Database Query Results : , , Cav1

Cav1, Caveolin-1: Click to Expand ⟱
Source:
Type: protein
Caveolin-1 (Cav-1) is a protein that plays a crucial role in the structure and function of caveolae, which are small, flask-shaped invaginations of the plasma membrane found in many cell types. Cav-1 has been implicated in various cellular processes, including cell signaling, cholesterol transport, and apoptosis.

In the context of cancer, Cav-1 has been found to have both tumor-suppressive and tumor-promoting roles, depending on the type of cancer and the stage of disease progression.
Scientific Papers found: Click to Expand⟱
2603- Ba,    Baicalein inhibits prostate cancer cell growth and metastasis via the caveolin-1/AKT/mTOR pathway
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCG↓, Apoptosis↑, Cav1↓, p‑Akt↓, p‑mTOR↓, Bax:Bcl2↑, survivin↓, cl‑PARP↑, BioAv↓,
943- BetA,    Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-κB/c-Myc pathway
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
Glycolysis↓, lactateProd↓, GlucoseCon↓, ECAR↓, cMyc↓, LDHA↓, p‑PDK1↓, PDK1↓, Cav1↑, *Glycolysis↑, selectivity↑, OCR↓, OXPHOS↓,
2064- PB,  Rad,    Phenylbutyrate Attenuates the Expression of Bcl-XL, DNA-PK, Caveolin-1, and VEGF in Prostate Cancer Cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
Bcl-xL↓, Cav1↓, VEGF↓, RadioS↑, chemoP↑, HDAC↓, *toxicity↓, Diff↑, Prot↓,
942- UA,    Ursolic Acid Inhibits Breast Cancer Metastasis by Suppressing Glycolytic Metabolism via Activating SP1/Caveolin-1 Signaling
- vitro+vivo, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Cav1↑, Glycolysis↓, cMyc↓, LDHA↓, Nrf1↓, PGC-1α↓, Sp1/3/4↑, TumCG↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Nrf1↓, 1,   OXPHOS↓, 1,  

Mitochondria & Bioenergetics ⓘ

OCR↓, 1,   PGC-1α↓, 1,  

Core Metabolism/Glycolysis ⓘ

Cav1↓, 2,   Cav1↑, 2,   cMyc↓, 2,   ECAR↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 2,   lactateProd↓, 1,   LDHA↓, 2,   PDK1↓, 1,   p‑PDK1↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Apoptosis↑, 1,   Bax:Bcl2↑, 1,   Bcl-xL↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↑, 1,  

Transcription & Epigenetics ⓘ

Prot↓, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1,   HDAC↓, 1,   p‑mTOR↓, 1,   TumCG↓, 2,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   RadioS↑, 1,   selectivity↑, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,  
Total Targets: 31

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

Glycolysis↑, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: Cav1, Caveolin-1
1 Baicalein
1 Betulinic acid
1 Phenylbutyrate
1 Radiotherapy/Radiation
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:922  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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