Database Query Results : , , TAMS

TAMS, tumor-associated macrophages: Click to Expand ⟱
Source:
Type:
Tumor-Associated Macrophages (TAMs)
TAMs are a type of immune cell found abundantly within the tumor microenvironment. They originate from circulating monocytes that differentiate into macrophages upon migrating into tissues.
TAMs produce various growth factors, such as epidermal growth factor (EGF) and transforming growth factor-beta (TGF-β), which can directly stimulate tumor cell proliferation and survival.
By secreting vascular endothelial growth factor (VEGF) and other pro-angiogenic factors, TAMs facilitate the formation of new blood vessels, ensuring that tumors receive an adequate supply of oxygen and nutrients.

High densities of TAMs are found in many tumor types, including breast, lung, colorectal, and pancreatic cancers, among others.
high infiltration of TAMs in tumors is correlated with worse overall survival, aggressive disease, increased metastatic potential, and resistance to therapy.
Scientific Papers found: Click to Expand⟱
3041- SK,    Promising Nanomedicines of Shikonin for Cancer Therapy
- Review, Var, NA
Glycolysis↓, TAMS↝, BioAv↓, Half-Life↝, P21↑, ERK↓, ROS↑, GSH↓, MMP↓, TrxR↓, MMP13↓, MMP2↓, MMP9↓, SIRT2↑, Hif1a↓, PKM2↓, TumCP↓, TumMeta↓, TumCI↓,
4853- Uro,    Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
- vitro+vivo, PC, MIA PaCa-2 - in-vitro, NA, PANC1
p‑Akt↓, p‑p70S6↓, TumCG↓, OS↑, PI3K↓, mTOR↓, TumCP↓, TumCMig↓, Apoptosis↑, TAMS↓, Treg lymp↓, Wnt↓, IGF-1↓, *toxicity↓, *BioAv↑, Half-Life↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   ROS↑, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 1,   PKM2↓, 1,   SIRT2↑, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Apoptosis↑, 1,  

Kinase & Signal Transduction ⓘ

p‑p70S6↓, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   IGF-1↓, 1,   mTOR↓, 1,   PI3K↓, 1,   TumCG↓, 1,   Wnt↓, 1,  

Migration ⓘ

MMP13↓, 1,   MMP2↓, 1,   MMP9↓, 1,   Treg lymp↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 2,   TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   TAMS↓, 1,   TAMS↝, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   Half-Life↝, 2,  

Functional Outcomes ⓘ

OS↑, 1,  
Total Targets: 31

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance ⓘ

BioAv↑, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: TAMS, tumor-associated macrophages
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:912  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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