Database Query Results : , , ASK1

ASK1, Apoptosis Signal-regulating Kinase 1: Click to Expand ⟱
Source:
Type:
ASK1 (Apoptosis Signal-regulating Kinase 1) is a protein kinase that plays a crucial role in cell signaling pathways, particularly in the regulation of apoptosis (programmed cell death) and cell survival.
ASK1 if often overexpressed and has been linked to tumor progression and poor prognosis.
Scientific Papers found: Click to Expand⟱
2617- Ba,    Potential of baicalein in the prevention and treatment of cancer: A scientometric analyses based review
- Review, Var, NA
Ca+2↑, MMP2↓, MMP9↓, Vim↓, Snail↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, i-ROS↑, Bcl-2↓, BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, STAT3↓, IL6↓, MMP2↓, MMP9↓, NOTCH↓, PPARγ↓, p‑NRF2↓, HK2↓, LDHA↓, PDK1↓, Glycolysis↓, PTEN↑, Akt↓, Hif1a↓, MMP↓, VEGF↓, VEGFR2↓, TOP2↓, uPA↓, TIMP1↓, TIMP2↓, cMyc↓, TrxR↓, ASK1↑, Vim↓, ZO-1↑, E-cadherin↑, SOX2↓, OCT4↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, XIAP↓,
1860- dietFMD,  Chemo,    Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
- in-vitro, BC, SUM159 - in-vitro, BC, 4T1
PI3K↑, Akt↑, mTOR↑, CDK4↑, CDK6↑, hyperG↓, TumCG↓, TumVol↓, Casp3↑, BG↓, eff↑, eff∅, PKA↓, KLF5↓, p‑GSK‐3β↑, Nanog↓, OCT4↓, KLF2↓, eff↑, ROS↑, BIM↑, ASK1↑, PI3K↑, Akt↑, mTOR↑, CDK1↓, CDK4↑, CDK6↑, eff↑,
2508- H2,    Molecular hydrogen is a promising therapeutic agent for pulmonary disease
- Review, Var, NA - Review, Sepsis, NA
*ROS↓, eff↝, *Inflam↓, *NRF2↑, *HO-1↑, *SOD↑, *Catalase↑, *MPO↑, *ASK1↓, *NADPH↓, *Sepsis↓, *HMGB1↓, ROS↑, NLRP3↑, GSDMD↑, chemoP↑, eff↑,
2028- PB,    Potential of Phenylbutyrate as Adjuvant Chemotherapy: An Overview of Cellular and Molecular Anticancer Mechanisms
- Review, Var, NA
HDAC↓, TumCCA↑, P21↑, Dose↝, Telomerase↓, IGFBP3↑, p‑p38↑, JNK↑, ERK↑, BAX↑, Casp3↑, Bcl-2↓, Cyt‑c↝, FAK↓, survivin↓, VEGF↓, angioG↓, DNArepair↓, TumMeta↓, HSP27↑, ASK1↑, ROS↑, eff↑, ER Stress↓, GRP78/BiP↓, CHOP↑, AR↓, other?,
914- QC,    Quercetin and Cancer Chemoprevention
- Review, NA, NA
GSH↓, ROS↑, TumCCA↑, Ca+2↑, MMP↓, Casp3↑, Casp8↑, Casp9↑, β-catenin/ZEB1↓, AMPKα↑, ASK1↑, p38↑, TRAIL↑, DR5↑, cFLIP↓, Apoptosis↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   hyperG↓, 1,   p‑NRF2↓, 1,   ROS↑, 4,   i-ROS↑, 1,   TrxR↓, 1,  

Metal & Cofactor Biology ⓘ

KLF5↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 2,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   LDHA↓, 1,   PDK1↓, 1,   PPARγ↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 2,   p‑Akt↓, 1,   Apoptosis↑, 1,   ASK1↑, 4,   BAX↑, 2,   Bcl-2↓, 2,   BIM↑, 1,   Casp3↑, 4,   Casp8↑, 1,   Casp9↑, 2,   cFLIP↓, 1,   Cyt‑c↑, 1,   Cyt‑c↝, 1,   DR5↑, 1,   GSDMD↑, 1,   JNK↑, 1,   p38↑, 1,   p‑p38↑, 1,   survivin↓, 1,   Telomerase↓, 1,   TRAIL↑, 1,  

Kinase & Signal Transduction ⓘ

AMPKα↑, 1,  

Transcription & Epigenetics ⓘ

other?, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   HSP27↑, 1,  

DNA Damage & Repair ⓘ

DNArepair↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK4↑, 2,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,   Gli1↓, 1,   p‑GSK‐3β↑, 1,   HDAC↓, 1,   IGFBP3↑, 1,   mTOR↑, 2,   p‑mTOR↓, 1,   Nanog↓, 1,   NOTCH↓, 1,   OCT4↓, 2,   PI3K↑, 2,   PTEN↑, 1,   Shh↓, 1,   Smo↓, 1,   SOX2↓, 1,   STAT3↓, 1,   TOP2↓, 1,   TumCG↓, 1,   Wnt↓, 1,  

Migration ⓘ

Ca+2↑, 2,   E-cadherin↑, 2,   FAK↓, 1,   KLF2↓, 1,   MMP2↓, 2,   MMP9↓, 2,   N-cadherin↓, 1,   PKA↓, 1,   Snail↓, 1,   TIMP1↓, 1,   TIMP2↓, 1,   TumMeta↓, 1,   uPA↓, 1,   Vim↓, 2,   ZO-1↑, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 1,   VEGF↓, 2,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL6↓, 1,   NF-kB↓, 1,  

Protein Aggregation ⓘ

NLRP3↑, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↑, 2,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↑, 5,   eff↝, 1,   eff∅, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   BG↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,   TumVol↓, 1,  
Total Targets: 101

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   HO-1↑, 1,   MPO↑, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

NADPH↓, 1,  

Cell Death ⓘ

ASK1↓, 1,  

Immune & Inflammatory Signaling ⓘ

HMGB1↓, 1,   Inflam↓, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 11

Scientific Paper Hit Count for: ASK1, Apoptosis Signal-regulating Kinase 1
1 Baicalein
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Hydrogen Gas
1 Phenylbutyrate
1 Quercetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:918  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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