumCCA↑, P21↑, p27↑, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Cyt‑c↑, cl‑PARP↓, DNAdam↑, Casp3↑, FASN↓, Casp8↑,

1091-

GA,

Gallic acid reduces cell viability, proliferation, invasion and angiogenesis in human cervical cancer cells

in-vitro,

Cerv,

HeLa

in-vitro,

Cerv,

HTB-35

tumCV↓, TumCP↓, ADAM17↓, EGFR↓, p‑Akt↓, p‑ERK↓,

1968-

GamB,

Gambogic Acid Shows Anti-Proliferative Effects on Non-Small Cell Lung Cancer (NSCLC) Cells by Activating Reactive Oxygen Species (ROS)-Induced Endoplasmic Reticulum (ER) Stress-Mediated Apoptosis

in-vitro,

Lung,

A549

0, 0.5, and 1.0 μmol/l

tumCV↓, ROS↑, GRP78/BiP↑, CHOP↑, ATF6↑, Casp12↑, p‑PERK↑,

1956-

GamB,

Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis

in-vitro,

Melanoma,

A375

1-10 μg/ml

tumCV↓, Apoptosis↑, ROS↑, p66Shc↑,

1959-

GamB,

Gambogic acid induces GSDME dependent pyroptotic signaling pathway via ROS/P53/Mitochondria/Caspase-3 in ovarian cancer cells

in-vitro,

Ovarian,

in-vivo,

NA,

mice

AntiCan↑, Pyro↑, tumCV?, CellMemb↓, cl‑Casp3↑, GSDME-N↑, ROS?, p‑P53↑, eff↓, MMP↓, Bcl-2↓, BAX↑, mtDam↑, Cyt‑c↑, TumCG↓, CD4+↑, CD8+↑,

808-

GAR,

CUR,

Synergistic effect of garcinol and curcumin on antiproliferative and apoptotic activity in pancreatic cancer cells

in-vitro,

PC,

Bxpc-3

10uM(Gar), 5uM(Cur)

combination of garcinol and curcumin was 2 to 10 fold that of the individual agents

in-vitro,

PC,

PANC1

tumCV↓, Apoptosis↑, Casp3↑, Casp9↑,

828-

GAR,

Cisplatin,

Garcinol Alone and in Combination With Cisplatin Affect Cellular Behavior and PI3K/AKT Protein Phosphorylation in Human Ovarian Cancer Cells

in-vitro,

Ovarian,

OVCAR-3

tumCV↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, p‑PI3K↓, p‑Akt↓, NF-kB↓,

1186-

Gb,

Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis

in-vitro,

PC,

in-vitro,

Nor,

HUVECs

in-vivo,

PC,

tumCV↓, *toxicity∅, TumCMig↓, TumCI↓, Apoptosis↑, AMPK↑, lipoGen↓, ACC↓, FASN↓,

4509-

GLA,

Gamma-linolenic Acid (GLA) sensitizes pancreatic cancer cells to gemcitabine

in-vitro,

PC,

PANC1

tumCV↑, selectivity↑, ChemoSen↑,

844-

Gra,

Annona muricata Leaf Extract Triggered Intrinsic Apoptotic Pathway to Attenuate Cancerous Features of Triple Negative Breast Cancer MDA-MB-231 Cells

in-vitro,

BC,

MDA-MB-231

0-200ug/mL

in-vitro,

BC,

MCF-7

tumCV↓, TumCI↓, ROS↑,

839-

Gra,

Functional proteomic analysis revels that the ethanol extract of Annona muricata L. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway

in-vitro,

Liver,

HepG2

tumCV↓, Apoptosis↑, HSP70/HSPA5↑, GRP94↑, ER Stress↑, p‑PERK↑, p‑eIF2α↑, GRP78/BiP↑, CHOP↑,

852-

Gra,

Silver Nanoparticles from Annona muricata Peel and Leaf Extracts as a Potential Potent, Biocompatible and Low Cost Antitumor Tool

in-vitro,

BC,

MCF-7

2-3ug/mL

AgNPs-PE, AgNPs-LE

in-vitro,

Colon,

HCT116

2ug/mL

AgNPs-PE, AgNPs-LE

in-vitro,

Melanoma,

A375

3-8ug/mL

AgNPs-PE, AgNPs-LE

tumCV↓,

857-

Gra,

The Value of Caspase-3 after the Application of Annona muricata Leaf Extract in COLO-205 Colorectal Cancer Cell Line

in-vitro,

CRC,

COLO205

Casp3↑, tumCV↓,

1629-

HCA,

Tam,

Hydroxycitric acid reverses tamoxifen resistance through inhibition of ATP citrate lyase

in-vitro,

BC,

MCF-7

ACLY↓, eff↓, tumCV↓, eff↑, Casp3↑, BAX↑, Bcl-2↓,

1153-

HNK,

Honokiol Eliminates Glioma/Glioblastoma Stem Cell-Like Cells via JAK-STAT3 Signaling and Inhibits Tumor Progression by Targeting Epidermal Growth Factor Receptor

in-vitro,

GBM,

U251

in-vitro,

GBM,

U87MG

in-vivo,

NA,

mice + zebrafish

tumCV↓, Apoptosis↑, TumCMig↓, TumCI↓, Bcl-2↓, EGFR↓, CD133↓, Nestin↓, Akt↓, ERK↓, Casp3↑, p‑STAT3↓, TumCG↓,

2881-

HNK,

Honokiol Suppressed Pancreatic Cancer Progression via miR-101/Mcl-1 Axis

in-vitro,

PC,

PANC1

 50 µM

tumCV↓, Casp3↑, Apoptosis↑, TumCCA↑, TumCI↓, Mcl-1↓, EMT↓,

2879-

HNK,

Honokiol Inhibits Lung Tumorigenesis through Inhibition of Mitochondrial Function

in-vitro,

Lung,

H226

in-vivo,

NA,

mouse

tumCV↓, selectivity↑, TumCP↓, TumCCA↑, Apoptosis↑, mt-ROS↑, Casp3↑, Casp7↑, OCR↓, Cyt‑c↑, ATP↓, mitResp↓, AMP↑, AMPK↑,

2880-

HNK,

Honokiol inhibits breast cancer cell metastasis by blocking EMT through modulation of Snail/Slug protein translation

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

4T1

in-vivo,

NA,

50 mg/kg every day, intraperitoneal (i.p.), 6 times per week for 30 days

mouse

tumCV↓, E-cadherin↑, Snail↓, Slug↓, Vim↓, TumMeta↓, p‑eIF2α↑,

2868-

HNK,

Honokiol: A review of its pharmacological potential and therapeutic insights

Review,

Var,

Review,

Sepsis,

*P-gp↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,

2875-

HNK,

Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo

in-vitro,

Lung,

A549

20, 40 and 60 µM

in-vitro,

Lung,

H1299

in-vitro,

Lung,

H460

in-vitro,

SCC,

H226

HDAC↓, tumCV↓, TumCCA↑, cycD1/CCND1↓, ac‑H3↑, ac‑H4↑, selectivity↑, CDK2↓, CDK4↓,

4522-

HNK,

MAG,

Honokiol Is More Potent than Magnolol in Reducing Head and Neck Cancer Cell Growth

in-vitro,

HNSCC,

FaDu

AntiCan↑, tumCV↓, eff↑, survivin↓, RadioS↑,

2080-

HNK,

Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells

in-vitro,

AML,

THP1

20 μM

in-vitro,

AML,

U937

35 μM

in-vitro,

AML,

SK-HEP-1

30 μM

tumCV↓, TumCCA↑, Ferroptosis↑, lipid-P↑, HO-1↑, GPx4∅,

2081-

HNK,

Honokiol induces ferroptosis in colon cancer cells by regulating GPX4 activity

in-vitro,

Colon,

RKO

11.42 μM

in-vitro,

Colon,

HCT116

47.65 μM

in-vitro,

Colon,

SW48

in-vitro,

Colon,

HT-29

in-vitro,

Colon,

LS174T

in-vitro,

Colon,

HCT8

in-vitro,

Colon,

SW480

in-vivo,

NA,

mice

tumCV↓, ROS↑, Iron↑, GPx4↓, mtDam↑, Ferroptosis↑, TumVol↓, TumW↓,

4644-

HT,

The Hydroxytyrosol Induces the Death for Apoptosis of Human Melanoma Cells

in-vitro,

Melanoma,

tumCV↓, Apoptosis↑, P53↑, γH2AX↑, Akt↓, ROS↑, DNAdam↑,

2177-

itraC,

Itraconazole improves survival outcomes in patients with colon cancer by inducing autophagic cell death and inhibiting transketolase expression

Study,

Colon,

present study analyzed extensive data from patients diagnosed with colon cancer using itraconazole between January 2011 and December 2015

in-vitro,

CRC,

COLO205

in-vitro,

CRC,

HCT116

OS↑, tumCV↓, Casp3↑, TumCCA↑, HH↓, TumAuto↑, LC3B↑, p62↑, TKT↓,

1917-

JG,

Inhibition of human leukemia cells growth by juglone is mediated via autophagy induction, endogenous ROS production, and inhibition of cell migration and invasion

in-vitro,

AML,

HL-60

0-80uM

selectivity↑, LC3I↑, LC3II↑, Beclin-1↑, ROS↑, tumCV↓, Dose↝, TumAuto↑,

1922-

JG,

Juglone induces apoptosis of tumor stem-like cells through ROS-p38 pathway in glioblastoma

in-vitro,

GBM,

U87MG

(0, 10, 20, and 40 μM)

tumCV↓, TumCP↓, ROS↑, p‑p38↑, eff↓, Apoptosis↑, OS↑,

2915-

LT,

Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells

in-vitro,

Colon,

HT29

30 μM

in-vitro,

CRC,

SNU-407

30 μM

in-vitro,

Nor,

FHC

65 μM

DNMTs↓, TET1↑, NRF2↑, HDAC↓, tumCV↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, ROS↓, GSS↑, Catalase↑, HO-1↑, DNMT1↓, DNMT3A↓, TET1↑, TET3↑, TET2↓, P53↑, P21↑,

2910-

LT,

FA,

Folic acid-modified ROS-responsive nanoparticles encapsulating luteolin for targeted breast cancer treatment

in-vitro,

BC,

4T1

in-vivo,

NA,

mice

BioAv↓, BioAv↑, eff↑, tumCV↓, e-H2O2↓, i-H2O2∅,

4777-

Lyco,

Lycopene Inhibits Activation of Epidermal Growth Factor Receptor and Expression of Cyclooxygenase-2 in Gastric Cancer Cells

in-vitro,

GC,

AGS

*antiOx↑, tumCV↓, DNAdam↑, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, ROS↓, NF-kB↓, COX2↓, EGFR↓, p38↓,

4779-

Lyco,

Lycopene Inhibits Reactive Oxygen Species-Mediated NF-κB Signaling and Induces Apoptosis in Pancreatic Cancer Cells

in-vitro,

PC,

PANC1

ROS↓, NF-kB↓, tumCV↓, Casp3↑, Apoptosis↑, OCR↓, MMP↓, CIP2A↓, survivin↓, Casp3↑, Bax:Bcl2↑,

4803-

Lyco,

Enhanced cytotoxic and apoptosis inducing activity of lycopene oxidation products in different cancer cell lines

in-vitro,

Pca,

PC3

(LYC) oxidative products generated through autoxidation (AOL) or chemical (KMnO4) oxidation (COL) against proliferation of selected cancer cells

in-vitro,

BC,

MCF-7

in-vitro,

Melanoma,

A431

in-vitro,

Liver,

HepG2

in-vitro,

Cerv,

HeLa

in-vitro,

Lung,

A549

tumCV↓, GSH↓, MDA↑, ROS↑, Apoptosis↑,

2547-

M-Blu,

SDT,

The effect of dual-frequency ultrasound waves on B16F10 melanoma cells: Sonodynamic therapy using nanoliposomes containing methylene blue

in-vitro,

Melanoma,

B16-BL6

tumCV↓, ROS↑, mtDam↑,

2535-

M-Blu,

SDT,

Apoptosis of ovarian cancer cells induced by methylene blue-mediated sonodynamic action

in-vitro,

Ovarian,

HO-8910

tumCV↓, ROS↑,

2531-

M-Blu,

Anticancer activity of methylene blue via inhibition of heat shock protein 70

in-vitro,

Lung,

A549

2.5uM

in-vivo,

NA,

mice

tumCV↓, HSP70/HSPA5↓, LDH↓, SOD↑,

4518-

MAG,

Cisplatin,

Evaluating the Magnolol Anticancer Potential in MKN-45 Gastric Cancer Cells

in-vitro,

GC,

MKN45

ChemoSen↑, tumCV↓, BAX↑, Bcl-2↓, P21↑, P53↑, MMP9↓,

4537-

MAG,

Effects of magnolol on UVB-induced skin cancer development in mice and its possible mechanism of action

in-vivo,

Melanoma,

 SKH-1 mice

in-vitro,

Melanoma,

A431

*cl‑Casp8↑, *PARP↑, *P21↑, tumCV↓, TumCP↓, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK4↓, CDC2↓, P21↑, Apoptosis↑,

2384-

MET,

Integration of metabolomics and transcriptomics reveals metformin suppresses thyroid cancer progression via inhibiting glycolysis and restraining DNA replication

in-vitro,

Thyroid,

BCPAP

BCPAP cell lines were treated with 10 and 20 mM metformin for 24 h in subsequent experiments

in-vivo,

NA,

nude mice

in-vitro,

Thyroid,

TPC-1

Glycolysis↓, OXPHOS↑, tumCV↓, TumCI↓, TumCMig↓, EMT↓, Apoptosis↑, TumCCA↑, LDHA↓, PKM2↓, IDH1↑, TumCG↓,

2387-

MET,

GEM,

Metformin Increases the Response of Cholangiocarcinoma Cells to Gemcitabine by Suppressing Pyruvate Kinase M2 to Activate Mitochondrial Apoptosis

in-vitro,

CCA,

HCC9810

eff↑, tumCV↓, TumCMig↓, TumCI↓, Apoptosis↑, PKM2↓, PDHB↓,

2375-

MET,

Metformin inhibits gastric cancer via the inhibition of HIF1α/PKM2 signaling

in-vitro,

GC,

SGC-7901

0-50mM

tumCV↓, TumCI↓, TumCMig↓, Apoptosis↑, PARP↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, COX2↓,

2249-

MF,

Pulsed electromagnetic fields modulate energy metabolism during wound healing process: an in vitro model study

in-vitro,

Nor,

L929

4mT, 80 Hz

 pulsed burst (burst width, 2 ms; pulse width, 10.5 ms).

*TumCMig↑, *tumCV↑, *Glycolysis↑, *ROS↓, *mitResp↓, *other↝, *OXPHOS↓, *pH↑, *antiOx↑, *PFKM↑, *PFKL↑, *PKM2↑, *HK2↑, *GLUT1↑, *GPx1↑, *GPx4↑, *SOD1↑,

4354-

MF,

doxoR,

Modulated TRPC1 Expression Predicts Sensitivity of Breast Cancer to Doxorubicin and Magnetic Field Therapy: Segue Towards a Precision Medicine Approach

in-vivo,

BC,

MDA-MB-231

3mT, PEMFs stimulation for 1 h weekly for 5 weeks

NSG mice were purchased from The Jackson’s Laboratory and used at 8-10 weeks of age.

in-vivo,

BC,

MCF-7

selectivity↑, Apoptosis↑, TumCI↓, tumCV↓, TumVol↓, eff↓, eff↑, ROS↑, Ca+2↑, TumCMig↓,

3486-

MF,

Pulsed electromagnetic field potentiates etoposide-induced MCF-7 cell death

in-vitro,

NA,

ChemoSen↑, tumCV↓, cl‑PARP↑, Casp7↑, Casp9↑, survivin↓, BAX↑, DNAdam↑, ROS↑, eff↓,

1762-

MF,

Fe,

Triggering the apoptosis of targeted human renal cancer cells by the vibration of anisotropic magnetic particles attached to the cell membrane

in-vitro,

RCC,

low frequencies (∼20 Hz) and in weak magnetic fields (∼30 mT)

Dose∅, Apoptosis↑, Casp↑, tumCV↓, Casp3↑, Casp7↑, Ca+2↑, Cyt‑c↑,

516-

MFrot,

immuno,

MF,

Anti-tumor effect of innovative tumor treatment device OM-100 through enhancing anti-PD-1 immunotherapy in glioblastoma growth

vitro+vivo,

GBM,

U87MG

1mT, 120Hz (7200rpm), 24, 48, and 72 h

OM‑100 device (motor driven pulses)

TumCP↓, Apoptosis↑, TumCMig↓, ROS↑, PD-L1↑, TumVol↓, eff↑, *toxicity∅, eff↑, *toxicity∅, Dose↝, tumCV↓, TumCI↓,

3496-

MFrot,

GoldNP,

MF,

Enhancement of chemotherapy effects by non-lethal magneto-mechanical actuation of gold-coated magnetic nanoparticles

in-vitro,

Cerv,

HeLa

eff↑, tumCV↓,

1737-

MFrot,

Fe,

MF,

Feature Matching of Microsecond-Pulsed Magnetic Fields Combined with Fe3O4 Particles for Killing A375 Melanoma Cells

in-vitro,

MB,

A375

Dose∅, tumCV↓,

3847-

MSM,

Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement

Review,

Arthritis,

*Inflam↓, *Pain↓, *ROS↓, *antiOx↑, *Dose↝, *Half-Life↝, *NF-kB↓, *IL1↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2↓, *NLRP3↓, *NRF2↑, *STAT↓, *Cartilage↑, *eff↑, *eff↑, *GSH↑, *uricA↓, tumCV↓, TumCCA↑, necrosis↑, Apoptosis↑, VEGF↓, HSP90↓, IGF-1?,

1203-

MSM,

Methylsulfonylmethane Suppresses Breast Cancer Growth by Down-Regulating STAT3 and STAT5b Pathways

vitro+vivo,

BC,

MDA-MB-231

tumCV↓, STAT3↓, STAT5↓, IGF-1↓, Hif1a↓, VEGF↓, Brk/PTK6↓, IGF-1R↓,

1170-

MushCha,

Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism

in-vitro,

Oral,

HSC4

0, 160, 200, 400, and 800 μg/mL

tumCV↓, TumCP↓, TumCCA↑, STAT3↓, Glycolysis↓, MMP↓, TumAuto↑, p38↑, NF-kB↑,

1311-

NarG,

Rad,

Naringenin sensitizes lung cancer NCI-H23 cells to radiation by downregulation of akt expression and metastasis while promoting apoptosis

in-vitro,

Lung,

H23

tumCV↓, ROS↑, Casp3↑, p‑Akt↓, Akt↓, MMP2↓, P21↓,

1807-

NarG,

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

Review,

NA,

AntiTum↑, TumCP↓, tumCV↓, TumCCA↑, Mcl-1↓, RAS↓, e-Raf↓, VEGF↓, AntiAg↑, MMP2↓, MMP9↓, TIMP2↑, TIMP1↑, p38↓, Wnt↓, β-catenin/ZEB1↑, Casp↑, P53↑, BAX↑, COX2↓, GLO-I↓, CYP1A1↑, lipid-P↓, p‑Akt↓, p‑mTOR↓, VCAM-1↓, P-gp↓, survivin↓, Bcl-2↓, ROS↑, ROS↑, MAPK↑, STAT3↓, chemoP↑,

4975-

Nimb,

Nimbolide Induces Cell Apoptosis via Mediating ER Stress-Regulated Apoptotic Signaling in Human Oral Squamous Cell Carcinoma

in-vitro,

Oral,

Apoptosis↑, ROS↑, Ca+2↑, ER Stress↑, Casp↑, MMP↓, tumCV↓,

4973-

Nimb,

Nimbolide Exhibits Potent Anticancer Activity Through ROS-Mediated ER Stress and DNA Damage in Human Non-small Cell Lung Cancer Cells

in-vitro,

NSCLC,

A549

tumCV↓, ROS↑, ER Stress↑, DNAdam↑, Apoptosis↑, eff↓,

4627-

OLE,

Oleuropein regulates ubiquitination-mediated Mcl-1 turnover and exhibits antitumor activity

in-vitro,

Oral,

tumCV↓, Mcl-1↓, TumCG↓, toxicity∅, RadioS↑, AntiTum↑,

1994-

Part,

Parthenolide Inhibits Tumor Cell Growth and Metastasis in Melanoma A2058 Cells

in-vitro,

Melanoma,

A2058

20uM

in-vitro,

Nor,

L929

27uM

tumCV↓, selectivity?, ROS?, BAX↑, TumCCA?, MMP2↓, MMP9↓, TumCMig↓, eff↑,

1993-

Part,

Parthenolide induces apoptosis and autophagy through the suppression of PI3K/Akt signaling pathway in cervical cancer

in-vitro,

Cerv,

HeLa

6 µM

tumCV↓, TumAuto↑, Casp3↑, BAX↑, Beclin-1↑, ATG3↑, ATG5↑, Bcl-2↓, mTOR↓, PI3K↓, Akt↓, PTEN↑, ROS↑, MMP↓,

2057-

PB,

Trichomonas vaginalis induces apoptosis via ROS and ER stress response through ER–mitochondria crosstalk in SiHa cells

in-vitro,

Cerv,

SiHa

4-PBA (0, 0.2, 1, 2 mM)

ROS↓, tumCV∅, cl‑PARP↓, cl‑Casp3↓, MMP∅, ER Stress↓,

1679-

PBG,

Constituents of Propolis: Chrysin, Caffeic Acid, p-Coumaric Acid, and Ferulic Acid Induce PRODH/POX-Dependent Apoptosis in Human Tongue Squamous Cell Carcinoma Cell (CAL-27)

in-vitro,

SCC,

CAL27

tumCV↓, P53↑, Casp9↑, Casp3↑, GSH↓, proline↓,

1674-

PBG,

SDT,

HPT,

Study on the effect of a triple cancer treatment of propolis, thermal cycling-hyperthermia, and low-intensity ultrasound on PANC-1 cells

in-vitro,

PC,

PANC1

in-vitro,

Nor,

H6c7

tumCV↓, ROS↑, eff↑, Dose∅, selectivity↑, MMP↓, mtDam↑, cl‑PARP↑, p‑ERK↓, p‑JNK↑, p‑p38↑, eff↓, ChemoSen↑,

1675-

PBG,

Portuguese Propolis Antitumoral Activity in Melanoma Involves ROS Production and Induction of Apoptosis

in-vitro,

Melanoma,

A375

in-vitro,

Melanoma,

WM983B

tumCV↓, ROS↑, antiOx↑, Apoptosis↑, BAX↑, P53↑, Casp3↑, Casp9↑,

1676-

PBG,

Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies

Review,

Var,

20-250ug/mL

ROS↑, MMP↓, Bcl-2↓, eff↑, tumCV↓, TumCCA↑, angioG↓, PAK1↓, HDAC1↓, HDAC2↓, P53↑, PCNA↓, cycD1/CCND1↓, cycE/CCNE↓, P21?, BAX↑, cl‑Casp3↑, cl‑PARP↑, ChemoSen↑,

4933-

PEITC,

Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated TLE1 m6A modification

vitro+vivo,

Lung,

H1299

 17.6 uM

vitro+vivo,

SCC,

H226

15.2 μM

AntiCan↓, TumCP↓, TumMeta↓, ChemoSen↑, tumCV↓, TumCI↓, TumCMig↓, FTO↓, TLE1↓, Akt↓, NF-kB↓,

4935-

PEITC,

Phenethyl Isothiocyanate Suppresses Inhibitor of Apoptosis Family Protein Expression in Prostate Cancer Cells in Culture and In Vivo

in-vivo,

Pca,

LNCaP

2.5 and 5 μM

in-vivo,

Pca,

PC3

Apoptosis↑, XIAP↓, survivin↓, *BioAv↑, tumCV↓, eff↓,

4937-

PEITC,

PEITC: Functional Compound for Primary and Tertiary Chemoprevention of Cancer

chemoPv↑, tumCV↓, GSH↓, ROS↑, *toxicity↝,

4925-

PEITC,

PEITC triggers multiple forms of cell death by GSH-iron-ROS regulation in K7M2 murine osteosarcoma cells

in-vitro,

OS,

 33.49 μM at 24 h

tumCV↓, TumCP↓, TumCCA↑, GSH↓, ROS↑, Ferroptosis↑, Apoptosis↑, TumAuto↑, MAPK↑, TumCG↓, Dose⇅,

4920-

PEITC,

Cisplatin,

PEITC restores chemosensitivity in cisplatin-resistant non-small cell lung cancer by targeting c-Myc/miR-424-5p

vitro+vivo,

NSCLC,

A549

0, 0.125, 0.25, 0.5, 1, 2, 4, 8, 16, 32, 64 μM

 mouse xenograft model

TumCG↓, ChemoSen↑, cMyc↓, PI3K↓, Akt↓, mTOR↓, BioAv↝, tumCV↓, ChemoSen↑,

4940-

PEITC,

Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G 0/G 1 Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death

in-vitro,

Oral,

HSC3

TumCCA↑, Apoptosis↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, tumCV↓, ROS↑, Ca+2↑, CDC25↓, CDK6↓, cycD1/CCND1↓, CDK2↓, cycE/CCNE↓, P53↑, p27↑, P21↑, Casp9↑, Casp3↑, GRP78/BiP↑,

4945-

PEITC,

Phenethyl isothiocyanate (PEITC) promotes G2/M phase arrest via p53 expression and induces apoptosis through caspase- and mitochondria-dependent signaling pathways in human prostate cancer DU 145 cells

in-vitro,

Pca,

DU145

AntiCan↑, TumCG↓, Apoptosis↑, tumCV↓, TumCCA↑, DNAdam↑, P53↑, CDC25↓, Casp9↑, Casp8↑, mtDam↑, Cyt‑c↑,

4941-

PEITC,

PEITC: A resounding molecule averts metastasis in breast cancer cells in vitro by regulating PKCδ/Aurora A interplay

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

PKCδ↑, Apoptosis↓, selectivity↑, tumCV↓, p‑NRF2↑, cl‑PARP1↑, TumCMig↓, ROS↓, Hif1a↓,

1131-

PI,

Piperlongumine‑loaded nanoparticles inhibit the growth, migration and invasion and epithelial‑to‑mesenchymal transition of triple‑negative breast cancer cells

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

BT549

TumCG↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, Slug↓, N-cadherin↓, β-catenin/ZEB1↓, SMAD3↓, E-cadherin↑, EMT↓,

1163-

PI,

The Effect of Piperine on MMP-9, VEGF, and E-cadherin Expression in Breast Cancer MCF-7 Cell Line

in-vitro,

BC,

MC38

 (5, 10, 25, 50, 75, and 100 μM) for 24 hours

tumCV↓, VEGF↓, MMP9↓, E-cadherin↓,

1939-

PL,

Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP

in-vitro,

HCC,

HepG2

5-20 μM

in-vitro,

HCC,

HUH7

in-vivo,

NA,

(1.5 mg/kg

mice

TumCMig↓, TumCI↓, ER Stress↑, selectivity↑, tumCV↓, ROS↑, GSH↓, eff↓, Ca+2↑, MAPK↑, CHOP↑, Dose↝,

2948-

PL,

The promising potential of piperlongumine as an emerging therapeutics for cancer

Review,

Var,

tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,

2944-

PL,

Piperlongumine, a Potent Anticancer Phytotherapeutic, Induces Cell Cycle Arrest and Apoptosis In Vitro and In Vivo through the ROS/Akt Pathway in Human Thyroid Cancer Cells

in-vitro,

Thyroid,

IHH4

 2 and 3 μM

in-vitro,

Thyroid,

8505C

in-vivo,

NA,

10 mg/kg

Nude mice

ROS↑, selectivity↑, tumCV↓, TumCCA↑, Apoptosis↑, ERK↑, Akt↓, mTOR↓, neuroP↑, Bcl-2↓, Casp3↑, PARP↑, JNK↑, *toxicity↓, eff↓, TumW↓,

2006-

Plum,

Plumbagin induces apoptosis in human osteosarcoma through ROS generation, endoplasmic reticulum stress and mitochondrial apoptosis pathway

in-vitro,

OS,

MG63

in-vitro,

Nor,

hFOB1.19

tumCV↓, selectivity↑, mtDam↑, Ca+2↓, ER Stress↑, ROS↑, Casp3↑, Casp9↑, Apoptosis↑, eff↓,

2005-

Plum,

Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2)

in-vivo,

Nor,

EL4

mouse

in-vitro,

AML,

Jurkat

JNK↑, Cyt‑c↑, FasL↑, BAX↑, ROS↑, *ROS↑, MKP1↓, MKP2↓, selectivity∅, tumCV↑, Cyt‑c↑, Casp3↑, GSH/GSSG↓, ROS↑, mt-ROS↑, *ROS↑, eff↓,

4702-

PTS,

Pterostilbene Inhibits Pancreatic Cancer In Vitro

in-vitro,

PC,

MIA PaCa-2

in-vitro,

PC,

PANC1

tumCV↓, TumCG↓, BioAv↑,

3353-

QC,

Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells

in-vitro,

Oral,

KON

 0, 1.5625, 3.125, 6.25, 12.5, 25, 50, 100, and 400 µg/mL

50ug/L @ 72h

in-vitro,

Nor,

MRC-5

tumCV↓, selectivity↑, TumCCA↑, TumCMig↓, TumCI↓, Apoptosis↑, TumMeta↓, Bcl-2↓, BAX↑, TIMP1↑, MMP2↓, MMP9↓, *Inflam↓, *neuroP↑, *cardioP↑, p38↓, MAPK↓, Twist↓, P21↓, cycD1/CCND1↓, Casp3↑, Casp9↑, p‑Akt↓, p‑ERK↓, CD44↓, CD24↓, ChemoSen↑, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑, Hif1a↓, VEGF↓,

3343-

QC,

Quercetin, a Flavonoid with Great Pharmacological Capacity

Review,

Var,

Review,

AD,

Review,

Arthritis,

*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, eff↑, P-gp↓, eff↑, eff↑, eff↑, eff↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,

3379-

QC,

The Effect of Quercetin Nanosuspension on Prostate Cancer Cell Line LNCaP via Hedgehog Signaling Pathway

in-vitro,

Pca,

LNCaP

tumCV↓, HH↓,

3376-

QC,

Inhibiting CDK6 Activity by Quercetin Is an Attractive Strategy for Cancer Therapy

in-vitro,

BC,

MCF-7

in-vitro,

Lung,

A549

CDK6↓, tumCV↓, Apoptosis↑, ROS↓, eff↑,

3374-

QC,

Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis

Review,

Oral,

Review,

AD,

α-SMA↓, α-SMA↑, TumCP↓, tumCV↓, TumVol↓, TumCI↓, TumMeta↓, TumCMig↓, ROS↑, Apoptosis↑, BioAv↓, *neuroP↑, *antiOx↑, *Inflam↓, *Aβ↓, *cardioP↑, MMP↓, Cyt‑c↑, MMP2↓, MMP9↓, EMT↓, MMPs↓, Twist↓, Slug↓, Ca+2↑, AIF↑, Endon↑, P-gp↓, LDH↑, HK2↓, PKA↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, GRP78/BiP↑, Casp12↑, CHOP↑,

3362-

QC,

The effect of quercetin on cervical cancer cells as determined by inducing tumor endoplasmic reticulum stress and apoptosis and its mechanism of action

in-vitro,

Cerv,

HeLa

Apoptosis↑, cycD1/CCND1↓, Casp3↑, GRP78/BiP↑, CHOP↑, tumCV↓, IRE1↑, p‑PERK↑, c-ATF6↑, ER Stress↑,

3339-

QC,

Quercetin suppresses ROS production and migration by specifically targeting Rac1 activation in gliomas

in-vitro,

GBM,

(25 μM, 50 μM, 100 μM, and 200 µM) for different time points (12, 24, 48, or 72 h)

in-vitro,

GBM,

IMR32

BBB↑, tumCV↓, TumCMig↓, Rac1↓, p66Shc↓, ROS↓,

913-

QC,

Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression

in-vitro,

BC,

SkBr3

in-vitro,

BC,

MDA-MB-435

TumCP↓, TumCCA↑, DNAdam↑, Chk2↑, CycB/CCNB1↓, CDK1↓, tumCV↓, p‑RB1↓, P21↑,

910-

QC,

The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism

tumCV↓, Apoptosis↑, PI3k/Akt/mTOR↓, Wnt/(β-catenin)↓, MAPK↝, ERK↝, TumCCA↑, H2O2↑, ROS↑, TumAuto↑, MMPs↓, P53↑, Casp3↑, Hif1a↓, cFLIP↓, IL6↓, IL10↓, lactateProd↓, Glycolysis↓, PKM2↓, GLUT1↓, COX2↓, VEGF↓, OCR↓, ECAR↓, STAT3↓, MMP2↓, MMP9:TIMP1↓, mTOR↓,

3072-

RES,

Resveratrol ameliorates glioblastoma inflammatory response by reducing NLRP3 inflammasome activation through inhibition of the JAK2/STAT3 pathway

in-vitro,

GBM,

LN229

17.90 μM

in-vitro,

GBM,

U87MG

 25 μM

tumCV↓, TumCP↓, TumCMig↓, Apoptosis↑, NLRP3↓, JAK2↓, STAT3↓, IL1β↓, IL18↓, IL6↓, TNF-α↓, Inflam↓,

2982-

RES,

The flavonoid resveratrol suppresses growth of human malignant pleural mesothelioma cells through direct inhibition of specificity protein 1

in-vitro,

Melanoma,

MSTO-211H

IC50 for Res was 17 µM in MSTO-211H cells.

tumCV↓, Apoptosis↑, Sp1/3/4↓, p27↓, P21↓, cycD1/CCND1↓, Mcl-1↓, survivin↓,

3094-

RES,

Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

CSCs↓, tumCV↓, FASN↑, BNIP3↑, *cardioP↑, *antiOx↑, NF-kB↓, COX2↓, MMP9↓, IGF-1↓, ERK↓, lipid-P↓, CD24↓,

3092-

RES,

Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action

Review,

BC,

MDA-MB-231

Review,

BC,

MCF-7

TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, eff↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,

1745-

RosA,

Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications

Review,

Var,

Review,

AD,

ChemoSideEff↓, ChemoSen↑, antiOx↑, MMP2↓, MMP9↓, p‑AMPK↑, DNMTs↓, tumCV↓, COX2↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, Casp3↑, Casp9↓, ROS↓, GSH↑, ERK↓, Akt↓, ROS↓, NF-kB↓, p‑IκB↓, p50↓, p65↓, neuroP↑, Dose↝,

3029-

RosA,

Rosmarinic Acid, a Component of Rosemary Tea, Induced the Cell Cycle Arrest and Apoptosis through Modulation of HDAC2 Expression in Prostate Cancer Cell Lines

in-vitro,

Pca,

PC3

in-vitro,

Pca,

DU145

TumCP↓, tumCV↓, Apoptosis↑, HDAC2↓, PCNA↓, cycD1/CCND1↓, cycE/CCNE↓, P21↑, DNAdam↑, Casp3↑,

3017-

RosA,

Per,

Molecular Mechanism of Antioxidant and Anti-Inflammatory Effects of Omega-3 Fatty Acids in Perilla Seed Oil and Rosmarinic Acid Rich Fraction Extracted from Perilla Seed Meal on TNF-α Induced A549 Lung Adenocarcinoma Cells

in-vitro,

Lung,

A549

TumCD∅, ROS↓, IL1β↓, IL6↓, IL8↓, TNF-α↓, COX2↓, SOD2↓, FOXO1↓, NF-kB↓, JNK↓, antiOx↑, tumCV∅,

3016-

RosA,

Rosmarinic Acid Inhibits Cell Growth and Migration in Head and Neck Squamous Cell Carcinoma Cell Lines by Attenuating Epidermal Growth Factor Receptor Signaling

in-vitro,

HNSCC,

UM-SCC-6

in-vitro,

HNSCC,

UM-SCC-10B

chemoP↓, EGF↓, tumCV↓, TumCMig↓, ROS↓, PI3K↓, Akt↓, ERK↓, antiOx↑, p‑EGFR↓,

3008-

RosA,

Rosmarinic acid decreases viability, inhibits migration and modulates expression of apoptosis-related CASP8/CASP3/NLRP3 genes in human metastatic melanoma cells

in-vitro,

Melanoma,

SK-MEL-28

tumCV↓, TumCMig↓, ROS↓, Casp3↑, selectivity↑, Casp8↑, NLRP3↓,

1132-

RT,

Rutin Promotes Proliferation and Orchestrates Epithelial–Mesenchymal Transition and Angiogenesis in MCF-7 and MDA-MB-231 Breast Cancer Cells

in-vitro,

BC,

MDA-MB-231

>100uM

rutin may act as a breast-cancer-promoting phytoestrogen.

in-vitro,

BC,

MCF-7

Vim↑, N-cadherin↑, E-cadherin↓, TumCP↑, TumCMig↑, tumCV↑, MKI67↑,

4908-

Sal,

Salinomycin triggers prostate cancer cell apoptosis by inducing oxidative and endoplasmic reticulum stress via suppressing Nrf2 signaling

in-vitro,

Pca,

PC3

0, 2, 5, 10, 20 and 50 µM

in-vitro,

Pca,

DU145

tumCV↓, ROS↑, lipid-P↑, UPR↑, ER Stress↑, NRF2↓, NADPH↓, HO-1↓, SOD↓, Catalase↓, GPx↓, eff↓, TumCP↓,

4995-

Sal,

Salinomycin possesses anti-tumor activity and inhibits breast cancer stem-like cells via an apoptosis-independent pathway

vitro+vivo,

BC,

MDA-MB-231

ALDH↓, Nanog↓, OCT4↓, SOX2↓, CSCs↓, tumCV↓, cycD1/CCND1↓, P21↑, TumCG↓, CD44↓, Apoptosis∅,

1388-

Sco,

Scoulerine promotes cell viability reduction and apoptosis by activating ROS-dependent endoplasmic reticulum stress in colorectal cancer cells

in-vitro,

CRC,

tumCV↓, Apoptosis↑, Casp3↑, Casp7↑, BAX↑, Bcl-2↓, ROS↑, GSH↓, SOD↓, ER Stress↑, GRP78/BiP↑, CHOP↑, eff↓,

1403-

SDT,

BBR,

From 2D to 3D In Vitro World: Sonodynamically-Induced Prooxidant Proapoptotic Effects of C60-Berberine Nanocomplex on Cancer Cells

in-vitro,

Cerv,

HeLa

 1 MHz, 1 W/cm2 US and  20 µM C60-Ber for 24 h

in-vitro,

Lung,

LLC1

eff↑, tumCV↓, ATP↓, ROS↑, Casp3↑, Casp7↑, mtDam↑,

2549-

SDT,

Landscape of Cellular Bioeffects Triggered by Ultrasound-Induced Sonoporation

Review,

Var,

sonoP↑, tumCV↓, MMP↓, ROS↑, Ca+2↑, eff↝, eff↑, selectivity↑, Half-Life↝, Dose↝, P-gp↓, ER Stress↑, other↑,

4752-

Se,

CUR,

Chemo,

Curcumin-Modified Selenium Nanoparticles Improve S180 Tumour Therapy in Mice by Regulating the Gut Microbiota and Chemotherapy

in-vitro,

Cerv,

HeLa

 6.86 nm

in-vitro,

sarcoma,

S180

8.4 μg/mL

tumCV↓, ROS↑, *GutMicro↑, BioAv↑, other↝, Dose↝,

4473-

Se,

Anti-cancerous effect and biological evaluation of green synthesized Selenium nanoparticles on MCF-7 breast cancer and HUVEC cell lines

in-vitro,

BC,

MCF-7

65 nm and 34 nm

in-vitro,

Nor,

HUVECs

AntiCan↑, selectivity↓, *Bacteria↓, *antiOx↑, *toxicity↓, ROS↑, tumCV↓,

4488-

Se,

Chit,

PEG,

Anticancer effect of selenium/chitosan/polyethylene glycol/allyl isothiocyanate nanocomposites against diethylnitrosamine-induced liver cancer in rats

in-vivo,

Liver,

HepG2

 size ranging from 390 to 450 nm

diethylnitrosamine (DEN)-induced liver cancer in rats

in-vivo,

Nor,

HL7702

tumCV↓, Apoptosis↑, *GSH↑, *VitC↑, *VitE↑, *SOD↑, *GPx↑, *GR↑, ALAT↓, ALP↓, AST↓, LDH↓, selectivity↑, eff↑,

4484-

Se,

Chit,

PEG,

Anti-cancer potential of selenium-chitosan-polyethylene glycol-carvacrol nanocomposites in multiple myeloma U266 cells

in-vitro,

Melanoma,

U266

tumCV↓, selectivity↑, ROS↑, MMP↓, Apoptosis↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓,

3182-

SFN,

Sulforaphane Modulates AQP8-Linked Redox Signalling in Leukemia Cells

in-vitro,

AML,

 10 and 30 μM SFN

B1647 cell line

Prx↓, AQPs↓, NOX↓, tumCV↓, AntiCan↑, cardioP↑, neuroP↑, Inflam↓, chemoPv↑, angioG↓, TumMeta↓, selectivity↑, ROS↓,

2405-

SFN,

Sulforaphane Targets the TBX15/KIF2C Pathway to Repress Glycolysis and Cell Proliferation in Gastric Carcinoma Cells

in-vitro,

GC,

SGC-7901

in-vitro,

GC,

BGC-823

TumCP↓, Glycolysis↓, TBX15↑, GlucoseCon↓, lactateProd↓, tumCV↓, PKM2↓, KIF2C↓,

1482-

SFN,

Sulforaphane induces apoptosis in T24 human urinary bladder cancer cells through a reactive oxygen species-mediated mitochondrial pathway: the involvement of endoplasmic reticulum stress and the Nrf2 signaling pathway

in-vitro,

Bladder,

T24

tumCV↓, Apoptosis↑, Cyt‑c↑, Bax:Bcl2↑, Casp9↑, Casp3↑, Casp8∅, cl‑PARP↑, ROS↑, MMP↓, eff↓, ER Stress↑, p‑NRF2↑, HO-1↑,

1434-

SFN,

GEM,

Sulforaphane Potentiates Gemcitabine-Mediated Anti-Cancer Effects against Intrahepatic Cholangiocarcinoma by Inhibiting HDAC Activity

in-vitro,

CCA,

HuCCT1

 SFN (0–80 μM) or GEM (0–10 μM) for 24 h

27.4uM(SFN),0.57 μM(GEM)

in-vitro,

CCA,

HuH28

34.2 μM(SFN), 0.71um(GEM)

in-vivo,

NA,

50 mg/kg/day

tumors of SFN- and GEM-treated mice

HDAC↓, ac‑H3↑, ChemoSen↑, tumCV↓, TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, TumCI↓, VEGF↓, VEGFR2↓, Hif1a↓, eNOS↓, EMT?, TumCG↓, Ki-67↓, TUNEL↑, P21↑, p‑Chk2↑, CDC25↓, BAX↑, *ROS↓, NQO1?,

1456-

SFN,

Sulforaphane regulates cell proliferation and induces apoptotic cell death mediated by ROS-cell cycle arrest in pancreatic cancer cells

in-vitro,

PC,

MIA PaCa-2

 0, 7.5, and 15 µM

in-vitro,

PC,

PANC1

tumCV↓, TumCP↓, cl‑PARP↑, cl‑Casp3↑, TumCCA↑, ROS↑, MMP↓, γH2AX↑, eff↓, *toxicity↓,

1463-

SFN,

Sulforaphane induces reactive oxygen species-mediated mitotic arrest and subsequent apoptosis in human bladder cancer 5637 cells

in-vitro,

Bladder,

5637

tumCV↓, CycB/CCNB1↑, p‑CDK1↑, Apoptosis↑, Casp8↑, Casp9↑, Casp3↑, cl‑PARP↑, ROS↑, eff↓,

1480-

SFN,

Sulforaphane Induces Cell Death Through G2/M Phase Arrest and Triggers Apoptosis in HCT 116 Human Colon Cancer Cells

in-vitro,

CRC,

HCT116

tumCV↓, TumCCA↑, Apoptosis↑, cycA1/CCNA1↑, CycB/CCNB1↑, CDC25↓, CDK1↓, ROS↑, eff↓, Cyt‑c↑, AIF↑, ER Stress↑,

1476-

SFN,

PDT,

Enhancement of cytotoxic effect on human head and neck cancer cells by combination of photodynamic therapy and sulforaphane

in-vitro,

HNSCC,

eff↑, tumCV↓, ROS↑, eff↓, Casp↑,

1477-

SFN,

Sulforaphane Induces Oxidative Stress and Death by p53-Independent Mechanism: Implication of Impaired Glutathione Recycling

in-vitro,

OS,

MG63

>10 μM

tumCV↓, Apoptosis↑, Casp3↑, ROS↑, GSR↓, GPx↓,

1479-

SFN,

Sulforaphane triggers Sirtuin 3-mediated ferroptosis in colorectal cancer cells via activating the adenosine 5'-monophosphate (AMP)-activated protein kinase/ mechanistic target of rapamycin signaling pathway

in-vitro,

CRC,

HCT116

Ferroptosis↑, SIRT3↑, AMPK↑, mTOR↑, tumCV↓, ROS↑, MDA↑, Iron↑,

1513-

SFN,

acetaz,

Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis

in-vitro,

BrCC,

H720

AZ, SFN, and AZ+SFN (10 μM, 20 μM, and 40 μM)

in-vivo,

BrCC,

AZ (20 mg/kg), SFN (40 mg/kg), and a combination of AZ (20 mg/kg) plus SFN (40 mg/kg), daily for two weeks

mice

in-vitro,

BrCC,

H727

eff↑, tumCV↓, Apoptosis↑, P21↑, PI3K↓, Akt↓, mTOR↓, 5HT↓, NRF2↑,

3304-

SIL,

Silymarin induces inhibition of growth and apoptosis through modulation of the MAPK signaling pathway in AGS human gastric cancer cells

in-vitro,

GC,

AGS

0, 20, 40, 60, 80, 100 and 120 µg/ml for 24 h

in-vivo,

NA,

100 mg/kg silymarin injection group mice

BAX↑, p‑JNK↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, Apoptosis↑, tumCV↓,

3305-

SIL,

Silymarin inhibits proliferation of human breast cancer cells via regulation of the MAPK signaling pathway and induction of apoptosis

in-vitro,

BC,

MDA-MB-231

0, 25, 50, 75, 100, 150 or 200 µg/ml silymarin for 24 h

in-vitro,

BC,

MCF-7

in-vivo,

NA,

mice

TumCP↓, tumCV↓, BAX↑, cl‑PARP↑, Casp9↑, p‑JNK↑, Bcl-2↓, p‑p38↓, p‑ERK↓, *toxicity∅, Dose↝, *hepatoP↑, Inflam↓, AntiCan↑,

3299-

SIL,

Silymarin Effect on Mitophagy Pathway in the Human Colon Cancer HT-29 Cells

in-vitro,

Colon,

HT29

0 (control), 25, 50, and 100 μ, g/ml of Silymarin for 48

tumCV↓, MMP↓, ROS↑, selectivity↑,

3290-

SIL,

A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents

Analysis,

Var,

hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,

2232-

SK,

Shikonin Induces Autophagy and Apoptosis in Esophageal Cancer EC9706 Cells by Regulating the AMPK/mTOR/ULK Axis

in-vitro,

ESCC,

EC9706

2.26 ± 0.12 µM

tumCV↓, TumCMig↓, TumCI↓, TumAuto↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, AMPK↑, mTOR↑, TumVol↓, OS↑, LC3I↑,

2221-

SK,

Shikonin Induces Apoptosis, Necrosis, and Premature Senescence of Human A549 Lung Cancer Cells through Upregulation of p53 Expression

in-vitro,

Lung,

A549

0.5, 1.0, 2.5, 5.0, or 10.0 μg/mL)

3.52ug/mL

Apoptosis↑, TumCP↓, tumCV↓, Necroptosis↑, P53↑, ROS↑, NF-kB↓,

2418-

SK,

Experimental Study of Hepatocellular Carcinoma Treatment by Shikonin Through Regulating PKM2

in-vitro,

HCC,

SMMC-7721 cell

in-vitro,

HCC,

HUH7

in-vitro,

HCC,

HepG2

tumCV↓, GlucoseCon↓, lactateProd↓, ChemoSen↑, PKM2↓, Glycolysis↓,

3048-

SK,

Shikonin inhibits triple-negative breast cancer-cell metastasis by reversing the epithelial-to-mesenchymal transition via glycogen synthase kinase 3β-regulated suppression of β-catenin signaling

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

4T1

in-vitro,

Nor,

MCF12A

in-vivo,

NA,

tumCV↓, selectivity↑, EMT↓, TumCMig↓, TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, β-catenin/ZEB1↓, GSK‐3β↑,

2007-

SK,

Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells

in-vitro,

lymphoma,

U937

<10uM

in-vitro,

BC,

MCF-7

in-vitro,

BC,

SkBr3

in-vitro,

CRC,

HCT116

in-vitro,

OS,

U2OS

NA,

Nor,

RPE-1

RPE-1-GFP-EB3 cells were treated with 25 μM shikonin

tumCV↓, selectivity↑, Dose↝, other↑, MMP↓, ROS↑, DNAdam↑, Ca+2↑, Casp9↑, Cyt‑c↑, *toxicity↓,

2182-

SK,

Cisplatin,

Shikonin inhibited glycolysis and sensitized cisplatin treatment in non-small cell lung cancer cells via the exosomal pyruvate kinase M2 pathway

in-vitro,

Lung,

A549

2 µM, 4 µM, 6 µM, and 8 µM

5.739 µM

in-vitro,

Lung,

PC9

6.302 µM

in-vivo,

NA,

mice

tumCV↓, TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, PKM2↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, ChemoSen↑, TumVol↓, TumW↓, GLUT1↓,

2194-

SK,

Efficacy of Shikonin against Esophageal Cancer Cells and its possible mechanisms in vitro and in vivo

in-vitro,

ESCC,

Eca109

in-vitro,

ESCC,

EC9706

in-vivo,

NA,

(20μg/dose/day)

mice

tumCV↓, TumCCA↑, Apoptosis↑, EGFR↓, PI3K↓, Hif1a↓, PKM2↓, cycD1/CCND1↓, AntiTum↑,

346-

SNP,

RSQ,

Investigating Silver Nanoparticles and Resiquimod as a Local Melanoma Treatment

in-vivo,

Melanoma,

SK-MEL-28

 AgNP (2 mg/kg) and RSQ (25 mg/kg) administration routes used were peri- and intratumora

 mice

in-vivo,

Melanoma,

WM35

ROS↑, Ca+2↝, Casp3↑, Casp8↑, Casp9↑, CD4+↑, CD8+↑, tumCV↓, eff↓, *toxicity↓,

2539-

SNP,

SDT,

Combined effect of silver nanoparticles and therapeutical ultrasound on ovarian carcinoma cells A2780

in-vitro,

Melanoma,

A2780S

tumCV↓, sonoP↑, BioEnh↑,

4555-

SNP,

Silver nanoparticles from Dendropanax morbifera Léveille inhibit cell migration, induce apoptosis, and increase generation of reactive oxygen species in A549 lung cancer cells

in-vitro,

Lung,

A549

in-vitro,

Liver,

HepG2

*Bacteria↓, tumCV↓, selectivity↑, ROS↑, Apoptosis↑, TumCMig↓, AntiCan↑,

4549-

SNP,

Silver nanoparticles: Synthesis, medical applications and biosafety

Review,

Var,

Review,

Diabetic,

ROS↑, eff↑, other↝, DNAdam↑, EPR↑, eff↑, eff↑, TumMeta↓, angioG↓, *Bacteria↓, *eff↑, *AntiViral↑, *AntiFungal↑, eff↑, eff↑, TumCP↓, tumCV↓, P53↝, HIF-1↓, TumCCA↑, lipid-P↑, ATP↓, Cyt‑c↑, MMPs↓, PI3K↓, Akt↓, *Wound Healing↑, *Inflam↓, *Bone Healing↑, *glucose↓, *AntiDiabetic↑, *BBB↑,

4427-

SNP,

Silver nanoparticles induce apoptosis and G2/M arrest via PKCζ-dependent signaling in A549 lung cells

in-vitro,

Lung,

A549

tumCV↓, LDH↑, TumCCA↑, BAX↑, BID↑, Bcl-2↓, PKCδ↓,

4428-

SNP,

p38 MAPK Activation, DNA Damage, Cell Cycle Arrest and Apoptosis As Mechanisms of Toxicity of Silver Nanoparticles in Jurkat T Cells

in-vitro,

AML,

Jurkat

toxicity↝, tumCV↓, ROS↑, p38↑, NRF2↓, NF-kB↝, DNAdam↑, Apoptosis↑,

4380-

SNP,

Silver nanoparticles induce toxicity in A549 cells via ROS-dependent and ROS-independent pathways

in-vitro,

Lung,

A549

ROS↑, tumCV↓, MMP↓, TumCCA↑, PCNA↓, eff↓,

4370-

SNP,

Effect of silver nanoparticles in the induction of apoptosis on human hepatocellular carcinoma (HepG2) cell line

in-vitro,

Liver,

HepG2

 30.71 nm

75 μg/mL

tumCV↓, ROS↑, Apoptosis↑,

4396-

SNP,

Identification of possible reductants in the aqueous leaf extract of mangrove plant Rhizophora apiculata for the fabrication and cytotoxicity of silver nanoparticles against human osteosarcoma MG-63 cells

in-vitro,

OS,

MG63

AntiCan↑, tumCV↓,

4403-

SNP,

Silver Nanoparticles Decorated UiO-66-NH2 Metal-Organic Framework for Combination Therapy in Cancer Treatment

in-vitro,

GBM,

U251

in-vitro,

GBM,

U87MG

in-vitro,

GBM,

GL26

in-vitro,

Cerv,

HeLa

in-vitro,

CRC,

RKO

AntiCan↑, eff↑, EPR↑, selectivity↑, ROS↑, Casp↑, Apoptosis↑, DNAdam↑, tumCV↓, eff↑,

4397-

SNP,

Synthesis and Characterization of Silver Nanoparticles from Rhizophora apiculata and Studies on Their Wound Healing, Antioxidant, Anti-Inflammatory, and Cytotoxic Activity

NA,

Wounds,

 99 nm, with a zeta potential of −6 mV

selectivity↑, tumCV↓, antiOx↑, Inflam↓,

4389-

SNP,

Graphene Oxide-Silver Nanocomposite Enhances Cytotoxic and Apoptotic Potential of Salinomycin in Human Ovarian Cancer Stem Cells (OvCSCs): A Novel Approach for Cancer Therapy

in-vitro,

Ovarian,

tumCV↓, ROS↑, LDH↓, MMP↑, CSCs↓, AntiCan↑,

4388-

SNP,

Differential Cytotoxic Potential of Silver Nanoparticles in Human Ovarian Cancer Cells and Ovarian Cancer Stem Cells

in-vitro,

Cerv,

47.5 nm

tumCV↓, CSCs↓, selectivity↑, Apoptosis↑, ROS↑, LDH↓, Casp3↑, BAX↑, Bak↑, cMyc↑, MMP↓,

4415-

SNP,

SDT,

CUR,

Examining the Impact of Sonodynamic Therapy With Ultrasound Wave in the Presence of Curcumin-Coated Silver Nanoparticles on the Apoptosis of MCF7 Breast Cancer Cells

in-vitro,

BC,

MCF-7

29.3 ± 5.6 nm

 48.23 µg/ml

SDT was performed using an US frequency of 1 MHz, intensity of 2 W/cm2, and a distance of 2 cm.

tumCV↓, BAX↑, Casp3↑, Bcl-2↓, eff↑, ROS↑, sonoS↑, eff↑, MMP↓, Cyt‑c↑,

4414-

SNP,

Silver nanoparticles: Forging a new frontline in lung cancer therapy

Review,

Lung,

tumCV↑, ROS↑, MMP↓, TumCCA↑, Apoptosis↑, angioG↓,

4411-

SNP,

Eco-friendly synthesis of silver nanoparticles using Anemone coronaria bulb extract and their potent anticancer and antibacterial activities

in-vitro,

Lung,

A549

in-vitro,

PC,

MIA PaCa-2

in-vitro,

Pca,

PC3

in-vitro,

Nor,

HEK293

AntiCan↑, selectivity↑, Apoptosis↑, TumCCA↑, Bacteria↓, tumCV↓, selectivity↑, Apoptosis↑, TumCCA↑,

4410-

SNP,

Green-synthesized silver nanoparticles: a sustainable nanoplatform for targeted colon cancer therapy

Review,

Colon,

AntiCan↑, ROS↑, mtDam↑, tumCV↓, selectivity↑,

4409-

SNP,

Plant-based synthesis of gold and silver nanoparticles using Artocarpus heterophyllus aqueous leaf extract and its anticancer activities

in-vitro,

BC,

MCF-7

12.75 nm

54.981 µg/mL

tumCV↓, TumCCA↑, cycD1/CCND1↓, COX2↓, HER2/EBBR2↓,

4408-

SNP,

Chitosan-coated silver nanoparticles synthesized using Moringa oleifera flower extract: A potential therapeutic approach against triple-negative breast cancer

in-vitro,

BC,

MDA-MB-231

 27 ± 0.5 μg/mL

tumCV↓,

4406-

SNP,

Silver nanoparticles achieve cytotoxicity against breast cancer by regulating long-chain noncoding RNA XLOC_006390-mediated pathway

in-vitro,

BC,

MCF-7

63.1 ± 8.3 nm

tissues from 64 patients

in-vitro,

BC,

T47D

in-vitro,

BC,

MDA-MB-231

TumCD↑, other↓, P53↑, TumCCA↑, Apoptosis↑, ChemoSen↑, tumCV↓, γH2AX↑, SOX4↓,

3402-

TQ,

Enhanced Apoptosis in Pancreatic Cancer Cells through Thymoquinone-rich Nigella sativa L. Methanol Extract: Targeting NRF2/HO-1 and TNF-α Pathways

in-vitro,

PC,

PANC1

in-vitro,

PC,

MIA PaCa-2

tumCV↓, NRF2↑, HO-1↑, TNF-α↓,

3403-

TQ,

A multiple endpoint approach reveals potential in vitro anticancer properties of thymoquinone in human renal carcinoma cells

in-vitro,

RCC,

786-O

TQ (1-100 μM) for 24 and 48 h

8.4 uM for 48 h

tumCV↓, ROS↑, TumCCA↑, eff↓, TumCI↓,

3415-

TQ,

The anti-neoplastic impact of thymoquinone from Nigella sativa on small cell lung cancer: In vitro and in vivo investigations

in-vitro,

Lung,

H446

1-100uM

tumCV↓, TumCCA↑, ROS↓, CycB/CCNB1↑, CycD3↑, cycA1/CCNA1↓, cycE/CCNE↓, cDC2↓, antiOx↑, PARP↓, NRF2↓, ARE/EpRE↑, eff↑,

3413-

TQ,

Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase

in-vitro,

CRC,

HCT116

tumCV↓, Apoptosis↓, BAX↑, Bcl-2↓, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, STAT3↓, survivin↓, cMyc↓, cycD1/CCND1↓, p27↑, P21↑, EGFR↓, ROS↑,

3414-

TQ,

Thymoquinone induces apoptosis through inhibition of JAK2/STAT3 signaling via production of ROS in human renal cancer Caki cells

in-vitro,

RCC,

Caki-1

tumCV↓, Apoptosis↑, P53↑, BAX↑, Cyt‑c↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, p‑STAT3↓, p‑JAK2↓, STAT3↓, survivin↓, cycD1/CCND1↓, ROS↑, eff↓,

1308-

TQ,

Thymoquinone induces apoptosis via targeting the Bax/BAD and Bcl-2 pathway in breast cancer cells

in-vitro,

BC,

MCF-7

tumCV↓, TumCP↓, BAX↑, P53⇅, Apoptosis↑,

2135-

TQ,

Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets

in-vitro,

Nor,

HaCaT

TQ (1, 5,
10, 20 lM) for 6 h

skin cells

*HO-1↑, *NRF2↑, *e-ERK↑, *e-Akt↑, *AMPKα↑, *ROS⇅, *eff↓, *tumCV∅,

2099-

TQ,

Cisplatin,

Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo

in-vitro,

Lung,

H460

in-vitro,

Lung,

H146

in-vivo,

NA,

mice

ChemoSen↑, TumCP↓, tumCV↓, Apoptosis↑, NF-kB↓,

2105-

TQ,

Thymoquinone Promotes Pancreatic Cancer Cell Death and Reduction of Tumor Size through Combined Inhibition of Histone Deacetylation and Induction of Histone Acetylation

in-vitro,

PC,

AsPC-1

10–50 μM

in-vitro,

PC,

MIA PaCa-2

in-vitro,

PC,

Hs766t

in-vivo,

NA,

mice

tumCV↓, TumCP↓, TumCCA↑, Apoptosis↑, P53↑, Bcl-2↓, P21↑, ac‑H4↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, TumVol↓,

2107-

TQ,

Cytotoxicity of Nigella sativa seed oil and extract against human lung cancer cell line

in-vitro,

Lung,

A549

tumCV↑,

2110-

TQ,

Nigella sativa seed oil suppresses cell proliferation and induces ROS dependent mitochondrial apoptosis through p53 pathway in hepatocellular carcinoma cells

in-vitro,

HCC,

HepG2

50–250 μg/ml) of NSO

44.6 μg/ml

in-vitro,

BC,

MCF-7

46.2 μg/ml

in-vitro,

Lung,

A549

245 μg/ml

in-vitro,

Nor,

HEK293

1136 μg/ml

indicates selectivity

P53↑, lipid-P↑, GSH↓, ROS↑, MMP↓, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, tumCV↓, selectivity↑,

1929-

TQ,

Thymoquinone Suppresses the Proliferation, Migration and Invasiveness through Regulating ROS, Autophagic Flux and miR-877-5p in Human Bladder Carcinoma Cells

in-vitro,

Bladder,

5637

0-50uM

 75 µM

in-vitro,

Bladder,

T24

60 µM

tumCV↓, TumCP↓, TumCI↓, Casp↑, ROS↑, PD-L1↓, EMT↓, MMP↓, eff↓,

1931-

TQ,

doxoR,

Thymoquinone enhances the anticancer activity of doxorubicin against adult T-cell leukemia in vitro and in vivo through ROS-dependent mechanisms

in-vivo,

AML,

Dox  50-750 nM, TQ 5-40uM

mice

eff↑, tumCV↓, TumCCA↑, ROS↑, MMP↓, eff↑, TumVol↓, eff↑, Ki-67↓,

5021-

UA,

Anticancer effect of ursolic acid via mitochondria-dependent pathways

Review,

Var,

Inflam↓, TNF-α↓, IL6↓, IL17↓, NF-kB↓, COX2↓, *AntiDiabetic↑, *hepatoP↑, ALAT↓, AST↓, TumCP↓, Apoptosis↑, TumCCA↑, TumAuto↑, tumCV↓, TumCMig↓, Glycolysis↓, ATP↓, lactateProd↓, HK2↓, PKA↓, COX2↓, mtDam↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, ROS↑, MMP↓, P53↑,

5020-

UA,

Anticancer activity of ursolic acid on human ovarian cancer cells via ROS and MMP mediated apoptosis, cell cycle arrest and downregulation of PI3K/AKT pathway

in-vitro,

Ovarian,

 IC50 of 35 µM in cancer cells and IC50 of 75 µM in normal cell lines

tumCV↓, selectivity↑, BAX↑, Bcl-2↓, Apoptosis↑, ROS↑, TumCCA↑, Akt↓, PI3K↓,

4857-

Uro,

Evaluation and comparison of the anti-proliferative and anti-metastatic effects of urolithin A and urolithin B against esophageal cancer cells: an in vitro and in silico study

in-vitro,

ESCC,

KYSE-30

tumCV↓, selectivity↑, TumCCA↑, ROS↑, Bcl-2↓, BAX↑, P21↑, MMP2↓, MMP9↓,

4840-

Uro,

Urolithin A: A promising selective estrogen receptor modulator and 27-hydroxycholesterol attenuator in breast cancer

vitro+vivo,

BC,

MMP↓, TumCP↓, Apoptosis↑, tumCV↓, ER-α36↝, *toxicity↓,

4839-

Uro,

Urolithin A induces prostate cancer cell death in p53-dependent and in p53-independent manner

in-vitro,

Pca,

22Rv1

in-vitro,

Pca,

LNCaP

tumCV↓, Apoptosis↓, P53↑, P21↑, PUMA↑, NOXA↑, MDM2↓, XIAP↓,

1836-

VitC,

VitK3,

Chemo,

Vitamins C and K3: A Powerful Redox System for Sensitizing Leukemia Lymphocytes to Everolimus and Barasertib

in-vitro,

AML,

tumCV↓, selectivity↑, Apoptosis↑, eff↑, ChemoSen↑,

1216-

VitC,

Ascorbic acid induces ferroptosis via STAT3/GPX4 signaling in oropharyngeal cancer

in-vitro,

Laryn,

FaDu

in-vitro,

SCC,

SCC-154

Iron↝, ROS↑, tumCV↓, Ki-67↓, TumCCA↑, Ferroptosis↑, GSH↓, ROS↑, MDA↑, STAT3↓, GPx4↓, p‑STAT3↓,

3119-

VitC,

Ascorbic acid–induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma

in-vitro,

RCC,

TET2↑, TumCG↓, tumCV↓,

3141-

VitC,

High-dose Vitamin C inhibits PD-L1 expression by activating AMPK in colorectal cancer

in-vitro,

CRC,

HCT116

Glycolysis↓, eff↑, PD-L1↓, AMPK↑, HK2↓, NF-kB↓, Warburg↓, tumCV↓, GLUT1↓, PKM2↓, LDHA↓, CD4+↑, CD8+↑,

2366-

VitD3,

Vitamin D3 decreases glycolysis and invasiveness, and increases cellular stiffness in breast cancer cells

in-vitro,

BC,

MCF-7

Glycolysis↓, tumCV↓, Apoptosis↑, mTOR↓, AMPK↑, EMT↓, E-cadherin↑, F-actin↑, Vim↓,

2279-

VitK2,

Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways

in-vitro,

Bladder,

T24

0-100uM

in-vitro,

Bladder,

J82

in-vitro,

Nor,

HEK293

in-vitro,

Nor,

L02

in-vivo,

NA,

mice

MMP↓, Cyt‑c↑, Casp3↑, p‑JNK↑, p‑p38↑, ROS↑, eff↓, tumCV↓, selectivity↑, *toxicity↓, TumVol↓,

1838-

VitK3,

PDT,

Photodynamic Effects of Vitamin K3 on Cervical Carcinoma Cells Activating Mitochondrial Apoptosis Pathways

in-vitro,

Cerv,

eff↑, ROS↑, tumCV↓, TumCG↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, Bcl-xL↑, Cyt‑c↑, Bcl-2↓,

1755-

WBV,

Reduction of breast cancer extravasation via vibration activated osteocyte regulation

Dose∅, TumMeta↑, eff∅, Piezo1↑, COX2↑, RANKL↓, TumCG∅, tumCV∅, TumCI↓,

4887-

ZER,

Rad,

Cisplatin,

Zerumbone acts as a radiosensitizer in head and neck squamous cell carcinoma

in-vitro,

HNSCC,

CAL27

Apoptosis↑, ChemoSen↑, RadioS↑, tumCV↓,

4888-

ZER,

5-FU,

Modulation of the tumor microenvironment by zerumbone and 5-fluorouracil in colorectal cancer by target in cancer-associated fibroblasts

in-vitro,

CRC,

CT26

TumVol↓, *tumCV↓, survivin↓, β-catenin/ZEB1↓, Vim↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 253

Pathway results for Effect on Cancer / Diseased Cells:

Infection & Microbiome ⓘ

Bacteria↓, 1, CD8+↑, 4,
Total Targets: 554

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 13, Catalase↑, 2, GPx↑, 1, GPx1↑, 1, GPx4↑, 1, GSH↑, 5, HO-1↑, 3, Keap1↓, 1, lipid-P↓, 3, Nrf1↑, 1, NRF2↑, 5, OXPHOS↓, 1, ROS↓, 8, ROS↑, 3, ROS⇅, 1, SOD↑, 2, SOD1↑, 1, uricA↓, 1, VitC↑, 2, VitE↑, 1,

Mitochondria & Bioenergetics ⓘ

mitResp↓, 1, MMP↓, 1,

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1, glucose↓, 1, Glycolysis↑, 1, HK2↑, 1, NADPH↓, 1, PFKL↑, 1, PFKM↑, 1, PKM2↑, 1,

Cell Death ⓘ

e-Akt↑, 1, Bax:Bcl2↑, 1, Casp3↓, 1, Casp3↑, 1, Casp8↑, 1, cl‑Casp8↑, 1, Casp9↑, 1, Fas↑, 1, iNOS↓, 1,

Kinase & Signal Transduction ⓘ

AMPKα↑, 1,

Transcription & Epigenetics ⓘ

other↝, 2, tumCV↓, 2, tumCV↑, 1, tumCV∅, 1,

DNA Damage & Repair ⓘ

P53↑, 1, PARP↑, 1, cl‑PARP↑, 1,

Cell Cycle & Senescence ⓘ

CDK2↓, 1, cycA1/CCNA1↓, 1, cycE/CCNE↑, 1, P21↑, 3, TumCCA↑, 1,

Proliferation, Differentiation & Cell State ⓘ

e-ERK↑, 1, GSK‐3β↓, 1, STAT↓, 1,

Migration ⓘ

Cartilage↑, 1, p‑Rac1↓, 1, TumCMig↑, 1,

Angiogenesis & Vasculature ⓘ

angioG↓, 1,

Barriers & Transport ⓘ

BBB↑, 1, GLUT1↑, 1, P-gp↓, 1,

Immune & Inflammatory Signaling ⓘ

COX2↓, 3, IKKα↑, 1, IL1↓, 1, IL10↓, 2, IL17↓, 1, IL1β↓, 2, IL6↓, 3, Inflam↓, 9, MCP1↓, 1, NF-kB↓, 2, PGE2↓, 1, TNF-α↓, 4,

Cellular Microenvironment ⓘ

pH↑, 1,

Synaptic & Neurotransmission ⓘ

tau↓, 2,

Protein Aggregation ⓘ

Aβ↓, 2, NLRP3↓, 1,

Hormonal & Nuclear Receptors ⓘ

GR↑, 1,

Drug Metabolism & Resistance ⓘ

BioAv↓, 2, BioAv↑, 1, Dose↝, 1, eff↓, 1, eff↑, 3, Half-Life↑, 1, Half-Life↝, 1,

Clinical Biomarkers ⓘ

ALAT↓, 1, ALP↓, 1, AST↓, 1, BP↓, 1, GutMicro↑, 1, IL6↓, 3,

Functional Outcomes ⓘ

AntiDiabetic↑, 2, AntiTum↑, 1, Bone Healing↑, 1, cardioP↑, 6, hepatoP↑, 5, memory↑, 1, neuroP↑, 6, Pain↓, 2, RenoP↑, 1, toxicity↓, 10, toxicity↝, 1, toxicity∅, 5, Wound Healing↑, 1,

Infection & Microbiome ⓘ

AntiFungal↑, 1, AntiViral↑, 1, Bacteria↓, 3,
Total Targets: 108

Scientific Paper Hit Count for: tumCV, Cell Viability

20 Silver-NanoParticles
13 Thymoquinone
12 Sulforaphane (mainly Broccoli)
9 Curcumin
9 Honokiol
9 Quercetin
8 Betulinic acid
8 Phenethyl isothiocyanate
7 Cisplatin
7 SonoDynamic Therapy UltraSound
7 Magnetic Fields
7 Shikonin
6 Berberine
6 Fisetin
5 Allicin (mainly Garlic)
5 Selenium
5 Resveratrol
5 Rosmarinic acid
4 Apigenin (mainly Parsley)
4 Metformin
4 Radiotherapy/Radiation
4 Shilajit/Fulvic Acid
4 Graviola
4 Propolis -bee glue
4 Silymarin (Milk Thistle) silibinin
4 Vitamin C (Ascorbic Acid)
3 Ashwagandha(Withaferin A)
3 Astaxanthin
3 Baicalein
3 Gemcitabine (Gemzar)
3 5-fluorouracil
3 chitosan
3 Chrysin
3 Citric Acid
3 Emodin
3 Gallic acid
3 Gambogic Acid
3 Magnolol
3 Lycopene
3 Methylene blue
3 Magnetic Field Rotating
3 Piperlongumine
3 Urolithin
2 Alpha-Lipoic-Acid
2 Boswellia (frankincense)
2 Coenzyme Q10
2 Copper and Cu NanoParticlex
2 Hydroxycinnamic-acid
2 Garcinol
2 Juglone
2 Luteolin
2 doxorubicin
2 Iron
2 Methylsulfonylmethane
2 Naringin
2 Nimbolide
2 Parthenolide
2 Piperine
2 Plumbagin
2 salinomycin
2 Chemotherapy
2 polyethylene glycol
2 Photodynamic Therapy
2 Ursolic acid
2 VitK3,menadione
2 Zerumbone
1 Andrographis
1 Artemisinin
1 Melatonin
1 Boron
1 Carvacrol
1 Catechins
1 Selenate
1 Vitamin E
1 Dichloroacetate
1 Disulfiram
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 Electrical Pulses
1 Estrogen
1 Fucoidan
1 Ferulic acid
1 Ginkgo biloba
1 γ-linolenic acid (Borage Oil)
1 HydroxyCitric Acid
1 tamoxifen
1 HydroxyTyrosol
1 itraconazole
1 Folic Acid
1 immunotherapy
1 Gold NanoParticles
1 Mushroom Chaga
1 Oleuropein
1 Phenylbutyrate
1 Hyperthermia
1 Pterostilbene
1 Perilla
1 Rutin
1 Scoulerine
1 acetazolamide
1 Resiquimod
1 Vitamin D3
1 Vitamin K2
1 Whole Body Vibration

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:897  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Database Query Results : , , tumCV

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned ⓘ

Redox & Oxidative Stress ⓘ

Metal & Cofactor Biology ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Cellular Microenvironment ⓘ

Synaptic & Neurotransmission ⓘ

Protein Aggregation ⓘ

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Cellular Microenvironment ⓘ

Synaptic & Neurotransmission ⓘ

Protein Aggregation ⓘ

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

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