Database Query Results : , , CPT1A

CPT1A, Carnitine Palmitoyltransferase 1A: Click to Expand ⟱
Source:
Type:
Carnitine Palmitoyltransferase 1A (CPT1A) is an enzyme that plays a crucial role in the regulation of fatty acid metabolism, particularly in the transport of long-chain fatty acids into mitochondria for beta-oxidation. In cancer, CPT1A has been implicated in the regulation of tumor cell metabolism, proliferation, and survival.

CPT1A typically overexpressed and is associated with poor prognosis and reduced overall survival in breast, lung, and colon cancers.
CPT1A expression is also associated with increased risk of metastasis and recurrence in various types of cancer.
Scientific Papers found: Click to Expand⟱
1172- Ash,    Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary Tumors
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
FASN↓, ACLY↓, ACC1↓, CPT1A↓, SREBP1↓,
2740- BetA,    Effects and mechanisms of fatty acid metabolism-mediated glycolysis regulated by betulinic acid-loaded nanoliposomes in colorectal cancer
- in-vitro, CRC, HCT116
TumCP↓, Glycolysis↓, HK2↓, PFK1↓, PKM2↓, ACSL1↓, CPT1A↓, FASN↓, FAO↓, GlucoseCon↓, lactateProd↓,
1576- Citrate,    Targeting citrate as a novel therapeutic strategy in cancer treatment
- Review, Var, NA
TCA↓, T-Cell↝, Glycolysis↓, PKM2↓, PFK2?, SDH↓, PDH↓, β-oxidation↓, CPT1A↓, FASN↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, cl‑PARP↑, Hif1a↓, GLUT1↓, angioG↓, Ca+2↓, ROS↓, eff↓, Dose↓, eff↑, Mcl-1↓, HK2↓, IGF-1R↓, PTEN↑, citrate↓, Dose∅, eff↑, eff↑, eff↑, eff↑,
1006- CUR,    The effect of Curcuma longa extract and its active component (curcumin) on gene expression profiles of lipid metabolism pathway in liver cancer cell line (HepG2)
- in-vitro, Liver, HepG2
TumCP↓, PGC1A↑, CPT1A↑, ACOX1↑, SCD1↓, SREBF2↓, DGAT1↓,
2404- SFN,    Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism
- in-vitro, Pca, LNCaP - in-vitro, Pca, 22Rv1 - in-vivo, NA, NA
ACC1↓, FASN↓, CPT1A↓, β-oxidation↓, SREBP1?, HK2↓, PKM2↓, LDHA↓, Glycolysis↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Mitochondria & Bioenergetics ⓘ

SDH↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACC1↓, 2,   ACLY↓, 1,   ACOX1↑, 1,   ACSL1↓, 1,   citrate↓, 1,   CPT1A↓, 4,   CPT1A↑, 1,   DGAT1↓, 1,   FAO↓, 1,   FASN↓, 3,   FASN↑, 1,   GlucoseCon↓, 1,   Glycolysis↓, 3,   HK2↓, 3,   lactateProd↓, 1,   LDHA↓, 1,   PDH↓, 1,   PFK1↓, 1,   PFK2?, 1,   PGC1A↑, 1,   PKM2↓, 3,   SCD1↓, 1,   SREBF2↓, 1,   SREBP1?, 1,   SREBP1↓, 1,   TCA↓, 1,   β-oxidation↓, 2,  

Cell Death ⓘ

Casp2↑, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Mcl-1↓, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1R↓, 1,   PTEN↑, 1,  

Migration ⓘ

Ca+2↓, 1,   TumCP↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

T-Cell↝, 1,  

Drug Metabolism & Resistance ⓘ

Dose↓, 1,   Dose∅, 1,   eff↓, 1,   eff↑, 5,  
Total Targets: 47

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CPT1A, Carnitine Palmitoyltransferase 1A
1 Ashwagandha(Withaferin A)
1 Betulinic acid
1 Citric Acid
1 Curcumin
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:956  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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