Database Query Results : , , PHDs

PHDs, Prolyl Hydroxylases: Click to Expand ⟱
Source:
Type:
Prolyl Hydroxylases (PHDs) are a family of enzymes that play a crucial role in regulating the activity of the transcription factor hypoxia-inducible factor (HIF). PHDs are responsible for hydroxylating specific proline residues on HIF, which leads to its degradation and prevents its activation.

Generally low expression in cancers, with poor prognosis.
Scientific Papers found: Click to Expand⟱
1650- CA,    Adjuvant Properties of Caffeic Acid in Cancer Treatment
- Review, Var, NA
ROS↑, antiOx↑, Inflam↓, AntiCan↑, NF-kB↓, STAT3↓, ERK↓, ChemoSen↑, RadioS↑, AMPK↑, eff↑, selectivity↑, COX2↓, Dose∅, PHDs↓, MMP9↓, MMP2↓, Dose∅, Dose∅, Ca+2↑, Dose?, MMP↓, RadioS↑,
970- MET,    Metformin suppresses HIF-1α expression in cancer-associated fibroblasts to prevent tumor-stromal cross talk in breast cancer
CAFs/TAFs↝, p‑AMPK↑, PHDs↑, Hif1a↓, TumCI↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   p‑AMPK↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   STAT3↓, 1,  

Migration ⓘ

Ca+2↑, 1,   CAFs/TAFs↝, 1,   MMP2↓, 1,   MMP9↓, 1,   TumCI↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   PHDs↓, 1,   PHDs↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Inflam↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose?, 1,   Dose∅, 3,   eff↑, 1,   RadioS↑, 2,   selectivity↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 25

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PHDs, Prolyl Hydroxylases
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:936  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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