Database Query Results : , , GLUT3

GLUT3, GLUT3: Click to Expand ⟱
Source:
Type:
GLUT3 is a member of the glucose transporter family, which plays a crucial role in glucose uptake and metabolism in cells. In the context of cancer, GLUT3 has been found to be overexpressed in various types of tumors, including brain, breast, colon, and lung cancers.
GLUT3 is overexpressed in cancer cells compared to normal cells. This overexpression is thought to contribute to the increased glucose uptake and metabolism observed in cancer cells.
Scientific Papers found: Click to Expand⟱
3441- ALA,    α-Lipoic Acid Maintains Brain Glucose Metabolism via BDNF/TrkB/HIF-1α Signaling Pathway in P301S Mice
- in-vivo, AD, NA
*tau↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, *VEGF↑, *HO-1↑, *Glycolysis↑, *HK1↑, *PGC-1α↑, *Hif1a↑, *neuroP↑,
3271- ALA,    Decrypting the potential role of α-lipoic acid in Alzheimer's disease
- Review, AD, NA
*antiOx↑, *memory↑, *neuroP↑, *Inflam↓, *IronCh↑, *NRF2↑, *BBB↑, *GlucoseCon↑, *Ach↑, *ROS↓, *p‑tau↓, *Aβ↓, *cognitive↑, *Hif1a↑, *Ca+2↓, *GLUT3↑, *GLUT4↑, *HO-1↑, *VEGF↑, *PDKs↓, *PDH↑, *VCAM-1↓, *GSH↑, *NRF2↑, *hepatoP↑, *ChAT↑,
3547- ALA,    Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration
- Review, AD, NA - Review, Park, NA
*memory↑, *neuroP↑, *motorD↑, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *5HT↑, *lipid-P↓, *IronCh↑, *AChE↓, *Inflam↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, NF-kB↓, *IGF-1↑, *IL1β↓, *TNF-α↓, *cognitive↑, *ChAT↑, *HO-1↑, *NQO1↑,
2319- Api,    Apigenin sensitizes radiotherapy of mouse subcutaneous glioma through attenuations of cell stemness and DNA damage repair by inhibiting NF-κB/HIF-1α-mediated glycolysis
- in-vitro, GBM, NA
Glycolysis↓, NF-kB↓, p65↓, Hif1a↓, GLUT1↓, GLUT3↓, PKM2↓, RadioS↑, TumVol↓, TumW↓,
2291- Ba,  BA,    Baicalein and Baicalin Promote Melanoma Apoptosis and Senescence via Metabolic Inhibition
- in-vitro, Melanoma, SK-MEL-28 - in-vitro, Melanoma, A375
LDHA↓, ENO1↓, PKM2↓, GLUT1↓, GLUT3↓, HK2↓, PFK1↓, GPI↓, TPI↓, GlucoseCon↓, TumCG↓, TumCP↓, mTORC1↓, Hif1a↓, Ki-67↓,
1640- CA,  MET,    Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines
- in-vitro, Cerv, SiHa
GLS↓, NADPH↓, ROS↑, TumCD↑, AMPK↑, Hif1a↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDH↓, cMyc↓, BAX↓, cycD1/CCND1↓, PDH↓, ROS↑, Apoptosis↑, eff↑, ACLY↓, FASN↓, Bcl-2↓, Glycolysis↓,
2310- EGCG,    Epigallocatechin-3-gallate downregulates PDHA1 interfering the metabolic pathways in human herpesvirus 8 harboring primary effusion lymphoma cells
- in-vitro, lymphoma, PEL
GLUT3↑, PDHA1↓, GDH↓, ROS↑, Glycolysis↓, OXPHOS↓,
1782- MEL,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, eff↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX↑, P21↑, p27↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
946- Nimb,    Nimbolide retards T cell lymphoma progression by altering apoptosis, glucose metabolism, pH regulation, and ROS homeostasis
- in-vivo, NA, NA
Apoptosis↑, Bcl-2↓, P53↑, cl‑Casp3↑, Cyt‑c↑, ROS↑, SOD↓, Catalase↓, Glycolysis↓, GLUT3↓, LDHA↓, MCT1↓, NHE1↓, ATPase↓, CAIX↓,
1231- PBG,    Caffeic acid phenethyl ester inhibits MDA-MB-231 cell proliferation in inflammatory microenvironment by suppressing glycolysis and lipid metabolism
- in-vitro, BC, MDA-MB-231
TumCP↓, TumCMig↓, TumCI↓, MMP↓, TLR4↓, TNF-α↓, NF-kB↓, IL1β↓, IL6↓, IRAK4↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDHA↓, ACC↓, FASN↓, eff↓,
2417- SK,    Shikonin inhibits the Warburg effect, cell proliferation, invasion and migration by downregulating PFKFB2 expression in lung cancer
- in-vitro, Lung, A549 - in-vitro, Lung, H446
TumCP↓, TumCMig↓, TumCI↓, GlucoseCon↓, lactateProd↓, PFKFB2↓, Warburg↓, GLUT1∅, LDHA∅, PKM2∅, GLUT3∅, PDH∅,
2419- SK,    Regulation of glycolysis and the Warburg effect in wound healing
- in-vivo, Nor, NA
Glycolysis↓, GLUT1↓, GLUT3↓, HK2↓, HK1↓, PFK1↓, PFK2↓, PKM2↓, lactateProd↓, GlucoseCon↓,
3950- Taur,    Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes
- Review, Diabetic, NA - Review, Stroke, NA - Review, AD, NA
*Ca+2↝, *neuroP↑, *other↝, *pH↝, *ROS∅, eff↑, *MMP↑, *Apoptosis↓, *other↝, *ER Stress↓, *Bcl-xL↓, *BAX↑, *Cyt‑c↑, *cal2↓, *Casp3↓, *UPR↓, *other↝, *NF-kB↓, *NRF2↑, *GLUT1↑, *GLUT3↑, *memory↑,
2397- Wor,    Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action
- Review, Var, NA
lactateProd↓, GlucoseCon↓, GLUT3↓, HK2↓, PKM2↓, LDHA↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 14

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   HK1↓, 1,   OXPHOS↓, 1,   ROS↑, 4,   SOD↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   ACLY↓, 1,   AMPK↑, 1,   CAIX↓, 1,   CAIX↑, 1,   cMyc↓, 1,   ENO1↓, 1,   FASN↓, 2,   GDH↓, 1,   GLS↓, 1,   GlucoseCon↓, 4,   Glycolysis↓, 5,   GPI↓, 1,   HK2↓, 5,   lactateProd↓, 3,   LDH↓, 1,   LDHA↓, 4,   LDHA∅, 1,   NADPH↓, 1,   PDH↓, 1,   PDH∅, 1,   PDHA1↓, 1,   PFK↓, 2,   PFK1↓, 2,   PFK2↓, 1,   PFKFB2↓, 1,   PKM2↓, 6,   PKM2∅, 1,   TPI↓, 1,   Warburg↓, 2,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 3,   BAX↓, 1,   BAX↑, 1,   Bcl-2↓, 3,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   JNK↑, 1,   MAPK↑, 1,   MCT1↓, 1,   p27↑, 1,   TumCD↑, 1,  

DNA Damage & Repair ⓘ

DNArepair↑, 1,   P53↑, 2,  

Cell Cycle & Senescence ⓘ

CDK4↓, 2,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1R↓, 1,   mTORC1↓, 1,   PI3K↓, 1,   PTEN↑, 1,   STAT3↓, 1,   TumCG↓, 1,   TumCG↑, 1,  

Migration ⓘ

ATPase↓, 1,   E-cadherin↑, 1,   Ki-67↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP9↓, 1,   Treg lymp↓, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 4,   TumMeta↑, 1,   Vim↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 4,   NO↓, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 5,   GLUT1↑, 1,   GLUT1∅, 1,   GLUT3↓, 7,   GLUT3↑, 2,   GLUT3∅, 1,   NHE1↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1,   COX2↓, 1,   FOXP3↓, 1,   IL1β↓, 1,   IL6↓, 2,   IL8↓, 1,   IRAK4↓, 1,   NF-kB↓, 4,   NK cell↑, 1,   p65↓, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TLR4↓, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors ⓘ

RANKL↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 1,   ChemoSen↑, 1,   Dose∅, 1,   eff↓, 1,   eff↑, 3,   RadioS↑, 2,  

Clinical Biomarkers ⓘ

IL6↓, 2,   Ki-67↓, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   ChemoSideEff↓, 1,   OS↑, 1,   radioP↑, 1,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 116

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 2,   GPx↑, 2,   GSH↑, 3,   HK1↑, 1,   HO-1↑, 3,   lipid-P↓, 1,   NQO1↑, 1,   NRF2↑, 3,   ROS↓, 2,   ROS∅, 1,   SOD↑, 2,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

GlucoseCon↑, 3,   Glycolysis↑, 1,   PDH↑, 1,   PDKs↓, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   BAX↑, 1,   Bcl-xL↓, 1,   Casp3↓, 1,   Cyt‑c↑, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↝, 3,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,   UPR↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↑, 1,  

Migration ⓘ

Ca+2↓, 1,   Ca+2↝, 1,   cal2↓, 1,   VCAM-1↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↑, 2,   VEGF↑, 2,  

Barriers & Transport ⓘ

BBB↑, 1,   GLUT1↑, 1,   GLUT3↑, 4,   GLUT4↑, 3,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   Inflam↓, 2,   NF-kB↓, 1,   TNF-α↓, 1,  

Cellular Microenvironment ⓘ

pH↝, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 1,   ChAT↑, 2,   tau↓, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 2,   hepatoP↑, 1,   memory↑, 3,   motorD↑, 1,   neuroP↑, 4,  
Total Targets: 57

Scientific Paper Hit Count for: GLUT3, GLUT3
3 Alpha-Lipoic-Acid
2 Shikonin
1 Apigenin (mainly Parsley)
1 Baicalein
1 Baicalin
1 Caffeic acid
1 Metformin
1 EGCG (Epigallocatechin Gallate)
1 Melatonin
1 Nimbolide
1 Propolis -bee glue
1 Taurine
1 Worenine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:928  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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