Database Query Results : , , CXCR2

CXCR2, CXCR2: Click to Expand ⟱
Source:
Type: chemokine receptor
CXCR2 is a chemokine receptor that plays a crucial role in the progression and metastasis of various types of cancer.
CXCR2 is often over expression and is associated with poor prognosis and increased risk of metastasis.
Several CXCR2 inhibitors, such as SB225002 and AZD5069, have been developed and are being evaluated in preclinical and clinical studies for their potential to treat various types of cancer.
Scientific Papers found: Click to Expand⟱
3522- Bor,    The Boron Advantage: The Evolution and Diversification of Boron’s Applications in Medicinal Chemistry
- Review, Var, NA
Hif1a↓, HDAC↓, *CXCR2↑, ROS↑,
924- RES,    Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells
- in-vitro, OS, U2OS - in-vitro, Lung, A549
TumCCA↑, ROS↑, γH2AX↑, ATM↑, p‑CHK1↑, cellSen↑, CXCR2↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 2,  

DNA Damage & Repair ⓘ

ATM↑, 1,   p‑CHK1↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Immune & Inflammatory Signaling ⓘ

cellSen↑, 1,   CXCR2↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Immune & Inflammatory Signaling ⓘ

CXCR2↑, 1,  
Total Targets: 1

Scientific Paper Hit Count for: CXCR2, CXCR2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:921  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page