Database Query Results : , , HRI

HRI, Heme-regulated eIF2α kinase: Click to Expand ⟱
Source:
Type:
Heme-regulated eIF2α kinase (HRI) is a protein kinase that plays a crucial role in regulating protein synthesis in response to cellular stress, including hypoxia, oxidative stress, and nutrient deprivation. HRI is activated by the depletion of heme, a key component of hemoglobin and other hemoproteins, and phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF2α), leading to the inhibition of protein synthesis.
The heme-regulated eIF2α kinase (HRI) is an Hsp90 client kinase which, upon folding by Hsp90, will activate, or mature, by autophosphorylation when heme is deficient.
HRI is part of the eIF2α kinase family, which includes other kinases like PERK, GCN2, and PKR, all of which phosphorylate the eukaryotic initiation factor 2 alpha (eIF2α) to inhibit protein translation.
Scientific Papers found: Click to Expand⟱
809- GAR,    High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors
- Review, NA, NA
HRI↓, HSP90↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Protein Folding & ER Stress ⓘ

HRI↓, 1,   HSP90↓, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HRI, Heme-regulated eIF2α kinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:898  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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