Database Query Results : , , eff

eff, efficacy: Click to Expand ⟱

Source:

Type:

Power to enhance an anti cancer effect

Scientific Papers found: Click to Expand⟱

4384-

Silver nanoparticles: synthesis, properties, and therapeutic applications

Review,

Var,

AntiCan↑, RadioS↑, CellMemb↑, ROS↑, DNAdam↑, PhotoS↑, eff↑,

2325-

2DG,

Research Progress of Warburg Effect in Hepatocellular Carcinoma

Review,

Var,

HK2↓, Glycolysis↓, PKM2↓, LDHA↓, TumCD↑, ChemoSen↑, eff↑,

2327-

2DG,

2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents

Review,

Var,

Glycolysis↓, HK2↓, mt-ROS↑, AMPK↑, PPP↓, NADPH↓, GSH↓, Bax:Bcl2↑, Apoptosis↑, RadioS↑, eff↓, Half-Life↓, other↝, eff↓,

1340-

3BP,

Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study

Review,

NA,

Glycolysis↓, HK2↓, LDH↓, OXPHOS↓, angioG↓, H2O2↑, eff↑,

1341-

3BP,

The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate

Review,

NA,

Glycolysis↓, OXPHOS↓, *toxicity↓, ROS↑, GSH↓, eff↑,

5282-

3BP,

Rad,

3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

MDA-MB-468

Glycolysis↓, RadioS↑, eff↑, GAPDH↓, PPP↑, GSH↓, ECAR↓,

5278-

3BP,

effect-of-3-bromopyruvate-on-human-colorectal">The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression

in-vitro,

CRC,

HCT116

in-vitro,

CRC,

Caco-2

in-vitro,

CRC,

SW48

ATP↓, TumCD↑, selectivity↑, toxicity↓, OS↑, HK2?, Cyt‑c↑, eff↑, p‑Akt↑,

5274-

3BP,

ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1

in-vitro,

PC,

eff↑, TumCG↓, TumMeta↓, toxicity↝, Glycolysis↓, toxicity↓, Dose↝,

5272-

3BP,

The efficacy of the anticancer 3-bromopyruvate is potentiated by antimycin and menadione by unbalancing mitochondrial ROS production and disposal in U118 glioblastoma cells

in-vitro,

GBM,

U87MG

in-vitro,

Nor,

HEK293

Glycolysis↓, ROS↑, GPx↓, eff↓, OXPHOS↓, HK2↓, ATP↓, ROS↑, ER Stress↑, BioAv↓, Cyt‑c↑, eff↑,

5263-

3BP,

CET,

3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis

in-vitro,

CRC,

DLD1

NA,

HCT116

eff↑, Ferroptosis↓, TumAuto↑, Apoptosis↑, FOXO3↑, AMPKα↑, p‑Beclin-1↑, HK2↓, ATP↓, ROS↑, Dose↝, TumVol↓, TumW↓, xCT↑, GSH↓, eff↓, MDA↑,

5259-

3BP,

Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP

in-vivo,

HCC,

highly glycolytic cancers.  young rats. Advanced cancers (2-3cm) developed

ATP↓, TumCD↑, toxicity↓, eff↑, tumCV↓, Dose↝,

5260-

3BP,

Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer

in-vivo,

PC,

TumCG↓, toxicity↓, BioAv↝, GAPDH↓, toxicity↑, Dose↝, ATP↓, eff↑, TumCI↓, MMP9↓, toxicity↓,

5261-

3BP,

The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH

in-vitro,

BC,

eff↑, eff↓,

5269-

3BP,

The anti-metabolite KAT/3BP has in vitro and in vivo anti-tumor activity in lymphoma models.

in-vitro,

HCC,

toxicity↑, eff↝, eff↑, Glycolysis↓, HK2↓, AIF↑, Apoptosis↑, NK cell↑, toxicity↑, toxicity↓, Dose↝, AntiTum↑,

5264-

3BP,

Candidate cancer drug suspected after death of three patients at an alternative medicine clinic

Review,

Var,

toxicity↑, Glycolysis↓, eff↑, OS↑, QoL↑, toxicity↝,

5266-

3BP,

3-bromopyruvate-based agent KAT-101

Review,

Var,

eff↑, Glycolysis↓, OXPHOS↓, ATP↓, TumCP↓, Apoptosis↑, HK2↓, MPT↑, LDH↓, PDH↓,

3452-

5-ALA,

5-ALA Is a Potent Lactate Dehydrogenase Inhibitor but Not a Substrate: Implications for Cell Glycolysis and New Avenues in 5-ALA-Mediated Anticancer Action

in-vitro,

GBM,

T98G

in-vitro,

GBM,

LN-18

in-vitro,

GBM,

U87MG

Glycolysis↓, LDH↓, eff↝, ECAR↓,

4774-

5-FU,

TQ,

CoQ10,

Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation

in-vitro,

CRC,

AntiCan↑, TumCCA↑, Apoptosis↑, eff↑, Bcl-2↓, survivin↓, P21↑, p27↑, BAX↑, Cyt‑c↑, Casp3↑, PI3K↓, Akt↓, mTOR↓, Hif1a↓, PTEN↑, AMPKα↑, PDH↑, LDHA↓, antiOx↓, ROS↑, AntiCan↑,

3941-

5HT,

dietMed,

VitB12,

FA,

VitC

Nutrition strategies that improve cognitive function

Review,

AD,

*other↑, *other↓, *cognitive↑, *eff↑, *eff↑,

3968-

ACNs,

Enhanced Neuronal Activation with Blueberry Supplementation in Mild Cognitive Impairment

Human,

AD,

freeze dried, whole fruit blueberry powder

*BOLD↑, *cognitive?, *eff↑,

3972-

ACNs,

Recent Research on the Health Benefits of Blueberries and Their Anthocyanins

Review,

AD,

Review,

Park,

*cardioP↑, *neuroP↑, *Inflam↓, *antiOx↓, *GutMicro↑, *Half-Life↑, *LDL↓, *adiP↓, *HDL↑, *CRP↓, *IL1β↓, *Risk↓, *Risk↓, *cognitive↑, *memory↑, *other↑, *BOLD↑, *NO↓, *MDA↓, *GSH↑, *VitC↑, *SOD↑, *GPx↑, *eff↓, *eff↓, *eff↓, *eff↝, *Risk↓,

3973-

ACNs,

Saskatoon and wild blueberries have higher anthocyanin contents than other Manitoba berries

Analysis,

AD,

eff↑,

1900-

AF,

Potential Anticancer Activity of Auranofin

Review,

Var,

TrxR↓, ROS↑, Apoptosis↓, TumCP↓, eff↑,

5459-

AF,

Auranofin Induces Lethality Driven by Reactive Oxygen Species in High-Grade Serous Ovarian Cancer Cells

in-vitro,

Ovarian,

ROS↑, TrxR↓, MMP↓, Apoptosis↑, eff↓, Casp3↑, Casp7↑, DNAdam↑, eff↑, GSH↓, angioG↓, ChemoSen↑, cl‑PARP↑, eff↑,

5464-

AF,

Inhibition of Thioredoxin-Reductase by Auranofin as a Pro-Oxidant Anticancer Strategy for Glioblastoma: In Vitro and In Vivo Studies

vitro+vivo,

GBM,

TrxR↓, BioAv↓, ROS↑, eff↝, TET1?, BioAv↑,

5460-

AF,

Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species

vitro+vivo,

Var,

4T1

RadioS↑, ROS↑, eff↓, mt-OCR↓, DNAdam↑, Apoptosis↑, TrxR↓, eff↑,

5469-

AF,

Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation

in-vitro,

CRC,

HCT116

eff↑, Half-Life↑,

5458-

AF,

Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell lung cancer

in-vitro,

NSCLC,

TrxR↓, AntiCan↓, GPx4↓, DNAdam↑, toxicity↓, eff↝,

5472-

AF,

Auranofin induces apoptosis and necrosis in HeLa cells via oxidative stress and glutathione depletion

in-vitro,

Cerv,

HeLa

TrxR↓, AntiCan↑, TumCG↓, Apoptosis↑, necrosis↑, cl‑PARP↑, MMP↓, ROS↑, GSH↓, eff↓,

5468-

AF,

The gold complex auranofin: new perspectives for cancer therapy

Review,

Var,

TrxR↓, ROS↑, eff↑, Apoptosis↑, TumCG↓, TumCP↓, Akt↓, NF-kB↓, DNAdam↑, eff↝, eff↓, PI3K↓, Akt↓, mTOR↓, Hif1a↓, VEGF↓, Casp3↑, CSCs↓, ATP↓, Glycolysis↓, eff↑, eff↑, MMP↓, AIF↑, toxicity↓,

5467-

AF,

Auranofin Inhibition of Thioredoxin Reductase Sensitizes Lung Neuroendocrine Tumor Cells (NETs) and Small Cell Lung Cancer (SCLC) Cells to Sorafenib as well as Inhibiting SCLC Xenograft Growth

in-vitro,

Lung,

DMS53 human small cell lung cancer cells

TrxR↓, eff↑, Dose↝, OS↑, eff↑,

5444-

AG,

A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine

Review,

Var,

*Imm↑, *antiOx↑, *Inflam↓, AntiTum↑, eff↑, chemoP↑, Dose↝, TumCMig↓, TumCP↓, Akt↓, GSK‐3β↓, MMP2↓, MMP9↓, EMT↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TGF-β1↓, TNF-α↓, IL6↓, Fas↓, FasL↓, NOTCH1↓, JNK↓, TumCG↓,

5431-

AG,

Advances in research on the anti-tumor mechanism of Astragalus polysaccharides

Review,

Var,

AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT↓, AMPK↑, Beclin-1↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,

5432-

AG,

Astragalus polysaccharides combined with radiochemotherapy for cervical cancer: a systematic review and meta-analysis of randomized controlled studies

Review,

Cerv,

ChemoSen↑, eff↑, RadioS↑, CEA↓, Wnt↓, β-catenin/ZEB1↓, γH2AX↑, ER Stress↑, mt-TumAuto↑, QoL↑, Imm↑,

5434-

AG,

Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview

Review,

Liver,

AntiCan↑, Apoptosis↑, TumCP↓, EMT↓, Imm↑, ChemoSen↑, BioAv↓, TumCG↓, IL2↑, IL12↑, TNF-α↑, P-gp↓, MDR1↓, QoL↑, Casp↑, DNAdam↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, NOTCH1↓, GSK‐3β↓, TumCCA↑, GSH↓, ROS↑, lipid-P↑, c-Iron↑, GPx4↓, ACSL4↑, Ferroptosis↑, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, Akt↓, PI3K↓, mTOR↓, CXCR4↓, Vim↓, PD-L1↓, eff↑, eff↑, ChemoSen↑, ChemoSen↑, chemoP↑,

5441-

AG,

Chemo,

Astragalus-containing Chinese herbal combinations for advanced non-small-cell lung cancer: a meta-analysis of 65 clinical trials enrolling 4751 patients

Review,

Lung,

 65 RCTs enrolling 4751 patients.

eff↑, ChemoSen↑,

326-

AgNPs,

TSA,

Modulating chromatin structure and DNA accessibility by deacetylase inhibition enhances the anti-cancer activity of silver nanoparticles

in-vitro,

Cerv,

HeLa

Apoptosis↑, ChrMod↝, eff↑,

312-

AgNPs,

wortm,

Inhibition of autophagy enhances the anticancer activity of silver nanoparticles

vitro+vivo,

Cerv,

HeLa

 10 μg/mL(10ppm)

 39.25 μg/mL

APA↑, p62↓, PIK3CA↑, TumVol↓, TumAuto↑, eff↑,

306-

AgNPs,

Cancer Therapy by Silver Nanoparticles: Fiction or Reality?

Analysis,

NA,

EPR↝, ROS↑, IL1↑, IL8↑, ER Stress↑, MMP9↑, MMP↓, Cyt‑c↑, Apoptosis↑, Hif1a↑, BBB↑, GutMicro↝, eff↑, eff↑, RadioS↑,

346-

AgNPs,

RSQ,

Investigating Silver Nanoparticles and Resiquimod as a Local Melanoma Treatment

in-vivo,

Melanoma,

SK-MEL-28

 AgNP (2 mg/kg) and RSQ (25 mg/kg) administration routes used were peri- and intratumora

 mice

in-vivo,

Melanoma,

WM35

ROS↑, Ca+2↝, Casp3↑, Casp8↑, Casp9↑, CD4+↑, CD8+↑, tumCV↓, eff↓, *toxicity↓,

356-

AgNPs,

MF,

Anticancer and antibacterial potentials induced post short-term exposure to electromagnetic field and silver nanoparticles and related pathological and genetic alterations: in vitro study

in-vitro,

BC,

MCF-7

 10 µM/ml + 1mT,2hr

 likely 50-60Hz and 1mT

in-vitro,

Bladder,

HTB-22

4uM/ml

 calculated IC50 value of AgNPs was 4.15 ± 0.20 μM/ml

Apoptosis↑, P53↑, iNOS↑, NF-kB↑, Bcl-2↓, ROS↑, SOD↑, TumCCA↑, eff↑, Catalase↑, other↑,

357-

AgNPs,

Hypoxia-mediated autophagic flux inhibits silver nanoparticle-triggered apoptosis in human lung cancer cells

in-vitro,

Lung,

A549

in-vitro,

Lung,

L132

mtDam↑, ROS↑, Hif1a↑, LC3s↑, p62↑, eff↓,

1907-

AgNPs,

GoldNP,

Cu,

In vitro antitumour activity of water soluble Cu(I), Ag(I) and Au(I) complexes supported by hydrophilic alkyl phosphine ligands

in-vitro,

Lung,

A549

in-vitro,

BC,

MCF-7

in-vitro,

Melanoma,

A375

in-vitro,

Colon,

HCT15

in-vitro,

Cerv,

HeLa

TrxR↓, eff↓, eff↓, other∅,

1906-

AgNPs,

GoldNP,

Cu,

Current Progresses in Metal-based Anticancer Complexes as Mammalian TrxR Inhibitors

Review,

Var,

TrxR↓, eff↓, eff↓,

1903-

AgNPs,

Novel Silver Complexes Based on Phosphanes and Ester Derivatives of Bis(pyrazol-1-yl)acetate Ligands Targeting TrxR: New Promising Chemotherapeutic Tools Relevant to SCLC Managemen

in-vitro,

Lung,

U1285

2uM, 24hr

TrxR↓, eff↝, ROS↑,

5236-

AgNPs,

Adaptive regulations of Nrf2 alleviates silver nanoparticles-induced oxidative stress-related liver cells injury

in-vitro,

Liver,

HepG2

in-vitro,

Nor,

L02

tumCV↓, ROS↑, *ROS↑, DNAdam↑, *DNAdam↑, eff↓, selectivity↑,

5237-

AgNPs,

Nrf2 Activation Mitigates Silver Nanoparticle-Induced Ferroptosis in Hepatocytes

in-vitro,

Liver,

HepG2

Ferroptosis↑, p62↑, NRF2↝, eff↓,

4403-

AgNPs,

Silver Nanoparticles Decorated UiO-66-NH2 Metal-Organic Framework for Combination Therapy in Cancer Treatment

in-vitro,

GBM,

U251

in-vitro,

GBM,

U87MG

in-vitro,

GBM,

GL26

in-vitro,

Cerv,

HeLa

in-vitro,

CRC,

RKO

AntiCan↑, eff↑, EPR↑, selectivity↑, ROS↑, Casp↑, Apoptosis↑, DNAdam↑, tumCV↓, eff↑,

4404-

AgNPs,

Rad,

Main Approaches to Enhance Radiosensitization in Cancer Cells by Nanoparticles: A Systematic Review

Review,

Var,

eff↑, ROS↑,

4400-

AgNPs,

Rad,

Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells

in-vitro,

BC,

MCF-7

in-vitro,

Nor,

MCF10

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

BT549

in-vivo,

BC,

MDA-MB-231

right hind flanks of the mice

ROS↑, DNAdam↑, selectivity↑, TumCG↓, RadioS↑, Dose↝, selectivity↑, other↝, eff↓, eff↑, γH2AX↑, Dose↓, eff↑,

4399-

AgNPs,

Chit,

Silver nanoparticles impregnated alginate-chitosan-blended nanocarrier induces apoptosis in human glioblastoma cells

in-vitro,

GBM,

U87MG

 2.4 μg mL(-1) for Ag NPs

DNAdam↑, ROS↑, MMP↓, eff↑,

4398-

AgNPs,

Induction of apoptosis in cancer cells at low silver nanoparticle concentrations using chitosan nanocarrier

in-vitro,

Colon,

HT29

0.33 μg mL(-1)

Apoptosis↑, MMP↓, Casp3↑, ROS↑, eff↑,

4392-

AgNPs,

Hepatocurative activity of biosynthesized silver nanoparticles fabricated using Andrographis paniculata

in-vivo,

LiverDam,

13-27 nm. Zeta potential was -34.3 mV indicating stable AgNPs.

 CCl(4) induced liver injury.

*antiOx↑, *eff?,

4423-

AgNPs,

Pongamia pinnata seed extract-mediated green synthesis of silver nanoparticle loaded nanogel for estimation of their antipsoriatic properties

in-vivo,

PSA,

 116 nm

*eff↑, *other↑,

4421-

AgNPs,

Effect of Biologically Synthesized Silver Nanoparticles on Human Cancer Cells

in-vitro,

Cerv,

selectivity↑, eff↝, other↝,

4424-

AgNPs,

Understanding the prospective of nano-formulations towards the treatment of psoriasis

in-vivo,

PSA,

*eff↑,

4415-

AgNPs,

SDT,

CUR,

Examining the Impact of Sonodynamic Therapy With Ultrasound Wave in the Presence of Curcumin-Coated Silver Nanoparticles on the Apoptosis of MCF7 Breast Cancer Cells

in-vitro,

BC,

MCF-7

29.3 ± 5.6 nm

 48.23 µg/ml

SDT was performed using an US frequency of 1 MHz, intensity of 2 W/cm2, and a distance of 2 cm.

tumCV↓, BAX↑, Casp3↑, Bcl-2↓, eff↑, ROS↑, sonoS↑, eff↑, MMP↓, Cyt‑c↑,

4413-

AgNPs,

Anzaroot,

Green synthesis of silver nanoparticles from plant Astragalus fasciculifolius Bioss and evaluating cytotoxic effects on MCF7 human breast cancer cells

in-vitro,

BC,

MCF-7

12.35 μg/mL

The IC50 value for root extract-mediated SNPs was found to be 21.73 μg/mL

chemoP↑, TumCG↓, eff↑, CellMemb↑, selectivity↑, ROS↑, P53↑,

4412-

AgNPs,

Biosynthesis and characterization of silver nanoparticles from Asplenium dalhousiae and their potential biological properties

in-vitro,

CRC,

HCT116

in-vitro,

Melanoma,

A2780S

Bacteria↓, antiOx↑, AntiCan↑, eff↑,

4405-

AgNPs,

Silver nanoparticles defeat p53-positive and p53-negative osteosarcoma cells by triggering mitochondrial stress and apoptosis

in-vitro,

OS,

Apoptosis↑, other↑, ROS↑, eff↑, P53↝, Apoptosis↑, cl‑Casp3↑, survivin↓, MMP↓, Cyt‑c↑,

4362-

AgNPs,

Enhancing Colorectal Cancer Radiation Therapy Efficacy using Silver Nanoprisms Decorated with Graphene as Radiosensitizers

in-vitro,

CRC,

HCT116

18–45 nm.

in-vitro,

CRC,

HT29

in-vivo,

NA,

Male Swiss nu/nu mice aged 5–8 weeks

eff↑, TumCG↓, OS↑, RadioS↑, eff↑, ROS↑, DNAdam↑, eff↝,

4360-

AgNPs,

Silver Nanoparticles as Real Topical Bullets for Wound Healing

Study,

Nor,

*other↝, *toxicity↓, *eff↑, *eff↑, *Inflam↓, *IL6↓, *TGF-β↑, *MMP9↓, *eff↑,

4359-

AgNPs,

Antimicrobial Silver Nanoparticles for Wound Healing Application: Progress and Future Trends

NA,

Wounds,

*Bacteria↓, *eff↑, *other↝, *toxicity↓,

4358-

AgNPs,

HPT,

Rad,

Silver nanocrystals mediated combination therapy of radiation with magnetic hyperthermia on glioma cells

in-vitro,

GBM,

U251

10 nm silver nanoparticles (AgNPs) on human glioma U251 c

RadioS↑, eff↑, TumCD↑,

4447-

AgNPs,

Anti-inflammatory action of silver nanoparticles in vivo: systematic review and meta-analysis

Review,

Nor,

*Inflam↓, *COX2↓, *ROS↓, *Dose↝, *eff↑, *toxicity↓, *IL4↑, *IL5↑, *IL10↑, *IL1↓, *IL6↓, *TNF-α↓, *NF-kB↓, *MDA↓, *GSH↑,

4381-

AgNPs,

Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells

in-vitro,

Liver,

HepG2

 human hepatoma cells.

eff↓, ROS↑, other↑,

4380-

AgNPs,

Silver nanoparticles induce toxicity in A549 cells via ROS-dependent and ROS-independent pathways

in-vitro,

Lung,

A549

ROS↑, tumCV↓, MMP↓, TumCCA↑, PCNA↓, eff↓,

4379-

AgNPs,

Exposure to silver nanoparticles induces size- and dose-dependent oxidative stress and cytotoxicity in human colon carcinoma cells

in-vitro,

CRC,

LoVo

eff↑, TumCD↑, ROS↑, Bacteria↓,

4378-

AgNPs,

Exploring silver nanoparticles for cancer therapy and diagnosis

Review,

Var,

AntiTum↑, ROS↑, eff↑, RadioS↑,

4377-

AgNPs,

Interaction between silver nanoparticles of 20 nm (AgNP20 ) and human neutrophils: induction of apoptosis and inhibition of de novo protein synthesis by AgNP20 aggregates

in-vitro,

NA,

human neutrophils (white blood cell) ie transportation

eff↑, Apoptosis↑,

4376-

AgNPs,

Interaction of multi-functional silver nanoparticles with living cells

in-vitro,

Nor,

L929

in-vitro,

Lung,

A549

eff↑, selectivity↑,

4375-

AgNPs,

The cellular uptake and cytotoxic effect of silver nanoparticles on chronic myeloid leukemia cells

in-vitro,

AML,

K562

eff↑, ROS↑, Apoptosis↑, eff↓,

4374-

AgNPs,

Enhancing antitumor activity of silver nanoparticles by modification with cell-penetrating peptides

in-vitro,

BC,

MCF-7

eff↑, TumCD↑,

4365-

AgNPs,

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

Review,

Var,

ROS↑, *toxicity↓, *Bacteria↓, *Inf↓, *Diff↑, *eff↑, RadioS↑, selectivity↑,

4383-

AgNPs,

Exploring the Potentials of Silver Nanoparticles in Overcoming Cisplatin Resistance in Lung Adenocarcinoma: Insights from Proteomic and Xenograft Mice Studies

in-vitro,

Lung,

A549

AgNPs was 23.45 nm, with zeta potentials lying on −20.33 mV.

in-vivo,

Lung,

A549

A549 and A549/DDP-bearing mice

Apoptosis↑, VEGF↓, P53↓, TumCCA↑, ROS↑, AntiTum↑, eff↑, ATP↓, eff↑, CTR1↑,

4552-

AgNPs,

ART/DHA,

Green synthesis of silver nanoparticles using Artemisia turcomanica leaf extract and the study of anti-cancer effect and apoptosis induction on gastric cancer cell line (AGS)

in-vitro,

GC,

AGS

AntiCan↑, Apoptosis↑, eff↑,

4564-

AgNPs,

GoldNP,

Cu,

Chemo,

PDT

Cytotoxicity and targeted drug delivery of green synthesized metallic nanoparticles against oral Cancer: A review

Review,

Var,

ROS↑, DNAdam↑, TumCCA↑, eff↑, Apoptosis↑, eff↓, ChemoSen↑,

4561-

AgNPs,

VitC,

Cellular Effects Nanosilver on Cancer and Non-cancer Cells: Potential Environmental and Human Health Impacts

in-vitro,

CRC,

HCT116

in-vitro,

Nor,

HEK293

NRF2↑, TumCCA↑, ROS↑, selectivity↑, *AntiViral↑, *toxicity↝, ETC↓, MMP↓, DNAdam↑, Apoptosis↑, lipid-P↑, other↝, UPR↑, *GRP78/BiP↑, *p‑PERK↑, *cl‑eIF2α↑, *CHOP↑, *JNK↑, Hif1a↓, AntiCan↑, *toxicity↓, eff↑,

4554-

AgNPs,

Involvement of telomerase activity inhibition and telomere dysfunction in silver nanoparticles anticancer effects

in-vitro,

Cerv,

HeLa

Telomerase↓, eff↝,

4553-

AgNPs,

Cytotoxicity induced by engineered silver nanocrystallites is dependent on surface coatings and cell types

in-vitro,

Nor,

RAW264.7

*Wound Healing↑, *eff↝, *toxicity↝,

4551-

AgNPs,

Fenb,

Ångstrom-Scale Silver Particles as a Promising Agent for Low-Toxicity Broad-Spectrum Potent Anticancer Therapy

in-vivo,

Lung,

mice

eff↑, eff↑, Apoptosis↑, selectivity↓, TumCG↓,

4549-

AgNPs,

Silver nanoparticles: Synthesis, medical applications and biosafety

Review,

Var,

Review,

Diabetic,

ROS↑, eff↑, other↝, DNAdam↑, EPR↑, eff↑, eff↑, TumMeta↓, angioG↓, *Bacteria↓, *eff↑, *AntiViral↑, *AntiFungal↑, eff↑, eff↑, TumCP↓, tumCV↓, P53↝, HIF-1↓, TumCCA↑, lipid-P↑, ATP↓, Cyt‑c↑, MMPs↓, PI3K↓, Akt↓, *Wound Healing↑, *Inflam↓, *Bone Healing↑, *glucose↓, *AntiDiabetic↑, *BBB↑,

4547-

AgNPs,

GoldNP,

VitC,

Exploration of Biocompatible Ascorbic Acid Reduced and Stabilized Gold Nanoparticles, as Sensitive and Selective Detection Nanoplatform for Silver Ion in Solution

Study,

NA,

*eff↑,

4545-

AgNPs,

VitC,

Citrate,

Ascorbic Acid-assisted Green Synthesis of Silver Nanoparticles: pH and Stability Study

Study,

NA,

average size of
22.4 ± 13.2 nm

*other↝, *other↝, *eff↑, *eff↑,

4544-

AgNPs,

VitC,

Current Research on Silver Nanoparticles: Synthesis, Characterization, and Applications

Review,

Nor,

*Bacteria↓, *eff↑,

4574-

AgNPs,

Advances in nano silver-based biomaterials and their biomedical applications

Review,

NA,

*Wound Healing↑, *AntiThr↑, *AntiAg↑, eff↑,

4600-

AgNPs,

Effects of particle size and coating on toxicologic parameters, fecal elimination kinetics and tissue distribution of acutely ingested silver nanoparticles in a mouse model

in-vivo,

Nor,

Mice

*Half-Life↝, *toxicity↓, *Dose↑, *other↝, *eff↝, *BioAv↓,

5147-

AgNPs,

Size dependent anti-invasiveness of silver nanoparticles in lung cancer cells

in-vitro,

Lung,

A549

TumCMig↓, TumCI↓, ROS↑, p‑NF-kB↑, selectivity↑, eff↝,

5144-

AgNPs,

Differential effects of silver nanoparticles on DNA damage and DNA repair gene expression in Ogg1-deficient and wild type mice

in-vivo,

Nor,

orally to 4 mg/kg of citrate-coated AgNPs over a period of 7 d.

wild type mice

*DNAdam↑, *toxicity↝, eff↝,

5142-

AgNPs,

Biosynthesized Protein-Capped Silver Nanoparticles Induce ROS-Dependent Proapoptotic Signals and Prosurvival Autophagy in Cancer Cells

in-vitro,

CRC,

HUH7

220 and 249 nm

ROS↑, Apoptosis↑, eff↑, ChemoSen↑, EPR↑, Casp↑, MAPK↑,

2287-

AgNPs,

Silver nanoparticles induce endothelial cytotoxicity through ROS-mediated mitochondria-lysosome damage and autophagy perturbation: The protective role of N-acetylcysteine

in-vitro,

Nor,

HUVECs

*TumCP↓, *ROS↑, *eff↓, *MDA↑, *GSH↓, *MMP↓, *ATP↓, *LC3II↑, *p62↑, *Bcl-2↓, *BAX↑, *Casp3↑,

2286-

AgNPs,

Short-term changes in intracellular ROS localisation after the silver nanoparticles exposure depending on particle size

in-vitro,

Nor,

3T3

, we used AgNPs-70 and AgNPs-1 as well as AgNO3 as a
source of Ag+

*eff↑, *mt-ROS↑, *eff↑,

2837-

AgNPs,

Trojan-Horse Mechanism in the Cellular Uptake of Silver Nanoparticles Verified by Direct Intra- and Extracellular Silver Speciation Analysis

in-vitro,

NA,

eff↑,

2836-

AgNPs,

Gluc,

Glucose capped silver nanoparticles induce cell cycle arrest in HeLa cells

in-vitro,

Cerv,

HeLa

eff↝, TumCCA↑, eff↑, eff↑, ROS↑, GSH↓, SOD↓, lipid-P↑, LDH↑,

2835-

AgNPs,

Gluc,

Carbohydrate functionalization of silver nanoparticles modulates cytotoxicity and cellular uptake

in-vitro,

Liver,

HepG2

Dose↝, eff↑, ROS↑, eff↝, eff↑, eff↝, eff↑, eff↝,

2207-

AgNPs,

TQ,

Protective effects of Nigella sativa L. seeds aqueous extract-based silver nanoparticles on sepsis-induced damages in rats

in-vivo,

Nor,

Rats

*eff↑, *RenoP↑, *hepatoP↑, *MDA↓, *SOD↑, *GSH↑, *TNF-α↓, *IL1β↓,

2205-

AgNPs,

Potential protective efficacy of biogenic silver nanoparticles synthesised from earthworm extract in a septic mice model

in-vivo,

Nor,

mice, septic

*Dose↝, *eff↑, *RenoP↑, *antiOx↑, *MDA↓, *NO↓, *hepatoP↑, *toxicity↝, *GSH↑, *SOD↑, *GSTs↑, *Catalase↑,

2538-

AgNPs,

SDT,

Dual-functional silver nanoparticle-enhanced ZnO nanorods for improved reactive oxygen species generation and cancer treatment

Study,

Var,

vitro+vivo,

NA,

mice

ROS↑, eff↑, eff↑, TumCP↓, toxicity↓,

5341-

Ajoene,

Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy

Review,

AML,

eff↑, AntiThr↑, Bacteria↓, LDH↓, TumCP↓, TumCCA↑, Bcl-2↓, Cyt‑c↑, Casp3↑,

5350-

Akk,

immuno,

Enhancing Immune Response in Immunotherapy-Resistant Melanoma Through Fecal Microbiota Transplantation: A Systematic Review

eff↑,

5349-

Akk,

immuno,

Improved survival in advanced melanoma patients treated with fecal microbiota transplantation using healthy donor stool in combination with anti-PD1: final results of the MIMic phase 1 trial

Case Report,

Melanoma,

 20 patients received FMT and anti-PD1 therapy.

eff↑, OS↑, eff↑,

5348-

Akk,

immuno,

Gut Microbiota Modulation through Akkermansia spp. Supplementation Increases CAR T-cell Potency

Human,

Var,

other↑, eff↑,

5347-

Akk,

immuno,

Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer

Human,

NSCLC,

eff↑,

5346-

Akk,

immuno,

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

in-vivo,

Var,

eff↑,

235-

AL,

Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway

in-vitro,

GBM,

U87MG

 90 μM

Apoptosis↑, Bcl-2↓, BAX↑, MAPK↑, p‑ERK↑, ROS↑, eff↓,

234-

AL,

Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy

in-vitro,

HCC,

Hep3B

 0, 15, 20, 25, 35, 40 and 50 Î¼M of allicin for 24 h

 35 uM @24h

ROS↑, *toxicity∅, MMP↓, BAX↑, Bcl-2↓, AIF↑, Casp3↑, Casp8↑, Casp9↑, eff↓, γH2AX↑, selectivity↑, DNA-PK↑,

2646-

AL,

Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress

in-vitro,

Pca,

DU145

in-vitro,

Melanoma,

RPMI-8226

AntiCan↑, eff↓, ChemoSen↑, ER Stress↑, tumCV↓, DNAdam↑, GSH∅, HSP70/HSPA5↓, UPR↑, β-catenin/ZEB1↓, ROS↑, HO-2↑, SIRT1↑, GlucoseCon∅, lactateProd∅, chemoP↑,

2660-

AL,

Allicin: A review of its important pharmacological activities

Review,

AD,

Review,

Var,

Review,

Park,

Review,

Stroke,

*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2↓, p‑FAK↓,

1916-

AL,

Allicin Bioavailability and Bioequivalence from Garlic Supplements and Garlic Foods

Review,

Nor,

*BioAv↝, *eff↓, *BioAv↝, *BioAv↝, *eff↑, *Half-Life∅, *eff↑, *eff↑, *Dose∅, *eff↑,

278-

ALA,

The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment

Review,

NA,

ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, eff↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,

281-

ALA,

Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation

in-vitro,

Lung,

H460

0-100uM

mt-ROS↑, Apoptosis↑, Casp9↑, Bcl-2↓, eff↓, eff↑, H2O2↑, Dose↑,

3272-

ALA,

Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential

Review,

AD,

*antiOx↑, *glucose↑, *eNOS↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cardioP↑, *cognitive↑, *eff↓, *BBB↑, *IronCh↑, *GSH↑, *PKCδ↑, *ERK↑, *p38↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GLUT1↑, *Inflam↓,

3456-

ALA,

Renal-Protective Roles of Lipoic Acid in Kidney Disease

Review,

NA,

*RenoP↑, *ROS↓, *antiOx↑, *Inflam↓, *Sepsis↓, *IronCh↑, *BUN↓, *creat↓, *TNF-α↓, *IL6↓, *IL1β↓, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *chemoP↑, *eff↑, *NF-kB↓,

3439-

ALA,

The effect of alpha lipoic acid on the developmental competence of mouse isolated preantral follicles

in-vitro,

NA,

100uM

Pre-antral follicles were isolated from immature mouse ovaries and were cultured in α- minimal essential medium supplemented

*ROS↓, *TAC↑, *eff↑, *SOD↑, *GPx↑, *Catalase↑, *GlucoseCon↑, *antiOx↑,

3443-

ALA,

Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention

Review,

Var,

Review,

AD,

*antiOx↑, *ROS↓, *IronCh↑, *cognitive↑, *cardioP↓, AntiCan↑, *neuroP↑, *Inflam↓, *BioAv↓, *AntiAge↑, *Half-Life↓, *BioAv↝, other↝, EGFR↓, Akt↓, ROS↓, TumCCA↑, p27↑, PDH↑, Glycolysis↓, ROS↑, *eff↑, *memory↑, *motorD↑, *GutMicro↑,

3454-

ALA,

Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness

in-vitro,

BC,

MCF-7

(0.5 mM, 1 mM, 2.5 mM, and 5 mM)

in-vitro,

BC,

MDA-MB-231

TumCG↑, Glycolysis↓, ROS↑, CSCs↓, selectivity↑, LC3B-II↑, MMP↓, mitResp↓, ATP↓, OCR↓, NAD↓, p‑AMPK↑, GlucoseCon↓, lactateProd↓, HK2↓, PFK↓, LDHA↓, eff↓, mTOR↓, ECAR↓, ALDH↓, CD44↓, CD24↓,

3539-

ALA,

Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential

Review,

AD,

*ROS↓, *IronCh↑, *GSH↑, *antiOx↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cognitive↑, *Inflam↓, *BioAv↝, *BioAv↝, *BBB↑, *H2O2∅, *neuroP↑, *PKCδ↑, *ERK↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GlucoseCon↑, *BP↝, *eff↑, *ICAM-1↓, *VCAM-1↓, *Dose↝,

3550-

ALA,

Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?

Review,

AD,

*antiOx↑, *Inflam↓, *PGE2↓, *COX2↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *BioAv↓, *Ach↑, *ROS↓, *cognitive↑, *neuroP↑, *BBB↑, *Half-Life↓, *BioAv↑, *Casp3↓, *Casp9↓, *ChAT↑, *cognitive↑, *eff↑, *cAMP↑, *IL2↓, *INF-γ↓, *TNF-α↓, *SIRT1↑, *SOD↑, *GPx↑, *MDA↓, *NRF2↑,

5324-

ALC,

The anti-wasting effects of L-carnitine supplementation on cancer: experimental data and clinical studies

Review,

Var,

*cachexia↓, *Apoptosis↓, *Inflam↓, QoL↑, Dose↝, Weight↑, OS↝, fatigue↓, eff↝,

5360-

almon,

BEV,

Case report: Almonertinib in combination with bevacizumab for leptomeningeal metastases from epidermal growth factor receptor-mutation non-small cell lung cancer: Case series

Case Report,

NSCLC,

BBB↑, Dose↝, eff↓, OS↑,

5359-

almon,

Aumolertinib as adjuvant therapy in resected EGFR-mutated non-small-cell lung cancer (ARTS): a double-blind, multicentre, randomised, controlled, phase 3 trial

Trial,

NSCLC,

 214 patients were randomly assigned to receive aumolertinib or placebo

eff↑, EGFR↓,

5357-

almon,

AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or MetastaticNon-Small-Cell Lung Cancer With EGFR Exon 19 Deletion or L858R Mutations

Trial,

NSCLC,

429 patients

EGFR↓, eff↝, OS↑,

1440-

AMQ,

Lysosomotropism depends on glucose: a chloroquine resistance mechanism

in-vitro,

BC,

4T1

eff↑, Apoptosis↓, Necroptosis↑, eff↓, ChemoSen↑, eff↓,

1158-

And,

GEM,

Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer

TumCP↓, TumCCA↑, Apoptosis↑, STAT3↓, Akt↓, P21↑, BAX↑, cycD1/CCND1↓, cycE/CCNE↓, survivin↓, XIAP↓, Bcl-2↓, eff↑,

1354-

And,

Andrographolide induces protective autophagy and targeting DJ-1 triggers reactive oxygen species-induced cell death in pancreatic cancer

in-vitro,

PC,

0, 10, 20, 40 µM

in-vivo,

PC,

Apoptosis↑, DJ-1↓, ROS↑, TumAuto↑, TumCCA↑, TumCP↓, TumW↓, eff↓,

1351-

And,

MEL,

Impact of Andrographolide and Melatonin Combinatorial Drug Therapy on Metastatic Colon Cancer Cells and Organoids

in-vitro,

CRC,

T84

in-vitro,

CRC,

COLO205

in-vitro,

CRC,

HT-29

in-vitro,

CRC,

DLD1

eff↑, Ki-67↓, Casp3↑, ER Stress↑, ROS↑, BAX↑, XBP-1↑, CHOP↑, eff↑,

1348-

And,

Andrographolide Inhibits ER-Positive Breast Cancer Growth and Enhances Fulvestrant Efficacy via ROS-FOXM1-ER-α Axis

in-vitro,

BC,

MCF-7

in-vitro,

BC,

T47D

in-vivo,

NA,

AD (150 mg/kg per day), fulvestrant (5 mg/mouse administered subcutaneously, once per week)

mice

ERα/ESR1↓, TumCG↓, ROS↑, FOXM1↓, eff↑,

4759-

antiOx,

Chemo,

Potential Contributions of Antioxidants to Cancer Therapy: Immunomodulation and Radiosensitization

Review,

Var,

TumCD↑, TumCG↓, ROS⇅, eff↑, RadioS↑, TumCG↓, OS↑, toxicity∅, toxicity↑,

4765-

antiOx,

Chemo,

Antioxidants as precision weapons in war against cancer chemotherapy induced toxicity – Exploring the armoury of obscurity

Review,

Var,

chemoP↑, ChemoSen↑, OS↑, Dose↑, Risk↓, eff↓,

4746-

antiOx,

Chemo,

VitA,RetA,

VitC,

Using Supplements During Chemo: Yes or No?

Review,

Var,

eff↓, ChemoSen↓, RadioS↓, other↝,

1152-

Api,

Does Oral Apigenin Have Real Potential for a Therapeutic Effect in the Context of Human Gastrointestinal and Other Cancers?

Analysis,

Nor,

1–5μmol/L as the target

*BioAv↓, Half-Life∅, *BioAv↓, Dose∅, eff↑, CYP1A2↓, CYP2C9↓, CYP3A4↓,

1554-

Api,

A Review on Flavonoid Apigenin: Dietary Intake, ADME, Antimicrobial Effects, and Interactions with Human Gut Microbiota

Review,

NA,

*BioAv↑, *BioAv↑, *BioAv↑, *BioAv↓, *eff↑,

1549-

Api,

Chemo,

Chemoprotective and chemosensitizing effects of apigenin on cancer therapy

Review,

NA,

ChemoSideEff↓, *toxicity∅, ChemoSen↑, eff↑, eff↑, eff↑,

1547-

Api,

Apigenin: Molecular Mechanisms and Therapeutic Potential against Cancer Spreading

Review,

NA,

angioG↓, EMT↓, CSCs↓, TumCCA↑, Dose∅, ROS↑, MMP↓, Catalase↓, GSH↓, PI3K↓, Akt↓, NF-kB↓, OCT4↓, Nanog↓, SIRT3↓, SIRT6↓, eff↑, eff↑, Cyt‑c↑, Bax:Bcl2↑, p‑GSK‐3β↓, FOXO3↑, p‑STAT3↓, MMP2↓, MMP9↓, COX2↓, MMPs↓, NRF2↓, HDAC↓, Telomerase↓, eff↑, eff↑, eff↑, eff↑, eff↑, XIAP↓, survivin↓, CK2↓, HSP90↓, Hif1a↓, FAK↓, EMT↓,

1539-

Api,

LT,

Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells

in-vitro,

Liver,

HepG2

1,10,25uM

SREBP2↓, eff↑, p‑MEK↓, p‑ERK↓,

1536-

Api,

Apigenin causes necroptosis by inducing ROS accumulation, mitochondrial dysfunction, and ATP depletion in malignant mesothelioma cells

in-vitro,

MM,

MSTO-211H

0, 10, 30, and 50 µM) of apigenin for 48 h and 72 h

in-vitro,

MM,

H2452

tumCV↓, ROS↑, MMP↓, ATP↓, Apoptosis↑, Necroptosis↑, DNAdam↑, TumCCA↑, Casp3↑, cl‑PARP↑, MLKL↑, p‑RIP3↑, Bax:Bcl2↑, eff↓, eff↓,

1564-

Api,

Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation

in-vitro,

Pca,

22Rv1

10–80 μM

in-vivo,

NA,

MDM2↓, NF-kB↓, p65↓, P21↑, ROS↑, GSH↓, MMP↓, Cyt‑c↑, Apoptosis↑, P53↑, eff↓, Bcl-xL↓, Bcl-2↓, BAX↑, Casp↑, TumCG↓, TumVol↓, TumW↓,

1563-

Api,

MET,

Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells

in-vitro,

Nor,

HDFa

metformin (5 mM), apigenin (1 or 20 µM),

in-vitro,

PC,

AsPC-1

in-vitro,

PC,

MIA PaCa-2

in-vitro,

Pca,

DU145

in-vitro,

Pca,

LNCaP

in-vivo,

NA,

mice

selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,

1558-

Api,

Preparation, characterization and antitumor activity evaluation of apigenin nanoparticles by the liquid antisolvent precipitation technique

in-vitro,

Liver,

HepG2

BioAv↑, *toxicity∅, eff↑,

2632-

Api,

Apigenin inhibits migration and induces apoptosis of human endometrial carcinoma Ishikawa cells via PI3K-AKT-GSK-3β pathway and endoplasmic reticulum stress

in-vitro,

EC,

 20–60 μM

45.55 μM

TumCP↓, TumCCA↑, Apoptosis↑, Bcl-2↓, BAX↑, Bak↑, Casp↑, ER Stress↑, Ca+2↑, ATF4↑, CHOP↑, ROS↑, MMP↓, TumCMig↓, TumCI↓, eff↑, P53↑, P21↑, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-xL↓,

2635-

Api,

CUR,

Synergistic Effect of Apigenin and Curcumin on Apoptosis, Paraptosis and Autophagy-related Cell Death in HeLa Cells

in-vitro,

Cerv,

HeLa

TumCD↑, eff↑, TumAuto↑, ER Stress↑, Paraptosis↑, GRP78/BiP↓, Dose↝,

2639-

Api,

Plant flavone apigenin: An emerging anticancer agent

Review,

Var,

*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,

2640-

Api,

Apigenin: A Promising Molecule for Cancer Prevention

Review,

Var,

chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, eff↑, AntiAg↑, eff↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,

2584-

Api,

Chemo,

The versatility of apigenin: Especially as a chemopreventive agent for cancer

Review,

Var,

ChemoSen↑, RadioS↑, eff↝, DR5↑, selectivity↑, angioG↓, selectivity↑, chemoP↑, MAPK↓, PI3K↓, Akt↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, GLUT1↓, radioP↑, BioAv↓, chemoPv↑,

206-

Api,

Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress

in-vitro,

Lung,

H1299

 20 uM

in-vitro,

Lung,

H460

in-vitro,

Lung,

A549

 40 uM

in-vitro,

CRC,

HCT116

in-vitro,

Melanoma,

A375

in-vitro,

Lung,

H2030

in-vitro,

CRC,

SW480

Glycolysis↓, lactateProd↓, PGK1↓, ALDOA↓, GLUT1↓, ENO1↓, ATP↓, Casp9↑, Casp3↑, cl‑PARP↑, PI3K/Akt↓, HK1↓, HK2↓, ROS↑, Apoptosis↑, eff↓, NADPH↓, PPP↓,

3817-

Aroma,

Therapeutic potential of aromatic plant extracts in Alzheimer's disease: Comprehensive review of their underlying mechanisms

Review,

AD,

*BChE↓, *AChE↓, *other↓, *other?, *Ach?, *eff↑, *antiOx↑, *ROS↓, *cognitive↑, *Mood↑, *Sleep↑,

3824-

Aroma,

Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties

Human,

AD,

 20 healthy, young participants

*cognitive↑, *memory↑, *AChE∅, *Mood↑, *eff↝,

3382-

ART/DHA,

Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?

Review,

Var,

1.20–15.2 μM

AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1/CCND1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,

3383-

ART/DHA,

Dihydroartemisinin: A Potential Natural Anticancer Drug

Review,

Var,

TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2↓, JNK↑, Beclin-1↑, GRP78/BiP↑, eff↑, eff↑, eff↑, eff↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE/CCNE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2↓, MMP9↓,

3389-

ART/DHA,

Emerging mechanisms and applications of ferroptosis in the treatment of resistant cancers

Review,

Var,

GSH↓, ROS↑, NRF2↑, eff↑,

3345-

ART/DHA,

Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells

in-vitro,

GBM,

ROS↑, Ferroptosis↑, lipid-P↑, HSP70/HSPA5↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MDA↑, GSH↓, eff↑, GPx4↑,

3391-

ART/DHA,

Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug

Review,

Var,

TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,

2575-

ART/DHA,

docx,

Artemisia santolinifolia-Mediated Chemosensitization via Activation of Distinct Cell Death Modes and Suppression of STAT3/Survivin-Signaling Pathways in NSCLC

in-vitro,

Lung,

H23

AS at concentrations of 100 and 200 μg/mL in combination with DTX at concentrations of 0.5, 1 and 2.5 nM for 48 h.

ChemoSen↑, GPx4↓, ROS↑, Ferroptosis↑, eff↑,

2573-

ART/DHA,

effects_of_halofuginone_and_artemisinin_in_colorectal_cancer_cells">Cell death mechanisms induced by synergistic effects of halofuginone and artemisinin in colorectal cancer cells

in-vitro,

CRC,

HCT116

eff↑,

2574-

ART/DHA,

Artemisinin: A Promising Adjunct for Cancer Therapy

Review,

Var,

selectivity↑, eff↑,

2576-

ART/DHA,

AL,

The Synergistic Anticancer Effect of Artesunate Combined with Allicin in Osteosarcoma Cell Line in Vitro and in Vivo

in-vitro,

OS,

MG63

in-vivo,

NA,

0 mg/kg per
day, i.p.), allicin (5 mg/kg per day, i.p.)

mice

eff↑, tumCV↓, Casp3↑, Casp9↑, Apoptosis↑, TumCG↓,

2577-

ART/DHA,

Artemisinin and its derivatives in cancer therapy: status of progress, mechanism of action, and future perspectives

Review,

Var,

eff↑, TumCCA↑, BioAv↑, eff↑, ChemoSen↑,

2578-

ART/DHA,

RES,

Synergic effects of artemisinin and resveratrol in cancer cells

in-vitro,

Liver,

HepG2

in-vitro,

Cerv,

HeLa

Dose↝, TumCMig↓, Apoptosis↑, necrosis↑, ROS↑, eff↑,

2580-

ART/DHA,

VitC,

Effects of Antioxidants and Pro-oxidants on Cytotoxicity of Dihydroartemisinin to Molt-4 Human Leukemia Cells

in-vitro,

AML,

Molt-4 cell culture

eff↓, other↝, ROS↑, eff↓, eff↓,

2581-

ART/DHA,

PB,

Synergistic cytotoxicity of artemisinin and sodium butyrate on human cancer cells

in-vitro,

AML,

Molt-4 cells

eff↑, selectivity↑,

2582-

ART/DHA,

5-ALA,

Mechanistic Investigation of the Specific Anticancer Property of Artemisinin and Its Combination with Aminolevulinic Acid for Enhanced Anticolorectal Cancer Activity

in-vivo,

CRC,

HCT116

mouse xenograft CRC model

in-vitro,

CRC,

HCT116

eff↑, ROS↑, selectivity↑, TumCG↓, toxicity↓,

5381-

ART/DHA,

Artemisitene triggers calcium-dependent ferroptosis by disrupting the LSH-EWSR1 interaction in colorectal cancer

in-vitro,

CRC,

HCT116

in-vitro,

Nor,

NCM460

in-vitro,

CRC,

HT29

in-vitro,

CRC,

HCT8

Ferroptosis↑, CYP24A1↓, Ca+2↑, SCD1↓, FAO↑, lipid-P↑, eff↑, selectivity↑, other?,

5380-

ART/DHA,

Artemisinin and Its Derivatives as Potential Anticancer Agents

Review,

Var,

TumCG↓, angioG↓, Ferroptosis↑, TumCP↑, TumAuto↑, CSCs↑, eff↑, YAP/TEAD↓, TumCCA↑, ROS↑, ChemoSen↑, N-cadherin↓, Vim↓, MMP9↓, eff↑, STAT3↓, CD133↓, CD44↓, Nanog↓, cMyc↓, OCT4↓, Akt↓, mTOR↓,

5379-

ART/DHA,

Iron-fueled ferroptosis: a new axis for immunomodulation to overcome cancer drug resistance—from immune microenvironment crosstalk to therapeutic translation

Ferritin↓, Iron↑, Fenton↑, lipid-P↑, ChemoSen↑, ROS↑, eff↝,

5378-

ART/DHA,

Natural Agents Modulating Ferroptosis in Cancer: Molecular Pathways and Therapeutic Perspectives

Review,

Var,

Ferroptosis↑, Iron↑, lipid-P↑, MOMP↑, AntiCan↑, NCOA4↑, GSH↓, GPx4↓, ROS↑, ChemoSen↑, ER Stress↑, DNAdam↑, angioG↓, TumCCA↑, eff↓,

5377-

ART/DHA,

Dihydroartemisinin-induced ferroptosis in acute myeloid leukemia: links to iron metabolism and metallothionein

in-vitro,

AML,

AntiCan↑, Ferroptosis↑, Iron↑, Mets↑, eff↑, GSH↝, eff↑, other↓, eff↑, other↓,

5376-

ART/DHA,

Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis

in-vitro,

CRC,

HCT116

in-vitro,

CRC,

HT29

in-vitro,

CRC,

SW48

in-vitro,

BC,

MDA-MB-453

Ferroptosis↑, Ferritin↓, Iron↑, eff↑, TumAuto↑, LC3II↑, ROS↑,

5129-

ART/DHA,

Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds

in-vitro,

AML,

HL-60

Casp↑, Apoptosis↑, MMP↓, TumCCA↑, eff↑, eff↑,

5137-

ART/DHA,

Autophagy-dependent cell cycle arrest in esophageal cancer cells exposed to dihydroartemisinin

vitro+vivo,

ESCC,

Eca109

tumCV↓, TumCCA↑, ROS↑, TumAuto↑, eff↓, TRF2↓, TumCP↓,

5130-

ART/DHA,

Dihydroartemisinin Induces Apoptosis in Human Bladder Cancer Cell Lines Through Reactive Oxygen Species, Mitochondrial Membrane Potential, and Cytochrome C Pathway

in-vitro,

Bladder,

T24/HTB-9

tumCV↓, eff↓, Apoptosis↑, Casp3↑, ROS↑, Cyt‑c↑, MMP↓, Bcl-2↓, BAX↑, MOMP↑, TumCG↓,

1028-

ASA,

Aspirin Suppressed PD-L1 Expression through Suppressing KAT5 and Subsequently Inhibited PD-1 and PD-L1 Signaling to Attenuate OC Development

vitro+vivo,

Ovarian,

TumCP↓, TumW↓, PD-L1↓, Ki-67↓, H3K27ac∅, eff↑,

5409-

ASA,

Role of aspirin in cancer prevention

Review,

Var,

Imm↑, *Inflam↓, *AntiAg↑, *GutMicro↑, eff↑, TumMeta↓, angioG↓, Risk↓, Risk↓,

2461-

ASA,

Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis

Review,

NA,

AntiAg↑, COX1↓, eff↑,

1369-

Ash,

Withaferin A inhibits cell proliferation of U266B1 and IM-9 human myeloma cells by inducing intrinsic apoptosis

in-vitro,

Melanoma,

U266

9 μM

tumCV↓, Apoptosis↑, BAX↑, Cyt‑c↑, Bcl-2↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, ROS↑, eff↓,

1370-

Ash,

Withaferin A induces mitochondrial-dependent apoptosis in non-small cell lung cancer cells via generation of reactive oxygen species

in-vitro,

Lung,

A549

ROS↑, eff↓,

1371-

Ash,

Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic cell death of human myeloid leukemia HL-60 cells by a dietary compound withaferin A with concomitant protection by N-acetyl cysteine

in-vitro,

AML,

HL-60

ROS↑, MMP↓, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, eff↓,

1373-

Ash,

Endoplasmic reticulum stress mediates withaferin A-induced apoptosis in human renal carcinoma cells

in-vitro,

Kidney,

Caki-1

ER Stress↑, p‑eIF2α↑, XBP-1↑, GRP78/BiP↑, CHOP↑, eff↓,

1355-

Ash,

Withaferin A-Induced Apoptosis in Human Breast Cancer Cells Is Mediated by Reactive Oxygen Species

in-vitro,

BC,

MDA-MB-231

2.5 or 5 µM WA

WA treatment caused ROS production in MDA-MB-231 and MCF-7 cells, but not in a normal human mammary epithelial cell line (HMEC). The HMEC was also resistant to WA-induced apoptosis.

in-vitro,

BC,

MCF-7

in-vitro,

Nor,

HMEC

eff↑, mt-ROS↑, mitResp↓, OXPHOS↓, compIII↑, BAX↑, Bak↑, other↓, ATP∅, *ROS∅,

1357-

Ash,

Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways

in-vitro,

GBM,

U87MG

 1.07±0.071µM

in-vitro,

GBM,

U251

0.69±0.041µM

in-vitro,

GBM,

GL26

0.23±0.015µM

mouse line

TumCP↓, TumCCA↑, Akt↓, mTOR↓, p70S6↓, p85S6K↓, AMPKα↑, TSC2↑, HSP70/HSPA5↑, HO-1↑, HSF1↓, Apoptosis↑, ROS↑, eff↓,

1358-

Ash,

Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms

Review,

Var,

TumCCA↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, CSCs↓, TumMeta↓, EMT↓, angioG↓, Vim↓, HSP90↓, annexin II↓, m-FAM72A↓, BCR-ABL↓, Mortalin↓, NRF2↓, cMYB↓, ROS↑, ChemoSen↑, eff↑, ChemoSen↑, ChemoSen↑, eff↑, *BioAv↓, ROCK1↓, TumCI↓, Sp1/3/4↓, VEGF↓, Hif1a↓, EGFR↓,

1360-

Ash,

immuno,

Withaferin A Increases the Effectiveness of Immune Checkpoint Blocker for the Treatment of Non-Small Cell Lung Cancer

in-vitro,

Lung,

H1650

in-vitro,

Lung,

A549

in-vitro,

CRC,

HCT116

in-vitro,

BC,

MDA-MB-231

in-vivo,

NA,

mice

PD-L1↑, eff↓, ROS↑, ER Stress↑, Apoptosis↑, BAX↑, Bak↑, BAD↑, Bcl-2↓, XIAP↓, survivin↓, cl‑PARP↑, CHOP↑, p‑eIF2α↑, ICD↑, eff↑,

1361-

Ash,

SRF,

Withaferin A, a natural thioredoxin reductase 1 (TrxR1) inhibitor, synergistically enhances the antitumor efficacy of sorafenib through ROS-mediated ER stress and DNA damage in hepatocellular carcinoma cells

in-vitro,

Liver,

HUH7

in-vivo,

Liver,

HUH7

TrxR↓, ROS↑, DNA-PK↑, ER Stress↑, Apoptosis↑, eff↓,

1364-

Ash,

Withaferin a Triggers Apoptosis and DNA Damage in Bladder Cancer J82 Cells through Oxidative Stress

in-vitro,

Bladder,

J82

cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, ROS↑, MMP↓, DNAdam↑, eff↓,

1365-

Ash,

Withaferin A Induces Oxidative Stress-Mediated Apoptosis and DNA Damage in Oral Cancer Cells

in-vitro,

Oral,

Ca9-22

0.5, 1, 2, and 3 μM

in-vitro,

Oral,

CAL27

ROS↑, *toxicity↓, Apoptosis↑, TumCCA↑, MMP↓, p‑γH2AX↑, DNAdam↑, eff↓,

1433-

Ash,

SFN,

A Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer Cells

in-vitro,

BC,

MCF-7

1.0 µM WA and 5.0 µM SFN

in-vitro,

BC,

MDA-MB-231

eff↑, Bcl-2↓, BAX↑, tumCV↓, DNMT1↓, DNMT3A↓, HDAC↓,

2001-

Ash,

Withania somnifera: from prevention to treatment of cancer

Review,

Var,

toxicity↓, TumW↓, Dose?, eff↝, Ki-67↓, survivin↓, XIAP↓, PERK↑, p‑RSK↑, CHOP↑, DR5↑, Dose↝, BG↓, DNMTs↓,

5173-

Ash,

2DG,

Withaferin A inhibits lysosomal activity to block autophagic flux and induces apoptosis via energetic impairment in breast cancer cells

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

MDA-MB-468

in-vitro,

BC,

T47D

autoF↓, lysosome↓, TumAuto↑, p‑LDH↓, ATP↓, AMPK↑, eff↑, TumCG↓, CTSD↓, CTSB↓, CTSL↑, cl‑PARP1↑, LDHA↓, TCA↓,

5175-

Ash,

Withaferin A Induces Proteasome Inhibition, Endoplasmic Reticulum Stress, the Heat Shock Response and Acquisition of Thermotolerance

in-vitro,

Cerv,

CCL-102

Inflam↓, AntiTum↑, Proteasome↓, ER Stress↑, HSPs↑, GRP94↑, Akt↑, eff↑, HSP70/HSPA5↑,

3175-

Ash,

SFN,

Withaferin A and sulforaphane regulate breast cancer cell cycle progression through epigenetic mechanisms

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

MCF-7

DNMTs↓, HDAC↓, eff↑,

1142-

Ash,

Ashwagandha-Induced Programmed Cell Death in the Treatment of Breast Cancer

Review,

BC,

MCF-7

typ 2-5uM

Ashwagandha was well tolerated at a dose of 300 mg per day in an eight-week study [147]. For insomnia, a dose of 600 milligrams per day has been found to be safe and <span class="wphighlight">eff</span>ective

NA,

BC,

MDA-MB-231

NA,

Nor,

HMEC

Apoptosis↑, ROS↑, DNAdam↑, OXPHOS↓, *ROS∅, Bcl-2↓, XIAP↓, survivin↓, DR5↑, IKKα↓, NF-kB↓, selectivity↑, *ROS∅, eff↓, Paraptosis↑,

3155-

Ash,

Overview of the anticancer activity of withaferin A, an active constituent of the Indian ginseng Withania somnifera

Review,

Var,

Half-Life↝, Inflam↓, antiOx↓, angioG↓, ROS↑, BAX↑, Bak↑, E6↓, E7↓, P53↑, Casp3↑, cl‑PARP↑, STAT3↓, eff↑, HSP90↓, TGF-β↓, TNF-α↓, EMT↑, mTOR↓, NOTCH1↓, p‑Akt↓, NF-kB↓, Dose↝,

3160-

Ash,

Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal

Review,

Var,

TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,

3166-

Ash,

Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives

Review,

Var,

*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, eff↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, eff↑,

5384-

AsP,

MEL,

Synergistic Anticancer Effect of Melatonin and Ascorbyl Palmitate Nanoformulation: A Promising Combination for Cancer Therapy

in-vivo,

Var,

melatonin (MEL)
and ascorbyl palmitate-loaded pluronic nanoparticles (APnp) combination on Ehrlich ascites carcinoma
(EAC)-bearing mice.

AntiCan↑, TumCG↓, Apoptosis↑, DNAdam↑, TumCCA↑, IL6↓, STAT3↓, TumCP↓, Ki-67↓, TumCI↓, TumMeta↓, MMP9↓, eff↑, *Catalase↑, *SOD↑, *GSH↑, *MDA↓, *NO↓, *antiOx↑, *hepatoP↑, *RenoP↑,

5389-

AsP,

Tras,

ASCORBYL PALMITATE ENHANCES ANTI-PROLIFERATIVE EFFECT OF TRASTUZUMAB IN HER2-POSITIVE BREAST CANCER CELLS

tumCV↓, eff↑, P53↑, BAX↑, Casp3↑, Casp8↑, Bcl-2↓, Apoptosis↑, p‑p38↓, ERK↓, PI3K↓,

5426-

ASTX,

Cisplatin,

Astaxanthin Prevents a Decrease of Hemopoietic Activity in Head and Neck Cancer Patients Receiving Cisplatin Chemotherapy (Randomized Controlled Trial)

Trial,

HNSCC,

astaxanthin 2x4 mg

ROS↓, SOD↑, MDA↓, eff↑,

5420-

ASTX,

A New Tailored Nanodroplet Carrier of Astaxanthin Can Improve Its Pharmacokinetic Profile and Antioxidant and Anti-Inflammatory Efficacies

in-vivo,

Nor,

*eff↑, *SOD↑, *BioAv↑,

5424-

ASTX,

Astaxanthin exerts an adjunctive anti-cancer effect through the modulation of gut microbiota and mucosal immunity

in-vivo,

Nor,

mice

*GutMicro↑, AntiCan↑, eff↑, AntiTum↑, ChemoSen↑,

4818-

ASTX,

MEL,

Effect of astaxanthin and melatonin on cell viability and DNA damage in human breast cancer cell lines

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

T47D

in-vitro,

Nor,

MCF10

TumCD↑, DNAdam↑, *antiOx↑, *AntiTum↑, Inflam↓, tumCV↓, Bcl-2↓, Apoptosis↓, selectivity↑, eff↑, Dose↓,

4804-

ASTX,

Astaxanthin in cancer therapy and prevention (Review)

Review,

Var,

Review,

AD,

*antiOx↑, *Inflam↓, ChemoSen⇅, chemoP↑, BioAv↑, TumCP↑, ROS⇅, Apoptosis↑, PI3K↑, Akt↑, GSK‐3β↑, NRF2↑, AntiCan↑, *neuroP↑, eff↑, AntiTum↑,

5375-

ATO,

Improved Outcome with ATRA-Arsenic Trioxide Compared to ATRA-Chemotherapy in Non-High Risk Acute Promyelocytic Leukemia – Updated Results of the Italian-German APL0406 Trial on the Extended Final Series

Trial,

APL,

 254 patients were evaluable for response to induction

eff↑, OS↑,

5453-

ATV,

Epidemiologic Analysis Along the Mevalonate Pathway Reveals Improved Cancer Survival in Patients Who Receive Statins Alone and in Combination With Bisphosphonates

Trial,

Var,

312,907 identified patients with cancer,

OS↑, eff↑, other↝,

5450-

ATV,

The Mevalonate Pathway in the Radiation Response of Cancer

vitro+vivo,

Var,

eff↑, RadioS↑,

5448-

ATV,

Beyond cardiovascular health: The pharmacotherapeutic potential of statins in oncology

Review,

Var,

Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, eff↑, HMGCR↓, LDL↓, cardioP↑, AntiTum↑, ChemoSen↑, RadioS↑, toxicity↓,

5449-

ATV,

Pleiotropic effects of statins: A focus on cancer

NA,

Var,

lipid-P↓, TumCG↓, Apoptosis↑, ChemoSen↑, RAS↓, HMG-CoA↓, HMGCR↓, LDL↓, toxicity↓, Risk↓, P21↑, HDAC↓, Bcl-2↓, BAX↑, BIM↑, Casp↑, cl‑PARP↑, MMP↓, ROS↑, angioG↓, TumMeta↓, PTEN↑, eff↑, OS↑, Remission↑,

4981-

ATV,

Crosstalk between Statins and Cancer Prevention and Therapy: An Update

Apoptosis↑, selectivity↑, eff↑, HMG-CoA↓, *cardioP↑, OS↑, IL1β↓, IL6↓, IL8↓, TNF-α↓, TumAuto↑, Histones↝, ac‑H3↑, ac‑H4↑, HDAC↓,

4985-

ATV,

Dipy,

Repurposing of the Cardiovascular Drug Statin for the Treatment of Cancers: Efficacy of Statin-Dipyridamole Combination Treatment in Melanoma Cell Lines

in-vivo,

Melanoma,

SK-MEL-28

in-vitro,

BC,

MDA-MB-435

HMG-CoA↓, SREBP2↓, eff↑, HMGCR⇅, ChemoSen↑,

4986-

ATV,

Dipy,

The combination of statins and dipyridamole is effective preclinically in AML, MM, and breast cancer

Review,

Var,

HMG-CoA↓, AntiAg↑, eff↑, Apoptosis↑, selectivity↑, *toxicity↓, TumCG↓, PDE4↓, other↑,

5362-

AV,

Anti-cancer effects of aloe-emodin: a systematic review

Review,

Var,

AntiCan↑, eff↝, TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, TumCD↑, MMP↓, ROS↑, Apoptosis↑, CDK1↓, CycB/CCNB1↓, Bcl-2↓, PCNA↓, ATP↓, ER Stress↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, MMP2↓, Ca+2↑, DNAdam↑, Akt↓, PKCδ↓, mTORC2↓, GSH↓, ChemoSen↑,

5367-

AV,

Rad,

Aloe vera for prevention of radiation-induced dermatitis: a self-controlled clinical trial

Trial,

Var,

60 patients

radioP↑, Dose↝, eff↑,

5371-

AV,

effect_of_Aloe_vera_polysaccharides_extracts_on_macrophages_functions">Assessment of the immunomodulatory effect of Aloe vera polysaccharides extracts on macrophages functions

Study,

Nor,

*eff↑, *IL6↑, *toxicity↓, *Imm↑,

5250-

Ba,

Exploring baicalein: A natural flavonoid for enhancing cancer prevention and treatment

Review,

Var,

Apoptosis↑, TumAuto↑, DNAdam↑, *antiOx↑, Inflam↓, PGE2↓, TumCCA↑, TumCMig↓, TumCI↓, angioG↓, selectivity↑, ChemoSen↑, HIF-1↓, cMyc↓, NF-kB↓, VEGF↓, P53↑, MMP2↓, CSCs↓, Bcl-xL↓, XIAP↓, survivin↓, tumCV↓, Casp3↑, Casp8↑, Bax:Bcl2↑, Akt↓, mTOR↓, PCNA↓, MMP↓, ROS↑, PARP↑, Casp9↑, BioAv↑, eff↑, P-gp↓, BioAv↑, selectivity↑,

2476-

Ba,

Baicalein Induces Caspase-dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells

in-vitro,

Lung,

A549

0-125uM

TumCG↓, Apoptosis↑, DR5↑, FasL↑, FADD↑, Casp8↑, cFLIP↓, Casp9↑, Casp3↑, cl‑PARP↑, MMP↓, BID↑, BAX↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑,

2474-

Ba,

Anticancer properties of baicalein: a review

Review,

Var,

in-vitro,

Nor,

BV2

ROS⇅, ROS↑, ER Stress↑, Ca+2↑, Apoptosis↑, eff↑, DR5↑, 12LOX↓, Cyt‑c↑, Casp7↑, Casp9↑, Casp3↑, cl‑PARP↑, TumCCA↑, cycE/CCNE↑, CDK4↓, cycD1/CCND1↓, VEGF↓, cMyc↓, Hif1a↓, NF-kB↓, BioEnh↑, BioEnh↑, P450↓, *Hif1a↓, *iNOS↓, *COX2↓, *VEGF↓, *ROS↓, *PI3K↓, *Akt↓,

2482-

Ba,

Modulation of Neuroinflammation in Poststroke Rehabilitation: The Role of 12/15-Lipoxygenase Inhibition and Baicalein

Review,

Stroke,

*12LOX↓, *neuroP↑, *eff↑,

2624-

Ba,

Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression

in-vitro,

Nor,

RAW264.7

*HO-1↑, *ERK↑, *ROS↓, *eff↑, *MMP↑, *Cyt‑c∅,

2605-

Ba,

BA,

Potential therapeutic effects of baicalin and baicalein

Review,

Var,

Review,

Stroke,

Review,

IBD,

Review,

Arthritis,

Review,

AD,

Review,

Park,

cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,

2597-

Ba,

Baicalein – An Intriguing Therapeutic Phytochemical in Pancreatic Cancer

Review,

PC,

chemoP↑, ChemoSen↑, 12LOX?, Bcl-2↓, BAX↑, Mcl-1↓, ERK↓, Prx6↑, Dose↝, BioAv↓, eff↑,

2625-

Ba,

LT,

Baicalein and luteolin inhibit ischemia/reperfusion-induced ferroptosis in rat cardiomyocyte

in-vivo,

Stroke,

rat

*lipid-P↓, *ACSL4∅, *NRF2∅, *GPx4∅, *Ferroptosis↓, *ROS↓, *MDA↓, *eff↑, *HO-1∅,

2612-

Ba,

MF,

effect_of_a_static_magnetic_field_and_baicalin_or_baicalein_interactions_on_amelanotic_melanoma_cell_cultures_C32">The effect of a static magnetic field and baicalin or baicalein interactions on amelanotic melanoma cell cultures (C32)

in-vitro,

Melanoma,

SOD1↑, SOD2↑, GPx1↑, Dose?, eff↝, SOD1↓, SOD2↓, GPx1↓,

2290-

Ba,

Research Progress of Scutellaria baicalensis in the Treatment of Gastrointestinal Cancer

Review,

GI,

p‑mTOR↓, p‑Akt↓, p‑IKKα↓, NF-kB↓, PI3K↓, Akt↓, ROCK1↓, GSK‐3β↓, CycB/CCNB1↓, cycD1/CCND1↓, cycA1/CCNA1↑, CDK4↓, P53↑, P21↑, TumCCA↑, MMP2↓, MMP9↓, EMT↓, Hif1a↓, Shh↓, PD-L1↓, STAT3↓, IL1β↓, IL2↓, IL6↓, PKM2↓, HDAC10↓, P-gp↓, Bcl-xL↓, eff↓, BioAv↓, BioAv↑,

2050-

BA,

The Role of Sodium Phenylbutyrate in Modifying the Methylome of Breast Cancer Cells

in-vitro,

BC,

MCF-7

3μM and 5μM

eff↑, HDAC↓, TumCG↓,

2047-

BA,

Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p/Bmi-1 axis in human bladder cancer cells

in-vitro,

CRC,

T24/HTB-9

0-10mM

in-vitro,

Nor,

SV-HUC-1

in-vitro,

Bladder,

5637

in-vivo,

NA,

200 mg/kg/day, i.g., n = 5

mice

HDAC↓, AntiTum↑, TumCMig↓, AMPK↑, mTOR↑, TumAuto↑, ROS↑, miR-139-5p↑, BMI1↓, TumCI?, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, Bcl-xL↓, MMP↓, PINK1↑, PARK2↑, TumMeta↓, TumCG↓, LC3II↑, p62↓, eff↓,

1529-

Ba,

Studies on the Inhibitory Mechanisms of Baicalein in B16F10 Melanoma Cell Proliferation

in-vitro,

Melanoma,

B16-F10

ROS↑, eff↓, tumCV↓, Casp3↑, necrosis↑,

1533-

Ba,

Baicalein, as a Prooxidant, Triggers Mitochondrial Apoptosis in MCF-7 Human Breast Cancer Cells Through Mobilization of Intracellular Copper and Reactive Oxygen Species Generation

in-vitro,

BrCC,

MCF-7

85μM for 24 h

in-vitro,

Nor,

MCF10

557uM

tumCV↓, i-ROS↑, MMP↓, Bcl-2↓, BAX↑, Cyt‑c↑, Casp9↑, Casp3↑, eff↓, selectivity↑, *toxicity∅, Apoptosis↑, Fenton↑,

1532-

Ba,

Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives

Review,

NA,

ROS↑, ER Stress↑, Ca+2↑, MMPs↓, Cyt‑c↑, Casp3↑, ROS↑, DR5↑, ROS↑, BAX↑, Bcl-2↓, MMP↓, Casp3↑, Casp9↑, P53↑, p16↑, P21↑, p27↑, HDAC10↑, MDM2↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, p‑IκB↓, IκB↑, BAX↑, Bcl-2↓, ROS⇅, BNIP3↑, p38↑, 12LOX↓, Mcl-1↓, Wnt?, GLI2↓, AR↓, eff↑,

1531-

Ba,

Proteomic analysis of the effects of baicalein on colorectal cancer cells

in-vitro,

CRC,

DLD1

(0-100uM) for 24 h

in-vitro,

CRC,

SW48

TumCP↓, ROS↓, Prx6↑, eff↓, TumCCA↑, ROS↝, *ROS∅,

1530-

Ba,

Baicalein Decreases Hydrogen Peroxide‐Induced Damage to NG108‐15 Cells via Upregulation of Nrf2

in-vitro,

Nor,

NG108-15

15 uM(H2O2) + 8uM(BA)

*12LOX↓, *ROS↓, *NRF2↑, *eff↑,

1528-

Ba,

Inhibiting reactive oxygen species-dependent autophagy enhanced baicalein-induced apoptosis in oral squamous cell carcinoma

in-vitro,

OS,

CAL27

1-100uM

Apoptosis↑, ROS↑, eff↓, TumAuto↑, cl‑PARP↑, Bax:Bcl2↑, Beclin-1↑, p62↓,

1525-

Ba,

almon,

Synergistic antitumor activity of baicalein combined with almonertinib in almonertinib-resistant non-small cell lung cancer cells through the reactive oxygen species-mediated PI3K/Akt pathway

in-vitro,

Lung,

H1975

in-vivo,

Lung,

mice

eff↑, TumCP↓, Apoptosis↑, cl‑Casp3↑, cl‑PARP↑, cl‑Casp9↑, p‑PI3K↓, p‑Akt↓, ROS↑, eff↓,

1524-

Ba,

Baicalein Induces Caspase‐dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells

in-vitro,

Lung,

A549

25–125 uM, 24hr

100uM

DR5↑, FADD↑, FasL↑, Casp8↑, cFLIP↓, Casp3↑, Casp9↑, cl‑PARP↑, MMP↓, BID↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑, Apoptosis↑, TumCCA↑, DR5↑, FasL↑, DR4∅, cFLIP↓, FADD↑, MMPs↓,

1523-

Ba,

Baicalein induces human osteosarcoma cell line MG-63 apoptosis via ROS-induced BNIP3 expression

in-vitro,

OS,

MG63

(12.5, 25, and 50 μM)

in-vitro,

Nor,

hFOB1.19

TumCD↑, Apoptosis↑, ROS↑, eff↓, Casp3↑, Bcl-2↓, selectivity↑, Cyt‑c↑, LDH?, BNIP3?, BAX↑,

1521-

Ba,

Baicalein induces apoptosis via ROS-dependent activation of caspases in human bladder cancer 5637 cells

in-vitro,

Bladder,

5637

0,50,150,250 uM

TumCG↓, Apoptosis↑, IAP1↓, IAP2↓, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, MMP↓, Casp8↑, BID↑, ROS?, eff↓, DR4↑, DR5↑, FasL↑, TRAIL↑,

1520-

Ba,

Baicalein Induces G2/M Cell Cycle Arrest Associated with ROS Generation and CHK2 Activation in Highly Invasive Human Ovarian Cancer Cells

in-vitro,

Ovarian,

SKOV3

50–200 µM baicalein for 48 and 72 h

54uM

in-vitro,

Ovarian,

TOV-21G

91uM

TumCG↓, TumCCA↑, ROS↑, DNAdam↑, Chk2↑, Dose∅, p‑γH2AX↑, CDC25↓, CHK1↓, cycD1/CCND1↓, eff↓, 12LOX↓,

1385-

BBR,

5-FU,

Low-Dose Berberine Attenuates the Anti-Breast Cancer Activity of Chemotherapeutic Agents via Induction of Autophagy and Antioxidation

in-vitro,

BC,

MCF-7

BBR (0-10 μM) with 5-FU (0-250 μM)

in-vitro,

BC,

MDA-MB-231

eff↓, ROS↑, TumCP↑, NRF2↑, ChemoSen↓,

1394-

BBR,

DL,

Synergistic Inhibitory Effect of Berberine and d-Limonene on Human Gastric Carcinoma Cell Line MGC803

in-vitro,

GC,

MGC803

eff↑, ROS↑, MMP↓, Casp3↑, Bcl-2↓, TumCCA↑,

1390-

BBR,

Rad,

Berberine Inhibited Radioresistant Effects and Enhanced Anti-Tumor Effects in the Irradiated-Human Prostate Cancer Cells

in-vitro,

Pca,

PC3

RadioS↑, Apoptosis↑, ROS↑, eff↑, BAX↑, Casp3↑, P53↑, p38↑, JNK↑, Bcl-2↓, ERK↓, HO-1↓,

1374-

BBR,

PDT,

Berberine associated photodynamic therapy promotes autophagy and apoptosis via ROS generation in renal carcinoma cells

in-vitro,

RCC,

786-O

5, 10, 20, 40, 80, 160 and 320 μM

40 μM of BBR presented viability <80 % in 48 h

in-vitro,

RCC,

HK-2

ROS↑, TumAuto↑, Apoptosis↑, Casp3↑, eff↑,

1378-

BBR,

Berberine induces non-small cell lung cancer apoptosis via the activation of the ROS/ASK1/JNK pathway

in-vitro,

Lung,

Apoptosis↑, Casp3↑, Cyt‑c↑, MMP↓, p‑JNK↑, eff↓,

1379-

BBR,

Berberine derivative DCZ0358 induce oxidative damage by ROS-mediated JNK signaling in DLBCL cells

in-vitro,

lymphoma,

TumCP↓, CDK4↓, CDK6↓, cycD1/CCND1↓, TumCCA↑, MMP↓, Ca+2↑, ATP↓, mtDam↑, Apoptosis↑, ROS↑, JNK↑, eff↓,

1402-

BBR,

Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction

in-vitro,

GBM,

T98G

tumCV↓, ROS↑, Ca+2↑, ER Stress↑, eff↓, Bax:Bcl2↑, MMP↓, Casp9↑, Casp3↑, cl‑PARP↑,

1404-

BBR,

Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation

in-vitro,

Pca,

PC3

Apoptosis↑, *Apoptosis∅, MMP↓, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, ROS↑, eff↓, Cyt‑c↑,

2022-

BBR,

GoldNP,

Rad,

Berberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition

in-vitro,

Liver,

SMMC-7721 cell

in-vitro,

Nor,

HL7702

*toxicity↓, radioP↑, BioAv↑, AntiTum↑, selectivity↑, eff↑, chemoP↑,

2021-

BBR,

Berberine: An Important Emphasis on Its Anticancer Effects through Modulation of Various Cell Signaling Pathways

Review,

NA,

*antiOx?, *Inflam↓, Apoptosis↑, TumCCA↑, BAX↑, eff↑, VEGF↓, PI3K↓, Akt↓, mTOR↓, Telomerase↓, β-catenin/ZEB1↓, Wnt↓, EGFR↓, AP-1↓, NF-kB↓, COX2↑, NRF2↓, RadioS↑, STAT3↓, ERK↓, AR↓, ROS↑, eff↑, selectivity↑, selectivity↑, BioAv↓, DNMT1↓, cMyc↓,

5179-

BBR,

Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy

Review,

Var,

AMPK↑, Casp3↑, cl‑PARP↑, Mcl-1↓, cFLIP↓, β-catenin/ZEB1↓, Wnt↓, STAT3↓, mTOR↓, Hif1a↓, NF-kB↓, SIRT1↑, DNMT1↓, DNMT3A↓, miR-29b↓, IGFBP1↑, eff↑, chemoPv↑, BioAv↓,

4275-

BBR,

Pharmacological effects of berberine on mood disorders

Review,

NA,

*antiOx↑, *Inflam↓, *hepatoP↑, *eff↑, *5HT↑, *Mood↑, *BDNF↑,

3754-

BBR,

CUR,

EGCG,

Hup,

Traditional Chinese medicinal herbs as potential AChE inhibitors for anti-Alzheimer’s disease: A review

*AChE↓, *Aβ↓, *LDL↓, *RenoP↑, *BChE↓, *eff↑, *BACE↓, *AChE↓, *eff↑,

2689-

BBR,

Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells

in-vitro,

Nor,

PC12

in-vitro,

AD,

in-vitro,

Stroke,

*ROS↓, *lipid-P↓, *DNAdam↓, *GSH↑, *SOD↑, *eff↑, *cl‑Casp3↓, *BAX↓, *neuroP↑, *Dose↝, *Ca+2↓,

2702-

BBR,

The enhancement of combination of berberine and metformin in inhibition of DNMT1 gene expression through interplay of SP1 and PDPK1

in-vitro,

Lung,

A549

in-vitro,

Lung,

H1975

TumCG↓, MAPK↓, FOXO3↑, TumCCA↑, TumCMig↓, TumCI↓, Sp1/3/4↓, PDK1↓, DNMT1↓, eff↑,

2678-

BBR,

Berberine as a Potential Agent for the Treatment of Colorectal Cancer

Review,

CRC,

*Inflam↓, *antiOx↑, *cardioP↑, *neuroP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDC2↓, AMPK↝, mTOR↝, Casp8↑, Casp9↑, Cyt‑c↑, TumCMig↓, TumCI↓, EMT↓, MMPs↓, E-cadherin↓, Telomerase↓, *toxicity↓, GRP78/BiP↓, EGFR↓, CDK4↓, COX2↓, PGE2↓, p‑JAK2↓, p‑STAT3↓, MMP2↓, MMP9↓, GutMicro↑, eff↝, *BioAv↓, BioAv↑,

2674-

BBR,

Berberine: A novel therapeutic strategy for cancer

Review,

Var,

Review,

IBD,

Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1↓, PGE2↓, COX2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,

2686-

BBR,

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

Review,

Nor,

Inflam↓, IL6↓, MCP1↓, COX2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, eff↑, EGFR↓, Glycolysis↓, Dose?, p27↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2↓, ChemoSen↑, eff↑, eff↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,

1473-

BCA,

SFN,

An Insight on Synergistic Anti-cancer Efficacy of Biochanin A and Sulforaphane Combination Against Breast Cancer

in-vitro,

BC,

MCF-7

eff↑, ROS↑, other↑, ERK↓, Apoptosis↑,

2718-

BetA,

The anti-cancer effect of betulinic acid in u937 human leukemia cells is mediated through ROS-dependent cell cycle arrest and apoptosis

in-vitro,

AML,

U937

TumCCA↑, Apoptosis↑, i-ROS↑, cycA1/CCNA1↓, CycB/CCNB1↓, P21↑, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp9↑, Casp3↑, PARP↓, eff↓, *antiOx↑, *Inflam↓, *hepatoP↑, selectivity↑, NF-kB↓, *ROS↓,

2728-

BetA,

Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy

in-vitro,

Var,

NF-kB↑, IKKα↑, eff↓,

2729-

BetA,

Betulinic acid in the treatment of tumour diseases: Application and research progress

Review,

Var,

ChemoSen↑, mt-ROS↑, STAT3↓, NF-kB↓, selectivity↑, *toxicity↓, eff↑, GRP78/BiP↑, MMP2↓, P90RSK↓, TumCI↓, EMT↓, MALAT1↓, Glycolysis↓, AMPK↑, Sp1/3/4↓, Hif1a↓, angioG↓, NF-kB↑, NF-kB↓, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, RadioS↑, PERK↑, CHOP↑, *toxicity↓,

2730-

BetA,

Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells

in-vitro,

Bladder,

T24/HTB-9

tumCV↓, TumCP↓, TumCMig↓, Casp↑, TumAuto↑, LC3B-II↑, p‑AMPK↑, mTOR↓, BMI1↓, ROS↑, eff↓,

2717-

BetA,

Betulinic Acid Induces ROS-Dependent Apoptosis and S-Phase Arrest by Inhibiting the NF-κB Pathway in Human Multiple Myeloma

in-vitro,

Melanoma,

U266

10-40uM

in-vivo,

Melanoma,

Nude Mouse Xenograft Model

in-vitro,

Melanoma,

RPMI-8226

Apoptosis↑, TumCCA↑, MMP↓, ROS↑, eff↓, NF-kB↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP1↑, MDA↑, SOD↓, SOD2↓, GCLM↓, GSTA1↓, FTH1↓, GSTs↓, TumVol↓,

2733-

BetA,

Betulinic Acid Inhibits Cell Proliferation in Human Oral Squamous Cell Carcinoma via Modulating ROS-Regulated p53 Signaling

in-vitro,

Oral,

12.5–100 μM BA for 24–72 h

in-vivo,

NA,

BA against OSCC in implanted mice in vivo

TumCP↓, TumVol↓, mt-Apoptosis↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↑, OCR↓, TumCCA↑, ROS↑, eff↓, P53↑, STAT3↓, cycD1/CCND1↑,

2737-

BetA,

Multiple molecular targets in breast cancer therapy by betulinic acid

Review,

Var,

TumCP↓, Cyc↓, TOP1↓, TumCCA↑, angioG↓, NF-kB↓, Sp1/3/4↓, VEGF↓, MMPs↓, ChemoSen↑, eff↑, MMP↓, ROS↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, lipid-P↑, RadioS↑, eff↑,

2771-

BetA,

Cardioprotective Effect of Betulinic Acid on Myocardial Ischemia Reperfusion Injury in Rats

in-vivo,

Nor,

Rats

in-vivo,

Stroke,

*cardioP↑, *LDH↓, eff↑,

2755-

BetA,

Cytotoxic Potential of Betulinic Acid Fatty Esters and Their Liposomal Formulations: Targeting Breast, Colon, and Lung Cancer Cell Lines

in-vitro,

Colon,

HT29

in-vitro,

BC,

MCF-7

in-vitro,

Lung,

H460

eff↑, Casp3↑, Casp7↑, NF-kB↓,

2753-

BetA,

Betulinic acid induces apoptosis by regulating PI3K/Akt signaling and mitochondrial pathways in human cervical cancer cells

in-vitro,

Cerv,

HeLa

30 µmol/l BA

PI3K↓, p‑Akt↓, ROS↑, TumCCA↑, p27↑, P21↑, mt-Apoptosis↑, BAD↑, Casp9↑, MMP↓, eff↓,

3987-

betaCar,

Lyco,

Carotenoid bioavailability is higher from salads ingested with full-fat than with fat-reduced salad dressings as measured with electrochemical detection

Trial,

AD,

*eff↑,

3988-

betaCar,

Lut,

Zeax,

Effects of egg consumption on carotenoid absorption from co-consumed, raw vegetables

Trial,

AD,

*eff↑, *eff↑, *eff↑,

5475-

BM,

https://pmc.ncbi.nlm.nih.gov/articles/PMC6070819/

in-vitro,

Colon,

HT29

in-vitro,

Colon,

SW48

in-vitro,

Colon,

SW-620

in-vitro,

CRC,

HCT116

AQPs↓, TumCG↓, TumCCA↓, Apoptosis↑, eff↝,

4620-

Bor,

BTZ,

Boron Compounds in the Breast Cancer Cells Chemoprevention and Chemotherapy

Review,

Var,

Review,

Arthritis,

Review,

Pca,

Risk↓, *memory↑, *Dose↑, Risk↓, other↝, *testos↑, other↝, Risk↓, TumCP↓, Apoptosis↑, eff↑,

4625-

Bor,

Boron and Inflammation

Review,

Arthritis,

Review,

ostP,

*Risk↓, *eff↑, *SOD↑, *NF-kB↓, *Risk↓, *CRP↓, *TNF-α↓, *Wound Healing↑,

4624-

Bor,

VitD3,

Boron as a Medicinal Ingredient in Oral Natural Health Products

Review,

Pca,

*Half-Life↝, *eff↑, PSA↓, TumVol↓, IGF-1↓, *memory↓, *motorD↓,

696-

Bor,

Nothing Boring About Boron

Review,

Var,

>3mg

upper intake level (UL) of 20 mg/d

*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *eff↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,

744-

Bor,

Borax affects cellular viability by inducing ER stress in hepatocellular carcinoma cells by targeting SLC12A5

in-vitro,

HCC,

HepG2

22.6 mM

in-vitro,

Nor,

HL7702

40.8 mM

TumCCA↑, SLC12A5↓, ATF6↑, CHOP↑, GRP78/BiP↑, Casp3↑, ER Stress↝, *toxicity↓, *eff↓,

746-

Bor,

Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope

Review,

NA,

50 mM CCL-233 colon

eff↑, *toxicity↓, ROS↑, LAT↓, AntiCan↑, AR↓, PSMB5↓, IGF-1↓, PSA↓, TumVol↓, eff↑, Rho↓, Cdc42↓, Ca+2↓, eff↑,

757-

Bor,

Phenylboronic acid is a more potent inhibitor than boric acid of key signaling networks involved in cancer cell migration

in-vitro,

Pca,

DU145

in-vitro,

Nor,

RWPE-1

Rho↓, Rac1↓, Cdc42↓, *eff↑,

732-

Bor,

Boron's neurophysiological effects and tumoricidal activity on glioblastoma cells with implications for clinical treatment

eff↑, IGF-1↝, Glycolysis↝,

3508-

Bor,

The Effect of Boron on the UPR in Prostate Cancer Cells is Biphasic

in-vitro,

Pca,

LNCaP

in-vitro,

Pca,

DU145

ER Stress↑, GRP78/BiP↑, p‑eIF2α↑, UPR↑, eff↓,

3867-

Bos,

Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers

Human,

Nor,

*eff↑, BioAv↝,

3868-

Bos,

Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract

*Inflam↓, *BioAv↓, *BioAv↑, *eff↑,

2775-

Bos,

The journey of boswellic acids from synthesis to pharmacological activities

Review,

Var,

Review,

AD,

Review,

PSA,

ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓,

2767-

Bos,

The potential role of boswellic acids in cancer prevention and treatment

Review,

Var,

*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,

1451-

Bos,

Phytochemical Analysis and Anti-cancer Investigation of Boswellia serrata Bioactive Constituents In Vitro

in-vitro,

CRC,

HepG2

1.58 and 5.82 μg/mL at 48 h

HepG2 cell line, extracts 1 and 2

in-vitro,

CRC,

HCT116

eff↑,

1651-

CA,

PBG,

Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer

Review,

Var,

Apoptosis↑, TumCCA↓, TumCMig↓, TumMeta↓, ChemoSen↑, eff↑, eff↑, eff↓, eff↝, Dose∅, AMPK↑, p62↓, LC3II↑, Ca+2↑, Bax:Bcl2↑, CDK4↑, CDK6↑, RB1↑, EMT↓, E-cadherin↑, Vim↓, β-catenin/ZEB1↓, NF-kB↓, angioG↑, VEGF↓, TSP-1↑, MMP9↓, MMP2↓, ChemoSen↑, eff↑, ROS↑, CSCs↓, Fas↑, P53↑, BAX↑, Casp↑, β-catenin/ZEB1↓, NDRG1↑, STAT3↓, MAPK↑, ERK↑, eff↑, eff↑, eff↑,

1640-

CA,

MET,

Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines

in-vitro,

Cerv,

SiHa

GLS↓, NADPH↓, ROS↑, TumCD↑, AMPK↑, Hif1a↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDH↓, cMyc↓, BAX↓, cycD1/CCND1↓, PDH↓, ROS↑, Apoptosis↑, eff↑, ACLY↓, FASN↓, Bcl-2↓, Glycolysis↓,

1650-

CA,

Adjuvant Properties of Caffeic Acid in Cancer Treatment

Review,

Var,

ROS↑, antiOx↑, Inflam↓, AntiCan↑, NF-kB↓, STAT3↓, ERK↓, ChemoSen↑, RadioS↑, AMPK↑, eff↑, selectivity↑, COX2↓, Dose∅, PHDs↓, MMP9↓, MMP2↓, Dose∅, Dose∅, Ca+2↑, Dose?, MMP↓, RadioS↑,

2399-

CA,

EA,

Polyphenol-rich diet mediates interplay between macrophage-neutrophil and gut microbiota to alleviate intestinal inflammation

Review,

Col,

eff↝, eff↑, Weight↑,

3758-

CA,

RT,

CGA,

Polyphenols and inhibitory effects of crude and purified extracts from tomato varieties on the formation of advanced glycation end products and the activity of angiotensin-converting and acetylcholinesterase enzymes

Analysis,

AD,

*AChE↓, *eff↑,

3784-

CA,

CGA,

Comparative Study on the Inhibitory Effect of Caffeic and Chlorogenic Acids on Key Enzymes Linked to Alzheimer’s Disease and Some Pro-oxidant Induced Oxidative Stress in Rats’ Brain-In Vitro

Study,

AD,

*AChE↓, *BChE↓, *eff↑, *ROS↓, *neuroP↑,

1653-

Caff,

Higher Caffeinated Coffee Intake Is Associated with Reduced Malignant Melanoma Risk: A Meta-Analysis Study

Review,

Melanoma,

AntiCan↑, eff↓,

5212-

CAP,

PI,

Chemo,

Capsaicin and Piperine Can Overcome Multidrug Resistance in Cancer Cells to Doxorubicin

in-vitro,

Colon,

Caco-2

ChemoSen↑, P-gp↓, eff↑,

5201-

CAP,

Inhibiting ROS-STAT3-dependent autophagy enhanced capsaicin-induced apoptosis in human hepatocellular carcinoma cells

NA,

HCC,

HepG2

50, 100 and 200μmol/L) for 6, 12, and 24 h.

AntiCan↓, Apoptosis↑, cl‑PARP↑, Bcl-2↑, TumAuto↑, LC3II↑, eff↑, STAT3↑, ROS↑, eff↓,

5199-

CAP,

Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation

vitro+vivo,

AML,

 i.p., capsaicin inhibited the growth of human multiple myeloma xenograft tumors in male athymic nu/nu mice.

STAT3↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, VEGF↓, TumCCA↑, Apoptosis↑, Casp↑, eff↑,

1518-

CAP,

Capsaicin-mediated tNOX (ENOX2) up-regulation enhances cell proliferation and migration in vitro and in vivo

in-vitro,

CRC,

HCT116

ENOX2↑, TumCP↑, TumCMig↑, Dose?, eff↑,

2013-

CAP,

Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells

in-vitro,

Pca,

PC3

0-5 x 10-4 mol/L

in-vitro,

Pca,

LNCaP

in-vitro,

Pca,

DU145

in-vivo,

NA,

5 mg/kg/d;

mice

TumCP↓, P53↑, P21↑, BAX↑, PSA↓, AR↓, NF-kB↓, Proteasome↓, TumVol↓, eff∅,

2014-

CAP,

Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells

in-vitro,

PC,

Bxpc-3

150uM

in-vitro,

Nor,

HPDE-6

150uM

normal pancreatic epithelial cells were resistant to the <span class="wphighlight">eff</span>ects of capsaicin.

in-vivo,

PC,

AsPC-1

mice orally fed with 2.5 mg/kg capsaicin

mice, 2.5 mg/kg capsaicin was given to mice by oral gavage, which is 0.202 mg/kg when converted to human equivalent dose (HED) and equates to 13.2 mg dose of capsaicin for a 60 kg person

ROS↑, *ROS∅, selectivity↑, compI↓, compIII↓, eff↑, selectivity↑, ATP↓, Cyt‑c↑, Casp9↑, Casp3↑, MMP↓, SOD↓, GSH/GSSG↓, Apoptosis↑, *toxicity∅, GSH↓, Catalase↓, GPx↓, Dose↝,

2015-

CAP,

CUR,

urea,

Anti-cancer Activity of Sustained Release Capsaicin Formulations

Review,

Var,

AntiCan↑, TumCG↓, angioG↓, TumMeta↓, BioAv↓, BioAv↓, BioAv↑, selectivity↑, EPR↑, eff↓, ChemoSen↑, Dose∅, Half-Life∅, eff↑,

2016-

CAP,

Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the anti-tumor effects of 17-AAG (Tanespimycin)

HSP90↓, ATPase↓, eff↑, HSP70/HSPA5↓, other↝, NF-kB↓, EGFR↓, CDK4↓, Src↓, VEGF↓, PI3K↓, Akt↓,

2018-

CAP,

MF,

Capsaicin: Effects on the Pathogenesis of Hepatocellular Carcinoma

Review,

HCC,

TRPV1↑, eff↑, Akt↓, mTOR↓, p‑STAT3↑, MMP2↑, ER Stress↑, Ca+2↑, ROS↑, selectivity↑, MMP↓, eff↑,

2019-

CAP,

Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer

Review,

Var,

chemoPv↑, Ca+2↑, antiOx↑, *ROS↓, *MMP∅, *Cyt‑c∅, *Casp3∅, *eff↑, *Inflam↓, *NF-kB↓, *COX2↓, iNOS↓, TRPV1↑, i-Ca+2?, MMP↓, Cyt‑c↑, Bax:Bcl2↑, P53↑, JNK↑, PI3K↓, Akt↓, mTOR↓, LC3II↑, ATG5↑, p62↑, Fap1↓, Casp3↑, Apoptosis↑, ROS↑, MMP9↓, eff↑, eff↓, eff↑, selectivity↑, eff↑, ChemoSen↑,

3869-

Carno,

Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation

Review,

AD,

Review,

Stroke,

*ROS↓, *IronCh↑, *AntiAge↑, *antiOx↑, *Inflam↓, *neuroP↑, *lipid-P↓, *toxicity↓, *NOX4↓, *SOD↑, *HNE↓, *IL6↓, *TNF-α↓, *IL1β↓, *Sepsis↓, *eff↑, *GABA↝, *Aβ↓, Glycolysis↓, AntiTum↑, p‑Akt↓, TumCCA↑, angioG↓, VEGFR2↓, NF-kB↓,

1244-

CGA,

immuno,

Cancer Differentiation Inducer Chlorogenic Acid Suppresses PD-L1 Expression and Boosts Antitumor Immunity of PD-1 Antibody

in-vivo,

NA,

murine tumor xenografts

PD-L1↓, T-Cell↑, eff↑,

2175-

Chemo,

VitB12,

FA,

Systemic Chemotherapy Interferes in Homocysteine Metabolism in Breast Cancer Patients

Study,

BC,

other↓, other↝, homoC↓, eff↝, other↝,

4479-

Chit,

Chitosan nanoparticles triggered the induction of ROS-mediated cytoprotective autophagy in cancer cells

in-vitro,

Cerv,

HeLa

in-vitro,

HCC,

SMMC-7721 cell

TumAuto↑, ROS↑, eff↓,

4490-

Chit,

FA,

Chitosan Nanoparticle-Based Drug Delivery Systems: Advances, Challenges, and Future Perspectives

Review,

NA,

EPR↑, *BioAv↑, *eff↑, *other↝, *Insulin↑, *Bacteria↓, eff↑, ChemoSen↑,

4489-

Chit,

SeNPs,

Inhibiting Metastasis and Improving Chemosensitivity via Chitosan-Coated Selenium Nanoparticles for Brain Cancer Therapy

in-vitro,

GBM,

U87MG

diameters of Cs-SeNPs with chitosan contents of 0.1, 0.15, and 0.2% were 88.66 ± 0.65, 88.90 ± 0.57, and 91.45 ± 2.57 nm

TumCG↓, TumCMig↓, TumCI↓, ChemoSen↑, *BBB↑, eff↑, eff↑, eff↑, selectivity↑, MMP2↓, MMP9↓, EPR↑,

4477-

Chit,

Recent Advances in Chitosan and its Derivatives in Cancer Treatment

Review,

NA,

*BioAv↑, AntiTum↑, eff↑, TumCG↓, angioG↓, TumMeta↓, eff↑, *toxicity↓, other↝,

3701-

Chol,

Lifelong choline supplementation ameliorates Alzheimer's disease pathology and associated cognitive deficits by attenuating microglia activation

in-vivo,

AD,

APP/PS1 mouse model of AD

*Ach↑, *Aβ↓, *memory↑, *APP↓, *eff↑, *neuroP↑, *Dose↑,

3704-

Chol,

Acetylcholine, aging, and Alzheimer's disease

Review,

AD,

*memory↑, *eff↑, *eff↑,

2803-

CHr,

5-FU,

Potentiating activities of chrysin in the therapeutic efficacy of 5-fluorouracil in gastric cancer cells

in-vitro,

GC,

AGS

chrysin doses of 40, 50, 60 and 80 µM, and 5-FU doses of 20, 25, 30 and 40 µM,

ChemoSen↑, TumCCA↑, eff↑, MDR1↓,

2806-

CHr,

Se,

Selenium-containing chrysin and quercetin derivatives: attractive scaffolds for cancer therapy

in-vitro,

Var,

eff↑, selectivity↑, Dose↝, TrxR↓, GSH↓, MMP↓, ROS↑, H2O2↑,

2781-

CHr,

PBG,

Chrysin a promising anticancer agent: recent perspectives

Review,

Var,

PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, eff↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2↓, NF-kB↓, PDK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,

2782-

CHr,

Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives

Review,

Var,

Review,

Stroke,

Review,

Park,

*antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *BioAv↓, *cardioP↑, *lipidLev↓, *RenoP↑, *TNF-α↓, *IL2↓, *PI3K↓, *Akt↓, *ROS↓, *cognitive↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, VEGF↓, p‑STAT3↓, TumMeta↓, TumCP↓, eff↑, eff↑, IL1β↓, IL6↓, NF-kB↓, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, ER Stress↑, Ca+2↑, TET1↑, Let-7↑, Twist↓, EMT↓, TumCCA↑, Casp3↑, Casp9↑, BAX↑, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, SHP1↑, N-cadherin↓, E-cadherin↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, RadioS↑, NOTCH1↑, NRF2↓, BioAv↑, eff↑,

2784-

CHr,

Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)

Review,

Var,

Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C↑, p‑STAT3↑, MMP2↓, MMP9↓, eff↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2↓, eff↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,

2785-

CHr,

Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

Review,

Var,

*NF-kB↓, *COX2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,

2789-

CHr,

Anticancer Activity of Ether Derivatives of Chrysin

Review,

Var,

eff↑, COX2↓, PGE2↓, eff↑,

2790-

CHr,

Chrysin: Pharmacological and therapeutic properties

Review,

Var,

*hepatoP↑, *neuroP↓, *ROS↓, *cardioP↑, *Inflam↓, eff↑, hTERT/TERT↓, cycD1/CCND1↓, MMP9↓, MMP2↓, TIMP1↑, TIMP2↑, BioAv↑, HK2↓, ROS↑, MMP↓, Casp3↑, ADP:ATP↑, Apoptosis↑, ER Stress↑, UPR↑, GRP78/BiP↝, eff↑, Ca+2↑,

3891-

Cin,

Identification of potential targets of cinnamon for treatment against Alzheimer's disease-related GABAergic synaptic dysfunction using network pharmacology

Analysis,

AD,

*BBB↑, *GABA↑, *eff↑, *antiOx↑, *Inflam↑, *Mood↑,

1592-

Citrate,

Inhibition of Mcl-1 expression by citrate enhances the effect of Bcl-xL inhibitors on human ovarian carcinoma cells

in-vitro,

Ovarian,

SKOV3

5mM,10mM

in-vitro,

Ovarian,

IGROV1

eff↑, tumCV↓, Mcl-1↓, eff↑,

1583-

Citrate,

Extracellular citrate and metabolic adaptations of cancer cells

Review,

NA,

Warburg↓, OXPHOS↓, Dose∅, TumCP↓, ATP↓, eff↑, Apoptosis↑, TumCG↓, PFK1↓,

1585-

Citrate,

Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer

in-vitro,

Ovarian,

SKOV3

15.93 mM

in-vitro,

Ovarian,

A2780S

16.8 mM

in-vitro,

Nor,

HEK293

Apoptosis↑, Ferroptosis↑, Ca+2↓, CaMKII ↓, Akt↓, mTOR↓, Hif1a↓, ROS↑, ChemoSen↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Cyt‑c↑, GlucoseCon↓, lactateProd↓, Pyruv↓, GLUT1↓, HK2↓, PFKP↓, Glycolysis↓, Hif1a↓, p‑Akt↓, p‑mTOR↓, Iron↑, lipid-P↑, MDA↑, ROS↑, H2O2↑, mtDam↑, GSH↓, GPx↓, GPx4↓, NADPH/NADP+↓, eff↓, FTH1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, NCOA4↑, eff↓, TumCG↓,

1584-

Citrate,

Anticancer effects of high-dose extracellular citrate treatment in pancreatic cancer cells under different glucose concentrations

in-vitro,

PC,

MIA PaCa-2

in-vitro,

PC,

PANC1

tumCV↓, i-Ca+2↓, TumCMig↓, CD133↓, pH↑, eff↑, Ki-67↓, eff↑,

1581-

Citrate,

Hypothesis proved. . .citric acid (citrate) does improve cancer:A case of a patient suffering from medullary thyroid cancer

Case Report,

Thyroid,

OS↑, Weight↑, Dose∅, eff↑,

1578-

Citrate,

Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update

Review,

Var,

10–20 mM

TCA↑, FASN↑, Glycolysis↓, glucoNG↑, PFK1↓, PFK2↓, FBPase↑, TumCP↓, eff↑, ACLY↓, Dose↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, Bcl-xL↓, Mcl-1↓, IGF-1R↓, PI3K↓, Akt↓, mTOR↓, PTEN↑, ChemoSen↑, Dose?,

1577-

Citrate,

Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high-fat diet

in-vivo,

PC,

30 mg·kg ·day citrate(injection)

mice

in-vitro,

PC,

PANC1

10 mmol·L citrate

in-vitro,

PC,

PATU-8988

in-vitro,

PC,

MIA PaCa-2

Apoptosis↑, TumCP↓, TumCG↑, SPARC↑, Glycolysis↓, OCR↓, pol-M1↑, pol-M2 MC↓, Weight∅, ATP↓, ECAR↓, mitResp↓, i-ATP↑, p65↓, i-Ca+2↑, eff↓,

1576-

Citrate,

Targeting citrate as a novel therapeutic strategy in cancer treatment

Review,

Var,

TCA↓, T-Cell↝, Glycolysis↓, PKM2↓, PFK2?, SDH↓, PDH↓, β-oxidation↓, CPT1A↓, FASN↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, cl‑PARP↑, Hif1a↓, GLUT1↓, angioG↓, Ca+2↓, ROS↓, eff↓, Dose↓, eff↑, Mcl-1↓, HK2↓, IGF-1R↓, PTEN↑, citrate↓, Dose∅, eff↑, eff↑, eff↑, eff↑,

1574-

Citrate,

Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway

in-vitro,

Lung,

A549

5,10,15mM

in-vitro,

Melanoma,

WM983B

in-vivo,

NA,

4 g/kg citrate twice a day for 4 week

mice. Plasma levels in chronically treated animals were approximately 3 mM

TumCG↓, eff↑, T-Cell↑, p‑IGF-1R↓, p‑Akt↓, PTEN↑, p‑eIF2α↑, OCR↓, ROS↓, ECAR∅, IL1↑, TNF-α↑, IL10↑, IGF-1R↓, eIF2α↑, PTEN↑, TCA↓, Glycolysis↓, selectivity↑, *toxicity∅, Dose∅,

2315-

Citrate,

Why and how citrate may sensitize malignant tumors to immunotherapy

Review,

Var,

Bcl-2↓, Mcl-1↓, survivin↓, Casp3↑, Casp9↑, Ferroptosis↑, lipid-P↑, Ca+2↓, Akt↓, mTOR↓, Hif1a↓, MCU↓, ATP↓, ROS↑, eff↑,

4767-

CoQ10,

Efficacy of Coenzyme Q10 for Improved Tolerability of Cancer Treatments: A Systematic Review

Review,

Var,

chemoP↑, cardioP↑, hepatoP↑, eff↝,

4770-

CoQ10,

VitK2,

Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer

in-vitro,

BC,

MDA-MB-231

other↑, *antiOx↑, Risk↓, other↑, TumMeta↓, ECM/TCF↓, Akt2↓, Ferroptosis↑, eff↑,

4772-

CoQ10,

The anti-tumor activities of coenzyme Q0 through ROS-mediated autophagic cell death in human triple-negative breast cells

in-vitro,

BC,

MDA-MB-468

 IC50 values of 4.8, 7.6, and 20.6 µM

in-vitro,

BC,

MDA-MB-231

TumCP↓, Apoptosis↑, Casp3↑, cl‑PARP↑, LC3II↑, eff↓, TumCG↓, Bax:Bcl2↑, Beclin-1↑, TumAuto↑, ROS↑,

4776-

CoQ10,

Antitumor properties of Coenzyme Q0 against human ovarian carcinoma cells via induction of ROS-mediated apoptosis and cytoprotective autophagy

vitro+vivo,

Ovarian,

SKOV3

(SKOV-3) cells and xenografted nude mice

ROS↑, eff↓, AntiCan↑, Apoptosis↑, tumCV↓, TumCG↓, TumCCA↑, LC3s↑, ERStress↑, Beclin-1↑, Bax:Bcl2↑, HER2/EBBR2↓, Akt↓, mTOR↓,

3994-

CoQ10,

Se,

Coenzyme Q10 Supplementation in Aging and Disease

Review,

AD,

Review,

Park,

*AntiAge↑, *cardioP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *QoL↑, *neuroP↑, *Dose↝, *BP↓, *IGF-1↑, *IGFBP1↑, *eff↑, *LDL↓, *HDL↑, *eff↑, *other↑, *RenoP↑, *ROS↓, *TNF-α↓, *IL6↓, *other↝, *other∅,

1604-

Cu,

Targeting copper metabolism: a promising strategy for cancer treatment

Review,

NA,

eff↓, eff↓, ROS↑, eff↑,

1603-

Cu,

BP,

SDT,

Glutathione Depletion-Induced ROS/NO Generation for Cascade Breast Cancer Therapy and Enhanced Anti-Tumor Immune Response

in-vitro,

BC,

4T1

in-vivo,

NA,

mice

GSH↓, Fenton↑, ROS↑, NO↑, sonoS↑, eff↑, NO↑, *toxicity∅, eff?,

1602-

Cu,

A simultaneously GSH-depleted bimetallic Cu(ii) complex for enhanced chemodynamic cancer therapy†

in-vitro,

BC,

MCF-7

3.2uM

in-vitro,

BC,

4T1

3.3uM

in-vitro,

Lung,

A549

4uM

in-vitro,

Liver,

HepG2

3.5uM

eff↑, GSH↓, H2O2↑, ROS↑, *BioAv↑, selectivity↑, TumCCA↑, Apoptosis↑, Fenton↑, *toxicity?,

1600-

Cu,

Cu(II) complex that synergistically potentiates cytotoxicity and an antitumor immune response by targeting cellular redox homeostasis

Review,

NA,

ER Stress↑, ROS↑, AntiTum↑, GSH↓, Ferroptosis↑, selectivity↑, GSH/GSSG↓, *ROS∅, eff↑,

1570-

Cu,

Development of copper nanoparticles and their prospective uses as antioxidants, antimicrobials, anticancer agents in the pharmaceutical sector

Review,

NA,

selectivity↑, antiOx↑, ROS↑, eff↑, GSH↓, lipid-P↑, Catalase↓, SOD↓, other↑,

1572-

Cu,

Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy

Review,

NA,

eff↑, Fenton↑, ROS↑, eff↑, mtDam↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, ER Stress↑, CHOP↑, Apoptosis↑, selectivity↑, eff↑, Pyro↑, Paraptosis↑, Cupro↑, ChemoSen↑, eff↑,

1595-

Cu,

The Multifaceted Roles of Copper in Cancer: A Trace Metal Element with Dysregulated Metabolism, but Also a Target or a Bullet for Therapy

Review,

NA,

eff↑, ROS↑, eff↓,

1598-

Cu,

Targeting copper in cancer therapy: 'Copper That Cancer'

Review,

NA,

eff↓, eff↑, Dose∅, eff↑, angioG↑, ROS↑,

1597-

Cu,

Anticancer potency of copper(II) complexes of thiosemicarbazones

Review,

NA,

eff↑, ROS↑,

1596-

Cu,

CDT,

Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review

Review,

NA,

TumCD↑, Apoptosis↓, ROS↑, angioG↑, Cupro↑, Paraptosis↑, eff↑, eff↓, selectivity↑, DNAdam↑, eff↑, eff↑, eff↑, eff↑, Fenton↑, H2O2↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑, *toxicity↝, other↑, eff↑,

1609-

CUR,

EA,

Curcumin and Ellagic acid synergistically induce ROS generation, DNA damage, p53 accumulation and apoptosis in HeLa cervical carcinoma cells

in-vitro,

Cerv,

eff↑, Dose∅, ROS↑, DNAdam↑, P53↑, P21↑, BAX↑, Dose∅,

1982-

CUR,

Inhibition of thioredoxin reductase by curcumin analogs

in-vitro,

NA,

IC50 values from the nano to
the low micromolar range.

eff↑, TrxR↓,

1981-

CUR,

Mitochondrial targeted curcumin exhibits anticancer effects through disruption of mitochondrial redox and modulation of TrxR2 activity

in-vitro,

Lung,

eff↑, ROS↑, mt-GSH↓, Bax:Bcl2↑, Cyt‑c↑, MMP↓, Casp3↑, Trx2↓, TrxR↓, mt-DNAdam↑,

1979-

CUR,

Rad,

Dimethoxycurcumin, a metabolically stable analogue of curcumin enhances the radiosensitivity of cancer cells: Possible involvement of ROS and thioredoxin reductase

in-vitro,

Lung,

A549

eff↑, ROS↑, GSH/GSSG↓, TrxR↓, selectivity↑,

1978-

CUR,

Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cells

in-vitro,

Cerv,

HeLa

TrxR1↓, ROS↑, DNA-PK↑, eff↑, Trx↓, Trx1↓,

1977-

CUR,

Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors

in-vitro,

BC,

MCF-7

in-vitro,

Cerv,

HeLa

in-vitro,

Lung,

A549

TrxR↓, Dose↝, eff↑,

1409-

CUR,

Curcumin analog WZ26 induces ROS and cell death via inhibition of STAT3 in cholangiocarcinoma

in-vivo,

CCA,

Walker256

mouse

TumCG↓, ROS↑, MMP↓, STAT3↓, TumCCA↑, eff↓,

1510-

CUR,

Chemo,

Combination therapy in combating cancer

Review,

NA,

*NRF2↑, *GSH↑, *ROS↓, ChemoSideEff↓, eff↑, OS↓, chemoP↑,

3583-

CUR,

Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers

Review,

Arthritis,

*TNF-α↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2↓, *MMPs↓, *eff↑,

3588-

CUR,

The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies

Review,

AD,

*cognitive↝, *BioAv↑, *Inflam↓, *COX2↓, *iNOS↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↓, *IL6↓, *IL8↓, *IL12↓, *ROS↓, *RNS↓, *antiOx↑, *BBB↑, *BioAv↓, *cognitive↑, *memory↑, *tau↓, *eff↑,

3582-

CUR,

PI,

Therapeutic and Preventive Effects of Piperine and its Combination with Curcumin as a Bioenhancer Against Aluminum-Induced Damage in the Astrocyte Cells

*eff↑, *IL6↓, *TGF-β↓, *BioAv↑,

3579-

CUR,

AgNPs,

Metal–Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin

Review,

NA,

*IronCh↑, *BioAv↑, *antiOx↑, *Inflam↓, *BioAv↑, ROS↑, *neuroP↑, *eff↑,

3578-

CUR,

SIL,

Curcumin, but not its degradation products, in combination with silibinin is primarily responsible for the inhibition of colon cancer cell proliferation

in-vitro,

CRC,

DLD1

eff↑, BioAv↓, TumCG↓,

3574-

CUR,

The effect of curcumin (turmeric) on Alzheimer's disease: An overview

Review,

AD,

*antiOx↑, *Inflam↓, *lipid-P↓, *cognitive↑, *memory↑, *Aβ↓, *COX2↓, *ROS↓, *AP-1↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *SOD↑, *GSH↑, *HO-1↑, *IronCh↑, *BioAv↓, *Half-Life↝, *Dose↝, *BBB↑, *BioAv↑, *toxicity∅, *eff↑,

2688-

CUR,

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

Review,

Var,

Review,

AD,

*ROS↓, *SOD↑, p16↑, JAK2↓, STAT3↓, CXCL12↓, IL6↓, MMP2↓, MMP9↓, TGF-β↓, α-SMA↓, LAMs↓, DNAdam↑, *memory↑, *cognitive↑, *Inflam↓, *antiOx↑, *NO↑, *MDA↓, *ROS↓, DNMT1↓, ROS↑, Casp3↑, Apoptosis↑, miR-21↓, LC3II↓, ChemoSen↑, NF-kB↓, CSCs↓, Nanog↓, OCT4↓, SOX2↓, eff↑, Sp1/3/4↓, miR-27a-3p↓, ZBTB10↑, SOX9?, ChemoSen↑, VEGF↓, XIAP↓, Bcl-2↓, cycD1/CCND1↓, BioAv↑, Hif1a↓, EMT↓, BioAv↓, PTEN↑, VEGF↓, Akt↑, EZH2↓, NOTCH1↓, TP53↑, NQO1↑, HO-1↑,

2812-

CUR,

Curcumin Induces High Levels of Topoisomerase I− and II−DNA Complexes in K562 Leukemia Cells

in-vitro,

AML,

K562

TOP1↑, TOP2↑, eff↓,

2808-

CUR,

Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation

in-vitro,

Liver,

HUH7

25 μM curcumin for 48 h

Ferritin↓, IronCh↑, TumAuto↑, Apoptosis↑, eff↝, Dose↝,

2978-

CUR,

N-acetyl cysteine mitigates curcumin-mediated telomerase inhibition through rescuing of Sp1 reduction in A549 cells

in-vitro,

Lung,

A549

ROS↑, hTERT/TERT↓, Sp1/3/4↓, eff↓,

143-

CUR,

Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress

in-vitro,

Pca,

LNCaP

in-vitro,

Pca,

DU145

in-vitro,

Pca,

PC3

ER Stress↑, CHOP↑, GRP78/BiP↑, ROS↑, LC3II↑, eff↓, tumCV↓,

135-

CUR,

Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation

in-vitro,

Pca,

DU145

 6-50uM

 CRPC Castration-Resistant Prostrate Cancer Cell

in-vitro,

Pca,

PC3

TfR1/CD71↑, IRP1↑, IronCh↑, Casp↑, eff↑,

117-

CUR,

Increased Intracellular Reactive Oxygen Species Mediates the Anti-Cancer Effects of WZ35 via Activating Mitochondrial Apoptosis Pathway in Prostate Cancer Cells

in-vivo,

Pca,

RM-1

in-vivo,

Pca,

DU145

ROS↑, tumCV↓, Apoptosis↑, TumCCA↑, Ca+2↑, eff↓, ER Stress↑,

118-

CUR,

Curcumin analog WZ35 induced cell death via ROS-dependent ER stress and G2/M cell cycle arrest in human prostate cancer cells

in-vitro,

Pca,

PC3

 2.2 μM

 for WZ35 analog. For Curcumin it is 20.9μM

in-vitro,

Pca,

DU145

ROS↑, Bcl-2↓, PARP↑, cDC2↓, CycB/CCNB1↓, MDM2↓, eff↓, eIF2α↑, ATF4↑, CHOP↑, ER Stress↑, TumCCA↑,

134-

CUR,

RES,

MEL,

SIL,

Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cells

in-vitro,

Pca,

LNCaP

in-vitro,

Pca,

PC3

Apoptosis↑, ROS↑, Trx1↓, TumCG↓, eff↓, TXNIP↑,

129-

CUR,

Curcumin suppressed the prostate cancer by inhibiting JNK pathways via epigenetic regulation

vitro+vivo,

Pca,

LNCaP

JNK↓, H3K4↓, TumCG↓, Apoptosis↑, eff↑,

130-

CUR,

Maspin Enhances the Anticancer Activity of Curcumin in Hormone-refractory Prostate Cancer Cells

in-vitro,

Pca,

DU145

 less senstive (with lower maspin expression)

in-vitro,

Pca,

PC3

 more senstive (higher maspin expression)

BAD↝, BAX↝, eff↑,

14-

CUR,

Curcumin, a Dietary Component, Has Anticancer, Chemosensitization, and Radiosensitization Effects by Down-regulating the MDM2 Oncogene through the PI3K/mTOR/ETS2 Pathway

vitro+vivo,

Pca,

PC3

 5-30 uM

PI3K/mTOR/ETS2↓, MDM2↓, P21↑, Apoptosis↑, TumCP↓, eff↑, RadioS↑,

12-

CUR,

Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells

in-vitro,

MB,

DAOY

 20 uM

HH↓, Shh↓, Gli1↓, PTCH1↓, cMyc↓, n-MYC↓, cycD1/CCND1↓, Bcl-2↓, NF-kB↓, Akt↓, β-catenin/ZEB1↓, survivin↓, Apoptosis↑, ChemoSen↑, RadioS↑, eff↑,

167-

CUR,

Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria

in-vitro,

Pca,

PC3

MAPK↑, JNK↑, Casp3↑, Casp8↑, Casp9↑, AIF↑, GSH↓, eff↓, Apoptosis↑, DNAdam↑,

4830-

CUR,

Curcumin and Its Derivatives Induce Apoptosis in Human Cancer Cells by Mobilizing and Redox Cycling Genomic Copper Ions

in-vitro,

Var,

eff↑, ROS↑, DNAdam↑, TumCG↓, Apoptosis↑, eff↓, Fenton↑, eff↑,

4826-

CUR,

The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer Management

Review,

Var,

*antiOx↑, *Inflam↑, *ROS↓, Apoptosis↑, TumCP↓, BioAv↓, Half-Life↓, eff↑, TumCCA↑, BAX↑, Bak↑, PUMA↑, BIM↑, NOXA↑, TRAIL↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, cMyc↓, Casp↑, NF-kB↓, STAT3↓, AP-1↓, angioG↓, TumMeta↑, VEGF↓, MMPs↓, DNMTs↓, HDAC↓, ROS↑,

1871-

DAP,

Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth

in-vitro,

AML,

U937

14.0 μM

in-vivo,

AML,

mouse

TumCP↓, Apoptosis↑, TumCG↓, PDK1↓, cl‑PARP↑, Bcl-xL↓, Bcl-2↓, Beclin-1↓, ATG3↓, PI3K↓, Akt↓, eff↑,

1878-

DCA,

5-FU,

Synergistic Antitumor Effect of Dichloroacetate in Combination with 5-Fluorouracil in Colorectal Cancer

in-vitro,

CRC,

LS174T

57mM

in-vitro,

CRC,

LoVo

29mM

in-vitro,

CRC,

SW-620

38mM

in-vitro,

CRC,

HT-29

47mM

tumCV↓, eff↑, PDKs↓, lactateProd↓, Glycolysis↓, mitResp↑, TumCCA↑, Bcl-2↓, BAX↑, Casp3↑,

1876-

DCA,

Chemo,

In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines

in-vivo,

Lung,

H727

eff↑, TumCG↓, Glycolysis↓, mitResp↑,

1875-

DCA,

Dichloroacetate inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells

in-vitro,

neuroblastoma,

in-vivo,

NA,

five mice were treated with 2.5 mg/kg/
dose of DCA, 14 mice were treated with 25 mg/kg/dose

mice

selectivity↑, AntiCan↑, TumVol↓, PDKs↓, mt-OXPHOS↑, MMP↓, Glycolysis↓, toxicity↓, Warburg↓, ROS↑, eff↑,

1864-

DCA,

MET,

Dichloroacetate Enhances Apoptotic Cell Death via Oxidative Damage and Attenuates Lactate Production in Metformin-Treated Breast Cancer Cells

in-vitro,

BC,

MCF-7

DCA (2.5 mM) and metformin (1 mM)

in-vitro,

BC,

T47D

in-vitro,

Nor,

MCF10

PDKs↓, eff↑, ROS↑, PDK1↓, lactateProd↓, p‑PDH↑, Dose∅, OCR↑, DNA-PK↑, γH2AX↑, cl‑PARP↑, selectivity↑, *toxicity∅,

1881-

DCA,

Chemo,

Co-treatment of dichloroacetate, omeprazole and tamoxifen exhibited synergistically antiproliferative effect on malignant tumors: in vivo experiments and a case report

in-vitro,

NA,

HT1080

in-vitro,

NA,

WI38

Case Report,

Var,

eff↑, selectivity↑, OS↑,

1884-

DCA,

Sal,

Dichloroacetate and Salinomycin Exert a Synergistic Cytotoxic Effect in Colorectal Cancer Cell Lines

in-vitro,

CRC,

DLD1

in-vitro,

CRC,

HCT116

eff↑, pH↓, PDKs↓, Warburg↓,

1873-

DCA,

Dual-targeting of aberrant glucose metabolism in glioblastoma

in-vitro,

GBM,

U87MG

in-vitro,

GBM,

U251

PDKs↓, eff↑, selectivity↑, MMP↓, ROS↑, Apoptosis↑, Warburg↓, eff↑, Dose∅, toxicity∅,

1870-

DCA,

Rad,

Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation

in-vitro,

Pca,

PC3

TumCCA↑, Apoptosis↑, MMP↓, eff↑, RadioS↑,

1868-

DCA,

MET,

Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy

Case Report,

NA,

eff↑, toxicity∅, MMP↓, Apoptosis↑, selectivity↑, pH↝, Dose↝, Dose↝, eff↑,

1867-

DCA,

Chemo,

Sensitization of breast cancer cells to paclitaxel by dichloroacetate through inhibiting autophagy

in-vivo,

BC,

mice

in-vitro,

BC,

TumCG↓, eff↑, OS↑, PDKs↓, PDH↑,

1866-

DCA,

MET,

BTZ,

Targeting metabolic pathways alleviates bortezomib-induced neuropathic pain without compromising anticancer efficacy in a sex-specific manner

in-vivo,

NA,

mice

eff↑, TumCG↓, Hif1a↓, PDH↑, lactateProd↓, TumVol↓, TumW↓, Glycolysis↑, neuroP↑,

1887-

DCA,

GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate

in-vitro,

Var,

GSTZ1∅, eff↓, PDKs↓, Chl∅, eff↓,

1885-

DCA,

Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate

in-vitro,

CRC,

HCT116

These three cell lines do not express SLC5A8

in-vitro,

CRC,

SW-620

in-vitro,

CRC,

HT-29

SMCT1∅, eff↓, eff↑, eff↑, PDKs↓, MMP↓, Glycolysis↓, mitResp↑, ROS↑, eff↑,

4901-

DCA,

Sal,

Dichloroacetate and Salinomycin as Therapeutic Agents in Cancer

Review,

NSCLC,

Glycolysis↓, OXPHOS↑, PDKs↓, ROS↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, RadioS↑, TumAuto↑, mTOR↓, LC3s↓, p62↑, TumCG↓, OS↑, toxicity↝, ChemoSen↑, eff↑, eff↑, Ferritin↓, CSCs↓, EMT↓, ROS↑, Cyt‑c↑, Casp3↑, ER Stress↑, selectivity↑, eff↑, TumCG↓,

4455-

DFE,

Ajwa Date (Phoenix dactylifera L.) Extract Inhibits Human Breast Adenocarcinoma (MCF7) Cells In Vitro by Inducing Apoptosis and Cell Cycle Arrest

in-vitro,

BC,

MCF-7

5, 10, 15, 20 and 25 mg/ml) of MEAD for 24, 48 and 72 h

18.2 mg/ml

in-vitro,

Nor,

3T3

 50 mg/ml

TumCCA↑, P53↑, BAX↑, Casp3↑, MMP↓, Fas↑, FasL↑, Bcl-2↓, Apoptosis↑, TumCP↓, TUNEL↑, eff↑, selectivity↑,

2169-

dietF,

Prolonged stabilization of platinum-resistant ovarian cancer in a single patient consuming a fermented soy therapy

Case Report,

Ovarian,

OS↑, CA125↓, eff↑,

2152-

dietFMD,

Prolonged Nightly Fasting and Breast Cancer Prognosis

Analysis,

BC,

eff↑, Dose↓, Risk↓,

1844-

dietFMD,

Unlocking the Potential: Caloric Restriction, Caloric Restriction Mimetics, and Their Impact on Cancer Prevention and Treatment

Review,

NA,

Risk↓, AMPK↑, Akt↓, mTOR↓, SIRT1↑, Hif1a↓, NRF2↓, SOD↑, ROS↑, IGF-1↓, p‑Akt↓, PI3K↑, GutMicro↑, OS↑, eff↝, ROS↑, TumCCA↑, *DNArepair↑, DNAdam↑,

1845-

dietFMD,

Fasting and fasting mimicking diets in cancer prevention and therapy

Review,

Var,

eff↑, selectivity↑, ChemoSen↑,

1863-

dietFMD,

Chemo,

Effect of fasting on cancer: A narrative review of scientific evidence

Review,

Var,

eff↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,

1847-

dietFMD,

VitC,

Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers

in-vitro,

PC,

PANC1

vitamin C (≥0.3 mM)

TumCG↓, ChemoSen↑, eff↑, HO-1↓, Ferritin↓, Iron↑, ROS↑, TumCD↑, IGF-1↓, eff↓, eff↓,

1848-

dietFMD,

Chemo,

Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial

Trial,

BC,

ChemoSideEff↓, ChemoSen↑, eff↑,

1849-

dietFMD,

The emerging role of fasting-mimicking diets in cancer treatment

Review,

Var,

TumCG↓, toxicity∅, BG↓, IGF-1↓, mTOR↓, M2 MC↓, eff↑, ChemoSen↑, QoL↑, RadioS↑, selectivity↑,

1850-

dietFMD,

Fasting-mimicking diet remodels gut microbiota and suppresses colorectal cancer progression

in-vivo,

CRC,

mice

TumCP↑, angioG↓, CD8+↑, GutMicro↑, eff↑,

1846-

dietFMD,

VitC,

A fasting-mimicking diet and vitamin C: turning anti-aging strategies against cancer

Study,

Var,

TumCG↓, ChemoSen↑, ChemoSideEff↓, ROS↑, Fenton↑, H2O2↑, eff↑, HO-1↓, DNAdam↑, eff↑,

1853-

dietFMD,

Impact of Fasting on Patients With Cancer: An Integrative Review

Review,

Var,

*toxicity∅, QoL∅, eff↑, eff↝, ChemoSideEff↓, TumCG↓, Dose↑, toxicity↝, eff↑, IGF-1↑, *OXPHOS↑, BG↓, Insulin↓, RadioS↑,

1854-

dietFMD,

How Far Are We from Prescribing Fasting as Anticancer Medicine?

Review,

Var,

ChemoSideEff↓, ChemoSen↑, IGF-1↓, IGFBP1↑, adiP↑, glyC↓, E-cadherin↑, MMPs↓, Casp3↑, ROS↑, ATP↓, AMPK↑, mTOR↓, ROS↑, Glycolysis↓, NADPH↓, OXPHOS↝, eff↑, eff↑, *RAS↓, *MAPK↓, *PI3K↓, *Akt↓, eff↑, ROS↑, Akt↑, Casp3↑,

1860-

dietFMD,

Chemo,

Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape

in-vitro,

BC,

SUM159

in-vitro,

BC,

4T1

PI3K↑, Akt↑, mTOR↑, CDK4↑, CDK6↑, hyperG↓, TumCG↓, TumVol↓, Casp3↑, BG↓, eff↑, eff∅, PKA↓, KLF5↓, p‑GSK‐3β↑, Nanog↓, OCT4↓, KLF2↓, eff↑, ROS↑, BIM↑, ASK1↑, PI3K↑, Akt↑, mTOR↑, CDK1↓, CDK4↑, CDK6↑, eff↑,

1843-

dietFMD,

BTZ,

Cyclic Fasting–Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia

in-vivo,

CLL,

mouse

AntiTum↓, Apoptosis↑, IGF-1↓, eff↑, OS↑, eff↑,

1842-

dietFMD,

Safety and Feasibility of Fasting-Mimicking Diet and Effects on Nutritional Status and Circulating Metabolic and Inflammatory Factors in Cancer Patients Undergoing Active Treatment

Trial,

Var,

Strength∅, Weight∅, IGF-1↓, IGFBP3↑, IGFBP1↑, eff↑,

1841-

dietFMD,

Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer

Trial,

Var,

BG↓, AntiCan↑, IFN-γ↑, eff↑, Dose↝, CD14↓, IGF-1↓, IGFR↓, CD8+↑, NK cell↑,

1810-

dietKeto,

Oxy,

The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer

in-vivo,

Var,

mice

BG↓, TumCG↓, OS↑, eff↑, Dose∅, KeyT↑, eff↑, cachexia↓, ChemoSen↑, *ROS↓, ROS↑, lipid-P↑, selectivity↑, toxicity∅,

5192-

dietMet,

Intermittent methionine restriction reduces IGF‐1 levels and produces similar healthspan benefits to continuous methionine restriction

OS↑, eff↝, IGF-1↓, adiP↑, Leptin↓, Weight↓,

5191-

dietMet,

Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade

in-vitro,

Colon,

HT29

ChemoSen↑, RadioS↑, Ferroptosis↑, eff↑, eff↑, GSH↓, eff↓,

1896-

dietMet,

Dietary methionine links nutrition and metabolism to the efficacy of cancer therapies

in-vivo,

CRC,

mice

TumCG↓, *GSH↓, RadioS↑, eff↑,

2170-

dietMet,

Low Protein Intake is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

Study,

Var,

OS↑, eff↝, other↝,

2271-

dietMet,

A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension

Review,

Nor,

*eff↑, *OS↓, *ROS↓, *Weight↓,

2268-

dietMet,

Methionine dependency and cancer treatment

Review,

Var,

ChemoSen↑, *eff↑, selectivity↑, eff↑,

2263-

dietMet,

Methionine Restriction and Cancer Biology

Review,

Var,

AntiCan↑, TumCP↓, TumCG↓, selectivity↑, ChemoSen↓, RadioS↑, Insulin↓, *GlucoseCon↑, *ROS↓, *antiOx↑, *GSH↑, GSH↑, eff↑, polyA↓, TS↓, Raf↓, Akt↓, Casp9↑, Bak↑, P21↑, p27↑, Insulin↓, IGF-1↓,

2264-

dietMet,

Methionine restriction for cancer therapy: From preclinical studies to clinical trials

Review,

Var,

TumCP↓, *ROS?, ChemoSen↑, RadioS↑, eff↑, ROS↑, selectivity↑, TS↓, eff↑,

2265-

dietMet,

Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase

in-vivo,

Nor,

Rats

*SCD1↓, *Weight↓, *Insulin↓, *IGF-1↓, *adiP↑, *eff↓,

2266-

dietMet,

Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction

in-vivo,

Nor,

Rats

*ROS↓, eff↓,

2161-

dietP,

Plant-Based Diets and Cancer Prognosis: a Review of Recent Research

Review,

NA,

OS↑, eff↑, eff↑,

2165-

dietP,

SFN,

Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects—results from the POUDER pilot study

Trial,

PC,

Dose↝, OS↑, eff↝,

2157-

dietP,

Plant-Based Diets and Disease Progression in Men With Prostate Cancer

Study,

Pca,

 cohort study of 2062 men diagnosed with nonmetastatic prostate cancer,

TumCG↓, Risk↓, eff↑,

2156-

dietP,

Phytochemical-rich vegetable and fruit juice alleviates oral mucositis during concurrent chemoradiotherapy in patients with locally advanced head and neck cancer

Human,

HNSCC,

chemoP↑, radioP↑, eff↑,

2155-

dietP,

Transepithelial Anti-Neuroblastoma Response to Kale among Four Vegetable Juices Using In Vitro Model Co-Culture System

in-vivo,

neuroblastoma,

Caco-2

NA,

SH-SY5Y

AntiCan↑, ROS↑, eff↑, eff↑, eff↑,

1626-

dietSTF,

dietFMD,

When less may be more: calorie restriction and response to cancer therapy

Review,

Var,

CRM↑, ChemoSen↑, RadioS↑, eff↑, eff↑, IGF-1↓, TumCG↓, AMPK↑, eff↑, ChemoSen↑, RadioS↑, ROS↑, DNAdam↑, eff↑, HO-1↓,

5070-

dietSTF,

A review of fasting effects on the response of cancer to chemotherapy

Review,

Var,

chemoP↑, ChemoSen↑, *DNArepair↑, *Apoptosis↓, *CD8+↑, UPR↑, eff↝, TumAuto↑,

4159-

dietSTF,

2DG,

CRMs,

Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms

Review,

AD,

*BDNF↑, *HSPs↑, *eff↑,

3708-

dietSTF,

Fasting as a Therapy in Neurological Disease

*PGC-1α↑, *AMPK↑, *adiP↑, *glucose↓, *Insulin↓, *mTOR↓, *IL6↓, *TNF-α↓, *cognitive↑, *Inflam↓, *eff↑, *neuroP↑, ChemoSen↑, eff↓, chemoP↑, *eff↑,

4984-

Dipy,

ATV,

Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop

in-vitro,

AML,

eff↑, Apoptosis↑, selectivity↑, TumCG↓, HMG-CoA↓, HMGCR↑,

4983-

Dipy,

ATV,

Targeting tumor cell metabolism via the mevalonate pathway: Two hits are better than one

Review,

Var,

HMG-CoA↓, AntiTum↓, eff↑,

5386-

docx,

AsP,

Co-delivery of docetaxel and palmitoyl ascorbate by liposome for enhanced synergistic antitumor efficacy

vitro+vivo,

Liver,

HepG2

in-vitro,

BC,

MCF-7

in-vitro,

Pca,

PC3

Dose↝, ROS↑, eff↑, eff↑,

4913-

DSF,

Anticancer effects of disulfiram: a systematic review of in vitro, animal, and human studies

Review,

Var,

Apoptosis↑, tumCV↑, eff↑, toxicity↓, antiNeop↑, ChemoSen↑, RadioS↑, OS↑, ROS↑, SOD↓, MMP1↓, eff↑, Half-Life↓,

4914-

DSF,

immuno,

Disulfiram and cancer immunotherapy: Advanced nano-delivery systems and potential therapeutic strategies

Review,

Var,

AntiTum↑, eff↑, ALDH↓, Dose↝, RadioS↑, angioG↓, TumMeta↓, BioAv↝, ROS↑, DNAdam↑, P-gp↓, CSCs↓, EMT↓, Imm↑, SOD↓, MAPK↓, NF-kB↓, ChemoSen↑, eff↑, toxicity↝, BioAv↑, *Inflam↓, Sepsis↓,

4916-

DSF,

Cu,

The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics

Review,

Var,

TumCP↓, TumCMig↓, TumCI↓, eff↑, Imm↑, ROS↑, NF-kB↓, chemoP↑, JNK↑, FOXO↑, Myc↑, TumCCA↑, Apoptosis↑, RadioS↑, PD-L1↑, eff↑, CSCs↓, Dose↝, Half-Life↑,

4915-

DSF,

Cu,

Disulfiram: A novel repurposed drug for cancer therapy

Review,

Var,

ROS↑, TumCD↑, NF-kB↓, CSCs↓, ChemoSen↑, RadioS↑, eff↑, selectivity↑, Proteasome?,

5008-

DSF,

Cu,

Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis

in-vitro,

HCC,

selectivity↑, TumCD↑, TumCMig↓, TumCI↓, angioG↓, mtDam↑, Iron↑, lipid-P↑, Ferroptosis↑, NF-kB↑, p‑p62↑, Keap1↓, eff↑, eff↓, ChemoSen↑,

5009-

DSF,

Cu,

Activation of Oxidative Stress and Down-Regulation of Nuclear Factor Erythroid 2-Related Factor May Be Responsible for Disulfiram/Copper Complex Induced Apoptosis in Lymphoid Malignancy Cell Lines

vitro+vivo,

lymphoma,

 (1μM) of Cu2+,

0.435±0.109μM and 0.085±0.015μM DS

AntiTum↑, ROS↑, JNK↑, NRF2↓, eff↓, TumCD↑,

5011-

DSF,

Cu,

Leveraging disulfiram to treat cancer: Mechanisms of action, delivery strategies, and treatment regimens

Review,

Var,

BioAv↓, eff↓, ChemoSen↑, RadioS↑,

5012-

DSF,

Cu,

Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems

ROS↑, ALDH↓, TumCP↓, CSCs↓, angioG↓, TumMeta↓, DNAdam↑, Proteasome↓, SOD1↓, GSR↓, ox-GSSG↑, GSH/GSSG↓, MMP↓, Akt↓, cycD1/CCND1↓, NF-kB↓, CSCs↓, MAPK↓, angioG↓, DrugR↓, EMT↓, Vim↓, BioAv↑, eff↑,

5006-

DSF,

Cu,

Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition

vitro+vivo,

lymphoma,

TumCD↑, TumCP↑, Apoptosis↑, NRF2↓, ROS↑, p‑JNK↑, p65↓, eff↓, NF-kB↓,

4832-

EA,

Experimental Evidence of the Antitumor, Antimetastatic and Antiangiogenic Activity of Ellagic Acid

*antiOx↑, *AntiCan↑, TumCMig↓, angioG↓, ChemoSen↑, RadioS↑, *chemoP↑, *BioAv↓, eff↓, selectivity↑, MMP2↓, MMP9↓, VEGF↓, TumCCA↑, Apoptosis↑, ROS↑, BioAv↑,

1605-

EA,

Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence

Review,

Var,

*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,

1619-

EA,

CUR,

effect-of-the-ellagic-acid-and-curcumin-combinations-2161-0525-1000296.pdf">Antimutagenic Effect of the Ellagic Acid and Curcumin Combinations

in-vitro,

Nor,

eff↑,

1608-

EA,

Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity

in-vitro,

Cerv,

HeLa

35 μg/mL

in-vitro,

Liver,

HepG2

220ug/mL

in-vitro,

BC,

MCF-7

75 ug/mL

in-vitro,

Lung,

A549

242um/mL

in-vitro,

Nor,

HUVECs

258um/mL

eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,

1611-

EA,

Targeting Myeloperoxidase Activity and Neutrophil ROS Production to Modulate Redox Process: Effect of Ellagic Acid and Analogues

in-vitro,

Mal,

*BioAv↓, eff↑, *BioAv↓, ROS↑,

1613-

EA,

Ellagitannins in Cancer Chemoprevention and Therapy

Review,

Var,

ROS↑, angioG↓, ChemoSen↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE1↓, TumCG↓, VEGF↓, Hif1a↓, eff↑, COX2↓, TumCCA↑, selectivity↑, Wnt/(β-catenin)↓, *toxicity∅,

1618-

EA,

A comprehensive review on Ellagic acid in breast cancer treatment: From cellular effects to molecular mechanisms of action

Review,

BC,

TumCCA↑, TumCMig↓, TumCI↓, TumMeta↓, Apoptosis↑, TGF-β↓, SMAD3↓, CDK6↓, PI3K↓, Akt↓, angioG↓, VEGFR2↓, MAPK↓, NEDD9↓, NF-kB↓, eff↑, eff↑, RadioS↑, ChemoSen↑, DNAdam↑, eff↑, *toxicity∅, *toxicity∅,

22-

EGCG,

Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics

in-vitro,

PC,

CD133+

in-vitro,

PC,

CD44+

in-vitro,

PC,

CD24+

in-vitro,

PC,

ESA+

 20-60 uM

HH↓, Smo↓, PTCH1↓, PTCH2↓, Gli1↓, GLI2↓, Gli↓, Bcl-2↓, XIAP↓, Shh↓, survivin↓, Casp3↑, Casp7↑, CSCs↓, Nanog↓, cMyc↓, OCT4↓, EMT↓, Snail↓, Slug↓, Zeb1↓, TumCMig↓, TumCI↓, eff↑,

645-

EGCG,

The Effect of Ultrasound, Oxygen and Sunlight on the Stability of (−)-Epigallocatechin Gallate

Analysis,

NA,

eff↑, pH↓,

660-

EGCG,

FA,

Epigallocatechin-3-gallate Delivered in Nanoparticles Increases Cytotoxicity in Three Breast Carcinoma Cell Lines

in-vitro,

BC,

MDA-MB-231

10-20uM

in-vitro,

BC,

MCF-7

in-vitro,

Nor,

MCF10

Apoptosis↑, *toxicity↓, *eff↓,

684-

EGCG,

effect_of_EGCG_in_colorectal_cancer_cells_by_blocking_EGCG-induced_YAP_activation">Improving the anti-tumor effect of EGCG in colorectal cancer cells by blocking EGCG-induced YAP activation

in-vitro,

CRC,

eff↑, Akt↓, VEGFR2↓, STAT3↓, P53↓, Hippo↓, YAP/TEAD↑,

3220-

EGCG,

Dual Roles of Nrf2 in Cancer

in-vitro,

Lung,

A549

NRF2↑, eff↓,

3241-

EGCG,

Epigallocatechin gallate triggers apoptosis by suppressing de novo lipogenesis in colorectal carcinoma cells

in-vitro,

CRC,

HCT116

0.5 ± 0.05 mm

in-vitro,

CRC,

HT29

0.8 ± 0.06 mm

in-vitro,

Liver,

HepG2

 > 1 mm

in-vitro,

Liver,

HUH7

 > 1 mm

tumCV↓, mtDam↑, Apoptosis↑, ATP↓, lipoGen↓, eff↑,

3215-

EGCG,

Epigallocatechin gallate modulates ferroptosis through downregulation of tsRNA-13502 in non-small cell lung cancer

in-vitro,

NSCLC,

A549

 111.1 μM

in-vitro,

NSCLC,

H1299

 5.564 μM

TumCP↓, Ki-67↓, GPx4↓, ACSL4↑, Iron↑, MDA↑, ROS↑, Ferroptosis↑, eff↑, NRF2↑, HO-1↑,

3202-

EGCG,

Epigallocatechin-3-gallate enhances ER stress-induced cancer cell apoptosis by directly targeting PARP16 activity

in-vitro,

Cerv,

HeLa

100uM

in-vitro,

HCC,

QGY-7703

PARP16↓, p‑PERK↓, Apoptosis↑, eIF2α↓, UPR↓, ER Stress↑, eff↑, GRP78/BiP↓,

3205-

EGCG,

The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseas

Review,

Var,

Review,

AD,

Beclin-1↑, ROS↑, Apoptosis↑, ER Stress↑, *Inflam↓, *cardioP↑, *antiOx↑, *LDL↓, *NF-kB↓, *MPO↓, *glucose↓, *ROS↓, ATG5↑, LC3B↑, MMP↑, lactateProd↓, VEGF↓, Zeb1↑, Wnt↑, IGF-1R↑, Fas↑, Bak↑, BAD↑, TP53↓, Myc↓, Casp8↓, LC3II↑, NOTCH3↓, eff↑, p‑Akt↓, PARP↑, *Cyt‑c↓, *BAX↓, *memory↑, *neuroP↑, *Ca+2?, GRP78/BiP↑, CHOP↑, ATF4↑, Casp3↑, Casp8↑, UPR↑,

3212-

EGCG,

EGCG maintained Nrf2-mediated redox homeostasis and minimized etoposide resistance in lung cancer cells

in-vitro,

Lung,

A549

in-vivo,

Lung,

NCIH23

NRF2⇅, eff↑, SOD1↑, SOD1↓, MMP2⇅, MMP9⇅,

1514-

EGCG,

Preferential inhibition by (-)-epigallocatechin-3-gallate of the cell surface NADH oxidase and growth of transformed cells in culture

in-vitro,

Cerv,

HeLa

1-50uM

in-vitro,

Nor,

MCF10

selectivity↑, *toxicity∅, TumCG↓, NADHdeh?, eff↑, ENOX2↓, Dose?,

1503-

EGCG,

Epigenetic targets of bioactive dietary components for cancer prevention and therapy

Review,

NA,

IC50 values ranging from 0.21 to 0.47 μM

selectivity↑, DNMT1↓, RECK↑, MMPs↓, TumCI↓, angioG↓, TumMeta↓, HATs↓, IκB↑, NF-kB↓, IL6↓, COX2↓, NOS2↓, ac‑H3↑, ac‑H4↑, eff↑,

1516-

EGCG,

Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential

Review,

NA,

*Dose∅, Half-Life∅, BioAv∅, BBB↑, toxicity∅, eff↓, Apoptosis↑, Casp3↑, Cyt‑c↑, cl‑PARP↑, DNMTs↓, Telomerase↓, angioG↓, Hif1a↓, NF-kB↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, IGF-1↓, H3↓, HDAC1↓, *LDH↓, *ROS↓,

1515-

EGCG,

Phen,

Reciprocal Relationship Between Cytosolic NADH and ENOX2 Inhibition Triggers Sphingolipid-Induced Apoptosis in HeLa Cells

in-vitro,

Cerv,

HeLa

0.003 uM

in-vitro,

Nor,

MCF10

exceeded 20 uM

 note IC50 not reached for normal cells

in-vitro,

BC,

BT20

0.01 uM

selectivity↑, ENOX2↓, NADH↑, SK↓, eff↑, aSmase↑,

2309-

EGCG,

Chemo,

Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts

in-vitro,

PC,

MIA PaCa-2

(20–100 μM) for 72 h

in-vitro,

Nor,

HPNE

in-vitro,

PC,

PANC1

in-vivo,

NA,

mice

TumCG↓, eff↑, ROS↑, ECAR↓, ChemoSen↑, selectivity↑, Glycolysis↓, PFK↓, PKA↓, HK2∅, LDHA∅, PFKP↓, PKM2↓, H2O2↑, TumW↓,

2501-

EGCG,

A Case of Complete and Durable Molecular Remission of Chronic Lymphocytic Leukemia Following Treatment with Epigallocatechin-3-gallate, an Extract of Green Tea

Case Report,

AML,

OS↑, Remission↑, eff↑, Dose↝,

2563-

EGCG,

Cardioprotective effect of epigallocatechin gallate in myocardial ischemia/reperfusion injury and myocardial infarction: a meta-analysis in preclinical animal studies

Review,

NA,

cardioP↑, ROS↑, AntiAg↑, eff↑, COX1↓,

2561-

EGCG,

ASA,

Anti-platelet effects of epigallocatechin-3-gallate in addition to the concomitant aspirin, clopidogrel or ticagrelor treatment

ex-vivo,

Nor,

40 participants

AntiAg↑, eff↑, Half-Life↝, other∅,

1322-

EMD,

The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers

Review,

Var,

7.22 μg/mL

Apoptosis↑, TumCP↓, ROS↑, TumAuto↑, EMT↓, TGF-β↓, DNAdam↑, ER Stress↑, TumCCA↑, ATP↓, NF-kB↓, CYP1A1↑, STAC2↓, JAK↓, PI3K↓, Akt↓, MAPK↓, FASN↓, HER2/EBBR2↓, ChemoSen↑, eff↑, ChemoSen↑, angioG↓, VEGF↓, MMP2↓, eNOS↓, FOXD3↑, MMP9↓, TIMP1↑,

1329-

EMD,

Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells

in-vitro,

Tong,

SCC4

30 microM

TumCCA↑, eff↓, P53↑, P21↑, p27↑, cycA1/CCNA1↓, cycE/CCNE↓, TS↓, CDC25↓, AIF↑, proCasp9↓, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp3↑, Casp9↑,

2204-

erastin,

Regulation of ferroptotic cancer cell death by GPX4

in-vitro,

fibroS,

HT1080

GSH↓, Ferroptosis↑, ROS↑, GPx↓, GPx4↓, lipid-P↑, eff↓, eff↑,

5047-

erastin,

The ferroptosis inducer erastin irreversibly inhibits system xc− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells

in-vitro,

Ovarian,

xCT↓, GSH↓, Ferroptosis↑, ChemoSen↑, eff↑,

5061-

Ex,

Role of physical exercise in modulating the insulin-like growth factor system for improving breast cancer outcomes: A meta-analysis

Review,

BC,

IGF-2↓, IGFBP1↓, HOMA↓, glucose∅, IGF-1∅, eff↑,

5235-

Ex,

Effect of Low-Intensity Aerobic Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Proteins in Healthy Men

Trial,

Nor,

 Fourteen healthy men participated in cycle ergometer training at lactate threshold intensity for 60 min/day, 5 days/week for 6 weeks.

Insulin↓, IGF-1↓, IGFBP1↑, eff↑,

4139-

Ex,

Impact of physical exercise on the regulation of brain-derived neurotrophic factor in people with neurodegenerative diseases

Review,

AD,

*BDNF↑, *eff↑, *eff↑, *cognitive↑, *memory↑, *BrainVol↑, *TrkB↑, *GABA↑,

4141-

Ex,

Effects of exercise on brain-derived neurotrophic factor in Alzheimer's disease models: A systematic review and meta-analysis

Review,

AD,

*BDNF↑, *other↑, *eff↑,

4143-

Ex,

Brain-Derived Neurotrophic Factor: A Connecting Link Between Nutrition, Lifestyle, and Alzheimer’s Disease

Review,

AD,

*BDNF↑, *eff↑, *other↓, *eff↑,

4145-

Ex,

Effects of different physical activities on brain-derived neurotrophic factor: A systematic review and bayesian network meta-analysis

Review,

AD,

*BDNF↑, *eff↑,

2144-

Ex,

Physical activity, hormone replacement therapy and breast cancer risk: A meta-analysis of prospective studies

Analysis,

NA,

Risk↓, Dose?, eff↑,

2145-

Ex,

Leisure time physical activity and cancer risk: evaluation of the WHO's recommendation based on 126 high-quality epidemiological studies

Analysis,

Var,

Risk↓, Dose↝, eff↑,

2146-

Ex,

A systematic review and meta-analysis of physical activity and endometrial cancer risk

Review,

Endo,

Risk↓, eff↑,

2153-

Ex,

The Impact of Exercise on Cancer Mortality, Recurrence, and Treatment-Related Adverse Effects

Review,

Var,

eff↑, BMD↑, cognitive↑, OS↑, Remission↑, eff↑,

2151-

Ex,

The effects of physical activity on overall survival among advanced cancer patients: a systematic review and meta-analysis

Review,

Var,

eff↑, eff↝,

2150-

Ex,

Roles and molecular mechanisms of physical exercise in cancer prevention and treatment

Review,

Var,

eff↓, Dose↝, TumCP↓, Apoptosis↓, ChemoSen↑, chemoP↑,

2149-

Ex,

Physical activity and exercise training in cancer patients

Analysis,

Var,

eff↑, Dose↑,

1622-

FA,

Folate and Its Impact on Cancer Risk

Review,

NA,

eff↓,

1654-

FA,

Molecular mechanism of ferulic acid and its derivatives in tumor progression

Review,

Var,

AntiCan↑, Inflam↓, RadioS↑, ROS↑, Apoptosis↑, TumCCA↑, TumCMig↑, TumCI↓, angioG↓, ChemoSen↑, ChemoSideEff↓, P53↑, cycD1/CCND1↓, CDK4↓, CDK6↓, TumW↓, miR-34a↑, Bcl-2↓, Casp3↑, BAX↑, β-catenin/ZEB1↓, cMyc↓, Bax:Bcl2↑, SOD↓, GSH↓, LDH↓, ERK↑, eff↑, JAK2↓, STAT6↓, NF-kB↓, PYCR1↓, PI3K↓, Akt↓, mTOR↓, Ki-67↓, VEGF↓, FGFR1↓, EMT↓, CAIX↓, LC3II↑, p62↑, PKM2↓, Glycolysis↓, *BioAv↓,

2173-

FA,

VitB12,

Elevated serum homocysteine levels associated with poor recurrence-free and overall survival in patients with colorectal cancer

Study,

CRC,

Risk↓, eff↝, eff↝, homoC↓,

2174-

FA,

VitB12,

Analysis,

Var,

homoC↓, eff↑, eff↑, eff↑, eff↝, homoC↝, other?,

2176-

FA,

VitB12,

Hyperhomocysteinemia and Cancer: The Role of Natural Products and Nutritional Interventions

Review,

Var,

homoC↓, eff↝,

4069-

FA,

Folate, folic acid and 5-methyltetrahydrofolate are not the same thing

Review,

AD,

*other↑, *BioAv↝, *other↝, *eff↑,

2499-

Fenb,

VitE,

Effects of fenbendazole and vitamin E succinate on the growth and survival of prostate cancer cells

in-vitro,

Pca,

PC3

TumCP∅, TumCP↓, toxicity↓, eff↑,

2498-

Fenb,

Unexpected Antitumorigenic Effect of Fenbendazole when Combined with Supplementary Vitamins

in-vivo,

lymphoma,

mice

eff↓, eff↑, TumVol↓, antiOx↑, Hif1a↓,

2496-

Fenb,

Impairment of the Ubiquitin-Proteasome Pathway by Methyl N-(6-Phenylsulfanyl-1H-benzimidazol-2-yl)carbamate Leads to a Potent Cytotoxic Effect in Tumor Cells

in-vitro,

NSCLC,

A549

1.6 μm

in-vitro,

NSCLC,

H460

1.2 uM

TumCG↓, selectivity↑, P53↑, IKKα↑, ER Stress↑, GRP78/BiP↑, CHOP↑, ATF3↑, IRE1↑, NOXA↑, ROS↑, MMP↓, Cyt‑c↑, selectivity↑, eff↝,

2494-

Fenb,

Oral Fenbendazole for Cancer Therapy in Humans and Animals

Review,

Var,

Glycolysis↓, GlucoseCon↓, ROS↑, Apoptosis↑, BioAv↓, eff↑, toxicity↓, BioAv↑, BioAv↑, hepatoP↓, eff↑,

2495-

Fenb,

Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells

in-vitro,

Melanoma,

A375

FBZ (1 and 2 μM)

P53↑, P21↑, TumCCA↑, MDM2↓, MDMX↓, eff↑,

1914-

Fer,

VitC,

TMZ,

Rad,

Pharmacologic Ascorbate and Ferumoxytol Combined with Temozolomide and Radiation Therapy for the Treatment of Newly Diagnosed Glioblastoma

Trial,

GBM,

eff↑,

1915-

Fer,

Vascular Imaging With Ferumoxytol as a Contrast Agent

Analysis,

Var,

eff↑, toxicity↓, other?,

2847-

FIS,

Fisetin-induced cell death, apoptosis, and antimigratory effects in cholangiocarcinoma cells

in-vitro,

CCA,

tumCV↓, ChemoSen↑, TumCMig↓, ROS↑, TumCI↓, angioG↓, CDK2↓, PI3K↓, Akt↓, mTOR↓, EGFR↓, Casp↑, mTORC1↓, mTORC2↑, cycD1/CCND1↓, cycE/CCNE↓, MMP2↓, MMP9↓, ER Stress↑, Ca+2↑, eff↓,

2849-

FIS,

Activation of reactive oxygen species/AMP activated protein kinase signaling mediates fisetin-induced apoptosis in multiple myeloma U266 cells

in-vitro,

Melanoma,

U266

40 μg/ml

TumCD↑, TumCCA↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, p‑Akt↓, p‑mTOR↓, ROS↑, eff↓,

2854-

FIS,

New Perspectives for Fisetin

Review,

Var,

Review,

Stroke,

Inflam↓, ChemoSen↑, chemoPv↑, eff↑, memory↑, neuroP↑, *Dose↑, BioAv↓, BBB↑,

2855-

FIS,

Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells

in-vitro,

RCC,

Caki-1

TumCCA↑, cl‑PARP↑, Apoptosis↑, Casp↑, P53↑, DR5↑, CHOP↑, ROS↑, ER Stress↑, ATF4↑, XBP-1↑, eff∅,

2856-

FIS,

N -acetyl- L -cysteine enhances fisetin-induced cytotoxicity via induction of ROS-independent apoptosis in human colonic cancer cells

in-vitro,

Colon,

COLO205

eff↑, ROS↑, tumCV↓, Casp3↑, Bcl-2↓, MMP↓, eff↑,

2857-

FIS,

A review on the chemotherapeutic potential of fisetin: In vitro evidences

Review,

Var,

COX2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP↑, eff↑, ChemoSen↑,

2861-

FIS,

The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress

Review,

Nor,

Review,

Stroke,

Review,

Park,

*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,

2845-

FIS,

Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy

Review,

Var,

PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, eff↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,

2825-

FIS,

Exploring the molecular targets of dietary flavonoid fisetin in cancer

Review,

Var,

*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, Half-Life↝,

2839-

FIS,

Dietary flavonoid fisetin for cancer prevention and treatment

Review,

Var,

DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp↓, PI3K↓, Akt↓, mTOR↓, eff↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑, COX2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, eff↑,

2842-

FIS,

Fisetin inhibits cellular proliferation and induces mitochondria-dependent apoptosis in human gastric cancer cells

in-vitro,

GC,

AGS

TumCCA↑, CDK2↓, P53↑, selectivity↑, MMP↓, DNAdam↑, cl‑PARP↑, mt-ROS↑, eff↓, survivin↓,

5392-

FIS,

AsP,

Fisetin topical delivery via ascorbyl palmitate/hyaluronan-enhanced limosomes: a novel paradigm for preventing UVB-induced skin photoaging

in-vivo,

Nor,

eff↑, *antiOx↑, *MMP9↓, *TNF-α↓, *NF-kB↓, *SOD↑, *Catalase↑, *AntiAge↑, *Inflam↓, *JNK↓,

2642-

Flav,

QC,

Api,

KaempF,

MCT

In Vitro–In Vivo Study of the Impact of Excipient Emulsions on the Bioavailability and Antioxidant Activity of Flavonoids: Influence of the Carrier Oil Type

in-vitro,

Nor,

in-vivo,

Nor,

rat

*BioAv↑, *eff↝, BioEnh↑,

4107-

FLS,

Ex,

Combined effects of aerobic exercise and 40-Hz light flicker exposure on early cognitive impairments in Alzheimer's disease of 3×Tg mice

in-vivo,

AD,

 12 wk of exercise with 40-Hz light flickering administered independently and in combination.

mice

*Aβ↓, *cognitive↑, *Inflam↓, *eff↑,

5152-

GamB,

Gambogic Acid as a Candidate for Cancer Therapy: A Review

Review,

Var,

AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumCI↓, TumMeta↓, angioG↓, eff↑, NF-kB↓, P53↑, P21↑, MDM2↓, HSP90↓, Bcl-2↓, Cyt‑c↑, Casp↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bax:Bcl2↑, ROS↑, SIRT1↓, TrxR1↓, Fas↓, FasL↑, FADD↑, APAF1↑, DNAdam↑, NF-kB↓, STAT3↓, MAPK↓, cFos↓, EGFR↓, Akt↓, mTOR↓, AMPK↑, TumCCA↑, ChemoSen↑, P-gp↓, survivin↓,

5148-

GamB,

Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics

Review,

Var,

AntiCan↑, angioG↓, ChemoSen↑, RadioS↑, VEGF↓, MMP2↓, MMP9↓, Telomerase↓, TrxR↓, ERK↓, HSP90↓, ROS↑, SIRT1↑, survivin↓, cFLIP↓, Casp3↑, Casp8↑, Casp9↑, BAD↓, BID↓, Bcl-2↓, BAX↑, STAT3↓, hTERT/TERT↓, NF-kB↓, Myc↓, Hif1a↓, FOXD3↑, BioAv↓, BioAv↑, P53↑, eff↓, OCR↓, MMP↓, PI3K↓, Akt↓, BBB↑, TumCG↓, TumMeta↓, BioAv↑,

5150-

GamB,

Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway

in-vitro,

CLL,

KBM-5

in-vitro,

Nor,

HEK293

Apoptosis↑, ChemoSen↑, IAP1↓, IAP2↓, Bcl-2↓, Bcl-xL↓, TRAF1↓, cycD1/CCND1↓, cMyc↓, COX2↓, MMP9↓, angioG↓, VEGF↓, NF-kB↓, eff↓,

1955-

GamB,

Gambogic acid inhibits thioredoxin activity and induces ROS-mediated cell death in castration-resistant prostate cancer

in-vitro,

Pca,

PC3

185nM

in-vitro,

Pca,

LNCaP

in-vitro,

Pca,

DU145

ROS↑, Apoptosis↑, Ferroptosis↑, Trx↓, eff↑, TrxR↓, Dose∅, MMP↓, eff↑, Casp↑, NADPH↓, TrxR↓, ChemoSen↑, AR↓,

1957-

GamB,

Nanoscale Features of Gambogic Acid Induced ROS-Dependent Apoptosis in Esophageal Cancer Cells Imaged by Atomic Force Microscopy

in-vitro,

ESCC,

EC9706

0-2uM

~1.4uM

AntiCan↑, toxicity↓, TumCP↓, Apoptosis↑, TumCCA↑, MMP↓, ROS↑, eff↓, RadioS↑,

1958-

GamB,

Gambogenic acid induces apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress via JNK pathway in prostate cancer cells

in-vitro,

Pca,

in-vivo,

NA,

AntiCan↑, TumCP↓, TumAuto↑, eff↑, JNK↑, ROS↑, ER Stress↑, eff↓, TumCG↓,

1959-

GamB,

Gambogic acid induces GSDME dependent pyroptotic signaling pathway via ROS/P53/Mitochondria/Caspase-3 in ovarian cancer cells

in-vitro,

Ovarian,

in-vivo,

NA,

mice

AntiCan↑, Pyro↑, tumCV?, CellMemb↓, cl‑Casp3↑, GSDME-N↑, ROS?, p‑P53↑, eff↓, MMP↓, Bcl-2↓, BAX↑, mtDam↑, Cyt‑c↑, TumCG↓, CD4+↑, CD8+↑,

1960-

GamB,

Vem,

Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation

in-vitro,

Liver,

HepG2

in-vitro,

AML,

K562

Proteasome↓, eff↑, Casp↑, ER Stress↑, ROS↑, eff↑,

1961-

GamB,

Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS

in-vitro,

Melanoma,

RPMI-8226

0-2.5uM

2uM

TumCG↓, Apoptosis↑, ROS↑, Casp3↑, cl‑PARP↑, SIRT1↓, eff↓,

1962-

GamB,

HCQ,

Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species

in-vitro,

PC,

LC3II↑, Beclin-1↑, p62↓, MMP↓, ROS↑, TumAuto↑, eff↑,

1965-

GamB,

doxoR,

Gambogic acid sensitizes ovarian cancer cells to doxorubicin through ROS-mediated apoptosis

in-vitro,

Ovarian,

SKOV3

eff↑, AntiCan↑, ROS↑, ChemoSen↑,

1966-

GamB,

Cisplatin,

Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling

in-vitro,

Lung,

A549

in-vitro,

Lung,

NCIH1299

TumCCA↑, PARP↑, eff↑, ROS↑, ChemoSen↑,

1970-

GamB,

Gambogic acid-induced autophagy in nonsmall cell lung cancer NCI-H441 cells through a reactive oxygen species pathway

NA,

Lung,

NCI-H441

TumCG↓, TumAuto↑, Beclin-1↑, LC3‑Ⅱ/LC3‑Ⅰ↑, ROS↑, eff↓,

1971-

GamB,

Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis

in-vitro,

Nor,

MCF10

in-vitro,

BC,

MDA-MB-435

1.5 μM

in-vitro,

BC,

MDA-MB-468

2.35 μM

in-vivo,

NA,

injections of saline or GA (4 or 8 mg/kg) twice

mice

Paraptosis↑, ER Stress↑, MMP↓, eff↓, selectivity↑, p‑ERK↑, p‑JNK↑, eff↓,

1972-

GamB,

doxoR,

Gambogic acid sensitizes resistant breast cancer cells to doxorubicin through inhibiting P-glycoprotein and suppressing survivin expression

in-vitro,

BC,

eff↑, P-gp↓, ROS↑, survivin↓, p38↑,

2060-

GamB,

Gambogenic acid induces apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress via JNK pathway in prostate cancer cells

in-vitro,

Pca,

TumCP↓, TumAuto↑, eff↑, ROS↑, ER Stress↑, JNK↑,

823-

GAR,

Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins

in-vitro,

BC,

MCF-7

in-vitro,

Nor,

MCF10

in-vitro,

CRC,

HCT116

Casp3↑, Casp9↑, Casp8↑, DR5↑, survivin↓, Bcl-2↓, XIAP↓, cFLIP↓, BAX↑, Cyt‑c↑, ROS↑, GSH↓, *eff↓,

1435-

GEN,

SFN,

The Effects of Combinatorial Genistein and Sulforaphane in Breast Tumor Inhibition: Role in Epigenetic Regulation

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

MCF-7

DNMTs↓, HDAC↓, eff↑, TumCCA↑, HMTs↓, HDAC2↓, HDAC3↓, KLF4↓, hTERT/TERT↓,

4664-

GEN,

CUR,

RES,

EGCG,

SFN

Targeting cancer stem cells by nutraceuticals for cancer therapy

Review,

Var,

CSCs↓, other↝, eff↑, CD44↓, p‑STAT3↓,

4302-

Gins,

Panax ginseng: A modulator of amyloid, tau pathology, and cognitive function in Alzheimer's disease

Review,

AD,

*neuroP↑, *Aβ↓, *p‑tau↓, *cognitive↑, *eff↑, *PKA↑, *CREB↑, *BACE↓, *ADAM10↑, *MAPK↑, *ERK↑, *PI3K↑, *Akt↑, *NRF2↑, *PPARγ↓, *IDE↑, *APP↓, *PP2A↑, *memory↑,

4301-

Gins,

Red Ginseng Inhibits Tau Aggregation and Promotes Tau Dissociation In Vitro

in-vitro,

AD,

*p‑tau↓, *eff↑, *Inflam↓,

4513-

GLA,

Antineoplastic Effects of Gamma Linolenic Acid on Hepatocellular Carcinoma Cell Lines

in-vitro,

Liver,

HUH7

TumCP↓, ROS↑, Apoptosis↑, HO-1↑, Trx↑, lipid-P↑, eff↓, MMP↓, DNAdam↑, selectivity↑,

4510-

GLA,

Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies

Review,

NA,

Apoptosis↑, selectivity↑, eff↓, ROS↑, lipid-P↑, P53↑, radioP↑, chemoP↑,

5390-

GoldNP,

GEM,

AsP,

Optimizing Gold Nanoparticles for Combination Therapy: Development of Hydrophobic Nanomedical Devices with Gemcitabine and Ascorbyl Palmitate

in-vitro,

BC,

4T1

EPR↑, eff↑,

1904-

GoldNP,

AgNPs,

Unveiling the Potential of Innovative Gold(I) and Silver(I) Selenourea Complexes as Anticancer Agents Targeting TrxR and Cellular Redox Homeostasis

in-vitro,

Lung,

H157

in-vitro,

BC,

MCF-7

in-vitro,

Colon,

HCT15

in-vitro,

Melanoma,

A375

TrxR↓, selectivity↑, eff↑, eff↝, ROS↑, MMP↓, Apoptosis↑, eff↑,

2517-

H2,

Molecular Hydrogen Enhances Proliferation of Cancer Cells That Exhibit Potent Mitochondrial Unfolded Protein Response

in-vitro,

Var,

A549

in-vitro,

NA,

HCT116

in-vitro,

NA,

HeLa

in-vitro,

NA,

HepG2

in-vitro,

NA,

HT1080

in-vitro,

NA,

PC3

in-vitro,

NA,

SH-SY5Y

TumCP↓, other↝, eff↝, mt-UPR↑,

2516-

H2,

Hydrogen Gas in Cancer Treatment

Review,

Var,

*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, eff↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,

2509-

H2,

Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway

in-vitro,

Endo,

AN3CA

in-vivo,

Endo,

endometrial tumors in a xenograft mouse model.

selectivity↑, mt-ROS↑, ROS↑, TumW↓, GSDMD↑, Pyro↑, Dose↝, eff↓, TumVol↓,

2508-

H2,

Molecular hydrogen is a promising therapeutic agent for pulmonary disease

Review,

Var,

Review,

Sepsis,

*ROS↓, eff↝, *Inflam↓, *NRF2↑, *HO-1↑, *SOD↑, *Catalase↑, *MPO↑, *ASK1↓, *NADPH↓, *Sepsis↓, *HMGB1↓, ROS↑, NLRP3↑, GSDMD↑, chemoP↑, eff↑,

2504-

H2,

Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer

Trial,

Lung,

A total of 42 of 56 patients with lung cancer treated with nivolumab received hydrogen gas

CD8+↑, OS↑, eff↝, CoQ10↑, PDT+↓, PGC-1α↑, Dose↝, *toxicity∅,

2528-

H2,

Local generation of hydrogen for enhanced photothermal therapy

in-vitro,

Var,

eff↑, ROS↓, selectivity↑, ROS↑, other↝, ROS↑,

2529-

H2,

Guidelines for the selection of hydrogen gas inhalers based on hydrogen explosion accidents

Analysis,

Nor,

other↑, eff↝, eff↝, other↝, other↝, other↝, other↝, other↝,

2530-

H2,

Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases

Case Report,

PSA,

eff↑, Dose↝, eff↑, IL6↓, eff↑,

3152-

H2,

VitC,

Rad,

Hydrogen and Vitamin C Combination Therapy: A Novel Method of Radioprotection

in-vitro,

Nor,

HUVECs

in-vivo,

NA,

AntiTum↑, OS↑, QoL↑, TumVol↓, radioP↑, Dose↑, Dose↝, eff↑,

1637-

HCA,

OLST,

Orlistat and Hydroxycitrate Ameliorate Colon Cancer in Rats: The Impact of Inflammatory Mediators

in-vivo,

Colon,

32 mg/kg/day(or)+(135 mg/kg/day(HCA)

rats

TumVol↓, OS↑, *IL6↓, *NF-kB↓, *eff↑, *Casp3↓, *TNF-α↓, *Catalase↑, *NO↓, *ROS↓, *Inflam↓, *Apoptosis↓,

1589-

HCA,

ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism

Review,

NA,

ACLY↓, eff↑,

1627-

HCA,

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

Review,

Var,

ChemoSen↑, eff↑, ACLY↓, LC3‑Ⅱ/LC3‑Ⅰ↑,

1628-

HCA,

ALA,

effreydachmd.com/2016/05/alpha-lipoic-acid-anticancer-agent-burt-berkson-md/">Addition of Hydroxy Citrate improves effect of ALA

Review,

Var,

ACLY↓, other↓, ROS↑, eff↑, PDKs↓,

1629-

HCA,

Tam,

Hydroxycitric acid reverses tamoxifen resistance through inhibition of ATP citrate lyase

in-vitro,

BC,

MCF-7

ACLY↓, eff↓, tumCV↓, eff↑, Casp3↑, BAX↑, Bcl-2↓,

1634-

HCA,

Hydroxycitrate: a potential new therapy for calcium urolithiasis

Human,

Nor,

*other↑, *eff↑,

1643-

HCAs,

Mechanisms involved in the anticancer effects of sinapic acid

Review,

Var,

*BioAv↓, *toxicity↓, Dose∅, ROS⇅, ROS↑, Igs↑, TumCCA↑, TumAuto↑, eff↑, angioG↓, TumCI↓, TumMeta↓, EMT↓, Vim↓, MMP9↓, MMP2↓, Snail↓, E-cadherin↑, p‑Akt↓, GSK‐3β↓, TumCP↓, ChemoSen↑,

1439-

HCQ,

Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine

in-vitro,

Melanoma,

 CQ (25, 50, 100 μM)

in-vitro,

CRC,

HCT116

TumAuto↓, eff↓, other↓,

2072-

HNK,

Honokiol Suppresses Cell Proliferation and Tumor Migration through ROS in Human Anaplastic Thyroid Cancer Cells

in-vitro,

Thyroid,

ROS↑, eff↓,

2073-

HNK,

Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo

in-vitro,

OS,

U2OS

21.5 μM

in-vivo,

NA,

40 mg/kg

TumCD↑, TumAuto↑, Apoptosis↑, TumCCA↑, GRP78/BiP↑, ROS↑, eff↓, p‑ERK↑, selectivity↑, Ca+2↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, LC3B-II↑, ATG5↑, TumVol↓, TumW↓, ER Stress↑,

2872-

HNK,

Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis

in-vivo,

ALS,

mice

NA,

Stroke,

NA,

AD,

NA,

Park,

*eff↑, *ROS↓, *GSH↑, *NRF2↑, *motorD↑, *OS↑, *neuroP↑, *BBB↑, *cognitive↑, *eff↑, *antiOx↑, *Cyt‑c↑, *PGC-1α↑,

2865-

HNK,

Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma

in-vitro,

MB,

DAOY

vitro+vivo,

NA,

BioAv↓, BioAv↓, TumCP↓, selectivity↑, P53↑, P21↑, CDK4↓, cycD1/CCND1↓, mtDam↑, ROS↑, eff↓, Casp3↑, BAX↑, LC3II↑, Beclin-1↑, ATG7↑, p62↑, eff↑, ChemoSen↑, *toxicity↓,

2864-

HNK,

Honokiol: A Review of Its Anticancer Potential and Mechanisms

Review,

Var,

TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp↓, Half-Life↓, Half-Life↝, eff↑, BioAv↓,

2886-

HNK,

Liposomal honokiol inhibits non-small cell lung cancer progression and enhances PD-1 blockade via suppressing M2 macrophages polarization

in-vitro,

Lung,

A549

in-vitro,

Lung,

H460

in-vivo,

NA,

 mouse Lewis lung cancer cell line (LL2

eff↑, BioAv↑, eff↑, PI3K↓, Akt↓,

2895-

HNK,

Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity

in-vitro,

Lung,

PC9

 0.26 μM

eff↑, TumCP↓, mt-ROS↑, Prx3↑, mt-STAT3↓, *toxicity∅, selectivity↑, ChemoSen↑,

4523-

HNK,

MAG,

BA,

Honokiol-Magnolol-Baicalin Possesses Synergistic Anticancer Potential and Enhances the Efficacy of Anti-PD-1 Immunotherapy in Colorectal Cancer by Triggering GSDME-Dependent Pyroptosis

in-vitro,

CRC,

HCT116

in-vitro,

CRC,

LoVo

in-vivo,

CRC,

HCT116

mice

AntiCan↑, eff↑, TumCP↓, TumCCA↓, cycD1/CCND1↓, Pyro↑, Apoptosis↑, cl‑GSDME↑, Bcl-2↓, Cyt‑c↑, Casp9↑, TumCG↓,

4522-

HNK,

MAG,

Honokiol Is More Potent than Magnolol in Reducing Head and Neck Cancer Cell Growth

in-vitro,

HNSCC,

FaDu

AntiCan↑, tumCV↓, eff↑, survivin↓, RadioS↑,

5054-

HPT,

Induction of Oxidative Stress by Hyperthermia and Enhancement of Hyperthermia-Induced Apoptosis by Oxidative Stress Modification

Review,

Var,

eff↓, ROS↑, Apoptosis↑,

5051-

HPT,

doxoR,

Hyperthermia Enhances Doxorubicin Therapeutic Efficacy against A375 and MNT-1 Melanoma Cells

in-vitro,

Melanoma,

A375

tumCV↓, TumCCA↑, ROS↑, eff↑,

4641-

HT,

Hydroxytyrosol induced ferroptosis through Nrf2 signaling pathway in colorectal cancer cells

in-vitro,

CRC,

HCT116

in-vitro,

CRC,

SW48

Ferroptosis↑, Iron↑, lipid-P↑, ROS↑, GSH↓, MMP↓, GPx4↓, TLR1↑, eff↓, NRF2↓, ROS↑,

2180-

itraC,

Repurposing Drugs in Oncology (ReDO)—itraconazole as an anti-cancer agent

Review,

Var,

Dose↝, toxicity↝, BioAv↑, Half-Life↝, BioAv↑, Dose↝, HH↓, TumAuto↑, Akt↓, mTOR↓, angioG↓, MDR1↓, TumCP↓, eff↑,

1925-

JG,

Redox regulation of mitochondrial functional activity by quinones

in-vitro,

NA,

other↓, ROS↑, MMP↓, eff↝,

1924-

JG,

Juglone triggers apoptosis of non-small cell lung cancer through the reactive oxygen species -mediated PI3K/Akt pathway

in-vitro,

Lung,

A549

2-8uM

9.47 μM@24h

TumCMig↓, TumCI↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, BAX↑, Cyt‑c↑, ROS↑, MDA↑, GPx4↓, SOD↓, PI3K↓, Akt↓, eff↓,

1922-

JG,

Juglone induces apoptosis of tumor stem-like cells through ROS-p38 pathway in glioblastoma

in-vitro,

GBM,

U87MG

(0, 10, 20, and 40 μM)

tumCV↓, TumCP↓, ROS↑, p‑p38↑, eff↓, Apoptosis↑, OS↑,

1919-

JG,

The Anti-Glioma Effect of Juglone Derivatives through ROS Generation

in-vitro,

GBM,

U87MG

 IC50 for U87 was 3.99, 3.28, 7.60, and 11.84 μM

in-vitro,

GBM,

U251

IC50 was 7.00, 5.43, 8.64, and 18.05 μM, respectively

ROS↑, Apoptosis↑, eff↓, eff↓,

5114-

JG,

Juglone, from Juglans mandshruica Maxim, inhibits growth and induces apoptosis in human leukemia cell HL-60 through a reactive oxygen species-dependent mechanism

in-vitro,

AML,

HL-60

IC50 value ∼8 μM

ROS↑, GSH↓, eff↓, cl‑PARP↑, proCasp3↑, proCasp9↑, MMP↓, Cyt‑c↑, Diablo↑,

5115-

JG,

Natural Products to Fight Cancer: A Focus on Juglans regia

Review,

Var,

Casp3↑, Casp9↑, MMP↓, AR↓, PSA↓, E-cadherin↑, N-cadherin↓, Vim↓, Akt↓, GSK‐3β↓, EMT↑, TumCI↓, MMP9↓, VEGF↓, MMP2↓, TumCCA↑, ROS↑, Apoptosis↑, GSH↓, Catalase↓, SOD↓, GPx↓, DNAdam↑, γH2AX↑, eff↑, BAX↑, Fas↑, Pin1↓,

4011-

K+,

Sodium and potassium intakes among US adults: NHANES 2003–2008

Analysis,

NA,

*Dose↓, *eff↑, *BP↓,

4014-

K+,

The effects of boiling and leaching on the content of potassium and other minerals in potatoes

Analysis,

NA,

*other↓, *eff↑, *other↓,

2390-

KaempF,

Kaempferol Can Reverse the 5-Fu Resistance of Colorectal Cancer Cells by Inhibiting PKM2-Mediated Glycolysis

in-vitro,

CRC,

HCT8

eff↑, GlucoseCon↓, lactateProd↓, PKM2↓, Glycolysis↓, glucose↑,

860-

Lae,

Amygdalin as a Promising Anticancer Agent: Molecular Mechanisms and Future Perspectives for the Development of New Nanoformulations for Its Delivery

Review,

NA,

eff↑, Casp3↑, Bcl-2↓,

2351-

lamb,

Anti-Warburg effect via generation of ROS and inhibition of PKM2/β-catenin mediates apoptosis of lambertianic acid in prostate cancer cells

in-vitro,

Pca,

DU145

in-vitro,

Pca,

PC3

proCasp3↓, proPARP↓, LDHA↓, Glycolysis↓, HK2↓, PKM2↓, lactateProd↓, p‑STAT3↓, cycD1/CCND1↓, cMyc↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, ROS↑, eff↓,

1790-

LEC,

DHA,

Dietary Crude Lecithin Increases Systemic Availability of Dietary Docosahexaenoic Acid with Combined Intake in Rats

in-vivo,

Nor,

rats

*eff↑, other↑,

1791-

LEC,

Vegetable lecithins: A review of their compositional diversity, impact on lipid metabolism and potential in cardiometabolic disease prevention

Review,

Nor,

*BioEnh↑, *antiOx↑, *BioEnh↑, *LDL↓, *HDL∅, *Obesity↓, eff↑, GutMicro↝,

1795-

LEC,

Chit,

Self-assembled lecithin-chitosan nanoparticles improve the oral bioavailability and alter the pharmacokinetics of raloxifene

in-vivo,

Nor,

Rats

eff↑, BioAv↑,

4292-

LT,

Luteolin for neurodegenerative diseases: a review

Review,

AD,

Review,

Park,

Review,

MS,

Review,

Stroke,

*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↝, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL33↓, *NF-kB↓, *BACE↓, *ROS↓, *SOD↑, *HO-1↑, *NRF2↑, *Casp3↓, *Casp9↑, *Bax:Bcl2↓, *UPR↑, *GRP78/BiP↑, *Aβ↓, *GSK‐3β↓, *tau↓, *CREB↑, *ATP↑, *cognitive↑, *BloodF↑, *BDNF↑, *TrkB↑, *memory↑, *PPARγ↑, *eff↑,

2907-

LT,

Protective effect of luteolin against oxidative stress‑mediated cell injury via enhancing antioxidant systems

in-vitro,

Nor,

Chinese hamster lung fibroblasts (V79-4)

*ROS↓, *Casp9↓, *Casp3↓, *Bcl-2↑, *BAX↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *HO-1↑, *antiOx↑, *lipid-P↓, *p‑γH2AX↓, eff↑,

2910-

LT,

FA,

Folic acid-modified ROS-responsive nanoparticles encapsulating luteolin for targeted breast cancer treatment

in-vitro,

BC,

4T1

in-vivo,

NA,

mice

BioAv↓, BioAv↑, eff↑, tumCV↓, e-H2O2↓, i-H2O2∅,

2904-

LT,

Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons

in-vitro,

Park,

SK-N-SH

in-vitro,

AD,

*ROS↓, *neuroP↑, *MMP↑, *Catalase↑, *GSH↑, selectivity↑, *eff↑, *Cyt‑c↓,

2903-

LT,

Luteolin induces apoptosis by ROS/ER stress and mitochondrial dysfunction in gliomablastoma

in-vitro,

GBM,

U251

in-vitro,

GBM,

U87MG

in-vivo,

NA,

mouse

ER Stress↑, ROS↑, PERK↑, eIF2α↑, ATF4↑, CHOP↑, Casp12↑, eff↓, UPR↑, MMP↓, Cyt‑c↑, Bcl-2↓, BAX↑, TumCG↓, Weight∅, ALAT∅, AST∅,

2920-

LT,

Formulation, characterization, in vitro and in vivo evaluations of self-nanoemulsifying drug delivery system of luteolin

in-vitro,

Nor,

in-vivo,

Nor,

BioAv↑, eff↑,

2919-

LT,

Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence

Review,

Var,

RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,

1534-

LT,

Api,

EGCG,

RES,

Plant polyphenol induced cell death in human cancer cells involves mobilization of intracellular copper ions and reactive oxygen species generation: a mechanism for cancer chemopreventive action

in-vitro,

Nor,

MCF10

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

MDA-MB-468

in-vitro,

PC,

Bxpc-3

TumCP↓, Apoptosis↑, eff↓, *toxicity↑, Dose?, eff↓, eff↓,

3980-

Lut,

Zeax,

Supplementation With Carotenoids, Omega-3 Fatty Acids, and Vitamin E Has a Positive Effect on the Symptoms and Progression of Alzheimer's Disease

Trial,

AD,

1 g fish oil (of which 500 mg DHA, 150 mg EPA), 22 mg carotenoids (10 mg lutein, 10 mg meso-zeaxanthin, 2 mg zeaxanthin), and 15 mg vitamin E or placebo for 12 months

*eff↑, *memory↑, *Mood↑, *QoL↑,

3982-

Lut,

Zeax,

Nutritional Intervention to Prevent Alzheimer's Disease: Potential Benefits of Xanthophyll Carotenoids and Omega-3 Fatty Acids Combined

Trial,

AD,

2; lutein:meso-zeaxanthin:zeaxanthin 10:10:2 mg/day plus 1 g/day of fish oil containing 430 mg docohexaenoic acid [DHA] and 90 mg eicopentaenoic acid [EPA]), respectively

*memory↑, *eff↑, *Mood↑,

3261-

Lyco,

Lycopene and Vascular Health

Review,

Stroke,

 endothelial cells

*Inflam↓, *antiOx↑, *AntiAg↑, *cardioP↑, *SOD↑, *Catalase↑, *ROS↓, *mtDam↓, *cardioP↑, *NF-kB↓, *NO↓, *COX2↓, *LDL↓, *eff↑, *ER Stress↓, *BioAv↑, *eff↑, *MMPs↓, *COX2↓, *RAGE↓,

3281-

Lyco,

Chemo,

Lycopene Supplementation for Patients Under Cancer Therapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Review,

Var,

eff↑, cardioP↑, eff?, PSA↓, RenoP↑,

3285-

Lyco,

Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: An in vitro study

in-vitro,

Nor,

*AntiAg↑, *eff↑,

3287-

Lyco,

Recent technological strategies for enhancing the stability of lycopene in processing and production

Review,

NA,

*eff↑,

1715-

Lyco,

Pro-oxidant Actions of Carotenoids in Triggering Apoptosis of Cancer Cells: A Review of Emerging Evidence

Review,

Var,

antiOx↑, ROS↑, ChemoSen↑, selectivity↑, eff↓, Casp3↑, Casp7↑, Casp9↑, P53↑, BAX↑, DNAdam↑, mtDam↑, eff↑,

1713-

Lyco,

Lycopene: A Potent Antioxidant with Multiple Health Benefits

Review,

Nor,

*antiOx↑, *ROS⇅, *Dose↝, *eff↑, *LDL↓, *RenoP↑, *Inflam↓, neuroP↑, Rho↓,

1712-

Lyco,

Lycopene Protects against Smoking-Induced Lung Cancer by Inducing Base Excision Repair

in-vitro,

Lung,

A549

ROS↓, ROS↑, eff↑,

1710-

Lyco,

Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases

Review,

CardioV,

antiOx↓, ROS↓, BP↓, LDL↓, *toxicity∅, eff↑, ROS↑, *Half-Life↑, *BioAv↓, *BioAv↑, *antiOx↑,

1708-

Lyco,

The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies

Review,

Var,

OS↑, ChemoSen↑, QoL↑, PSA∅, eff↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,

1041-

Lyco,

immuno,

Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells

in-vivo,

Lung,

mice

TumVol↓, TumW↓, eff↑, IL1↑, IFN-γ↑, IL4↓, IL10↓,

4791-

Lyco,

Investigating into anti-cancer potential of lycopene: Molecular targets

Review,

Var,

*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, eff↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, eff↑,

4798-

Lyco,

Enhancing Anticancer Treatment Efficacy With Lycopene: A Comprehensive Review of Clinical and Preclinical Evidence

Review,

Var,

AntiCan↑, ChemoSen↑, eff↑, eff↑,

4792-

Lyco,

A Comprehensive Review on the Molecular Mechanism of Lycopene in Cancer Therapy

Review,

Var,

*AntiCan↑, *antiOx↑, Inflam↓, Wnt↓, β-catenin/ZEB1↓, *ROS↓, BioAv↑, ROS↓, Risk↓, PGE2↓, COX2↓, p‑ERK↓, P21↑, MMP7↓, MMP9↓, ChemoSen↑, eff↑,

4790-

Lyco,

Role of Lycopene in the Control of ROS-Mediated Cell Growth: Implications in Cancer Prevention

Review,

Var,

*antiOx↑, *ROS⇅, TumCP↓, AP-1↓, eff↓,

2540-

M-Blu,

Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots

Review,

Var,

Review,

AD,

*OCR↑, *Glycolysis↓, *GlucoseCon↑, neuroP↑, Warburg↓, mt-OXPHOS↑, TumCCA↑, TumCP↓, ROS⇅, *cognitive↑, *mTOR↓, *mt-antiOx↑, *memory↑, *BBB↑, *eff↝, *ECAR↓, eff↑, lactateProd↓, NADPH↓, OXPHOS↑, AMPK↑, selectivity↑,

2533-

M-Blu,

PDT,

Methylene blue-mediated photodynamic therapy enhances apoptosis in lung cancer cells

in-vitro,

Lung,

A549

MMP↓, p‑MAPK↑, ROS↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, eff↓,

4528-

MAG,

Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update

Review,

Nor,

*Inflam↑, *cardioP↑, *angioG↓, *antiOx↑, *neuroP↑, *Bacteria↓, AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, Apoptosis↑, E-cadherin↑, NF-kB↓, TumCCA↑, cycD1/CCND1↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCG↓, Casp3↑, NF-kB↓, Akt↓, mTOR↓, LDH↓, Ca+2↑, eff↑, *toxicity↓, *BioAv↝, *PGE2↓, *TLR2↓, *TLR4↓, *MAPK↓, *PPARγ↓,

4517-

MAG,

Mitochondrion-targeted magnolol derivatives exert synergistic anticancer activity by modulating energy metabolism and tumor microenvironment

vitro+vivo,

Var,

eff↑, AntiCan↑, ROS↑, ER Stress↑, Apoptosis↑,

4525-

MAG,

HNK,

Magnolol and Honokiol: Two Natural Compounds with Similar Chemical Structure but Different Physicochemical and Stability Properties

Study,

Nor,

*BioAv↝, *eff↑,

2450-

Matr,

The Promoting Role of HK II in Tumor Development and the Research Progress of Its Inhibitors

Review,

Var,

HK2↓, eff↓,

2643-

MCT,

Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism

Review,

Nor,

*Akt↑, *AMPK↓, *TGF-β↓, eff↑, *BioEnh↑, *ATP↑, *PGC-1α↑, *p‑mTOR↑, *SMAD3↓,

2644-

MCT,

The Effects of Medium-Chain Triglyceride Oil Supplementation on Endurance Performance and Substrate Utilization in Healthy Populations: A Systematic Review

Review,

Nor,

*KeyT↑, *Dose↝, eff↑,

3903-

MCT,

Retrospective case studies of the efficacy of caprylic triglyceride in mild-to-moderate Alzheimer’s disease

Case Report,

AD,

*KeyT↑, *cognitive↑, *eff↑,

3905-

MCT,

Medium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer's disease. A systematic review and meta-analysis of human studies

Review,

AD,

Twelve records (422 participants) were included

*cognitive↑, *KeyT↑, *eff↑, *other↑, *toxicity↓,

1899-

MeJa,

Methyl jasmonate induces production of reactive oxygen species and alterations in mitochondrial dynamics that precede photosynthetic dysfunction and subsequent cell death

in-vitro,

NA,

100 mM

Plants

ROS↑, MMP↓, eff↓, H2O2?,

1782-

MEL,

Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities

Review,

Var,

AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, eff↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX↑, P21↑, p27↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,

1780-

MEL,

Utilizing Melatonin to Alleviate Side Effects of Chemotherapy: A Potentially Good Partner for Treating Cancer with Ageing

Review,

Var,

*antiOx↑, *toxicity↓, ChemoSen↑, *eff↑, *mitResp↑, *ATP↑, *ROS↓, *CardioT↓, *GSH↑, *NOS2↓, *lipid-P↓, eff↑, *HO-1↑, *NRF2↑, *NF-kB↑, TumCP↓, eff↑, neuroP↑,

1779-

MEL,

Therapeutic Potential of Melatonin Counteracting Chemotherapy-Induced Toxicity in Breast Cancer Patients: A Systematic Review

Review,

BC,

QoL↑, OS↑, Dose∅, antiOx↑, ROS↑, SOD↑, Catalase↑, GPx↑, Risk↓, NK cell↑, IL1β↓, IL6↓, TNF-α↓, radioP↑, chemoP↑, TumVol↓, TumMeta↓, angioG↓, ChemoSen↑, eff↑,

1778-

MEL,

Melatonin: a well-documented antioxidant with conditional pro-oxidant actions

Review,

Var,

Review,

AD,

*ROS↓, *antiOx↓, ROS↑, selectivity↑, Dose↑, *mitResp↑, *ATP↑, *ROS↓, eff↑, ROS↑, Dose↑, *toxicity∅, ROS↑, eff↓, ROS↝, Dose↑, other↑,

1777-

MEL,

Melatonin as an antioxidant: under promises but over delivers

Review,

NA,

*ROS↓, *Fenton↓, *antiOx↑, *toxicity∅, *GPx↑, *GSR↑, *GSH↑, *NO↓, *Iron↓, *Copper↓, *IL1β↓, *iNOS↓, *Casp3↓, *BBB↑, *RenoP↑, chemoP↑, *Ca+2↝, eff↑, *PKCδ?, ChemoSen↑, eff↑, Akt↓, DR5↑, selectivity↑, ROS↑, eff↑,

1043-

MET,

immuno,

Metformin reduces PD-L1 on tumor cells and enhances the anti-tumor immune response generated by vaccine immunotherapy

in-vitro,

NA,

eff↑, PD-L1↓, Ki-67↑, TIM-3↑, L-sel↑,

2379-

MET,

Down‐regulation of PKM2 enhances anticancer efficiency of THP on bladder cancer

in-vitro,

Bladder,

T24/HTB-9

in-vitro,

BC,

UMUC3

PKM2↓, p‑STAT3↓, TumCG↓, eff↑, chemoP↑, AMPK↑,

2383-

MET,

Activation of AMPK by metformin promotes renal cancer cell proliferation under glucose deprivation through its interaction with PKM2

in-vitro,

RCC,

A498

AMPK↑, TumCP↓, eff↓, eff↑,

2374-

MET,

Metformin Induces Apoptosis and Downregulates Pyruvate Kinase M2 in Breast Cancer Cells Only When Grown in Nutrient-Poor Conditions

in-vitro,

BC,

MCF-7

in-vitro,

BC,

SkBr3

in-vitro,

BC,

MDA-MB-231

eff↑, Apoptosis↑, Glycolysis↓, PKM2↓, mTOR↓, PARP↓,

2387-

MET,

GEM,

Metformin Increases the Response of Cholangiocarcinoma Cells to Gemcitabine by Suppressing Pyruvate Kinase M2 to Activate Mitochondrial Apoptosis

in-vitro,

CCA,

HCC9810

eff↑, tumCV↓, TumCMig↓, TumCI↓, Apoptosis↑, PKM2↓, PDHB↓,

2487-

metroC,

Metronomic Chemotherapy: Possible Clinical Application in Advanced Hepatocellular Carcinoma

Review,

HCC,

toxicity↓, toxicity↓, eff↝, angioG↓, CSCs↓, TSP-1↑, Hif1a↓, VEGF↓, eff↑,

2486-

metroC,

capec,

Sustained complete response of advanced hepatocellular carcinoma with metronomic capecitabine: a report of three cases

Case Report,

HCC,

OS↑, eff↝, Dose↝, AFP↓, Dose↝, TumVol↓, AFP↓,

2252-

MF,

HPT,

Cellular Response to ELF-MF and Heat: Evidence for a Common Involvement of Heat Shock Proteins?

Review,

NA,

HSPs∅, *HSPs↑, eff↝, *eff↑, eff↑, eff↓,

2243-

MF,

Pulsed electromagnetic fields increase osteogenetic commitment of MSCs via the mTOR pathway in TNF-α mediated inflammatory conditions: an in-vitro study

in-vitro,

Nor,

mesenchymal stem cells (MSCs)

*eff↑, *mTOR↑, *Akt↑, *PKA↑, *MAPK↑, *ERK↑, *BMP2↑, *Diff↑, *PKCδ↓, *VEGF↑, *IL10↑,

2236-

MF,

Changes in Ca2+ release in human red blood cells under pulsed magnetic field

in-vitro,

Nor,

 0.27 T at a transition time of 102 μs with pulse intervals of 1 Hz.

human red blood cells

*Ca+2↓, *eff↓, *ROS↓,

2238-

MF,

Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects

Review,

Var,

*BMD↑, *VGCC↑, *Ca+2↑, *NO↑, *eff↓,

2239-

MF,

Time-varying magnetic fields increase cytosolic free Ca2+ in HL-60 cells

in-vitro,

AML,

HL-60

Ca+2↑, eff↝,

2240-

MF,

Pulsed electromagnetic field induces Ca2+-dependent osteoblastogenesis in C3H10T1/2 mesenchymal cells through the Wnt-Ca2+/Wnt-β-catenin signaling pathway

in-vitro,

Nor,

C3H10T1/2

30 Hz, 1 mT, 2 h/day

PEMF output waveform consisted of a 400 kV/m pulsed burst (pulse width 0.2 m s; pulse wait 0.02 m s; burst width 5 m s; burst wait 60 m s; pulse rise 0.3 m s; pulse fall 2.0 m s) repeated at 30 Hz.

*Ca+2↑, *Diff↑, *BMD↑, *Wnt↑, *β-catenin/ZEB1↑, *eff↝,

2260-

MF,

Alternative magnetic field exposure suppresses tumor growth via metabolic reprogramming

in-vitro,

GBM,

U87MG

18 mT at the center

in-vitro,

GBM,

LN229

in-vivo,

NA,

AMF for 30 min daily, for a total of five sessions.

mice

TumCP↓, TumCG↓, OS↑, ROS↑, SOD2↑, eff↓, ECAR↓, OCR↑, selectivity↑, *toxicity∅, TumVol↓, PGC-1α↑, OXPHOS↑, Glycolysis↓, PKM2↓,

2257-

MF,

HPT,

HSP70 Inhibition Synergistically Enhances the Effects of Magnetic Fluid Hyperthermia in Ovarian Cancer

in-vitro,

Ovarian,

eff↑, eff↑,

528-

MF,

Caff,

Pulsed electromagnetic fields affect the intracellular calcium concentrations in human astrocytoma cells

in-vitro,

GBM,

U373MG

3mT, 50Hz

Ca+2↑, TumCP∅, TumCD∅, eff↑,

532-

MF,

A 50 Hz magnetic field influences the viability of breast cancer cells 96 h after exposure

in-vitro,

BC,

MDA-MB-231

0.1 mT and 1.0 mT, 50Hz, 96h

in-vitro,

BC,

MCF-7

in-vitro,

Nor,

MCF10

TumCP↓, MMP↓, ROS↑, eff↝, selectivity↑,

534-

MF,

Effect of extremely low frequency electromagnetic field parameters on the proliferation of human breast cancer

in-vitro,

BC,

MCF-7

0.5,1mT 8-39Hz

square wave

in-vitro,

BC,

MDA-MB-231

in-vivo,

Nor,

MCF10

Ca+2↑, Apoptosis↑, eff↝, eff↑, selectivity↑, eff↝, eff↝,

535-

MF,

Electromagnetic Fields Trigger Cell Death in Glioblastoma Cells through Increasing miR-126-5p and Intracellular Ca2+ Levels

in-vitro,

Pca,

PC3

2.4GHz

in-vitro,

GBM,

A172

in-vitro,

Pca,

HeLa

Apoptosis↑, miR-129-5p↑, Ca+2↑, eff↝,

537-

MF,

immuno,

Integrating electromagnetic cancer stress with immunotherapy: a therapeutic paradigm

Review,

Var,

Apoptosis↑, ROS↑, TumAuto↑, Ca+2↑, ATP↓, eff↑, eff↑,

539-

MF,

Pulsed Magnetic Field Improves the Transport of Iron Oxide Nanoparticles through Cell Barriers

in-vitro,

NA,

eff↑,

496-

MF,

Low-Frequency Magnetic Fields (LF-MFs) Inhibit Proliferation by Triggering Apoptosis and Altering Cell Cycle Distribution in Breast Cancer Cells

in-vitro,

BC,

MCF-7

1mT, 200Hz, 24h

200 Hz reached the optimum inhibition <span class="wphighlight">eff</span>ect

in-vitro,

BC,

ZR-75-1

in-vitro,

BC,

T47D

in-vitro,

BC,

MDA-MB-231

ROS↑, PI3K↓, Akt↓, GSK‐3β↑, Apoptosis↑, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, CycB/CCNB1↓, TumCCA↑, p‑Akt↓, TumCP↓, selectivity↑, eff↓,

520-

MF,

Exposure to a 50-Hz magnetic field induced mitochondrial permeability transition through the ROS/GSK-3β signaling pathway

in-vitro,

Nor,

50 Hz, 0.4 mT, 60mins

Human amniotic epithelial cells

*MPT↑, *Cyt‑c↑, *ROS↑, *p‑GSK‐3β↑, *eff↓, *MMP∅, *BAX↓, *Bcl-2∅,

523-

MF,

MTX,

Extremely low-frequency magnetic fields significantly enhance the cytotoxicity of methotrexate and can reduce migration of cancer cell lines via transiently induced plasma membrane damage

in-vitro,

AML,

THP1

10uM(MTX), 0.1 and 0.6 μT

in-vitro,

NA,

PC12

pheocrmomocytoma (PC12) Pheochromocytoma is a type of tumor

in-vivo,

Cerv,

HeLa

H2O2↑, TumCD↑, CellMemb↑, eff↑,

4097-

MF,

Theta Frequency Electromagnetic Stimulation Enhances Functional Recovery After Stroke

Trial,

Stroke,

mice

*motorD↑, *eff↑, *Dose↝,

4093-

MF,

Low-intensity electromagnetic fields induce human cryptochrome to modulate intracellular reactive oxygen species

in-vivo,

NA,

Drosophila fly

*ROS↑, *eff↑,

4118-

MF,

Effects of transcranial magnetic stimulation on neurobiological changes in Alzheimer's disease

Review,

AD,

*cognitive↑, *BDNF↑, *neuroP↑, *memory↑, *ROS↓, *antiOx↑, *Aβ↓, *eff↑,

4119-

MF,

Therapeutic potential and mechanisms of repetitive transcranial magnetic stimulation in Alzheimer’s disease: a literature review

Review,

AD,

*cognitive↑, *memory↑, *motorD↑, *eff↑, *eff↑, *Dose↝, *Dose↝, *Dose↝, *BDNF↑, *Aβ↓, *eff↑,

4101-

MF,

Benign Effect of Extremely Low-Frequency Electromagnetic Field on Brain Plasticity Assessed by Nitric Oxide Metabolism during Poststroke Rehabilitation

Human,

Stroke,

40 Hz, 7 mT, for 15 min/day

Forty-eight patients

*motorD↑, *cognitive↑, *eff↑, *NO↑, *other↝, *neuroP↑,

3741-

MF,

Promising application of Pulsed Electromagnetic Fields (PEMFs) in musculoskeletal disorders

Review,

NA,

usually less than 100 Hz and the magnetic flux density is between 0.1 m T and 30 m T.

*eff↑, *BMD↑, *Inflam↓, *PGE2↓, *IL6↓, *IL8↓, *NF-kB↓, *mTOR↝,

3457-

MF,

Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis

Review,

Var,

Apoptosis↑, H2O2↑, ROS↑, eff↑, eff↑, Ca+2↑, MAPK↑, *Catalase↑, *SOD1↑, *GPx1↑, *GPx4↑, *NRF2↑, TumAuto↑, ER Stress↑, HSPs↑, SIRT3↑, ChemoSen↑, UPR↑, other↑, PI3K↓, JNK↑, p38↑, eff↓, *toxicity?,

3568-

MF,

The Efficacy of Pulsed Electromagnetic Fields on Pain, Stiffness, and Physical Function in Osteoarthritis: A Systematic Review and Meta-Analysis

Review,

Arthritis,

OA patients treated with PEMF

*eff↑, *Pain↓, *motorD↑,

3481-

MF,

No effects of pulsed electromagnetic fields on expression of cell adhesion molecules (integrin, CD44) and matrix metalloproteinase-2/9 in osteosarcoma cell lines

in-vitro,

OS,

MG63

in-vitro,

OS,

SaOS2

ITGA1∅, ITGB1∅, ITGA5∅, ITGB3∅, ITGB4∅, MMP2∅, MMP9∅, eff↑,

3479-

MF,

Evaluation of Pulsed Electromagnetic Field Effects: A Systematic Review and Meta-Analysis on Highlights of Two Decades of Research In Vitro Studies

Review,

NA,

*eff↓, eff↝, *Hif1a↑, *VEGF↑, *TIMP1↑, *E2Fs↑, *MMP2↑, *MMP9↑, Apoptosis↑,

3477-

MF,

Electromagnetic fields regulate calcium-mediated cell fate of stem cells: osteogenesis, chondrogenesis and apoptosis

Review,

NA,

*Ca+2↑, *VEGF↑, *angioG↑, Ca+2↑, ROS↑, Necroptosis↑, TumCCA↑, Apoptosis↑, *ATP↑, *FAK↑, *Wnt↑, *β-catenin/ZEB1↑, *ROS↑, p38↑, MAPK↑, β-catenin/ZEB1↓, CSCs↓, TumCP↓, ROS↑, RadioS↑, Ca+2↑, eff↓, NO↑,

3476-

MF,

Pulsed Electromagnetic Fields Stimulate HIF-1α-Independent VEGF Release in 1321N1 Human Astrocytes Protecting Neuron-like SH-SY5Y Cells from Oxygen-Glucose Deprivation

in-vitro,

Stroke,

1321N1

1.5 ± 0.2 mT, pulse duration of 1.3 ms and frequency of 75 Hz, yielding a 0.1 duty cycle

in-vitro,

Park,

*VEGF↑, *eff↑, *neuroP↑, *other↑, *eff↑, *Inflam↓, *Hif1a∅,

3469-

MF,

Pulsed Electromagnetic Fields (PEMF)—Physiological Response and Its Potential in Trauma Treatment

Review,

NA,

*eff↑, *eff↝, *other↑, Ca+2↑, ROS↑, HSP70/HSPA5↑, *NOTCH↑, *HEY1↑, *p38↑, *MAPK↑,

3468-

MF,

An integrative review of pulsed electromagnetic field therapy (PEMF) and wound healing

Review,

NA,

*other↑, *necrosis↓, *IL6↑, *TGF-β↑, *iNOS↑, *MMP2↑, *MCP1↑, *HO-1↑, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *BioAv↑, eff⇅, DNAdam↑, Apoptosis↑, ROS↑, TumCP↓, *ROS↓, *FGF↑,

3486-

MF,

Pulsed electromagnetic field potentiates etoposide-induced MCF-7 cell death

in-vitro,

NA,

ChemoSen↑, tumCV↓, cl‑PARP↑, Casp7↑, Casp9↑, survivin↓, BAX↑, DNAdam↑, ROS↑, eff↓,

4355-

MF,

Ambient and supplemental magnetic fields promote myogenesis via a TRPC1-mitochondrial axis: evidence of a magnetic mitohormetic mechanism

in-vitro,

Nor,

C2C12

 1.5 mT

C2C12 mouse skeletal myoblasts

*mt-OCR↑, *mt-ROS↑, *ECAR↑, *Dose↝, *Ca+2↑, *ATP↑, *other↑, *eff↓, *eff↝,

4354-

MF,

doxoR,

Modulated TRPC1 Expression Predicts Sensitivity of Breast Cancer to Doxorubicin and Magnetic Field Therapy: Segue Towards a Precision Medicine Approach

in-vivo,

BC,

MDA-MB-231

3mT, PEMFs stimulation for 1 h weekly for 5 weeks

NSG mice were purchased from The Jackson’s Laboratory and used at 8-10 weeks of age.

in-vivo,

BC,

MCF-7

selectivity↑, Apoptosis↑, TumCI↓, tumCV↓, TumVol↓, eff↓, eff↑, ROS↑, Ca+2↑, TumCMig↓,

4353-

MF,

Chemo,

Pulsed Electromagnetic Field Enhances Doxorubicin-induced Reduction in the Viability of MCF-7 Breast Cancer Cells

in-vitro,

BC,

MCF-7

 1 hours PEMF session (2.5 mT at 70 Hz) thrice a day for three consecutive days.

TumCCA↑, Apoptosis↑, eff↑, TumCCA↑, Casp↝, p‑CDK2↓, cycE/CCNE↓, Fas↑, BAX↑, survivin↓, Mcl-1↓, cl‑PARP↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑,

4352-

MF,

Differences in lethality between cancer cells and human lymphocytes caused by LF-electromagnetic fields

in-vitro,

lymphoma,

K562

B < or = 15 mT 50/60 Hz

NA,

U937

NA,

HL-60

Apoptosis↑, eff↑,

3535-

MFrot,

MF,

Pulsed Electromagnetic Field Stimulation in Osteogenesis and Chondrogenesis: Signaling Pathways and Therapeutic Implications

Review,

Nor,

*eff↑, *COL2A1↑, *SOX9↑, *Ca+2↑, *FAK↑, *F-actin↑, *Inflam↓, *other↑, *Diff↑, *BMD↑,

3567-

MFrot,

MF,

The Effect of Extremely Low-Frequency Magnetic Field on Stroke Patients: A Systematic Review

Review,

Stroke,

*eff↑, *ROS↓, *Inflam↓, *cognitive↑, *Catalase↑, *SOD↑, *SOD1↑, *SOD2↑, *GPx1↑, *GPx4↑, *IL1β↑, *neuroP↑, *toxicity∅,

3492-

MFrot,

Chemo,

MF,

Synergistic Effect of Chemotherapy and Magnetomechanical Actuation of Fe-Cr-Nb-B Magnetic Particles on Cancer Cells

eff↑, TumCD↑,

3494-

MFrot,

MF,

Magnetically switchable mechano-chemotherapy for enhancing the death of tumour cells by overcoming drug-resistance

in-vitro,

Var,

eff↑, TumCD↑,

3496-

MFrot,

GoldNP,

MF,

Enhancement of chemotherapy effects by non-lethal magneto-mechanical actuation of gold-coated magnetic nanoparticles

in-vitro,

Cerv,

HeLa

eff↑, tumCV↓,

2262-

MFrot,

MF,

Effects of 0.4 T Rotating Magnetic Field Exposure on Density, Strength, Calcium and Metabolism of Rat Thigh Bones

in-vivo,

ostP,

0.4T, 8Hz, 30min/day, 30days

Rat

*BMD↑, *eff↓, *ALP↑, *other↑,

2259-

MFrot,

MF,

Method and apparatus for oncomagnetic treatment

in-vitro,

GBM,

Oncomagnetic patent

MMP↓, Bcl-2↓, BAX↑, Bak↑, Cyt‑c↑, Casp3↑, Casp9↑, DNAdam↑, ROS↑, lactateProd↑, Apoptosis↑, MPT↑, *selectivity↑, eff↑, MMP↓, selectivity↑, TCA?, H2O2↑, eff↑, *antiOx↑, H2O2↑, eff↓, GSH/GSSG↓, *toxicity∅, OS↑,

2258-

MFrot,

MF,

EXTH-68. ONCOMAGNETIC TREATMENT SELECTIVELY KILLS GLIOMA CANCER CELLS BY INDUCING OXIDATIVE STRESS AND DNA DAMAGE

in-vitro,

GBM,

GBM

in-vitro,

Nor,

SVGp12

TumVol↓, OS↑, γH2AX↑, DNAdam↑, selectivity↑, ROS↑, TumCD↑, eff↑, eff↓,

516-

MFrot,

immuno,

MF,

Anti-tumor effect of innovative tumor treatment device OM-100 through enhancing anti-PD-1 immunotherapy in glioblastoma growth

vitro+vivo,

GBM,

U87MG

1mT, 120Hz (7200rpm), 24, 48, and 72 h

OM‑100 device (motor driven pulses)

TumCP↓, Apoptosis↑, TumCMig↓, ROS↑, PD-L1↑, TumVol↓, eff↑, *toxicity∅, eff↑, *toxicity∅, Dose↝, tumCV↓, TumCI↓,

186-

MFrot,

MF,

Selective induction of rapid cytotoxic effect in glioblastoma cells by oscillating magnetic fields

in-vitro,

GBM,

GBM

 new device that generates oscillating magnetic fields (OMF) by rapid rotation of strong permanent magnets in specially designed patterns of frequency and timing

in-vitro,

Lung,

mt-ROS↑, Casp3↑, selectivity↑, TumCD↑, ETC↓, H2O2↑, eff↓, GSH↑, MMP↓,

229-

MFrot,

MF,

Molecular mechanism of effect of rotating constant magnetic field on organisms

in-vivo,

Nor,

New Zealand rabbits, rotating constant magnetic field on organisms

*NO↑, *5HT↓, *eff↝, *eff↝, *β-Endo↑, *other↓,

188-

MFrot,

MF,

Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells

in-vitro,

GBM,

GBM115

 0.4-58mT pulsed

  ~ 137 Hz and was large enough to generate a peak-topeak amplitude (PPA) of ~ 5 mT

in-vitro,

GBM,

DIPG

ROS↑, SDH↓, eff↓, RPM↑, eff↓, eff↑, eff↝, eff↝, Casp3↑, eff↝, SOD↓, ETC↓,

184-

MFrot,

MF,

Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells

in-vitro,

GBM,

GBM

 80mT pulsed

ROS↑, mitResp↓, mtDam↑, Dose↝, MMP?, OCR↓, mt-H2O2↑, eff↓, SDH↓, Thiols↓, GSH↓, TumCD↑, Casp3↑, Casp7↑, MPT↑, Cyt‑c↑, selectivity↑, GSH/GSSG↓, ETC↓,

226-

MFrot,

MF,

Involvement of midkine expression in the inhibitory effects of low-frequency magnetic fields on cancer cells

in-vitro,

NA,

A549

 0.4-T, 7.5 Hz

in-vitro,

NA,

LoVo

TumCP↓, eff↝,

215-

MFrot,

MF,

Magneto-mechanical destruction of cancer-associated fibroblasts using ultra-small iron oxide nanoparticles and low frequency rotating magnetic fields

in-vitro,

PC,

CAF

 1 Hz and 40 mT

 superparamagnetic iron oxide nanoparticles

TumVol↓, lysoMP↑, CAFs/TAFs↓, eff↑,

203-

MFrot,

MF,

Rotating Magnetic Field Induced Oscillation of Magnetic Particles for in vivo Mechanical Destruction of Malignant Glioma

vitro+vivo,

GBM,

U87MG

1T

lysoMP↓, TumVol↓, eff↑, Apoptosis↑, Ca+2↑,

595-

MFrot,

VitC,

MF,

The Effect of Alternating Magnetic Field Exposure and Vitamin C on Cancer Cells

in-vitro,

PC,

MIA PaCa-2

4mT, 1000rpm

51% reduction

reduces IC50 value of cells treated with Vit C and magnetic field

in-vitro,

CRC,

SW-620

23% reduction

in-vitro,

NA,

HT1080

37% reduction

in-vitro,

Pca,

PC3

40% reduction

in-vitro,

OS,

U2OS

46% reduction

in-vitro,

BC,

MCF-7

33% reduction

in-vitro,

Nor,

CCD-18Co

-7% reduction

health normal colon cells *****

TumCD↑, eff↑, *TumCG∅,

5243-

MFrot,

The assessment of the efficacy of the effect of a rotational magnetic field on the course of the tumor process in patients with generalized breast cancer

Human,

BC,

OS↑, eff↑,

786-

Mg,

VitC,

A narrative review on the role of magnesium in immune regulation, inflammation, infectious diseases, and cancer

Risk↓, *VitD↑, *pH↝, *ROS↓, TumCG↓, eff↑,

1890-

MGO,

The Dual-Role of Methylglyoxal in Tumor Progression – Novel Therapeutic Approaches

Review,

Var,

AntiCan?, TumCG↓, GAPDH↓, Apoptosis↑, TumCCA↑, MAPK↑, Bcl-2↓, MMP9↓, eff↑,

3838-

Moringa,

Characterization, Large-Scale HSCCC Separation and Neuroprotective Effects of Polyphenols from Moringa oleifera Leaves

in-vitro,

AD,

PC12

Review,

Stroke,

*Inflam↓, *neuroP↑, *antiOx↑, *ROS↓, *memory↑, *MDA↓, *AChE↓, *SOD↑, *Catalase↑, *eff↑,

3839-

Moringa,

Nutritional Value of Moringa oleifera Lam. Leaf Powder Extracts and Their Neuroprotective Effects via Antioxidative and Mitochondrial Regulation

*eff↑, *ROS↓, *lipid-P↓, *GSH↑, *antiOx↑, *Ca+2↓, *MMP↑, *neuroP↑, *BBB↑, *Catalase↑, *SOD↑, GPx↑,

3841-

Moringa,

Cerebroprotective effect of Moringa oleifera against focal ischemic stroke induced by middle cerebral artery occlusion

in-vivo,

Stroke,

100, 200 and 400 mg·kg−1

male Wistar rats (300–350 g) once daily

*MDA↓, *SOD↑, *neuroP↑, *ROS↓, *Inflam↓, *eff↝,

3844-

Moringa,

Review of the Safety and Efficacy of Moringa oleifera

Review,

NA,

*antiOx↑, *RenoP↑, *hepatoP↑, *radioP↑, *eff↑, *toxicity↓, *ROS↓, *lipid-P↓, *DNAdam↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *GSTs↑, *AST↓, *ALAT↓, *ALP↓, *Bil↓,

3845-

Moringa,

Protective effects of Moringa oleifera Lam. leaves against arsenic-induced toxicity in mice

in-vitro,

NA,

Swiss albino male mice

*eff↑,

3847-

MSM,

Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement

Review,

Arthritis,

*Inflam↓, *Pain↓, *ROS↓, *antiOx↑, *Dose↝, *Half-Life↝, *NF-kB↓, *IL1↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2↓, *NLRP3↓, *NRF2↑, *STAT↓, *Cartilage↑, *eff↑, *eff↑, *GSH↑, *uricA↓, tumCV↓, TumCCA↑, necrosis↑, Apoptosis↑, VEGF↓, HSP90↓, IGF-1?,

3846-

MSM,

Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy

Human,

NA,

*Dose↝, *BBB↑, *eff↓,

3815-

mushLions,

Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines

Review,

Stroke,

Review,

Park,

Review,

AD,

*eff↑, *cognitive↑,

2484-

mushLions,

Neurotrophic and Neuroprotective Effects of Hericium erinaceus

Review,

Stroke,

Review,

AD,

Review,

Park,

*eff↑, *BBB↑, *Dose↝, *neuroP↑, *cognitive↑, *toxicity∅,

1573-

MushReishi,

Ganoderma lucidum (Reishi mushroom) for cancer treatment

Review,

NA,

A total of five RCTs with 373 subjects were included in this review

ChemoSen↑, CR3↝, eff↑, NK cell↑, T-Cell↑, QoL↑,

1997-

Myr,

QC,

Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity

in-vitro,

Lung,

A549

50, 75, and 100 umol/L

<1uM

TrxR↓, eff↑, TumCCA↑, eff↓, ROS↑,

2931-

NAD,

NAD+ Repletion Rescues Female Fertility during Reproductive Aging

in-vivo,

Nor,

 NMN in drinking water (2 g/L)

mice

*eff↑, *SIRT2↑, *other↑, *Dose↝,

2933-

NAD,

Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns

Review,

Nor,

NA,

AD,

NA,

Diabetic,

NA,

Stroke,

NA,

LiverDam,

NA,

Park,

*mtDam↓, *BioAv↝, *BioAv↑, *OS↑, *eff↑, *eff↑, *cognitive↑, *DNAdam↓, *SIRT1↑, *cardioP↑, *ROS↓, *Dose↝, *BioAv↑, *hepatoP↑, *eff↑, *BG↓, *creat↓,

1805-

NarG,

Naringenin suppresses epithelial ovarian cancer by inhibiting proliferation and modulating gut microbiota

in-vitro,

Ovarian,

A2780S

200 μM

in-vivo,

NA,

mice

TumCP↓, TumCMig↓, PI3K↓, TumVol↓, TumW↓, BioAv↑, GutMicro↑, Dose∅, eff↑, EGFR↓, cycD1/CCND1↓, toxicity∅,

1801-

NarG,

A Narrative Review on Naringin and Naringenin as a Possible Bioenhancer in Various Drug-Delivery Formulations

Review,

Var,

AntiCan↓, CYP19↓, PI3K↓, Akt↓, TumAuto↑, eff↑, BioEnh↑,

4225-

NarG,

Naringin treatment improves functional recovery by increasing BDNF and VEGF expression, inhibiting neuronal apoptosis after spinal cord injury

in-vivo,

NA,

 40 mg/kg naringin-treated group

Sprague-Dawley rats

*motorD↑, *BDNF↑, *VEGF↑, *Bax:Bcl2↓, *Casp3↓, *Apoptosis↓, *eff↑,

5253-

NCL,

Niclosamide: Beyond an antihelminthic drug

Review,

Var,

TumCP↓, Apoptosis↑, EMT↓, β-catenin/ZEB1↓, TumCG↓, toxicity↓, Wnt↓, LRP6↓, eff↑, DR5↑, mTORC1↓, pH↓, CSCs↓, IL6↓, JAK1↓, STAT3↓, ChemoSen↑, TumCG↓, tumCV↓, NOTCH↓, NF-kB↓, EGFR↓, ROS↑, RadioS↑, cFos↓, cJun↓, E2Fs↓, cMyc↓, Half-Life↓, BioAv↝,

5254-

NCL,

The magic bullet: Niclosamide

Review,

Var,

Wnt↓, β-catenin/ZEB1↓, RAS↓, STAT3↓, NOTCH↓, E2Fs↓, mTOR↓, eff↑, PD-1↓, PD-L1↓, BioAv↝, toxicity↓, BioAv↑, ETC↑, NADH:NAD↓, TCA↑, Warburg↓, Diff↑, AMPK↑, P53↑, PP2A↑, HIF-1↓, KRAS↓, Myc↓, RadioS↑, ChemoSen↑, Dose↝, Dose↑,

4973-

Nimb,

Nimbolide Exhibits Potent Anticancer Activity Through ROS-Mediated ER Stress and DNA Damage in Human Non-small Cell Lung Cancer Cells

in-vitro,

NSCLC,

A549

tumCV↓, ROS↑, ER Stress↑, DNAdam↑, Apoptosis↑, eff↓,

4976-

Nimb,

Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition

vitro+vivo,

PC,

ROS↑, Apoptosis↑, TumAuto↑, TumCP↓, TumCMig↓, TumCI↓, EMT↓, Dose↓, selectivity↑, Akt↓, eff↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓,

4646-

OLEC,

Oleocanthal as a Multifunctional Anti-Cancer Agent: Mechanistic Insights, Advanced Delivery Strategies, and Synergies for Precision Oncology

Review,

Var,

BioAv↓, *Inflam↓, *antiOx↓, cMET↓, STAT3↓, TNF-α↓, COX2↓, EMT↓, angioG↓, *GutMicro↝, eff↑,

1226-

OLST,

Knockdown of PGM1 enhances anticancer effects of orlistat in gastric cancer under glucose deprivation

vitro+vivo,

GC,

PGM1∅, FASN↓, Apoptosis↑, lipidLev↑, GlucoseCon↑, eff↑,

2053-

PB,

4-Phenyl butyric acid prevents glucocorticoid-induced osteoblast apoptosis by attenuating endoplasmic reticulum stress

in-vitro,

ostP,

3T3

*ER Stress↓, *mtDam↓, *Apoptosis↓, eff↑,

2061-

PB,

Chemo,

Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells

in-vitro,

PC,

PANC1

in-vitro,

PC,

COLO357

in-vitro,

PC,

Bxpc-3

HDAC↓, Apoptosis↑, eff↑, selectivity↑, TumCCA↑, eff↑, selectivity↑,

2063-

PB,

Rad,

Phenylbutyrate sensitizes human glioblastoma cells lacking wild-type p53 function to ionizing radiation

in-vitro,

GBM,

U87MG

2 mM

NA,

U251

RadioS↑, eff↝, P53↝,

2065-

PB,

TMZ,

Inhibition of Mitochondria- and Endoplasmic Reticulum Stress-Mediated Autophagy Augments Temozolomide-Induced Apoptosis in Glioma Cells

in-vitro,

GBM,

eff↑, ROS↑, MMP↓, ER Stress↑, CHOP↑, GRP78/BiP↑, pro‑Casp12↓, eff↝, Ca+2↝,

2069-

PB,

Toxic and metabolic effect of sodium butyrate on SAS tongue cancer cells: role of cell cycle deregulation and redox changes

in-vitro,

Tong,

TumCG↓, ROS↑, P21↑, CycB/CCNB1↓, cDC2↓, CDC25↓, eff↓, TumCCA↑, Apoptosis↑,

2070-

PB,

Phenylbutyrate-induced apoptosis is associated with inactivation of NF-kappaB IN HT-29 colon cancer cells

in-vitro,

CRC,

HT-29

TumCG↓, Apoptosis↑, MMP↓, Casp3↑, PARP↓, NF-kB↓, eff↑,

2077-

PB,

Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells

in-vitro,

Liver,

HUH7

5mM

miR-22↑, SIRT1↓, ROS↑, Cyt‑c↑, Casp3↑, eff↓, TumCG↓, TumCP↓, HDAC↓, SIRT1↓, CD44↓, proMMP2↓, MMP↓, SOD↓,

2074-

PB,

Chemo,

The effect of combined treatment with sodium phenylbutyrate and cisplatin, erlotinib, or gefitinib on resistant NSCLC cells

in-vitro,

Lung,

A549

10uM

in-vitro,

Lung,

Calu-6

8.53uM

in-vitro,

Lung,

H1650

4.53uM

TumCG↓, eff↑, ChemoSen↑, HDAC↓,

2068-

PB,

Phenylbutyrate-induced glutamine depletion in humans: effect on leucine metabolism

in-vivo,

Nor,

glut↓, NH3↓, eff↝,

2048-

PB,

Sodium Phenylbutyrate Inhibits Tumor Growth and the Epithelial-Mesenchymal Transition of Oral Squamous Cell Carcinoma In Vitro and In Vivo

in-vitro,

OS,

CAL27

4mM

in-vitro,

Oral,

HSC3

3.7mM

in-vitro,

OS,

SCC4

3mM

in-vivo,

NA,

*NH3↓, *HDAC↓, *ER Stress↓, Apoptosis?, Bcl-2↓, cl‑Casp3↑, TGF-β↑, N-cadherin↓, E-cadherin↑, TumVol↓, eff↑,

2026-

PB,

Oral sodium phenylbutyrate in patients with recurrent malignant gliomas: A dose escalation and pharmacologic study

Trial,

GBM,

Twenty-three patients with supratentorial recurrent malignant gliomas were enrolled on this dose escalation trial

Dose↝, Dose↑, Dose↝, OS↑, HDAC↓, TumCCA↑, P21↑, other↝, BioAv↑, eff↑,

2028-

PB,

Potential of Phenylbutyrate as Adjuvant Chemotherapy: An Overview of Cellular and Molecular Anticancer Mechanisms

Review,

Var,

HDAC↓, TumCCA↑, P21↑, Dose↝, Telomerase↓, IGFBP3↑, p‑p38↑, JNK↑, ERK↑, BAX↑, Casp3↑, Bcl-2↓, Cyt‑c↝, FAK↓, survivin↓, VEGF↓, angioG↓, DNArepair↓, TumMeta↓, HSP27↑, ASK1↑, ROS↑, eff↑, ER Stress↓, GRP78/BiP↓, CHOP↑, AR↓, other?,

2036-

PB,

Phenylbutyrate induces apoptosis in human prostate cancer and is more potent than phenylacetate

in-vitro,

Pca,

in-vivo,

NA,

Copenhagen rats

TumCG↓, eff↑, Diff↑,

2049-

PB,

Modifying histones to tame cancer: clinical development of sodium phenylbutyrate and other histone deacetylase inhibitors

Review,

Var,

HDAC↓, ac‑H3↑, ac‑H4↑, ac‑H3↑, eff↝, toxicity↓,

2043-

PB,

Cisplatin,

Phenylbutyrate interferes with the Fanconi anemia and BRCA pathway and sensitizes head and neck cancer cells to cisplatin

in-vitro,

HNSCC,

UM-SCC-1

2 mM phenylbutyrate for 5 days

ChemoSen↑, eff↑, HDAC↓, BRCA1↓, RadioS↑,

2044-

PB,

DCA,

Differential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetate

in-vivo,

NA,

mice

PDK1↓, PDKs↓, eff↑, PDH↑,

1672-

PBG,

The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers

Review,

BC,

ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, eff↑, hTERT/TERT↓, cycD1/CCND1↓, eff↑, eff↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,

1674-

PBG,

SDT,

HPT,

Study on the effect of a triple cancer treatment of propolis, thermal cycling-hyperthermia, and low-intensity ultrasound on PANC-1 cells

in-vitro,

PC,

PANC1

in-vitro,

Nor,

H6c7

tumCV↓, ROS↑, eff↑, Dose∅, selectivity↑, MMP↓, mtDam↑, cl‑PARP↑, p‑ERK↓, p‑JNK↑, p‑p38↑, eff↓, ChemoSen↑,

1676-

PBG,

Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies

Review,

Var,

20-250ug/mL

ROS↑, MMP↓, Bcl-2↓, eff↑, tumCV↓, TumCCA↑, angioG↓, PAK1↓, HDAC1↓, HDAC2↓, P53↑, PCNA↓, cycD1/CCND1↓, cycE/CCNE↓, P21?, BAX↑, cl‑Casp3↑, cl‑PARP↑, ChemoSen↑,

1678-

PBG,

5-FU,

sericin,

In vitro and in vivo anti-colorectal cancer effect of the newly synthesized sericin/propolis/fluorouracil nanoplatform through modulation of PI3K/AKT/mTOR pathway

in-vitro,

CRC,

Caco-2

in-vivo,

NA,

105 in bred- albino mice

PI3K↓, Akt↓, mTOR↓, TumCP↓, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, ROS↓, FOXO1↑, *toxicity∅, eff↑,

1682-

PBG,

Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits

Review,

Var,

i-LDH↓, Akt↓, MAPK↓, NF-kB↓, IL1β↓, IL6↓, TNF-α↓, iNOS↓, COX2↓, ROS↓, Bcl-2↓, PARP↓, P53↑, BAX↑, Casp3↑, TumCCA↑, Cyt‑c↑, MMP↓, eff↑,

1648-

PBG,

Contribution of Green Propolis to the Antioxidant, Physical, and Sensory Properties of Fruity Jelly Candies Made with Sugars or Fructans

Review,

Nor,

Dose∅, Dose∅, eff↓, antiOx↑,

1660-

PBG,

Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents

Review,

Var,

MMPs↓, angioG↓, TumMeta↓, TumCCA↑, Apoptosis↑, ChemoSideEff↓, eff∅, HDAC↓, PTEN↑, p‑PTEN↓, p‑Akt↓, Casp3↑, p‑ERK↑, p‑FAK↑, Dose?, Akt↓, GSK‐3β↓, FOXO3↓, eff↑, IL2↑, IL10↑, NF-kB↓, VEGF↓, mtDam↑, ER Stress↑, AST↓, ALAT↓, ALP↓, COX2↓, eff↑, Bax:Bcl2↑,

1664-

PBG,

Anticancer Activity of Propolis and Its Compounds

Review,

Var,

Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27↑, CDK1↓, p‑CDK1↓, cycA1/CCNA1↓, CycB/CCNB1↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1/CCND1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,

1666-

PBG,

Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

Review,

Var,

ChemoSen↑, TumCCA↑, TumCP↓, Apoptosis↑, antiOx↓, ROS↑, COX2↑, ER(estro)↓, cycA1/CCNA1↓, CycB/CCNB1↓, CDK2↓, P21↑, p27↑, hTERT/TERT↓, HDAC↓, ROS⇅, Dose?, ROS↓, ROS↑, DNAdam↑, ChemoSen↑, LOX1↓, lipid-P↓, NO↑, Igs↑, NK cell↑, MMPs↓, VEGF↓, Hif1a↓, GLUT1↓, HK2↓, selectivity↑, RadioS↑, GlucoseCon↓, lactateProd↓, eff↓, *BioAv↓,

1668-

PBG,

Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms

Review,

Var,

antiOx↑, Inflam↓, AntiCan↑, TumCP↓, Apoptosis↑, eff↝, MMPs↓, TNF-α↓, iNOS↓, COX2↓, IL1β↑, *BioAv↓, BAX↑, Casp3↑, Cyt‑c↑, Bcl-2↓, eff↑, selectivity↑, P53↑, ROS↑, Casp↑, eff↑, ERK↓, Dose∅, TRAIL↑, NF-kB↑, ROS↑, Dose↑, MMP↓, DNAdam↑, TumAuto↑, LC3II↑, p62↓, EGF↓, Hif1a↓, VEGF↓, TLR4↓, GSK‐3β↓, NF-kB↓, Telomerase↓, ChemoSen↑, ChemoSideEff↓,

1231-

PBG,

Caffeic acid phenethyl ester inhibits MDA-MB-231 cell proliferation in inflammatory microenvironment by suppressing glycolysis and lipid metabolism

in-vitro,

BC,

MDA-MB-231

TumCP↓, TumCMig↓, TumCI↓, MMP↓, TLR4↓, TNF-α↓, NF-kB↓, IL1β↓, IL6↓, IRAK4↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDHA↓, ACC↓, FASN↓, eff↓,

2430-

PBG,

The cytotoxic effects of propolis on breast cancer cells involve PI3K/Akt and ERK1/2 pathways, mitochondrial membrane potential, and reactive oxygen species generation

in-vitro,

BC,

MDA-MB-231

TumCP↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eff↓, MMP↓, LDH↑, ATP↓, Ca+2↑,

4946-

PEITC,

Phenethyl Isothiocyanate Inhibits Oxidative Phosphorylation to Trigger Reactive Oxygen Species-mediated Death of Human Prostate Cancer Cells

in-vitro,

Pca,

LNCaP

in-vitro,

Pca,

PC3

Apoptosis↑, TumAuto↑, ROS↑, OXPHOS↓, ATP↓, selectivity↑, ETC↓, eff↓, eff↓, BAX↑,

4951-

PEITC,

ROS accumulation by PEITC selectively kills ovarian cancer cells via UPR-mediated apoptosis

in-vitro,

Ovarian,

PA1

5 μM

in-vitro,

Ovarian,

SKOV3

ROS↑, TumCP↓, GSH↓, selectivity↑, UPR↑, CHOP↑, ER Stress↑, GRP78/BiP↑, PERK↑, ATF6↑, eff↓, TumCG↓, Apoptosis↑, toxicity↓,

4953-

PEITC,

effective-in-killing">PEITC: a natural compound effective in killing primary leukemia cells and overcoming drug resistance

in-vitro,

CLL,

 4-8 µM

ROS↑, GSH↓, TumCD↓, eff↓, Mcl-1↓, Casp3↑,

4954-

PEITC,

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate

vitro+vivo,

Ovarian,

SKOV3

 5 μM

ROS↑, GSH↓, selectivity↑, mtDam↑, TumCD↑, OS↑, eff↑, *toxicity↓, H2O2↑, NO↑, eff↓, GPx↓, Dose↝, eff↑,

4959-

PEITC,

Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment

in-vitro,

Ovarian,

CSCs↓, ALDH↓, CSCsMark↓, eff↑,

4935-

PEITC,

Phenethyl Isothiocyanate Suppresses Inhibitor of Apoptosis Family Protein Expression in Prostate Cancer Cells in Culture and In Vivo

in-vivo,

Pca,

LNCaP

2.5 and 5 μM

in-vivo,

Pca,

PC3

Apoptosis↑, XIAP↓, survivin↓, *BioAv↑, tumCV↓, eff↓,

4944-

PEITC,

Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations

in-vitro,

Oral,

TumCG↓, TumCCA↑, Apoptosis↑, ROS↑, NO↑, GSH↓, MMP↓, DNAdam↑, ATM↑, Chk2↑, P53↑, eff↓,

4926-

PEITC,

PEITC inhibits the invasion and migration of colorectal cancer cells by blocking TGF-β-induced EMT

in-vitro,

CRC,

SW48

TumCI↓, TumCMig↓, EMT↓, Smad1↓, AntiCan↑, Snail↓, Slug↓, Zeb1↓, ZEB2↓, TGF-β1↓, eff↑, E-cadherin↑, N-cadherin↓, Vim↓,

4929-

PEITC,

PacT,

Phenethyl isothiocyanate and paclitaxel synergistically enhanced apoptosis and alpha-tubulin hyperacetylation in breast cancer cells

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

ChemoSen↑, Apoptosis↑, TumCCA↑, eff↑, CDK1↓, Bcl-2↓, BAX↑, cl‑PARP↑, SAL↑,

4934-

PEITC,

Differential induction of apoptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

GSH↓, ROS↑, chemoPv↑, Apoptosis↑, Casp9↑, Casp3↑, eff↓, TumCG↓, TumCCA↑, BAX↑, Nrf1↑, GSH↓, GSSG↓, GSH/GSSG↓,

4943-

PEITC,

Phenethyl isothiocyanate (PEITC) inhibits growth of ovarian cancer cells by inducing apoptosis: role of caspase and MAPK activation

in-vitro,

Ovarian,

OVCAR-3

23.2 microM

TumCD↑, TumCP↓, Apoptosis↑, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Akt↓, ERK↓, cMyc↓, p38↑, JNK↑, eff↓,

5183-

PEITC,

Cisplatin,

Phenethyl Isothiocyanate Induces Apoptosis Through ROS Generation and Caspase-3 Activation in Cervical Cancer Cells

in-vitro,

Cerv,

HeLa

in-vitro,

Nor,

HaCaT

DNAdam↑, Apoptosis↑, ChemoSen↑, ROS↑, mt-ROS↑, Casp↑, Casp3↑, selectivity↑, TumCP↓, tumCV↓, eff↓,

5184-

PEITC,

Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways

vitro+vivo,

AML,

U937

U937 xenograft

Casp3↑, Casp9↑, Casp8↑, cl‑PARP↑, Apoptosis↑, Mcl-1↓, Akt↓, JNK↑, eff↑,

5186-

PEITC,

Phenethyl Isothiocyanate inhibits STAT3 activation in prostate cancer cells

in-vitro,

Pca,

DU145

in-vitro,

Pca,

LNCaP

TumCP↓, TumCCA↑, STAT3↓, p‑JAK2↓, eff↓, TumCCA↑, AR↓, ROS↑,

1767-

PG,

Propyl gallate induces cell death in human pulmonary fibroblast through increasing reactive oxygen species levels and depleting glutathione

in-vitro,

Nor,

(100–1600 μM)

800 µM at 24 h

*ROS↑, *GSH↓, *SOD↓, *Catalase↓, eff↓,

1769-

PG,

The Anti-Apoptotic Effects of Caspase Inhibitors in Propyl Gallate-Treated Lung Cancer Cells Are Related to Changes in Reactive Oxygen Species and Glutathione Levels

in-vitro,

Lung,

Calu-6

in-vitro,

Lung,

A549

TumCP↓, eff↑, ROS↑, GSH↓,

1770-

PG,

Propyl gallate sensitizes human lung cancer cells to cisplatin-induced apoptosis by targeting heme oxygenase-1 for TRC8-mediated degradation

in-vitro,

Lung,

antiOx↑, Inflam↓, HO-1↓, eff↑, ChemoSen↑,

1765-

PG,

Enhanced cell death effects of MAP kinase inhibitors in propyl gallate-treated lung cancer cells are related to increased ROS levels and GSH depletion

in-vitro,

Lung,

A549

800 uM at 24 h

in-vitro,

Lung,

Calu-6

TumCD↑, MMP↓, ROS↑, GSH↓, Dose∅, eff↑,

1254-

PI,

VitC,

Piperlongumine combined with vitamin C as a new adjuvant therapy against gastric cancer regulates the ROS–STAT3 pathway

in-vivo,

GC,

15 µM PL and 3 mM

tumour xenograft

STAT3⇅, eff↑, ROS↑, Apoptosis↑,

5215-

PI,

Piperine impairs cell cycle progression and causes reactive oxygen species-dependent apoptosis in rectal cancer cells

in-vitro,

CRC,

TumCCA↑, Apoptosis↑, ROS↑, eff↓, BioEnh↑,

3587-

PI,

Piperine: A review of its biological effects

Review,

Park,

Review,

AD,

*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *eff↑, *BioAv↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑,

3595-

PI,

Black pepper and health claims: a comprehensive treatise

Review,

Var,

Review,

AD,

*antiOx↑, *ROS↓, *chemoP↑, TumCG↓, *cognitive↑, *MMPs↓, *PGE2↓, *AP-1↓, *5LO↓, *COX1↓, *other↑, *other↑, *other↑, *SOD↑, *Catalase↑, *GSTs↑, *GSR↑, *other↑, *Weight↓, *BioEnh↑, *BioAv↑, *eff↑, *CYP3A2↓, *neuroP↑, *BP↓, *other↑,

1940-

PL,

Piperlongumine Inhibits Migration of Glioblastoma Cells via Activation of ROS-Dependent p38 and JNK Signaling Pathways

in-vitro,

GBM,

LN229

1, 2, or 5 μM, 10uM

in-vitro,

GBM,

U87MG

ROS↑, GSH↓, p38↑, JNK↑, IKKα↑, NF-kB↓, eff↓,

1946-

PL,

PI,

Piperlonguminine and Piperine Analogues as TrxR Inhibitors that Promote ROS and Autophagy and Regulate p38 and Akt/mTOR Signaling

in-vitro,

Liver,

eff↑, toxicity↓, TrxR↓, ROS↑, MMP↓, p38↑, Akt↓, mTOR↓,

1947-

PL,

Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer

in-vitro,

GC,

SGC-7901

in-vitro,

GC,

TrxR1↓, ROS↑, ER Stress↑, mtDam↑, selectivity↑, NO↑, TumCCA↑, mt-ROS↑, Casp9↑, Bcl-2↓, Bcl-xL↓, cl‑PARP↑, eff↓, lipid-P↑,

1948-

PL,

born,

Natural borneol serves as an adjuvant agent to promote the cellular uptake of piperlongumine for improving its antiglioma efficacy

in-vitro,

GBM,

selectivity↑, ROS↑, BioAv↓, BioAv↑, Apoptosis↑, TumCCA↑, eff↑,

1950-

PL,

Increased Expression of FosB through Reactive Oxygen Species Accumulation Functions as Pro-Apoptotic Protein in Piperlongumine Treated MCF7 Breast Cancer Cells

in-vitro,

BC,

MCF-7

in-vitro,

Lung,

A549

selectivity↑, ROS↑, SETBP1↓, cl‑Casp9↑, eff↓, FOSB↑,

1951-

PL,

Piperlongumine Analogs Promote A549 Cell Apoptosis through Enhancing ROS Generation

in-vitro,

Lung,

A549

ROS↑, lipid-P↑, MMP↓, TumCCA↑, TrxR↓, eff↑,

1952-

PL,

5-FU,

Piperlongumine induces ROS accumulation to reverse resistance of 5-FU in human colorectal cancer via targeting TrxR

in-vivo,

CRC,

HCT8

10uM

mice

ROS↑, TrxR↓, eff↑, p‑Akt↓,

1944-

PL,

Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress

in-vitro,

HCC,

HUH7

0.625, 2.5, 5, 10, 15, 20, 30, 40, and 50 µM

in-vitro,

HCC,

HepG2

ER Stress↑, TrxR1↓, ROS↑, eff↓, Bcl-2↓, proCasp3↓, BAX↓, cl‑Casp3↑, TumCCA↑, p‑PERK↑, ATF4↑, TumCG↓, lipid-P↑, selectivity↑,

1941-

PL,

Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer

in-vitro,

HNSCC,

selectivity↑, eff↑, ROS↑, toxicity↑, GSH↓, GSSG↑, *GSSG∅, cl‑PARP↑, PUMA↑, GSTP1/GSTπ↓, ChemoSen↑,

1939-

PL,

Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP

in-vitro,

HCC,

HepG2

5-20 μM

in-vitro,

HCC,

HUH7

in-vivo,

NA,

(1.5 mg/kg

mice

TumCMig↓, TumCI↓, ER Stress↑, selectivity↑, tumCV↓, ROS↑, GSH↓, eff↓, Ca+2↑, MAPK↑, CHOP↑, Dose↝,

2966-

PL,

A strategy to improve the solubility and bioavailability of the insoluble drug piperlongumine through albumin nanoparticles

in-vitro,

LiverDam,

*Half-Life↑, *BioAv↑, eff↑, ROS↑,

2968-

PL,

Chit,

efficient_cancer_therapy">Preparation of piperlongumine-loaded chitosan nanoparticles for safe and efficient cancer therapy

in-vitro,

GC,

AGS

eff↑, Dose↝, ROS↑, BioAv↑,

2956-

PL,

Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis

in-vitro,

PC,

ROS↑, Ferroptosis↓, GSH↓, GPx↓, cl‑PARP∅, cl‑Casp3∅, eff↑, eff↑,

2964-

PL,

Preformulation Studies on Piperlongumine

Analysis,

Nor,

*BioAv↓, *BioAv↑, *other↝, *eff↓,

2940-

PL,

Piperlongumine Induces Reactive Oxygen Species (ROS)-dependent Downregulation of Specificity Protein Transcription Factors

in-vitro,

PC,

PANC1

 5-15 μM

in-vitro,

Lung,

A549

in-vitro,

Kidney,

786-O

in-vitro,

BC,

SkBr3

ROS↑, TumCP↓, Apoptosis↑, eff↓, Sp1/3/4↓, cycD1/CCND1↓, survivin↓, cMyc↓, EGFR↓, cMET↓,

2943-

PL,

Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin

in-vitro,

CRC,

HCT116

in-vitro,

Lung,

A549

in-vitro,

BC,

MCF-7

TrxR1?, TumCD↑, ROS↑, GSH↓, eff↑,

2944-

PL,

Piperlongumine, a Potent Anticancer Phytotherapeutic, Induces Cell Cycle Arrest and Apoptosis In Vitro and In Vivo through the ROS/Akt Pathway in Human Thyroid Cancer Cells

in-vitro,

Thyroid,

IHH4

 2 and 3 μM

in-vitro,

Thyroid,

8505C

in-vivo,

NA,

10 mg/kg

Nude mice

ROS↑, selectivity↑, tumCV↓, TumCCA↑, Apoptosis↑, ERK↑, Akt↓, mTOR↓, neuroP↑, Bcl-2↓, Casp3↑, PARP↑, JNK↑, *toxicity↓, eff↓, TumW↓,

2946-

PL,

Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent

Review,

Var,

ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp↓, MDR1↓, MRP1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,

2949-

PL,

Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation

in-vitro,

GBM,

LN229

5, 10 and 20 uM

in-vitro,

GBM,

U87MG

selectivity↑, ROS↑, JNK↑, p38↑, GSH↓, eff↓,

2951-

PL,

AF,

Synergistic Dual Targeting of Thioredoxin and Glutathione Systems Irrespective of p53 in Glioblastoma Stem Cells

in-vitro,

GBM,

U87MG

GSH↓, eff↑, GSTP1/GSTπ↓,

2953-

PL,

Piperlongumine Acts as an Immunosuppressant by Exerting Prooxidative Effects in Human T Cells Resulting in Diminished TH17 but Enhanced Treg Differentiation

in-vitro,

Nor,

10 μM PL up to 24 h

nvestigated the <span class="wphighlight">eff</span>ects of PL on the survival and function of primary human peripheral blood T cells (PBTs

*ROS↑, *GSTA1↓, eff↝, *toxicity↓, ROS↑, *Hif1a↓,

2965-

PL,

docx,

Piperlongumine for enhancing oral bioavailability and cytotoxicity of docetaxel in triple negative breast cancer

Analysis,

Var,

BioEnh↑, eff↑,

2962-

PL,

Synthesis of Piperlongumine Analogues and Discovery of Nuclear Factor Erythroid 2‑Related Factor 2 (Nrf2) Activators as Potential Neuroprotective Agents

in-vitro,

Nor,

PC12

*GSH↑, *NQO1↑, *Trx↑, *TrxR↑, *NRF2↑, *NRF2⇅, *eff↑, *BioAv↑, *ROS↓,

2958-

PL,

Natural product piperlongumine inhibits proliferation of oral squamous carcinoma cells by inducing ferroptosis and inhibiting intracellular antioxidant capacity

in-vitro,

Oral,

HSC3

14.71 µM (48 hr),

TumCP↓, lipid-P↑, ROS↑, DNMT1↑, FTH1↓, GPx4↓, eff↓, GSH↓, Ferroptosis↑, MDA↓,

2957-

PL,

Piperlongumine Induces Cell Cycle Arrest via Reactive Oxygen Species Accumulation and IKKβ Suppression in Human Breast Cancer Cells

in-vitro,

BC,

MCF-7

10–40 μM

TumCP↓, TumCMig↓, TumCCA↑, ROS↑, H2O2↑, GSH↓, IKKα↓, NF-kB↓, P21↑, eff↓,

2004-

PLB,

Plumbagin Inhibits Proliferative and Inflammatory Responses of T Cells Independent of ROS Generation But by Modulating Intracellular Thiols

in-vivo,

Var,

5 µM

mice

TumCP↓, TumCG↓, NF-kB↓, ROS↑, GSH↓, eff↓, i-Thiols↓, GSH/GSSG↓, *GSH↓, *ROS↑,

2006-

PLB,

Plumbagin induces apoptosis in human osteosarcoma through ROS generation, endoplasmic reticulum stress and mitochondrial apoptosis pathway

in-vitro,

OS,

MG63

in-vitro,

Nor,

hFOB1.19

tumCV↓, selectivity↑, mtDam↑, Ca+2↓, ER Stress↑, ROS↑, Casp3↑, Casp9↑, Apoptosis↑, eff↓,

2005-

PLB,

Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2)

in-vivo,

Nor,

EL4

mouse

in-vitro,

AML,

Jurkat

JNK↑, Cyt‑c↑, FasL↑, BAX↑, ROS↑, *ROS↑, MKP1↓, MKP2↓, selectivity∅, tumCV↑, Cyt‑c↑, Casp3↑, GSH/GSSG↓, ROS↑, mt-ROS↑, *ROS↑, eff↓,

5163-

PLB,

Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells

in-vitro,

SCC,

SCC25

TumCP↓, NRF2↓, TumCCA↑, EMT↓, CSCs↓, eff↓, ROS↑, CycB/CCNB1↓, CDK1↓, CDK2↓, CDC25↓, Vim↓, OCT4↓, SOX2↓, Nanog↓, BMI1↓, NQO1↓, GSTA1↓, HSP90↓, toxicity↓,

5162-

PLB,

Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells

vitro+vivo,

Melanoma,

A172

 nude mice model

TumCG↓, TumCCA↑, Apoptosis↑, P21↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDC2↓, CDC25↑, Bax:Bcl2↑, Casp9↑, ROS↑, JNK↑, ERK↑, eff↓,

5161-

PLB,

Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells

in-vitro,

SCC,

SCC25

TumCCA↑, Apoptosis↑, TumAuto↑, Bcl-2↓, Bcl-xL↓, BAX↑, PI3K↓, Akt↓, mTOR↓, GSK‐3β↓, MAPK↓, ROS↑, eff↓, CDC2↓, CycB/CCNB1↓, P21↑, p27↑, P53↑, Casp9↑, Casp3↑,

5159-

PLB,

Plumbagin treatment leads to apoptosis in human K562 leukemia cells through increased ROS and elevated TRAIL receptor expression

in-vitro,

AML,

K562

tumCV↓, Apoptosis↑, ROS↑, eff↓, DR4↑, DR5↑, TRAIL↑,

5158-

PLB,

Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells

in-vitro,

Cerv,

ME-180

TumCG↓, ROS↑, Apoptosis↑, MMP↓, DNAdam↑, Cyt‑c↑, AIF↑, Casp3↑, Casp9↑, eff↓,

3917-

PS,

Phosphatidylserine, inflammation, and central nervous system diseases

Review,

AD,

300 mg/day

Review,

Park,

Review,

Stroke,

*Inflam↓, *neuroP↑, *cognitive↑, *Choline↑, *IL1β↓, *IL6↓, *TNF-α↓, *Ach↑, *eff↑, *eff↑, *BioEnh↑, other↑,

3916-

PS,

The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study

Human,

AD,

12 weeks to 30 elderly volunteers

*memory↑, *cognitive↑, *BP↓, *Dose↝, *eff↑,

4965-

PSO,

Cisplatin,

The synergistic antitumor effects of psoralidin and cisplatin in gastric cancer by inducing ACSL4-mediated ferroptosis

vitro+vivo,

GC,

HGC27

2.5 to 120 µM)

Xenograft experiments in nude mice

vitro+vivo,

GC,

MKN45

TumCP↓, TumCMig↓, TumCI↓, TumCG↓, *toxicity↓, eff↑, Ferroptosis↑, ACSL4↑, GPx4↓, ChemoSen↑, chemoP↑, AntiTum↑, Sepsis↓,

1996-

PTL,

Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells

in-vitro,

CRC,

COLO205

Apoptosis↑, GSH↓, ROS↑, Ca+2↑, GRP78/BiP↑, ER Stress↑, eff↓, eff↑, Thiols↓,

1984-

PTL,

Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells

in-vitro,

Cerv,

HeLa

 ∼3 μm

AntiCan↑, TrxR1↓, TrxR2↓, ROS↑, Apoptosis↑, eff↓, eff↑,

1986-

PTL,

Modulation of Cell Surface Protein Free Thiols: A Potential Novel Mechanism of Action of the Sesquiterpene Lactone Parthenolide

in-vitro,

NA,

JNK↑, ROS↑, eff↓, NF-kB↓, Trx↓,

1989-

PTL,

Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties

Review,

Var,

eff↑, NF-kB↓, STAT↓, ROS↑, Inflam↓, Wnt↓, TCF-4↓, LEF1↓, GSH↓, MMP↓, Casp↑, eff↓, CSCs↓,

1990-

PTL,

Parthenolide alleviates cognitive dysfunction and neurotoxicity via regulation of AMPK/GSK3β(Ser9)/Nrf2 signaling pathway

in-vitro,

AD,

PC12

*Apoptosis↓, *ROS↓, *MMP↓, *memory↑, *eff↑,

1992-

PTL,

Parthenolide induces ROS-dependent cell death in human gastric cancer cell

in-vitro,

BC,

MGC803

TumCCA↑, Casp↑, Apoptosis↑, Necroptosis↑, RIP1↓, RIP3↑, MLKL↑, ROS↑, eff↓,

1994-

PTL,

Parthenolide Inhibits Tumor Cell Growth and Metastasis in Melanoma A2058 Cells

in-vitro,

Melanoma,

A2058

20uM

in-vitro,

Nor,

L929

27uM

tumCV↓, selectivity?, ROS?, BAX↑, TumCCA?, MMP2↓, MMP9↓, TumCMig↓, eff↑,

1983-

PTL,

Targeting thioredoxin reductase by micheliolide contributes to radiosensitizing and inducing apoptosis of HeLa cells

in-vitro,

Cerv,

HeLa

eff↑, TrxR↓, ROS↑, RadioS↑,

5032-

PTS,

Pterostilbene Decreases the Antioxidant Defenses of Aggressive Cancer Cells In Vivo: A Physiological Glucocorticoids- and Nrf2-Dependent Mechanism

in-vivo,

Melanoma,

melanomas), growing in nude mice as xenografts,

TumCG↓, NRF2↓, GR↓, BBB↑, ACTH↓, eff↑,

4703-

PTS,

RES,

Pterostilbene and resveratrol: Exploring their protective mechanisms against skin photoaging - A scoping review

NA,

Nor,

*AntiAge↑, *eff↑, *Inflam↓, *AntiCan↑, *ROS↓, *Catalase↑, *GSR↑, *HO-1↑, *NAD↑, *NQO1↑, *SOD↑, *NRF2↑,

4690-

PTS,

immuno,

Pterostilbene: Mechanisms of its action as oncostatic agent in cell models and in vivo studies

Review,

Var,

eff↑, Half-Life↑, TumCG↓, TumMeta↓, angioG↓, CSCs↓, Apoptosis↑, eff↑, CD44↓, CD24↓,

4689-

PTS,

Pterostilbene Suppresses both Cancer Cells and Cancer Stem-Like Cells in Cervical Cancer with Superior Bioavailability to Resveratrol

eff↑, TumCCA↑, ROS↑, MMP2↓, MMP9↓, CSCs↓, CD133↓, OCT4↓, SOX2↓, Nanog↓, STAT3↓, BioAv↑, TumCI↓, ROS↑, Apoptosis↑,

3607-

QC,

Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More

Review,

AD,

Review,

Park,

*neuroP↑, *NRF2↑, *PONs↑, *antiOx↑, *Inflam↓, *SIRT1↑, *eff↑, *ROS↓, *cognitive↑, *eff↑, *lipid-P↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑,

3611-

QC,

Quercetin and vitamin C supplementation: effects on lipid profile and muscle damage in male athletes

Trial,

Nor,

60 males for eight weeks

*eff↝, *LDH↓,

3380-

QC,

Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases

Review,

Var,

Review,

Park,

Review,

AD,

JAK↓, STAT↓, Inflam↓, NO↓, COX2↓, CRP↓, selectivity↑, *neuroP↑, STAT3↓, cycD1/CCND1↓, MMP2↓, STAT4↓, JAK2↓, TumCP↓, Diff↓, *eff↑, *IL6↓, *TNF-α↓, *IL1β↓, *Aβ↓,

3347-

QC,

Recent Advances in Potential Health Benefits of Quercetin

Review,

Var,

Review,

AD,

*antiOx↑, *ROS↓, *Inflam↓, TumCP↓, Apoptosis↑, *cardioP↑, *BP↓, TumMeta↓, MDR1↓, NADPH↓, ChemoSen↑, MMPs↓, TIMP2↑, *NLRP3↓, *IFN-γ↑, *COX2↓, *NF-kB↓, *MAPK↓, *CRP↓, *IL6↓, *TNF-α↓, *IL1β↓, *TLR4↑, *PKCδ↓, *AP-1↓, *ICAM-1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *neuroP↑, *eff↑, *memory↑, *cognitive↑, *AChE↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑,

3343-

QC,

Quercetin, a Flavonoid with Great Pharmacological Capacity

Review,

Var,

Review,

AD,

Review,

Arthritis,

*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, eff↑, P-gp↓, eff↑, eff↑, eff↑, eff↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,

3368-

QC,

The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update

Review,

Var,

*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, eff↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, eff↑, eff↑, eff↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,

3376-

QC,

Inhibiting CDK6 Activity by Quercetin Is an Attractive Strategy for Cancer Therapy

in-vitro,

BC,

MCF-7

in-vitro,

Lung,

A549

CDK6↓, tumCV↓, Apoptosis↑, ROS↓, eff↑,

4686-

QC,

Quercetin suppresses endometrial cancer stem cells via ERα-mediated inhibition of STAT3 signaling

in-vitro,

EC,

EMN8

in-vitro,

EC,

EMN21

CSCs↓, ALDH1A1↓, cMyc↓, Nanog↓, OCT4↓, STAT3↓, JAK2↓, STAT3↓, eff↑,

4827-

QC,

CUR,

Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin

Review,

Var,

*AntiCan↑, *Inflam↓, *Bacteria↓, *AntiDiabetic↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *NRF2↑, *Trx↑, *IronCh↑, *MDA↑, cycD1/CCND1↓, PI3K↓, Casp3↑, BAX↑, ChemoSen↑, ROS↑, eff↑, MMP↓, Cyt‑c↑, Akt↓, ERK↓,

5030-

QC,

Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy

in-vivo,

Nor,

*MitoP↑, *NRF2↑, eff↑, *eff↓, *GutMicro↑,

39-

QC,

A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells

Analysis,

NA,

ROS↑, GSH↓, IL6↓, COX2↓, IL8↓, iNOS↓, TNF-α↓, MAPK↑, ERK↑, SOD↑, ATP↓, Casp↑, PI3K/Akt↓, mTOR↓, NOTCH1↓, Bcl-2↓, BAX↑, IFN-γ↓, TumCP↓, TumCCA↑, Akt↓, P70S6K↓, *Keap1↓, *GPx↑, *Catalase↑, *HO-1↑, *NRF2↑, NRF2↑, eff↑, HIF-1↓,

41-

QC,

Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft

vitro+vivo,

AML,

HL-60

Casp8↑, Casp9↑, Casp3↑, ROS↑, ERK↑, cl‑PARP↑, MMP↓, eff↓,

50-

QC,

Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer

vitro+vivo,

Ovarian,

A2780S

Casp3↑, Casp9↑, Mcl-1↓, Bcl-2↓, BAX↑, angioG↓, TumCG↓, Apoptosis↑, p‑p44↓, Akt↓, TumCP↓, eff↑,

97-

QC,

HPT,

Effects of the flavonoid drug Quercetin on the response of human prostate tumours to hyperthermia in vitro and in vivo

in-vitro,

Pca,

PC3

 0-400 uM; 150mg/kg/day

HSP72↑, TumCG↓, eff↑, ChemoSen↑, RadioS↑,

94-

QC,

HPT,

Effects of quercetin on the heat-induced cytotoxicity of prostate cancer cells

in-vitro,

Pca,

LNCaP

 12.5, 25, 50, 100 umol/L

in-vitro,

Pca,

PC3

in-vitro,

Pca,

JCA-1

HSP70/HSPA5↓, TumCCA↑, TumCG↓, eff↑,

81-

QC,

EGCG,

Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea

in-vivo,

Pca,

 0.2%, 0.4%

COMT↓, MRP1↓, Ki-67↓, Bax:Bcl2↑, AR↓, Akt↓, p‑ERK↓, COMT↓, eff↑, chemoPv↑, BioAv↑,

75-

QC,

ENZ,

Quercetin targets hnRNPA1 to overcome enzalutamide resistance in prostate cancer cells

in-vitro,

Pca,

HEK293

 2.5, 5, 10, 20, 50 umol/L

in-vitro,

NA,

22Rv1

 22Rv1-Enza-R

in-vitro,

NA,

C4-2B

 C4-2B-Enza-R

hnRNPA1↓, PSA↓, NKX3.1↓, FKBP5↓, UBE2C↓, AR-FL↓, AR-V7↑, AR↓, eff↑, TumVol↓, BioAv↓,

77-

QC,

EGCG,

The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition

in-vitro,

Pca,

CD44+

 20 uM

 CD44+ and CD133+ CSCs can be isolated from PC-3 and LNCaP

in-vitro,

NA,

CD133+

in-vitro,

NA,

PC3

in-vitro,

NA,

LNCaP

Casp3↑, Casp7↑, Bcl-2↓, survivin↓, XIAP↓, EMT↓, Vim↓, Slug↓, Snail↓, β-catenin/ZEB1↓, LEF1↓, TCF↓, eff↑, CSCs↓, TumCG↓, tumCV↓,

2340-

QC,

Oral Squamous Cell Carcinoma Cells with Acquired Resistance to Erlotinib Are Sensitive to Anti-Cancer Effect of Quercetin via Pyruvate Kinase M2 (PKM2)

in-vitro,

OS,

TumCG↓, GlucoseCon↓, TumCI↓, GLUT1↓, PKM2↓, LDHA↓, Glycolysis↓, lactateProd↓, HK2↓, eff↑,

2341-

QC,

Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction

in-vitro,

BC,

MCF-7

30Î¼M

in-vitro,

BC,

MDA-MB-231

in-vivo,

NA,

intraperitoneally injected with 50 mg/kg quercetin twice daily for a
month

mice

MMP2↓, MMP9↓, VEGF↓, Glycolysis↓, lactateProd↓, PKM2↓, GLUT1↓, LDHA↓, TumAuto↑, Akt↓, mTOR↓, TumMeta↓, MMP3↓, eff↓, GlucoseCon↓, lactateProd↓, TumAuto↑, LC3B-II↑,

4666-

RES,

Structural modification of resveratrol analogue exhibits anticancer activity against lung cancer stem cells via suppression of Akt signaling pathway

in-vitro,

Lung,

H23

in-vitro,

Lung,

H292

in-vitro,

Lung,

A549

CSCs↓, eff↑, Akt↓, GSK‐3β↑, SOX2↓, cMyc↓, TumCCA↑, ROS↑, Apoptosis↑,

4662-

RES,

A Promising Resveratrol Analogue Suppresses CSCs in Non-Small-Cell Lung Cancer via Inhibition of the ErbB2 Signaling Pathway

in-vitro,

NSCLC,

A549

 25 and 50 μM

in-vitro,

NSCLC,

H460

CSCs↓, CD133↓, OCT4↓, β-catenin/ZEB1↓, HER2/EBBR2↓, TumCP↓, PI3K↓, Akt↓, ALDH1A1↓, eff↑,

2687-

RES,

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

Review,

NA,

Review,

AD,

NF-kB↓, P450↓, COX2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, eff↑, HK2↓, ROS↑, MMP↓,

2442-

RES,

High absorption but very low bioavailability of oral resveratrol in humans

in-vitro,

Nor,

BioAv↝, Half-Life↝, BioAv↓, eff↝,

2441-

RES,

Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions

Review,

Var,

*toxicity↓, *BioAv↝, *Dose↝, *hepatoP↑, *neuroP↑, *AntiAg↑, *COX2↓, *antiOx↑, *ROS↓, *ROS↑, PI3K↓, Akt↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, NRF2↑, GPx↑, HO-1↑, BioEnh?, PTEN↑, ChemoSen↑, eff↑, mt-ROS↑, Warburg↓, Glycolysis↓, GlucoseCon↓, GLUT1↓, lactateProd↓, HK2↓, EGFR↓, cMyc↓, ROS↝, MMPs↓, MMP7↓, survivin↓, TumCP↓, TumCMig↓, TumCI↓,

2567-

RES,

Neuroprotective Effects of Resveratrol in Ischemic Brain Injury

Review,

Stroke,

*eff↑, *neuroP↑, *antiOx↑, *Inflam↓, *cardioP↑, *AntiAg↑,

2566-

RES,

A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke

Review,

Stroke,

*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,

3079-

RES,

Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action

Review,

Var,

angioG↓, TumMeta↓, ChemoSen↑, NADPH↑, SIRT1↑, NF-kB↓, NLRP3↓, Dose↝, COX2↓, MMP9↓, PGE2↓, TIMP1↑, TIMP2↑, Sp1/3/4↓, p‑JNK↓, uPAR↓, ROS↓, CXCR4↓, IL6↓, Gli1↓, *ROS↓, *GSTs↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *GSH↑, eff↑, eff↑, eff↑,

3087-

RES,

Resveratrol cytotoxicity is energy-dependent

Review,

Var,

OXPHOS↓, eff↝, eff↑,

3092-

RES,

Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action

Review,

BC,

MDA-MB-231

Review,

BC,

MCF-7

TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, eff↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,

3052-

RES,

Resveratrol-Induced Downregulation of NAF-1 Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine via the ROS/Nrf2 Signaling Pathways

in-vitro,

PC,

PANC1

0, 25, 50, 100, and 200 μM) for 24 h, 48 h, and 72 h,

in-vitro,

PC,

MIA PaCa-2

in-vitro,

PC,

Bxpc-3

NAF1↓, ROS↑, NRF2↑, eff↑, TumCG↓,

3055-

RES,

Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets

Review,

Var,

BioAv↓, BioAv↓, Dose↑, eff↑, eff↑, Dose↑, BioAv↑, ROS↑, MMP↓, P21↑, p27↑, TumCCA↑, ChemoSen↑, COX2↓, 5LO↓, VEGF↓, IL1↓, IL6↓, IL8↓, AR↓, PSA↓, MAPK↓, Hif1a↓, Glycolysis↓, miR-21↓, PTEN↑, Half-Life↝, *IGF-1↓, *IGFBP3↑, Half-Life↓,

2991-

RES,

Chemo,

Synergistic anti-cancer effects of resveratrol and chemotherapeutic agent clofarabine against human malignant mesothelioma MSTO-211H cells

in-vitro,

Melanoma,

MSTO-211H

in-vitro,

Nor,

MeT5A

eff↑, selectivity↑, Sp1/3/4↓,

1511-

RES,

Chemo,

Combination therapy in combating cancer

Review,

NA,

eff↑, *NRF2↑, *GSH↑, *ROS↓, chemoPv↑, ChemoSideEff↓,

1391-

RES,

BBR,

Effects of Resveratrol, Berberine and Their Combinations on Reactive Oxygen Species, Survival and Apoptosis in Human Squamous Carcinoma (SCC-25) Cells

in-vitro,

Tong,

SCC25

10μg/ml each

ROS↑, eff↑,

3461-

RF,

Electromagnetic Field Stimulation Therapy for Alzheimer’s Disease

Review,

AD,

Repeated Electromagnetic Field Stimulation (REMFS) at 50 MHz is 2.0678–7 eV, at 64 MHz it is 2.64–7 eV, and at 915 MHz it is 3.7841–6 eV;

*Aβ↓, *HSF1↑, *ROS↓, *Inflam↓, *cognitive↑, *memory↑, *eff↑,

3490-

RF,

Multidimensional insights into the repeated electromagnetic field stimulation and biosystems interaction in aging and age-related diseases

Review,

AD,

Review,

Park,

*OS↑, *memory↑, *cognitive↑, *memory↑, *Aβ↓, *eff↑, *HSF1↑, *HSP70/HSPA5↑,

4357-

RF,

Targeted treatment of cancer with radiofrequency electromagnetic fields amplitude-modulated at tumor-specific frequencies

Review,

Var,

other↝, Dose↝, AntiTum↑, Ca+2↝, eff↝,

1749-

RosA,

Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer

Review,

Var,

antiOx↑, eff↑, *toxicity↝, *BioAv↑, *ROS↓, SOD↑, Catalase↑, GPx↑, lipid-P↓, P450↓, chemoP↑, hepatoP↑, ChemoSen↑,

1747-

RosA,

Molecular Pathways of Rosmarinic Acid Anticancer Activity in Triple-Negative Breast Cancer Cells: A Literature Review

Review,

BC,

MDA-MB-231

Review,

BC,

MDA-MB-468

TumCCA↑, TNF-α↑, GADD45A↑, BNIP3↑, survivin↓, Bcl-2↓, BAX↑, HH↓, eff↑, ChemoSen↑, RadioS↑, TumCP↓, TumCMig↓, Apoptosis↑, RenoP↑, CardioT↓,

1744-

RosA,

Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity

Review,

Var,

chemoR↓, ChemoSideEff↓, RadioS↑, ROS↓, ChemoSen↑, BioAv↑, Half-Life↝, antiOx↑, ROS↑, Fenton↑, DNAdam↑, Apoptosis↑, CSCs↓, HH↓, Bax:Bcl2↑, MDR1↓, P-gp↓, eff↑, eff↑, FOXO4↑, *eff↑, *ROS↓, *JNK↓, *ERK↓, *GSH↑, *H2O2↑, *MDA↓, *SOD↑, *HO-1↑, *CardioT↓, selectivity↑,

1743-

RosA,

New insights into the competition between antioxidant activities and pro-oxidant risks of rosmarinic acid

Analysis,

Var,

ROS↑, Fenton↑, eff↑, antiOx↑, Iron↓, ROS↑,

1742-

RosA,

Rosmarinic acid, a natural polyphenol, has a potential pro-oxidant risk via NADH-mediated oxidative DNA damage

Analysis,

Var,

ROS↑, eff↑, eff↑, eff↑, eff↑, eff↓, Dose↝, Dose↝,

3021-

RosA,

Rosmarinic acid ameliorates septic-associated mortality and lung injury in mice via GRP78/IRE1α/JNK pathway

in-vivo,

Sepsis,

mice

*eff↑, *SOD↑, *MDA↓, *GRP78/BiP↓, *IRE1↓, *JNK↓, *Sepsis↓,

3007-

RosA,

Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action

Review,

NA,

*ROS↓, *lipid-P↓, *Inflam↓, *neuroP↑, *angioG↓, *eff↑, *AST↓, *ALAT↓, *GSSG↓, *eNOS↓, *iNOS↓, *NO↓, *NF-kB↓, *MMP2↓, *MDA↓, *TNF-α↓, *GSH↑, *SOD↑, *IL6↓, *PGE2↓, *COX2↓, *mTOR↑,

3005-

RosA,

Nanoformulated rosemary extract impact on oral cancer: in vitro study

in-vitro,

Laryn,

HEp2

TumCCA↑, ROS↑, Bcl-2↓, BAX↑, Casp3↑, P53↑, necrosis↑, eff↑, BioAv↑,

3002-

RosA,

Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols

Review,

Var,

TumCG↓, TumCP↓, TumCCA↑, ChemoSen↑, NRF2↑, PERK↑, SESN2↑, HO-1↑, cl‑Casp3↑, ROS↑, UPR↑, ER Stress↑, CHOP↑, HER2/EBBR2↓, ER-α36↓, PSA↓, BAX↑, AR↓, P-gp↓, Cyt‑c↑, HSP70/HSPA5↑, eff↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, cl‑PARP↑, eff↑,

3034-

RosA,

RES,

Ba,

The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells

in-vitro,

BC,

MCF-7

DNMTs↓, eff↑, eff↝,

3028-

RosA,

Network pharmacology mechanism of Rosmarinus officinalis L.(Rosemary) to improve cell viability and reduces apoptosis in treating Alzheimer’s disease

in-vitro,

AD,

HT22

in-vivo,

NA,

*Aβ↓, *Apoptosis↓, *antiOx↑, *neuroP↑, *eff↑, *IGF-1↑, *MMP9↑, *Src↓, *MAPK↓, *MMP↑,

4899-

Sal,

Anticancer activity of salinomycin quaternary phosphonium salts

in-vitro,

Var,

eff↑, selectivity↑, CSCs↓, TumCCA↑, MMP↓, ROS↑, mitResp↑,

4900-

Sal,

Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications

Review,

BC,

CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27↑, CHOP↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,

4902-

Sal,

OXA,

Salinomycin and oxaliplatin synergistically enhances cytotoxic effect on human colorectal cancer cells in vitro and in vivo

vitro+vivo,

CRC,

RadioS↑, ChemoSen↑, TumCP↓, Apoptosis↑, ROS↑, MMP↓, MAPK↑, eff↓, TumCG↓, TumCCA↑,

5004-

Sal,

Targeting Telomerase Enhances Cytotoxicity of Salinomycin in Cancer Cells

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

eff↑, AntiCan↑, CSCs↑, Wnt↓, β-catenin/ZEB1↓, Diff↑, ROS↑, toxicity↝, selectivity↝, eff↑,

5003-

Sal,

Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review

Review,

Var,

CSCs↓, TumAuto↑, selectivity↑, DNAdam↑, TumCCA↑, P-gp↓, Wnt↓, β-catenin/ZEB1↓, RadioS↑, ChemoSen↑, Shh↓, eff↓, ROS↑, AMPK↑, JNK↑, ER Stress↑,

5000-

Sal,

Salinomycin kills cancer stem cells by sequestering iron in lysosomes

vitro+vivo,

BC,

CSCsMark↓, eff↑, Ferroptosis↑, ROS↑,

4904-

Sal,

CUR,

Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial–Mesenchymal Transition

CSCs↓, TumCCA↑, EMT↓, other↝, TumAuto↑, Iron↑, Ferroptosis↑, BioAv↓, ROS↑, lipid-P↑, GPx4↓, eff↑,

4906-

Sal,

A Concise Review of Prodigious Salinomycin and Its Derivatives Effective in Treatment of Breast Cancer: (2012–2022)

Review,

BC,

CSCs↓, Casp3↑, cl‑PARP↝, Apoptosis↑, ROS↑, ABC↓, OXPHOS↓, Glycolysis↓, eff↑, TumAuto↑, DNAdam↑, Wnt↓, Ferritin↓, Iron↑,

4908-

Sal,

Salinomycin triggers prostate cancer cell apoptosis by inducing oxidative and endoplasmic reticulum stress via suppressing Nrf2 signaling

in-vitro,

Pca,

PC3

0, 2, 5, 10, 20 and 50 µM

in-vitro,

Pca,

DU145

tumCV↓, ROS↑, lipid-P↑, UPR↑, ER Stress↑, NRF2↓, NADPH↓, HO-1↓, SOD↓, Catalase↓, GPx↓, eff↓, TumCP↓,

5042-

SAS,

xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling

Review,

Var,

xCT↓, GSH↓, TumCG↓, TumCI↓, ROS↑, RadioS↑, eff↓,

5041-

SAS,

Cisplatin,

Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism

in-vitro,

CRC,

xCT↓, Inflam↓, Apoptosis↓, GSH↓, ROS↑, TumCG↓, selectivity↑, eff↑, eff↓,

5138-

SAS,

Rad,

Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc-, leading to glutathione depletion

vitro+vivo,

GBM,

cystine↓, GSH↓, ROS↑, RadioS↑, eff↓, DNAdam↑, OS↑,

5036-

SAS,

Targeting xCT with sulfasalazine suppresses triple-negative breast cancer growth via inducing autophagy and coordinating cell cycle and proliferation

vitro+vivo,

BC,

MDA-MB-231

in-vitro,

BC,

MDA-MB-468

xCT↓, GSH↓, OS↑, Myc↓, CDK1↓, CD44↓, eff↑, TumCG↓,

1388-

Sco,

Scoulerine promotes cell viability reduction and apoptosis by activating ROS-dependent endoplasmic reticulum stress in colorectal cancer cells

in-vitro,

CRC,

tumCV↓, Apoptosis↑, Casp3↑, Casp7↑, BAX↑, Bcl-2↓, ROS↑, GSH↓, SOD↓, ER Stress↑, GRP78/BiP↑, CHOP↑, eff↓,

1403-

SDT,

BBR,

From 2D to 3D In Vitro World: Sonodynamically-Induced Prooxidant Proapoptotic Effects of C60-Berberine Nanocomplex on Cancer Cells

in-vitro,

Cerv,

HeLa

 1 MHz, 1 W/cm2 US and  20 µM C60-Ber for 24 h

in-vitro,

Lung,

LLC1

eff↑, tumCV↓, ATP↓, ROS↑, Casp3↑, Casp7↑, mtDam↑,

2549-

SDT,

Landscape of Cellular Bioeffects Triggered by Ultrasound-Induced Sonoporation

Review,

Var,

sonoP↑, tumCV↓, MMP↓, ROS↑, Ca+2↑, eff↝, eff↑, selectivity↑, Half-Life↝, Dose↝, P-gp↓, ER Stress↑, other↑,

2536-

SDT,

Sonodynamic Therapy: Rapid Progress and New Opportunities for Non-Invasive Tumor Cell Killing with Sound

Review,

Var,

ROS↑, eff↑, Dose?,

2537-

SDT,

Design and Challenges of Sonodynamic Therapy System for Cancer Theranostics: From Equipment to Sensitizers

Review,

Var,

Dose↝, eff↑, eff↑, eff↑, eff↑,

2548-

SDT,

Sonoporation, a Novel Frontier for Cancer Treatment: A Review of the Literature

Review,

Var,

sonoP↑, Dose↝, eff↓, Dose↝, BioEnh↑, toxicity↝,

2140-

Se,

Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression

Review,

Var,

Risk↓, antiOx↑, eff↑, eff↝,

1702-

Se,

Supplemental Selenium May Decrease Ovarian Cancer Risk in African-American Women

Human,

Ovarian,

Risk↓, eff∅,

1699-

Se,

Vegetarianism and colorectal cancer risk in a low-selenium environment: effect modification by selenium status? A possible factor contributing to the null results in British vegetarians

Analysis,

CRC,

Dose↑, eff↓, Dose↓,

1689-

Se,

Selenium and breast cancer - An update of clinical and epidemiological data

Analysis,

BC,

OS↑, eff↑, Dose∅, *toxicity↝, eff↑,

4483-

Se,

Chit,

Anti-cancer potential of chitosan-starch selenium Nanocomposite: Targeting osteoblastoma and insights of molecular docking

in-vitro,

OS,

AntiCan↑, TumCP↓, Apoptosis↑, ROS↑, eff↑, other↝, eff↑, TumCCA↑,

4488-

Se,

Chit,

PEG,

Anticancer effect of selenium/chitosan/polyethylene glycol/allyl isothiocyanate nanocomposites against diethylnitrosamine-induced liver cancer in rats

in-vivo,

Liver,

HepG2

 size ranging from 390 to 450 nm

diethylnitrosamine (DEN)-induced liver cancer in rats

in-vivo,

Nor,

HL7702

tumCV↓, Apoptosis↑, *GSH↑, *VitC↑, *VitE↑, *SOD↑, *GPx↑, *GR↑, ALAT↓, ALP↓, AST↓, LDH↓, selectivity↑, eff↑,

4726-

Se,

Oxy,

Oxygen therapy accelerates apoptosis induced by selenium compounds via regulating Nrf2/MAPK signaling pathway in hepatocellular carcinoma

in-vivo,

HCC,

tumor-bearing mice

eff↝, NRF2↓, p‑p38↑, Apoptosis↑, eff↑, TumVol↓, other↝, toxicity↓, Dose↝, NRF2↝, HO-1↓, Catalase↓, SOD↓, e-pH↓, pH∅, MAPK↑, eff↑,

4717-

Se,

A systematic review of Selenium as a complementary treatment in cancer patients

Review,

Var,

*antiOx↑, eff↝, radioP↑, chemoP↑, *selenoP↑, *GPx↑, TrxR↑, *ROS↓,

4713-

Se,

VitC,

VitK3,

Selenium supplementation protects cancer cells from the oxidative stress and cytotoxicity induced by the combination of ascorbate and menadione sodium bisulfite

in-vitro,

GBM,

eff↓,

4714-

Se,

SSE,

SeNPs,

Selenium in cancer management: exploring the therapeutic potential

Review,

Var,

Risk↓, *BioAv↑, eff↝, *ROS↓, MMP↓, ROS↑, P53↑, *toxicity↓, TumCP↓, Casp↑, Apoptosis↑,

4715-

Se,

The Interaction of Selenium with Chemotherapy and Radiation on Normal and Malignant Human Mononuclear Blood Cells

chemoP↑, radioP↑, selectivity↑, ChemoSen↑, GSH↓, *GSH↑, *DNAdam↓, DNAdam↑, eff↑,

4722-

Se,

The Yin and Yang of Nrf2-Regulated Selenoproteins in Carcinogenesis

Review,

Var,

Risk↓, *NRF2↓, NRF2↑, *NRF2↓, OS↑, eff↝, eff↝, NRF2↝,

4721-

SeNPs,

A review on selenium nanoparticles and their biomedical applications

Review,

AD,

Review,

Diabetic,

Review,

Arthritis,

*antiOx↑, *Inflam↓, *eff↝, *selenoP↑, *Bacteria↓, *neuroP↑, *ROS↓, ChemoSen↑,

4612-

SeNPs,

Rad,

Histopathological Evaluation of Radioprotective Effects: Selenium Nanoparticles Protect Lung Tissue from Radiation Damage

in-vivo,

Nor,

30 male Wistar rats

*radioP↑, *Inflam↓, *antiOx↑, *Dose↝, *DNAdam↓, *ROS↓, *SOD↑, *GPx↑, *Dose↝, *eff↑,

4608-

SeNPs,

Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

Review,

Var,

NA,

AD,

*toxicity↝, *toxicity↓, *other↝, ROS↑, *Dose↝, *selenoP↑, AntiCan↑, AntiTum↑, *Bacteria↓, *radioP↑, *BioAv↑, *Inflam↓, *Imm↑, ChemoSen↑, *AntiAg↑, selectivity↑, eff↑, other↝, *eff↑, *Aβ↓, *eff↑,

4607-

SeNPs,

AgNPs,

A Review on synthesis and their antibacterial activity of Silver and Selenium nanoparticles against biofilm forming Staphylococcus aureus

Review,

NA,

*Bacteria↓, *eff↑, ROS↑, *Dose↝, *eff↑, toxicity↝, *Sepsis↓, *other↝, eff↑,

4603-

SeNPs,

Therapeutic applications of selenium nanoparticles

Review,

Var,

AntiCan↑, Imm↑, *AntiDiabetic↑, *antiOx↑, *Inflam↓, ROS↑, ER Stress↑, DNAdam↑, *toxicity↓, *eff↑, *BioAv↑, selectivity↑, TumCCA↑, Risk↓, *lipid-P↓, *TNF-α↓, *CRP↓, TumMeta↓, angioG↓, selectivity↑, eff↑, *eff↑,

4459-

SeNPs,

VitC,

SSE,

Nano and mesosized selenium and its synthesis using the ascorbic acid route

*eff↑, *Dose↝, *Dose↝,

4464-

SeNPs,

Antioxidant Properties of Selenium Nanoparticles Synthesized Using Tea and Herb Water Extracts

Study,

NA,

*eff↑, *eff↝,

4465-

SeNPs,

VitC,

Selenium nanoparticles: Synthesis, in-vitro cytotoxicity, antioxidant activity and interaction studies with ct-DNA and HSA, HHb and Cyt c serum proteins

Study,

NA,

 average size of Nano-selenium is 146 nm

*other↝, *eff↑, AntiCan↑, *Dose↝, *BioAv↑, *other↝,

4469-

SeNPs,

Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential

Review,

Var,

antiOx↑, selectivity↑, eff↑, AntiCan↑, Apoptosis↑, ROS↑, MMP↓, Casp3↑, Casp9↑, AntiTum↑, TumCG↓, TumMeta↓, angioG↓, Cyt‑c↑, DNAdam↑, RadioS↑, BBB↑, *toxicity↓, ChemoSen↑,

4470-

SeNPs,

Chit,

Synthesis and cytotoxic activities of selenium nanoparticles incorporated nano-chitosan

in-vitro,

CRC,

HCT116

in-vitro,

Liver,

HepG2

in-vitro,

BC,

MCF-7

Dose↝, AntiCan↑, eff↑,

4471-

SeNPs,

Green synthesis of selenium nanoparticles with extract of hawthorn fruit induced HepG2 cells apoptosis

in-vitro,

Liver,

HepG2

stable SeNPs were prepared with an average size of 113 nm

eff↑, ROS↑, MMP↓, Casp9↑, Bcl-2↓, selectivity↑, Apoptosis↑,

4472-

SeNPs,

Therapeutic potential of selenium nanoparticles

Review,

Var,

*ROS↓, *BioAv↑, *antiOx↑, toxicity↓, eff↑, *other↝, EPR↑, selectivity↑, eff↑, RadioS↑, eff↑, *Bacteria↓,

4453-

SeNPs,

Selenium Nanoparticles: Green Synthesis and Biomedical Application

Review,

NA,

*toxicity↓, *Bacteria↓, ROS↑, MMP↓, ER Stress↑, P53↑, Apoptosis↑, Casp9↑, DNAdam↑, TumCCA↑, eff↑, Catalase↓, SOD↓, GSH↓, selectivity↓, selectivity↑, PCNA↓, eff↑, *ALAT↓, *AST↓, *ALP↓, *creat↓, *Inflam↓, *toxicity↓, selectivity↑,

4457-

SeNPs,

Selenium nanoparticles: a review on synthesis and biomedical applications

Review,

Var,

NA,

Diabetic,

*BioAv↑, *toxicity↓, *eff↑, chemoPv↑, *Inflam↓, antiOx↑, *selenoP↑, *ROS↓, *Dose↝, AntiCan↑, *Bacteria↓, eff↑, DNAdam↑, selectivity↑, *eff↑,

4458-

SeNPs,

Selenium Nanoparticles for Antioxidant Activity and Selenium Enrichment in Plants

*Dose↝, *eff↑, *Dose↝,

3198-

SFN,

Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells

in-vitro,

Pca,

Nanog↓, SOX2↓, E-cadherin↓, Snail↓, VEGFR2↓, Diff↓, TumCMig↓, EMT↓, CXCR4↓, NOTCH1↓, ALDH1A1↓, CSCs↓, eff↑,

2556-

SFN,

The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review

Review,

Var,

chemoPv↑, HDAC↓, Hif1a↓, angioG↓, CYP1A1↓, eff↑, BioAv↑,

1459-

SFN,

AF,

Auranofin Enhances Sulforaphane-Mediated Apoptosis in Hepatocellular Carcinoma Hep3B Cells through Inactivation of the PI3K/Akt Signaling Pathway

in-vitro,

Liver,

Hep3B

 auranofin (0.5, 1, 1.5, and 2 μM) or sulforaphane (2.5, 5, 7.5, and 10 μM)

in-vitro,

Liver,

HepG2

eff↑, TumCCA↑, Apoptosis↑, MMP↓, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, ROS↑, eff↓, PI3K↓, Akt↓, TrxR↓, BAX↑, Bcl-2∅,

1471-

SFN,

ROS-mediated activation of AMPK plays a critical role in sulforaphane-induced apoptosis and mitotic arrest in AGS human gastric cancer cells

in-vitro,

GC,

AGS

TumCP↓, Apoptosis↑, TumCCA↑, CycB/CCNB1↑, P21↑, p‑H3↑, p‑AMPK↑, eff↓, MMP↓, Cyt‑c↑, ROS↑, eff↓,

1470-

SFN,

Rad,

Sulforaphane induces ROS mediated induction of NKG2D ligands in human cancer cell lines and enhances susceptibility to NK cell mediated lysis

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

in-vitro,

Lung,

A549

in-vitro,

lymphoma,

U937

eff↓, ROS↑, NKG2D↑,

1469-

SFN,

Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis

in-vitro,

Pca,

PC3

in-vitro,

Pca,

LNCaP

in-vivo,

Pca,

orthotopically implanted PC-3 tumors

eff↑, ROS↑, MMP↓, Casp3↑, Casp9↑, DR4↑, DR5↑, BAX↑, Bak↑, BIM↑, NOXA↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, eff↓, TumCG↓, TumCP↓, eff↑, NF-kB↓, PI3K↓, Akt↓, MEK↓, ERK↓, angioG↓, FOXO3↑,

1467-

SFN,

Sulforaphane generates reactive oxygen species leading to mitochondrial perturbation for apoptosis in human leukemia U937 cells

in-vitro,

AML,

U937

Apoptosis↑, ROS↑, MMP↓, Casp3↑, Bcl-2↓, eff↓,

1466-

SFN,

Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway

vitro+vivo,

Thyroid,

FTC-133

10.8 to 19.6 μM

mice

TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, EMT↓, Slug↓, Twist↓, MMP2↓, MMP9↓, TumCG↓, p‑Akt↓, P21↑, ERK↑, p38↑, ROS↑, *toxicity∅, MMP↓, eff↓,

1465-

SFN,

TRAIL attenuates sulforaphane-mediated Nrf2 and sustains ROS generation, leading to apoptosis of TRAIL-resistant human bladder cancer cells

NA,

Bladder,

eff↑, Apoptosis↑, Casp↑, MMP↓, BID↑, DR5↑, ROS↑, NRF2↑, eff↑, eff↓,

1464-

SFN,

d,l-Sulforaphane Induces ROS-Dependent Apoptosis in Human Gliomablastoma Cells by Inactivating STAT3 Signaling Pathway

in-vitro,

GBM,

Apoptosis↑, Casp3↑, BAX↑, Bcl-2↓, ROS↑, p‑STAT3↓, JAK2↓, eff↓,

1463-

SFN,

Sulforaphane induces reactive oxygen species-mediated mitotic arrest and subsequent apoptosis in human bladder cancer 5637 cells

in-vitro,

Bladder,

5637

tumCV↓, CycB/CCNB1↑, p‑CDK1↑, Apoptosis↑, Casp8↑, Casp9↑, Casp3↑, cl‑PARP↑, ROS↑, eff↓,

1460-

SFN,

High levels of EGFR prevent sulforaphane-induced reactive oxygen species-mediated apoptosis in non-small-cell lung cancer cells

in-vitro,

Lung,

ROS↑, EGFR↓, eff↓, TumCCA↑, γH2AX↑, DNAdam↑, eff↓,

1458-

SFN,

Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma

Review,

Bladder,

HDAC↓, eff↓, TumW↓, TumW↓, angioG↓, *toxicity↓, GutMicro↝, AntiCan↑, ROS↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, Casp8∅, cl‑PARP↑, TRAIL↑, DR5↑, eff↓, NRF2↑, ER Stress↑, COX2↓, EGFR↓, HER2/EBBR2↓, ChemoSen↑, NF-kB↓, TumCCA?, p‑Akt↓, p‑mTOR↓, p70S6↓, p19↑, P21↑, CD44↓, CSCs↓,

1456-

SFN,

Sulforaphane regulates cell proliferation and induces apoptotic cell death mediated by ROS-cell cycle arrest in pancreatic cancer cells

in-vitro,

PC,

MIA PaCa-2

 0, 7.5, and 15 µM

in-vitro,

PC,

PANC1

tumCV↓, TumCP↓, cl‑PARP↑, cl‑Casp3↑, TumCCA↑, ROS↑, MMP↓, γH2AX↑, eff↓, *toxicity↓,

1455-

SFN,

Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress

in-vitro,

Cerv,

HeLa

SFN (10 or 15 μM) for 9 h

in-vitro,

Nor,

1321N1

*ROS↓, *BioAv↑, LC3II↑, LAMP1?, TumAuto↑, TFEB↑, ROS↑, eff↓,

1454-

SFN,

Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract

Human,

Nor,

Subjects consumed fresh broccoli sprouts or the BSE, each providing 200 μmol SFN daily, as a single dose and as two 100-μmol doses taken 12 h apart.

*HDAC↓, *eff↑, *eff↑, *eff↑, *BioAv↑, *BioAv↑,

1437-

SFN,

Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition

Review,

NA,

HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, HDAC8↓, eff↑, ac‑HSP90↑, DNMT1↓, DNMT3A↓, hTERT/TERT↓, NRF2↑, HO-1↑, NQO1↑, miR-155↓, miR-200c↑, SOX9↓, *toxicity↓,

1474-

SFN,

Sulforaphane induces p53‑deficient SW480 cell apoptosis via the ROS‑MAPK signaling pathway

in-vitro,

Colon,

SW480

5, 10, 15 and 20 µM

TumCG↓, Apoptosis↑, MMP↓, Bax:Bcl2↑, Casp3↑, Casp7↑, Casp9↑, ROS↑, e-ERK↑, p38↑, P53∅, eff↓, ChemoSen↑,

1509-

SFN,

Combination therapy in combating cancer

Review,

NA,

NRF2↑, ChemoSideEff↓, eff↑, TumCP↓, Apoptosis↑, TumCCA↑, eff↑, PSA↓, P53↑, Hif1a↓, CAIX↓, chemoR↓, 5HT↓,

1508-

SFN,

Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment

Review,

Var,

*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, eff↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,

1501-

SFN,

The Inhibitory Effect of Sulforaphane on Bladder Cancer Cell Depends on GSH Depletion-Induced by Nrf2 Translocation

in-vitro,

CRC,

T24/HTB-9

2.5 µM vs >10uM

Dose↝, NRF2↑, GSH↓, eff↑,

1496-

SFN,

VitD3,

Association between histone deacetylase activity and vitamin D-dependent gene expressions in relation to sulforaphane in human colorectal cancer cells

in-vitro,

CRC,

Caco-2

24 h to vitamin D (100 nmol L-1 ) either alone or in combination with SFN and trichostatin A (20 and 1 μmol L-1 , respectively)

eff↑, VDR↑, CYP11A1↓, HDAC↓,

1495-

SFN,

doxoR,

Sulforaphane protection against the development of doxorubicin-induced chronic heart failure is associated with Nrf2 Upregulation

in-vivo,

Nor,

Rats

*CardioT↓, *NRF2↑, *eff↓, *ROS↓,

1494-

SFN,

doxoR,

Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model

in-vivo,

BC,

rats

in-vitro,

BC,

MCF-7

in-vitro,

Nor,

MCF10

CardioT↓, *GSH↑, *ROS↓, *NRF2↑, NRF2∅, HDAC↓, DNMTs↓, Casp3↑, ER-α36↓, Remission↑, eff↑, ROS↑, selectivity?,

1484-

SFN,

Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action

Review,

Var,

Review,

AD,

neuroP↑, AntiCan↑, NRF2↑, HDAC↓, eff↑, *ROS↓, neuroP↑, HDAC↓, *toxicity∅, BioAv↑, eff↓, cycD1/CCND1↓, CDK4↓, p‑RB1↓, Glycolysis↓, miR-30a-5p↑, TumCCA↑, TumCG↓, TumMeta↓, eff↑, ChemoSen↑, RadioS↑, CardioT↓, angioG↓, Hif1a↓, VEGF↓, *BioAv?, *Half-Life∅,

1483-

SFN,

Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment

in-vitro,

OS,

143B

0-10uM

in-vitro,

Nor,

HEK293

in-vivo,

OS,

25-50mg/kg

subcutaneous tumor-bearing nude mouse model

AntiCan↑, *toxicity∅, Ferroptosis↑, ROS↑, lipid-P↑, GSH↓, p62↑, SLC12A5↓, eff↓, GPx4↓, i-Iron↑, eff↓, MDA↑, TumVol↓, TumW↓, Ki-67↓, LC3B↑, *Weight∅,

1482-

SFN,

Sulforaphane induces apoptosis in T24 human urinary bladder cancer cells through a reactive oxygen species-mediated mitochondrial pathway: the involvement of endoplasmic reticulum stress and the Nrf2 signaling pathway

in-vitro,

Bladder,

T24/HTB-9

tumCV↓, Apoptosis↑, Cyt‑c↑, Bax:Bcl2↑, Casp9↑, Casp3↑, Casp8∅, cl‑PARP↑, ROS↑, MMP↓, eff↓, ER Stress↑, p‑NRF2↑, HO-1↑,

1480-

SFN,

Sulforaphane Induces Cell Death Through G2/M Phase Arrest and Triggers Apoptosis in HCT 116 Human Colon Cancer Cells

in-vitro,

CRC,

HCT116

tumCV↓, TumCCA↑, Apoptosis↑, cycA1/CCNA1↑, CycB/CCNB1↑, CDC25↓, CDK1↓, ROS↑, eff↓, Cyt‑c↑, AIF↑, ER Stress↑,

1478-

SFN,

acet,

Anti-inflammatory and anti-oxidant effects of combination between sulforaphane and acetaminophen in LPS-stimulated RAW 264.7 macrophage cells

in-vitro,

Nor,

eff↑, NO↓, iNOS↓, COX2↓, IL1β↓, ROS↓,

1476-

SFN,

PDT,

Enhancement of cytotoxic effect on human head and neck cancer cells by combination of photodynamic therapy and sulforaphane

in-vitro,

HNSCC,

eff↑, tumCV↓, ROS↑, eff↓, Casp↑,

1475-

SFN,

Form,

Combination of Formononetin and Sulforaphane Natural Drug Repress the Proliferation of Cervical Cancer Cells via Impeding PI3K/AKT/mTOR Pathway

in-vitro,

Cerv,

HeLa

0-50 µM

TumCP↓, PI3K↓, Akt↓, mTOR↓, eff↑, ROS↑,

1513-

SFN,

acetaz,

Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis

in-vitro,

BrCC,

H720

AZ, SFN, and AZ+SFN (10 μM, 20 μM, and 40 μM)

in-vivo,

BrCC,

AZ (20 mg/kg), SFN (40 mg/kg), and a combination of AZ (20 mg/kg) plus SFN (40 mg/kg), daily for two weeks

mice

in-vitro,

BrCC,

H727

eff↑, tumCV↓, Apoptosis↑, P21↑, PI3K↓, Akt↓, mTOR↓, 5HT↓, NRF2↑,

1728-

SFN,

Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens

Review,

Nor,

eff↑, eff↓,

1729-

SFN,

Discovery and development of sulforaphane as a cancer chemopreventive phytochemical

Review,

Nor,

eff↑, angioG↓, VEGF↓, MMP9↓, MMP2↓,

1731-

SFN,

Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts

Review,

Var,

CSCs↓, ChemoSen↑, NF-kB↓, Shh↓, Smo↓, Gli1↓, GLI2↓, PI3K↓, Wnt↓, β-catenin/ZEB1↓, Nanog↓, COX2↓, Zeb1↓, Snail↓, ChemoSideEff↓, eff↑, *BioAv↑,

1727-

SFN,

Glucoraphanin, sulforaphane and myrosinase activity in germinating broccoli sprouts as affected by growth temperature and plant organs

Analysis,

Nor,

eff↑, eff↓,

1726-

SFN,

Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential

Review,

Var,

Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,

3301-

SIL,

Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid

Review,

Var,

Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, eff↑, eff↑, eff↑, HER2/EBBR2↓,

3307-

SIL,

Flavolignans from Silymarin as Nrf2 Bioactivators and Their Therapeutic Applications

Review,

Var,

*NRF2↑, *antiOx↑, *chemoP↑, *Inflam↓, *BioAv↑, eff↑, *NQO1↑, TNF-α↓, IL6↓, *GSH↑, *ROS↓, *MDA↓, eff↑, *hepatoP↑, *GPx↑, *SOD↑, *Catalase↑, *HO-1↑, *neuroP↑,

3298-

SIL,

Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells

in-vitro,

BC,

MCF-7

LC3II↑, Beclin-1↑, Bcl-2↓, ROS↑, MMP↓, ATP↓, eff↓, BNIP3?, TumAuto↑, eff↑,

3294-

SIL,

Silymarin: a review on paving the way towards promising pharmacological agent

Review,

Nor,

Review,

Arthritis,

*hepatoP↑, *Inflam↓, *chemoP↑, *glucose↓, *antiOx↑, *ROS↓, *ACC↓, *FASN↓, *radioP↑, *NF-kB↓, *TGF-β↓, *AST↓, *α-SMA↝, *eff↑, *neuroP↑, eff↑, ROS↓,

3293-

SIL,

Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer

Review,

Var,

hepatoP↑, TumMeta↓, Inflam↓, chemoP↑, radioP↑, Half-Life↝, *GSTs↑, p‑JNK↑, BAX↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, eff↑, TumCCA↑, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, Casp3↑, Casp9↑, eff↑, CXCR4↓, Dose↝,

3292-

SIL,

Fe,

Anti-tumor activity of silymarin nanoliposomes in combination with iron: In vitro and in vivo study

in-vitro,

BC,

4T1

in-vivo,

BC,

4T1

mice

*antiOx↑, ROS↑, OS↑, Weight↑, TumVol↓, eff↑, Fenton↑,

3289-

SIL,

Silymarin: a promising modulator of apoptosis and survival signaling in cancer

Review,

Var,

*BioAv↝, *BioAv↓, Fas↑, FasL↑, FADD↑, pro‑Casp8↑, Apoptosis↑, DR5↑, Bcl-2↑, BAX↑, Casp3↑, PI3K↓, FOXM1↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, Akt↑, angioG↓, STAT3↓, NF-kB↓, lipid-P↓, eff↑, CDK1↓, survivin↓, CycB/CCNB1↓, Mcl-1↓, Casp9↑, AP-1↓, BioAv↑,

3282-

SIL,

Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions

Review,

NA,

hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27↑, COX2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,

5103-

SK,

Attenuation of PI3K-Akt-mTOR Pathway to Reduce Cancer Stemness on Chemoresistant Lung Cancer Cells by Shikonin and Synergy with BEZ235 Inhibitor

in-vitro,

NSCLC,

A549

CSCs↓, TumCP↓, Nanog↓, OCT4↓, p‑Akt↓, P70S6K↓, PI3K↓, mTOR↓, eff↑,

5101-

SK,

Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis

vitro+vivo,

CRC,

SW-620

vitro+vivo,

CRC,

HCT116

Apoptosis↑, TumAuto↑, Gal1↑, TumCP↓, ROS↑, eff↑,

5100-

SK,

Shikonin-induced necroptosis in nasopharyngeal carcinoma cells via ROS overproduction and upregulation of RIPK1/RIPK3/MLKL expression

vitro+vivo,

NPC,

TumCP↓, RIP1↑, ROS↑, Necroptosis↑, Casp3↑, Casp8↑, eff↓, TumCG↓,

2358-

SK,

SIRT1 improves lactate homeostasis in the brain to alleviate parkinsonism via deacetylation and inhibition of PKM2

in-vivo,

Park,

mice

*eff↑, *PKM2↓, *motorD↑, *lactateProd↓,

2364-

SK,

Pyruvate Kinase M2 Mediates Glycolysis Contributes to Psoriasis by Promoting Keratinocyte Proliferation

in-vivo,

PSA,

For 2-DG or Shikonin treatment, mice were intraperitoneally injected with 2-DG (500 mg/kg in saline, daily for 5 days) or Shikonin (25 mg/kg in saline/1% DMSO. daily for 5 days).

mice

eff↑, lactateProd↓, PKM2↓,

2230-

SK,

Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer

in-vitro,

CRC,

HCT116

in-vivo,

NA,

TumCG↓, Bcl-2↓, ROS↑, Bcl-xL↓, MMP↓, Casp↑, selectivity↑, cycD1/CCND1↓, TumCCA↑, eff↓,

2201-

SK,

Shikonin promotes ferroptosis in HaCaT cells through Nrf2 and alleviates imiquimod-induced psoriasis in mice

in-vitro,

PSA,

HaCaT

in-vivo,

NA,

mice

*eff↑, *IL6↓, *IL17↓, *TNF-α↓, *lipid-P↑, *NRF2↓, *HO-1↝, *NCOA4↝, *GPx4↓, *Ferroptosis↓, *Inflam↓, *ROS↓, *Iron↓,

2196-

SK,

Research progress in mechanism of anticancer action of shikonin targeting reactive oxygen species

Review,

Var,

*ALAT↓, *AST↓, *Inflam?, *EMT↑, ROS?, TrxR1↓, PERK↑, eIF2α↑, ATF4↑, CHOP↑, IRE1↑, JNK↑, eff↝, DR5↑, Glycolysis↓, PKM2↓, ChemoSen↑, GPx4↓, HO-1↑,

2228-

SK,

Shikonin induced Apoptosis Mediated by Endoplasmic Reticulum Stress in Colorectal Cancer Cells

in-vitro,

CRC,

HCT116

0.25, 0.5, 1, 1.5, 2, 2.5 and 3 μM

in-vitro,

CRC,

HCT15

in-vivo,

NA,

 intraperitoneal injection (3 mg/kg, 3 times per week

mouse

Apoptosis↑, Bcl-2↓, Casp3↑, Casp9↑, cl‑PARP↑, GRP78/BiP↑, PERK↑, eIF2α↑, ATF4↑, CHOP↑, JNK↑, eff↓, ER Stress↑, ROS↑, TumCG↓,

2189-

SK,

PKM2 inhibitor shikonin suppresses TPA-induced mitochondrial malfunction and proliferation of skin epidermal JB6 cells

in-vitro,

Melanoma,

PKM2↓, chemoPv↑, eff↝, lactateProd↓, ROS↑, *ROS?, *PKM2↓,

2188-

SK,

Molecular mechanism of shikonin inhibiting tumor growth and potential application in cancer treatment

Review,

Var,

ROS↑, EGFR↓, PI3K↓, Akt↓, angioG↓, Apoptosis↑, Necroptosis↑, GSH↓, Ca+2↓, MMP↓, ERK↓, p38↑, proCasp3↑, eff↓, VEGF↓, FOXO3↑, EGR1↑, SIRT1↑, RIP1↑, RIP3↑, BioAv↓, NF-kB↓, Half-Life↓,

2186-

SK,

Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line

in-vitro,

HCC,

HepG2

in-vitro,

HCC,

HCCLM3

Glycolysis↓, PKM2↓, Apoptosis↑, ROS↑, OXPHOS⇅, eff↓,

2229-

SK,

Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways

in-vitro,

Melanoma,

A375

Apoptosis↑, TumAuto↑, TumCP↓, TumCCA↑, P21↑, cycD1/CCND1↓, ER Stress↑, p‑eIF2α↑, CHOP↑, cl‑Casp3↑, p38↑, LC3B-II↑, Beclin-1↑, ROS↑, eff↓,

2227-

SK,

Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species

in-vitro,

GC,

BGC-823

13.35uM

in-vitro,

GC,

SGC-7901

9.63uM

in-vitro,

Nor,

GES-1

>20 μM

selectivity↑, TumCP↓, TumCD↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, Endon↑, AIF↑, eff↓, ChemoSen↑, TumCCA↑, GSH/GSSG↓, lipid-P↑,

2226-

SK,

Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma

in-vitro,

HCC,

HUH7

in-vitro,

HCC,

Bel-7402

selectivity↑, ROS↑, eff↓, Akt↓, RIP1↓, NF-kB↓,

2224-

SK,

Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells

in-vitro,

HCC,

SMMC-7721 cell

in-vitro,

HCC,

HUH7

in-vitro,

HCC,

HepG2

PYCR1↓, PI3K↓, Akt↓, mTOR↓, eff↑,

2217-

SK,

Shikonin Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis to Attenuate Renal Ischemia/Reperfusion Injury by Activating the Sirt1/Nrf2/HO-1 Pathway

in-vivo,

Nor,

mice

in-vitro,

Nor,

HK-2

*ER Stress↓, *SIRT1↑, *NRF2↑, *HO-1↑, *eff↓, *RenoP↑, *GRP78/BiP↓, *CHOP↓, *Casp12↓, *BAX↓, *cl‑Casp3↓,

2215-

SK,

doxoR,

Shikonin alleviates doxorubicin-induced cardiotoxicity via Mst1/Nrf2 pathway in mice

in-vivo,

Nor,

mice

*cardioP↑, *ROS↓, *Inflam↓, *Mst1↓, *NRF2↑, *eff↓, *antiOx↑, *SOD↑, *GSH↑, *TNF-α↓, BAX↓, Bcl-2↑,

2213-

SK,

Shikonin attenuates cerebral ischemia/reperfusion injury via inhibiting NOD2/RIP2/NF-κB-mediated microglia polarization and neuroinflammation

in-vivo,

Stroke,

 MCAO/R rats

*neuroP↑, *Inflam↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *ARG↑, *TGF-β↑, *IL10↑, *NF-kB↓, *eff↓,

2210-

SK,

Shikonin inhibits the cell viability, adhesion, invasion and migration of the human gastric cancer cell line MGC-803 via the Toll-like receptor 2/nuclear factor-kappa B pathway

in-vitro,

BC,

MGC803

1.854 μm

TumCA↓, TumCI↓, TumCMig↓, MMP2↓, MMP7↓, TLR2↓, p65↓, NF-kB↓, eff↑, ROS↑,

3051-

SK,

Resveratrol mediates its anti-cancer effects by Nrf2 signaling pathway activation

Review,

Var,

Nrf1↑, Apoptosis↑, TumCP↓, eff⇅, chemoP↑, eff↑, VCAM-1↓, Hif1a↓,

3047-

SK,

Shikonin suppresses colon cancer cell growth and exerts synergistic effects by regulating ADAM17 and the IL-6/STAT3 signaling pathway

in-vitro,

CRC,

HCT116

in-vitro,

CRC,

SW48

TumCG↓, p‑STAT3↓, ADAM17↓, Apoptosis↑, Casp3↑, cl‑PARP↑, cycD1/CCND1↓, cycE/CCNE↓, TumCCA↑, JAK1?, p‑JAK1↓, p‑JAK2↓, p‑eIF2α↑, eff↓, ROS↑, IL6↓,

2469-

SK,

Shikonin induces the apoptosis and pyroptosis of EGFR-T790M-mutant drug-resistant non-small cell lung cancer cells via the degradation of cyclooxygenase-2

in-vitro,

Lung,

H1975

0-8uM

Apoptosis↑, Pyro↑, Casp↑, cl‑PARP↑, GSDME↑, ROS↑, COX2↓, PDK1↓, Akt↓, ERK↓, eff↓, eff↓, eff↑,

1281-

SK,

Enhancement of NK cells proliferation and function by Shikonin

in-vivo,

Colon,

Caco-2

mice

Perforin↑, GranB↑, p‑ERK↑, p‑Akt↑, NK cell↑, eff↝,

2009-

SK,

Necroptosis inhibits autophagy by regulating the formation of RIP3/p62/Keap1 complex in shikonin-induced ROS dependent cell death of human bladder cancer

in-vitro,

Bladder,

TumCG↓, selectivity↑, *toxicity∅, Necroptosis↑, ROS↑, p62↑, Keap1↑, *NRF2↑, eff↑,

2008-

SK,

Cisplatin,

Enhancement of cisplatin-induced colon cancer cells apoptosis by shikonin, a natural inducer of ROS in vitro and in vivo

in-vitro,

CRC,

HCT116

in-vivo,

NA,

mice

ChemoSen↑, selectivity↑, i-ROS↑, DNAdam↑, MMP↓, TumCCA↑, eff↓, *toxicity↓,

2010-

SK,

Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway

in-vitro,

Lung,

H1975

2.6uM

in-vitro,

Lung,

H1650

3.9uM

in-vitro,

Nor,

CCD19

12.2uM

Normal cells, shows selectivity

EGFR↓, selectivity↑, Casp↑, PARP↑, Apoptosis↑, ROS↑, eff↓, selectivity↑,

1344-

SK,

Novel multiple apoptotic mechanism of shikonin in human glioma cells

in-vitro,

GBM,

U87MG

in-vitro,

GBM,

Hs683

in-vitro,

GBM,

M059K

ROS↑, GSH↓, MMP↓, P53↑, cl‑PARP↑, Catalase↓, SOD1↑, Bcl-2↓, BAX↑, eff↓,

4892-

Sper,

erastin,

Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer

in-vitro,

Pca,

PC3

in-vivo,

Pca,

Male BALB/c nude mice (5 weeks of age)

Ferroptosis↑, lipid-P↑, Iron↑, eff↑, HO-1↑, NRF2↑, ROS↑, AntiTum↑, eff↓,

4893-

Sper,

immuno,

Chemoproteomic Identification of Spermidine-Binding Proteins and Antitumor-Immunity Activators

in-vitro,

Var,

*mt-FAO↑, eff↑,

4896-

Sper,

immuno,

Spermidine potentiates anti-tumor immune responses and immunotherapy sensitivity in breast cancer

vitro+vivo,

BC,

eff↑, AntiTum↑,

1512-

Squ,

Combination therapy in combating cancer

Review,

NA,

ChemoSideEff↓, *ROS↓, *GSH↑, eff↑, chemoP↑,

4739-

SSE,

Chemo,

Rad,

Therapeutic Benefits of Selenium in Hematological Malignancies

Review,

Var,

ChemoSen↑, radioP↑, QoL↑, Risk↓, *selenoP↑, TumCP↓, Inflam↓, ChemoSen↑, TumCCA↑, Apoptosis↑, angioG↓, Dose⇅, ROS↑, eff↑, Risk↓, eff∅, CSCs↓, ROS↑,

4727-

SSE,

Selenium inhibits ferroptosis in ulcerative colitis through the induction of Nrf2/Gpx4

in-vivo,

Col,

experimental colitis in mice treated with dextran sulfate sodium (DSS)

*Ferroptosis↓, *NRF2↑, *GPx4↑, *eff↑, *other↓, *antiOx↑, *Inflam↓, AntiTum↑,

4743-

SSE,

Selenium for alleviating the side effects of chemotherapy, radiotherapy and surgery in cancer patients

Review,

Var,

eff↝, chemoP↝, radioP↝,

4728-

SSE,

Selective Impact of Selenium Compounds on Two Cytokine Storm Players

NA,

Covid,

*IL6↓, *TNF-α↓, *NRF2↑, *other↑, *eff↑,

5079-

SSE,

Rad,

The solvent and treatment regimen of sodium selenite cause its effects to vary on the radiation response of human bronchial cells from tumour and normal tissues

in-vitro,

Lung,

A549

in-vitro,

Nor,

BEAS-2B

chemoP↑, eff↝, ROS↑, MMP↓, Cyt‑c↑, TumCG↓, RadioS↝, other↝,

5076-

SSE,

Sodium selenite inhibits the growth of cervical cancer cells through the PI3K/AKT pathway

in-vivo,

Cerv,

HeLa

BALB/c female nude mice, and then intraperitoneally injected with 3 mg/kg sodium selenite (SS) for 14 days

in-vivo,

Cerv,

SiHa

TumCG↓, toxicity↓, tumCV↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, eff↑,

5075-

SSE,

Sodium selenite inhibits proliferation and metastasis through ROS‐mediated NF‐κB signaling in renal cell carcinoma

vitro+vivo,

RCC,

786-O

BALB/c athymic mice (6–8 weeks of age)

TumCP↓, TumCMig↓, Apoptosis↑, ROS↑, NF-kB↓, eff↓, E-cadherin↑, cl‑Casp3↑, VEGF↓, MMP9↓, EMT↓, MMP↓, mtDam↑, BAX↑, Bcl-2↓,

5091-

SSE,

Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite

in-vitro,

GBM,

U87MG

in-vitro,

Cerv,

HeLa

in-vitro,

BC,

MCF-7

in-vitro,

Pca,

PC3

in-vitro,

CRC,

HT-29

in-vitro,

Nor,

SVGp12

Ferroptosis↑, xCT↓, GSH↓, GPx4↓, Iron↑, lipid-P↑, ROS↑, eff↓, TumCP↓, TumCD↑,

5093-

SSE,

Pharmacological mechanisms of the anticancer action of sodium selenite against peritoneal cancer in mice

in-vivo,

Var,

AntiCan↑, eff↑, selectivity↑, ROS↑, Dose↝, Trx↓, GSH↓,

5111-

SSE,

Sodium selenite induces apoptosis via ROS-mediated NF-κB signaling and activation of the Bax-caspase-9-caspase-3 axis in 4T1 cells

in-vitro,

BC,

4T1

ROS↑, NF-kB↓, p65↓, mtDam↑, Casp9↑, Casp3↑, Apoptosis↑, eff↓,

5109-

SSE,

Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells

in-vitro,

CRC,

HCT116

ROS↑, DNAdam↓, ATM↑, eff↓, TumCCA↑,

5106-

SSE,

GSH,

Dual role of glutathione in selenite-induced oxidative stress and apoptosis in human hepatoma cells

in-vitro,

Liver,

HepG2

ROS↑, Apoptosis↑, eff↑, GSH↓,

5105-

SSE,

Sodium selenite induces apoptosis by generation of superoxide via the mitochondrial-dependent pathway in human prostate cancer cells

in-vitro,

Pca,

LNCaP

0, 0.5, 1.0, 1.5, 2.0, or 2.5 μM selenite for 5 days

TumCD↑, Apoptosis↑, ROS↑, eff↓, MMP↓, Cyt‑c↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, necrosis↑, chemoPv↑,

5095-

SSE,

Extracellular thiol-assisted selenium uptake dependent on the xc− cystine transporter explains the cancer-specific cytotoxicity of selenite

in-vitro,

Lung,

H157

toxicity↝, eff↓, other↝, ROS↑, mtDam↑,

5087-

SSE,

Sodium Selenite Alleviates Breast Cancer-Related Lymphedema Independent of Antioxidant Defense System

Trial,

BC,

 five sessions of 0.9% saline and 500 μg sodium selenite (Selenase®) IV injections

double-blind, controlled trial was conducted on 26 participants

eff↑, Inflam↓, Imm↑, ROS↑, *NK cell↑,

5086-

SSE,

Sodium Selenite Induces Superoxide-Mediated Mitochondrial Damage and Subsequent Autophagic Cell Death in Malignant Glioma Cells

in-vitro,

GBM,

U87MG

in-vitro,

GBM,

T98G

in-vitro,

GBM,

A172

TumAuto↑, ROS↑, TumCD↑, tumCV↓, selectivity↑, MMP↓, eff↓, MitoP↑,

4750-

SSE,

Rad,

Selenium in Radiation Oncology—15 Years of Experiences in Germany

Review,

Var,

RadioS∅, radioP↑, eff↑,

1688-

SSE,

Potential Role of Selenium in the Treatment of Cancer and Viral Infections

Review,

Var,

IL2↑, INF-γ↑, Th1 response↑, Th2↑, Dose↑, AntiCan∅, Risk↑, chemoP↑, Hif1a↓, VEGF↓, selectivity↑, *GADD45A↑, NRF2↓, *NRF2↑, ChemoSen↑, angioG↓, PrxI↓, ChemoSideEff↓, eff↑,

1687-

SSE,

Selenium for preventing cancer

Analysis,

Var,

eff∅, AntiCan∅,

1706-

SSE,

Selenium in Prostate Cancer: Prevention, Progression, and Treatment

Review,

Pca,

Risk∅, ChemoSen↑, Risk↓, toxicity↝, Risk↑, eff↑, *toxicity↑, RadioS↑, eff↓, eff↑, ChemoSen↑, ChemoSideEff↓,

1575-

statins,

Citrate,

Inhibition of Lung Cancer Growth: ATP Citrate Lyase Knockdown and Statin Treatment Leads to Dual Blockade of Mitogen-Activated Protein Kinase (MAPK) and Phosphatidylinositol-3-Kinase (PI3K)/AKT Pathways

in-vitro,

NSCLC,

A549

Generation of ACL knockdown cell lines

eff↑, HMG-CoA↓, eff↑, AntiTum↑, EGFR↓, eff↑, ROS↑, EMT↓, E-cadherin↑, MUC1↑, p‑ACLY↓, p‑Akt↓, eff↑,

112-

SuD,

Inhibition of Gli/hedgehog signaling in prostate cancer cells by “cancer bush” Sutherlandia frutescens extract

in-vitro,

Pca,

PC3

 167 ug/mL

in-vitro,

Pca,

LNCaP

HH↓, Gli1↓, PTCH1↓, TumCG↓, chemoPv↑, eff↑,

4151-

Taur,

Gins,

Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage

in-vitro,

AD,

*BDNF↑, *antiOx↑, *neuroP↑, *eff↑,

3960-

Taur,

Versatile Triad Alliance: Bile Acid, Taurine and Microbiota

Review,

AD,

Review,

Stroke,

*ROS↓, *Inflam↓, *GABA↑, *memory↑, *cognitive↑, *iNOS↓, *CRP↓, *HO-1↑, *Prx↑, *Trx↑, *NRF2↑, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *MDA↓, *eff↝, *GutMicro↑, other↑,

3950-

Taur,

Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes

Review,

Diabetic,

Review,

Stroke,

Review,

AD,

*Ca+2↝, *neuroP↑, *other↝, *pH↝, *ROS∅, eff↑, *MMP↑, *Apoptosis↓, *other↝, *ER Stress↓, *Bcl-xL↓, *BAX↑, *Cyt‑c↑, *cal2↓, *Casp3↓, *UPR↓, *other↝, *NF-kB↓, *NRF2↑, *GLUT1↑, *GLUT3↑, *memory↑,

5332-

TFdiG,

Theaflavin-3,3′-digallate triggers apoptosis in osteosarcoma cells via the caspase pathway

vitro+vivo,

OS,

143B

mice

in-vitro,

OS,

U2OS

tumCV↓, cl‑Casp3↑, cl‑Casp9↑, p‑γH2AX↑, BAX↑, Bak↑, Cyt‑c↑, Mcl-1↓, survivin↓, TumVol↓, Wnt↓, β-catenin/ZEB1↓, Dose↝, ROS↑, eff↓, TumW↓, Ki-67↓,

5339-

TFdiG,

Pre-treated theaflavin-3,3′-digallate has a higher inhibitory effect on the HCT116 cell line

in-vitro,

CRC,

HCT116

eff↑, TumCCA↑, Inflam↓, COX2↓, iNOS↓, P53↑, P21↑, cl‑Casp3↑,

113-

TQ,

Selective Targeting of the Hedgehog Signaling Pathway by PBM Nanoparticles in Docetaxel-Resistant Prostate Cancer

vitro+vivo,

Pca,

C4-2B

 139 uM

 C4-2B-R

HH↓, Shh↓, Gli1↓, eff↑, TumCP↓,

2353-

TQ,

The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies

Review,

PC,

BioAv↝, BioAv↑, MUC4↓, PKM2↓, eff↑, TumVol↓, HDAC↓, NF-kB↓, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, COX2↓, PGE1↓,

1929-

TQ,

Thymoquinone Suppresses the Proliferation, Migration and Invasiveness through Regulating ROS, Autophagic Flux and miR-877-5p in Human Bladder Carcinoma Cells

in-vitro,

Bladder,

5637

0-50uM

 75 µM

in-vitro,

Bladder,

T24/HTB-9

60 µM

tumCV↓, TumCP↓, TumCI↓, Casp↑, ROS↑, PD-L1↓, EMT↓, MMP↓, eff↓,

1931-

TQ,

doxoR,

Thymoquinone enhances the anticancer activity of doxorubicin against adult T-cell leukemia in vitro and in vivo through ROS-dependent mechanisms

in-vivo,

AML,

Dox  50-750 nM, TQ 5-40uM

mice

eff↑, tumCV↓, TumCCA↑, ROS↑, MMP↓, eff↑, TumVol↓, eff↑, Ki-67↓,

1933-

TQ,

Thymoquinone: potential cure for inflammatory disorders and cancer

Review,

Var,

antiOx↑, Inflam↓, AntiCan↑, TumCCA↑, ROS↑, angioG↓, Apoptosis↑, Casp↑, eff↑, eff↝,

1934-

TQ,

Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species

in-vitro,

Pca,

PC3

25-150um/L

80uM

in-vitro,

Pca,

C4-2B

50uM

ROS↑, GSH↓, eff↓, AR↓,

2125-

TQ,

Thymoquinone Selectively Kills Hypoxic Renal Cancer Cells by Suppressing HIF-1α-Mediated Glycolysis

in-vitro,

RCC,

RCC4

in-vitro,

RCC,

Caki-1

Hif1a↓, eff↝, uPAR↓, VEGF↓, CAIX↓, PDK1↓, GLUT1↓, LDHA↓, Glycolysis↓, e-lactateProd↓, i-ATP↓,

2123-

TQ,

Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma

in-vitro,

lymphoma,

PEL

10, 25, 50 uM @ 24h

Akt↓, ROS↑, BAX↓, MMP↓, Cyt‑c↑, eff↑, Casp9↑, Casp3↑, cl‑PARP↑, DR5↑,

2121-

TQ,

Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

p‑p38↑, ROS↑, TumCP↓, eff↑, XIAP↓, survivin↓, Bcl-xL↓, Bcl-2↓, Ki-67↓, *Catalase↑, *SOD↑, *GSH↑, hepatoP↑, p‑MAPK↑, JNK↓, eff↓,

2120-

TQ,

Thymoquinone induces apoptosis of human epidermoid carcinoma A431 cells through ROS-mediated suppression of STAT3

in-vitro,

Melanoma,

A431

ROS↑, Apoptosis↑, P53↑, BAX↑, MDM2↓, Bcl-2↓, Bcl-xL↓, Casp9↑, Casp7↑, Casp3↑, STAT3↓, cycD1/CCND1↓, survivin↓, eff↓,

2127-

TQ,

Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways

Review,

GBM,

chemoP↑, ChemoSen↑, BioAv↑, PTEN↑, PI3K↓, Akt↓, TumCCA↓, NF-kB↓, p‑Akt↓, p65↓, XIAP↓, Bcl-2↓, COX2↓, VEGF↓, mTOR↓, RAS↓, Raf↓, MEK↓, ERK↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, Casp↑, cl‑PARP↑, ROS⇅, ROS↑, MMP↓, eff↑, Telomerase↓, DNAdam↑, Apoptosis↑, STAT3↓, RadioS↑,

2129-

TQ,

doxoR,

Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells

in-vitro,

BC,

MCF-7

25, 50 or 100 µM TQ

ChemoSen↑, PTEN↑, p‑Akt↓, TumCCA↑, P53↑, P21↑, Apoptosis↑, MMP↓, Casp↑, cl‑PARP↑, Bax:Bcl2↑, eff↓, DNAdam↓, p‑γH2AX↑, ROS↑,

2130-

TQ,

Thymoquinone Attenuates Brain Injury via an Anti-oxidative Pathway in a Status Epilepticus Rat Model

in-vivo,

Nor,

rat

*eff↑, *memory↑, *NRF2↑, *HO-1↑, *SOD↑, *ROS↓,

2131-

TQ,

Therapeutic impact of thymoquninone to alleviate ischemic brain injury via Nrf2/HO-1 pathway

in-vitro,

Stroke,

in-vivo,

Nor,

schemic brain damage in C57BL/6 J mice

*eff↑, *OS↑, *Inflam↓, *ROS↓, *NRF2↑, *HO-1↑,

2135-

TQ,

Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets

in-vitro,

Nor,

HaCaT

TQ (1, 5,
10, 20 lM) for 6 h

skin cells

*HO-1↑, *NRF2↑, *e-ERK↑, *e-Akt↑, *AMPKα↑, *ROS⇅, *eff↓, *tumCV∅,

2095-

TQ,

Review on the Potential Therapeutic Roles of Nigella sativa in the Treatment of Patients with Cancer: Involvement of Apoptosis

Review,

Var,

TumCCA↑, Apoptosis↑, ROS↑, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, cl‑PARP↑, P53↑, P21↑, cMyc↓, hTERT/TERT↓, cycD1/CCND1↓, CDK4↓, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, Bcl-xL↓, survivin↓, COX2↓, MMP9↓, VEGF↓, eff↑,

2096-

TQ,

Effect of total hydroalcholic extract of Nigella sativa and its n-hexane and ethyl acetate fractions on ACHN and GP-293 cell lines

in-vitro,

Nor,

GP-293

in-vitro,

Kidney,

ACHN

selectivity↑, eff↝,

2098-

TQ,

Anticancer activity of Nigella sativa (black seed) and its relationship with the thermal processing and quinone composition of the seed

in-vitro,

Colon,

MC38

in-vitro,

lymphoma,

L428

NF-kB↓, eff↑, eff↓,

2101-

TQ,

HDAC inhibition by Nigella sativa L. sprouts extract in hepatocellular carcinoma: an approach to study anti-cancer potential

Study,

HCC,

HDAC↓, eff↑, eff↑, AntiCan↑,

2104-

TQ,

The Potential Role of Nigella sativa Seed Oil as Epigenetic Therapy of Cancer

in-vitro,

BC,

MCF-7

in-vitro,

Cerv,

HeLa

TumCP↓, Apoptosis↑, UHRF1↓, DNMT1↓, HDAC1↓, eff↝,

2106-

TQ,

Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy

Review,

Var,

Apoptosis↑, TumCCA↑, ROS↑, *Catalase↑, *SOD↑, *GR↑, *GSTA1↓, *GPx↑, *H2O2↓, *ROS↓, *lipid-P↓, *HO-1↑, p‑Akt↓, AMPKα↑, NK cell↑, selectivity↑, Dose↝, eff↑, GSH↓, eff↓, P53↑, p‑STAT3↓, PI3K↑, MAPK↑, GSK‐3β↑, ChemoSen↑, RadioS↑, BioAv↓, NRF2↑,

3412-

TQ,

Thymoquinone induces oxidative stress-mediated apoptosis through downregulation of Jak2/STAT3 signaling pathway in human melanoma cells

in-vitro,

Melanoma,

SK-MEL-28

in-vivo,

NA,

SK-MEL-28 tumor xenografts

Apoptosis↑, JAK2↓, STAT3↓, cycD1/CCND1↓, survivin↓, ROS↑, eff↓,

3411-

TQ,

Anticancer and Anti-Metastatic Role of Thymoquinone: Regulation of Oncogenic Signaling Cascades by Thymoquinone

Review,

Var,

p‑STAT3↓, cycD1/CCND1↓, JAK2↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MET↓, p‑Akt↓, p‑mTOR↓, CXCR4↓, Bcl-2↓, BAX↑, ROS↑, Cyt‑c↑, Twist↓, Zeb1↓, E-cadherin↑, p‑p38↑, p‑MAPK↑, ERK↑, eff↑, ERK↓, TumCP↓, TumCMig↓, TumCI↓,

3408-

TQ,

Thymoquinone: A small molecule from nature with high therapeutic potential

Review,

AD,

Review,

Park,

*neuroP↑, *hepatoP↑, *cardioP↑, *Inflam↓, *antiOx↑, ChemoSen↑, eff↑, eff↑, TumCP↓, TumCCA↑, angioG↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓,

3414-

TQ,

Thymoquinone induces apoptosis through inhibition of JAK2/STAT3 signaling via production of ROS in human renal cancer Caki cells

in-vitro,

RCC,

Caki-1

tumCV↓, Apoptosis↑, P53↑, BAX↑, Cyt‑c↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, p‑STAT3↓, p‑JAK2↓, STAT3↓, survivin↓, cycD1/CCND1↓, ROS↑, eff↓,

3403-

TQ,

A multiple endpoint approach reveals potential in vitro anticancer properties of thymoquinone in human renal carcinoma cells

in-vitro,

RCC,

786-O

TQ (1-100 μM) for 24 and 48 h

8.4 uM for 48 h

tumCV↓, ROS↑, TumCCA↑, eff↓, TumCI↓,

3422-

TQ,

Thymoquinone, as a Novel Therapeutic Candidate of Cancers

Review,

Var,

selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, BioAv↝, eff↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2↓, Ki-67↓, COX2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, eff↑, EMT↓, ROS↑, DNMT1↓, eff↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *eff↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,

3415-

TQ,

The anti-neoplastic impact of thymoquinone from Nigella sativa on small cell lung cancer: In vitro and in vivo investigations

in-vitro,

Lung,

H446

1-100uM

tumCV↓, TumCCA↑, ROS↓, CycB/CCNB1↑, CycD3↑, cycA1/CCNA1↓, cycE/CCNE↓, cDC2↓, antiOx↑, PARP↓, NRF2↓, ARE/EpRE↑, eff↑,

3553-

TQ,

Study Effectiveness and Stability Formulation Nanoemulsion of Black Cumin Seed (Nigella sativa L.) Essential Oil: A Review

Review,

Nor,

*AntiCan↑, *Inflam↓, *antiOx↑, *AntiAge↑, *hepatoP↑, *cardioP↑, *neuroP↑, *eff↑,

3571-

TQ,

The Role of Thymoquinone in Inflammatory Response in Chronic Diseases

Review,

Var,

Review,

Stroke,

*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, eff↑, DNAdam↑, *iNOS↓,

2454-

Trip,

Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ

in-vitro,

HNSCC,

HaCaT

in-vivo,

NA,

 xenograft tumors in nude mice

GSDME-N↑, Pyro↑, cMyc↓, HK2↓, BAD↑, BAX↑, Casp3↑, NRF2↓, xCT↓, ROS↑, eff↑, Glycolysis↓, GlucoseCon↓, lactateProd↓, ATP↓, xCT↓, eff↑,

2412-

TTT,

A review of tumor treating fields (TTFields): advancements in clinical applications and mechanistic insights

Review,

GBM,

TumCG↓, eff↝, OS↑,

5017-

UA,

Ursolic acid disturbs ROS homeostasis and regulates survival-associated gene expression to induce apoptosis in intestinal cancer cells

in-vitro,

Cerv,

INT-407

34.7 μM

in-vitro,

CRC,

HCT116

AntiCan↑, TumCG↓, ROS↑, Apoptosis↑, TumCMig↓, CTNNB1↓, Twist↓, Bcl-2↓, survivin↓, NF-kB↓, Sp1/3/4↓, BAX↑, P21↑, P53↑, eff↓, TumCMig↓,

4869-

Uro,

Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges

Review,

AD,

Review,

Park,

Review,

Stroke,

*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *eff↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,

4861-

Uro,

Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions

in-vivo,

AD,

mice were treated with UA (200 mg/kg/day) by oral gavage for 5 months, ending at 17 months

three mouse models of AD

*memory↑, *Aβ↓, *toxicity↓, *BBB↑, *p‑tau↓, *eff↓, *IL1α↓, *MCP1↓, *MIP‑1α↓, *TNF-α↓, *IL2↓, *SIRT1↓, *DNAdam↓, *Dose↝, *Strength↑, *motorD↑, *CTSZ↓,

4875-

Uro,

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

Review,

AD,

Review,

Stroke,

Review,

ostP,

Review,

IBD,

*MitoP↓, *Strength↑, *PINK1↑, *PARK2↑, *Inflam↓, *COX2↓, *IL1β↓, *IL6↓, *TNF-α↓, *OS↑, *cardioP↑, *memory↑, *neuroG↑, *neuroP↑, *Cartilage↑, *Inflam↓, *RenoP↑, *eff↑, *Dose↝, *Half-Life↑, *NRF2↑, *GutMicro↑,

4876-

Uro,

Urolithin A in Health and Diseases: Prospects for Parkinson’s Disease Management

Review,

Park,

Review,

AD,

*Inflam↓, *antiOx↓, *neuroP↑, *p‑tau↓, *Aβ↓, *eff↑, *BioAv↓, *BioAv↑, *GSH↑, *SOD↑, *lipid-P↓, *Catalase↑, *GSR↑, *GPx↑, *ROS↓, *NRF2↑, *GutMicro↑, *Risk↓, *BBB↓, *NLRP3↓, *MAOA↓,

4856-

Uro,

Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro

in-vitro,

NPC,

CNE1

20–60 μM UroA

34.72 μM and 44.91 μM

in-vitro,

NPC,

CNE2

Apoptosis↑, MMP↓, ROS↑, E-cadherin↑, BAX↑, cl‑Casp3↑, PARP↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Snail↓, eff↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓,

4833-

Uro,

Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine

Review,

Var,

392 to 566 µM across various breast cancer cell lines

Review,

AD,

Review,

IBD,

BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,

4834-

Uro,

Urolithin A increases the natural killer activity of PBMCs in patients with prostate cancer

Human,

Pca,

eff↑, NK cell↑,

4842-

Uro,

Urolithin A inhibits breast cancer progression via activating TFEB-mediated mitophagy in tumor macrophages

vitro+vivo,

BC,

MDA-MB-231

Four weeks female BALB/c mice

in-vitro,

BC,

BT549

in-vitro,

BC,

MCF-7

in-vitro,

BC,

4T1

Inflam↓, IL6↓, TNF-α↓, eff↑, STAT3↓, TumCP↓, TumCMig↓,

4843-

Uro,

The effects of urolithins on the response of prostate cancer cells to non-steroidal antiandrogen bicalutamide

in-vitro,

Pca,

LNCaP

TumCP↓, eff↑, ChemoSen↝,

4312-

VitB1/Thiamine,

Pharmacological thiamine levels as a therapeutic approach in Alzheimer's disease

Review,

AD,

*eff↑, *cognitive↑, *memory↑, *GlucoseCon↑, *Aβ↓, *Inflam↓, *antiOx↑, *p‑tau↓, *AGEs↓, *Dose↝,

4049-

VitB1/Thiamine,

Vitamin B1 (thiamine) and dementia

Review,

AD,

*memory↑, *p‑tau↓, *cognitive↑, *Dose↝, *Dose↓, *Aβ↓, *other↝, *eff↑, *eff↑,

1888-

VitB1/Thiamine,

DCA,

High Dose Vitamin B1 Reduces Proliferation in Cancer Cell Lines Analogous to Dichloroacetate

in-vitro,

PC,

SK-N-BE

NA,

PC,

PANC1

p‑PDH↓, GlucoseCon↓, lactateProd↓, MMP↓, Casp3↑, eff↑, PDKs↓, selectivity↑, TumCG↓, Dose∅, MMP↓, ROS∅, toxicity↑, antiOx↑,

4043-

VitB12,

FA,

Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment

Trial,

AD,

folic acid 0.8 mg/d, vitamin B12 0.5 mg/d, vitamin B6 20 mg/d) on elderly volunteers with memory complaint

*other↑, *other↑, *eff↝, *homoC↓, *cognitive↑,

4033-

VitB3,

Can nicotinamide riboside protect against cognitive impairment?

in-vivo,

AD,

mouse

*memory↑, *DNAdam↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *BACE↓, *Aβ↓, *BBB↑, *GutMicro↑, *eff↑,

4326-

VitB5,

Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s Disease

in-vivo,

HD,

analysed short-post-mortem-delay brain tissue from 30 cases of HD and 19 controls

*Risk↓, *neuroP↑, *other?, *Ach↑, *other↝, *eff↓, *other↝,

4052-

VitB6,

B-Vitamin Intake and Biomarker Status in Relation to Cognitive Decline in Healthy Older Adults in a 4-Year Follow-Up Study

Study,

AD,

*neuroP↑, *other↑, *other↑, *cognitive↑, *eff↝, *Risk↑, *other↑,

1836-

VitC,

VitK3,

Chemo,

Vitamins C and K3: A Powerful Redox System for Sensitizing Leukemia Lymphocytes to Everolimus and Barasertib

in-vitro,

AML,

tumCV↓, selectivity↑, Apoptosis↑, eff↑, ChemoSen↑,

3136-

VitC,

Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer

in-vitro,

Colon,

SW48

in-vitro,

Colon,

LoVo

ERK↓, p‑PKM2↓, GLUT1↓, Warburg↓, TumCD↑, eff↑, ROS↓, cMyc↓,

3138-

VitC,

The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity

in-vitro,

RCC,

RCC4

in-vitro,

CRC,

HCT116

in-vitro,

BC,

MDA-MB-435

in-vitro,

Ovarian,

SKOV3

in-vitro,

Colon,

SW48

in-vitro,

GBM,

U251

eff↑, Warburg↓, BioAv↑, ROS↑, DNAdam↑, ATP↓, eff↑, necrosis↑, PARP↑,

3139-

VitC,

Vitamin C and sodium bicarbonate enhance the antioxidant ability of H9C2 cells and induce HSPs to relieve heat stress

in-vitro,

Nor,

H9c2

*Apoptosis∅, *LDH∅, *MDA∅, *SOD↓, eff↝,

3140-

VitC,

Vitamin-C-dependent downregulation of the citrate metabolism pathway potentiates pancreatic ductal adenocarcinoma growth arrest

in-vitro,

PC,

MIA PaCa-2

in-vitro,

Nor,

HEK293

citrate↓, FASN↓, ACLY↓, LDH↓, Glycolysis↓, Warburg↓, PDK1↓, GLUT1↓, LDHA↓, ECAR↓, PDH↑, eff↑,

3141-

VitC,

High-dose Vitamin C inhibits PD-L1 expression by activating AMPK in colorectal cancer

in-vitro,

CRC,

HCT116

Glycolysis↓, eff↑, PD-L1↓, AMPK↑, HK2↓, NF-kB↓, Warburg↓, tumCV↓, GLUT1↓, PKM2↓, LDHA↓, CD4+↑, CD8+↑,

3143-

VitC,

ATO,

Vitamin C enhances the sensitivity of osteosarcoma to arsenic trioxide via inhibiting aerobic glycolysis

in-vitro,

OS,

TumCP↓, TumCMig↓, TumCI↓, eff↑, Glycolysis↓, lactateProd↓, ATP↓, PGK1↓, PGM1↓, LDHA↓,

3148-

VitC,

Antioxidants in brain tumors: current therapeutic significance and future prospects

Review,

Var,

*antiOx↑, *ROS↓, chemoPv↑, ChemoSen↑, TET2↑, eff↑, OS↑, QoL↑, eff↑,

3153-

VitC,

Vitamin C Status and Cognitive Function: A Systematic Review

Review,

AD,

cognitive↑, eff↑,

3107-

VitC,

Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment

Review,

Var,

Risk↓, *ROS↓, ROS↑, VEGF↓, COX2↓, ER Stress↑, IRE1↑, JNK↑, CHOP↑, Hif1a↓, eff↑, Glycolysis↓, MMPs↓, TumMeta↓, YAP/TEAD↓, eff↑, TET1↑,

3114-

VitC,

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

in-vitro,

AML,

TET2↑, eff↑, ROS↑, Fenton↑, Hif1a↓,

3117-

VitC,

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

in-vitro,

Nor,

mESC

TET1↑, eff↝,

3121-

VitC,

immuno,

Ascorbic acid induced TET2 enzyme activation enhances cancer immunotherapy efficacy in renal cell carcinoma

in-vivo,

RCC,

A498

xenograft model

in-vitro,

RCC,

786-O

TET2↑, eff↑, eff↑,

3129-

VitC,

Therapeutic treatment with vitamin C reduces focal cerebral ischemia-induced brain infarction in rats by attenuating disruptions of blood brain barrier and cerebral neuronal apoptosis

in-vivo,

Stroke,

*BBB↑, *MMP9↓, *MMPs↓, *MMP2↓, *CLDN1↝, *ZO-1↝, eff↑,

4468-

VitC,

SSE,

Selenium modulates cancer cell response to pharmacologic ascorbate

in-vivo,

GBM,

U87MG

in-vitro,

CRC,

HCT116

eff↓, TumCD↑, ChemoSen↑, ROS⇅, DNAdam↑, PARP↑, NAD↓, Glycolysis↓, Fenton↑, lipid-P↑, eff↓, H2O2↑, other↝,

4086-

VitD3,

The beneficial role of vitamin D in Alzheimer's disease

Review,

AD,

*Mood↑, *cognitive↑, *eff↑,

1739-

VitD3,

Effect of Vitamin D3 Supplements on Development of Advanced Cancer

Trial,

Var,

AntiCan↑, Dose↝, Risk↓, TumCP↓, Inflam↓, eff∅,

1740-

VitD3,

Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms

Review,

Var,

Risk↓, eff↑, eff↑, Risk↓, Risk↓, ChemoSen↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp9↑, hTERT/TERT↓, eff↑, E-cadherin↑, CLDN2↑, ZO-1↑, Snail↓, Zeb1↓, Vim↓, VEGF↓, NK cell↑, Risk↓, eff↑,

1741-

VitD3,

Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging

Review,

Var,

*Inflam↓, *antiOx↑, *eff↑, *ROS↓, *NRF2↑, *GPx↑, *Dose↝, Dose↑,

1313-

VitD3,

MEL,

The effects of melatonin and vitamin D3 on the gene expression of BCl-2 and BAX in MCF-7 breast cancer cell line

in-vitro,

BC,

MCF-7

 optimum dose of melatonin (5 nM) and vitamin D3 (0.5 nM

BAX↑, Bcl-2↓, Bax:Bcl2↑, eff↑,

2171-

VitD3,

Vitamin D and the Immune System

Analysis,

Nor,

eff↑, Dose↝, eff↝, eff↑, eff↑,

2283-

VitK2,

Vitamin K Contribution to DNA Damage—Advantage or Disadvantage? A Human Health Response

Review,

Var,

*ER Stress↓, *toxicity↓, *toxicity↑, ROS↑, PI3K↑, Akt↑, Hif1a↑, GlucoseCon↑, lactateProd↑, ChemoSen↑, eff↑, eff↑,

2285-

VitK2,

New insights into vitamin K biology with relevance to cancer

Review,

Var,

Risk↓, AntiCan↑, eff↑, MMP↓, ROS↑, Cyt‑c↑, eff↓, SXR↑,

2278-

VitK2,

VitK3,

VitC,

Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect

Review,

Var,

ChemoSen↑, ROS↑, eff↑,

2279-

VitK2,

Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways

in-vitro,

Bladder,

T24/HTB-9

0-100uM

in-vitro,

Bladder,

J82

in-vitro,

Nor,

HEK293

in-vitro,

Nor,

L02

in-vivo,

NA,

mice

MMP↓, Cyt‑c↑, Casp3↑, p‑JNK↑, p‑p38↑, ROS↑, eff↓, tumCV↓, selectivity↑, *toxicity↓, TumVol↓,

2280-

VitK2,

Vitamin K2 induces non-apoptotic cell death along with autophagosome formation in breast cancer cell lines

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

MDA-MB-468

in-vitro,

AML,

HL-60

HL-60 leukemia cells were used as a control for VK2-induced apoptosis.

ROS↑, p62↓, eff↓,

1817-

VitK2,

Research progress on the anticancer effects of vitamin K2

Review,

Var,

TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, eff↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, eff↑, eff↑,

1824-

VitK2,

Vitamin K and its analogs: Potential avenues for prostate cancer management

Review,

Pca,

AntiCan↑, toxicity∅, Risk↓, Apoptosis↑, ROS↑, TumCCA↑, eff↑, DNAdam↑, MMP↓, Cyt‑c↑, pro‑Casp3↑, FasL↑, Fas↑, TumAuto↑, ChemoSen↑, RadioS↑,

1818-

VitK2,

New insights on vitamin K biology with relevance to cancer

Review,

Var,

TumCG↓, ChemoSen↑, toxicity∅, OS↑, BMD↑, eff↑, MMP↓, ROS↑, eff↓, ERK↑, JNK↑, p38↑, Cyt‑c↑, Casp↑, ATP↓, lactateProd↑, AMPK↑, Rho↓, TumCG↓, BioAv↑, cardioP↑, Risk↓,

1214-

VitK2,

Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells

in-vitro,

Bladder,

T24/HTB-9

50 μM

in-vitro,

Bladder,

J82

Glycolysis↑, GlucoseCon↑, lactateProd↑, TCA↓, PI3K↑, Akt↑, AMPK↑, mTORC1↓, TumAuto↑, GLUT1↑, HK2↑, LDHA↑, ACC↓, PDH↓, eff↓, cMyc↓, Hif1a↑, p‑Akt↑, eff↓, eff↓, eff↓, eff↓, ROS↑,

1828-

VitK3,

VitC,

Pankiller effect of prolonged exposure to menadione on glioma cells: potentiation by vitamin C

in-vivo,

GBM,

rats

eff↑, ROS↑, Dose∅,

1826-

VitK3,

PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug

in-vitro,

Cerv,

HeLa

in-vitro,

Lung,

A549

eff↑, ROS↑,

1834-

VitK3,

PDT,

Effects of Vitamin K3 Combined with UVB on the Proliferation and Apoptosis of Cutaneous Squamous Cell Carcinoma A431 Cells

in-vitro,

Melanoma,

A431

eff↑, TumCG↓, TumCP↓, ROS↑, MMP↓,

1837-

VitK3,

VitC,

Alpha-Tocopheryl Succinate Inhibits Autophagic Survival of Prostate Cancer Cells Induced by Vitamin K3 and Ascorbate to Trigger Cell Death

in-vivo,

Pca,

mice

eff↑, ROS↑, TumAuto↑,

1838-

VitK3,

PDT,

Photodynamic Effects of Vitamin K3 on Cervical Carcinoma Cells Activating Mitochondrial Apoptosis Pathways

in-vitro,

Cerv,

eff↑, ROS↑, tumCV↓, TumCG↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, Bcl-xL↑, Cyt‑c↑, Bcl-2↓,

1839-

VitK3,

Vitamin K3 derivative inhibits androgen receptor signaling in targeting aggressive prostate cancer cells

in-vitro,

Pca,

TumCP↓, Apoptosis↑, TumCCA↑, ROS↑, eff↓, AR↓, Trx↓, Bcl-2↓,

2372-

VitK3,

The role of pyruvate kinase M2 in anticancer therapeutic treatments

Review,

Var,

PKM2↓, eff↑, AntiCan↑,

1758-

WBV,

Whole-body vibration in breast cancer survivors: a pilot study exploring its effects on muscle activity and subjectively perceived exertion

Human,

BC,

eff↑,

1755-

WBV,

Reduction of breast cancer extravasation via vibration activated osteocyte regulation

Dose∅, TumMeta↑, eff∅, Piezo1↑, COX2↑, RANKL↓, TumCG∅, tumCV∅, TumCI↓,

1754-

WBV,

Vibration Therapy for Cancer-Related Bone Diseases

Review,

Var,

*BMD↑, *toxicity∅, other↓, Dose↝, Dose↑, eff↑, eff↑, eff↑,

1752-

WBV,

Chemo,

Feasibility of whole body vibration during intensive chemotherapy in patients with hematological malignancies – a randomized controlled pilot study

Trial,

Var,

*BP∅, eff↑, Dose∅, other↑, *toxicity∅, eff↑,

2427-

Wog,

Anti-cancer natural products isolated from chinese medicinal herbs

Review,

Var,

NO↓, PGE2↓, COX2↓, Ca+2↑, mtDam↑, *toxicity↓, eff↑, eff↓,

4197-

The Effect of Zinc Supplementation on Circulating Levels of Brain-Derived Neurotrophic Factor (BDNF): A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Review,

NA,

*BDNF↑, *other↓, *eff↑, *Inflam↓, *antiOx↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1086

Pathway results for Effect on Cancer / Diseased Cells:

Infection & Microbiome ⓘ

Bacteria↓, 3, CD8+↑, 8, Sepsis↓, 2,
Total Targets: 1168

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx?, 1, antiOx↓, 6, antiOx↑, 88, mt-antiOx↑, 1, Bil↓, 1, Catalase↓, 1, Catalase↑, 34, Copper↓, 1, Fenton↓, 1, Ferroptosis↓, 4, GPx↑, 23, GPx1↑, 2, GPx4↓, 1, GPx4↑, 3, GPx4∅, 1, GSH↓, 4, GSH↑, 45, GSR↑, 5, GSSG↓, 1, GSSG∅, 1, GSTA1↓, 2, GSTs↑, 9, H2O2↓, 2, H2O2↑, 1, H2O2∅, 1, HDL↑, 3, HDL∅, 1, HNE↓, 1, HO-1↑, 25, HO-1↝, 1, HO-1∅, 1, Iron↓, 2, Keap1↓, 3, lipid-P↓, 24, lipid-P↑, 1, mt-lipid-P↓, 1, MDA↓, 21, MDA↑, 2, MDA∅, 1, Mets↝, 1, MPO↓, 5, MPO↑, 1, NOX4↓, 1, NQO1↑, 5, Nrf1↑, 1, NRF2↓, 3, NRF2↑, 48, NRF2⇅, 1, NRF2∅, 1, OXPHOS↑, 1, PARK2↑, 2, Prx↑, 2, RNS↓, 1, ROS?, 3, ROS↓, 112, ROS↑, 11, ROS⇅, 3, ROS∅, 7, mt-ROS↑, 2, SAM-e↑, 1, selenoP↑, 5, SOD↓, 2, SOD↑, 53, SOD1↑, 2, SOD2↑, 2, TAC↑, 2, TBARS↓, 1, Trx↑, 3, TrxR↑, 1, uricA↓, 1, VitC↑, 2, VitE↑, 1,

Metal & Cofactor Biology ⓘ

IronCh↑, 8, NCOA4↝, 1,

Mitochondria & Bioenergetics ⓘ

ATP↓, 1, ATP↑, 8, ATP↝, 1, Insulin↓, 2, Insulin↑, 1, mitResp↑, 2, MMP↓, 2, MMP↑, 8, MMP∅, 2, MPT↑, 1, mtDam↓, 3, OCR↑, 1, mt-OCR↑, 1, PGC-1α↑, 4, PINK1↑, 1,

Core Metabolism/Glycolysis ⓘ

12LOX↓, 3, ACC↓, 1, ACSL4∅, 1, adiP↓, 1, adiP↑, 2, ALAT↓, 7, AMPK↓, 1, AMPK↑, 7, BUN↓, 1, cAMP↑, 1, p‑cMyc↑, 1, CREB↑, 2, CYP3A2↓, 1, ECAR↓, 1, ECAR↑, 1, mt-FAO↑, 1, FASN↓, 1, glucose↓, 4, glucose↑, 1, GlucoseCon↑, 5, Glycolysis↓, 1, H2S↑, 1, homoC↓, 1, KeyT↑, 3, lactateProd↓, 1, LDH↓, 5, LDH↑, 1, LDH∅, 1, LDL↓, 7, lipidLev↓, 1, NAD↑, 2, NAD↝, 1, NADH:NAD↑, 1, NADPH↓, 1, NH3↓, 1, PKM2↓, 2, PONs↑, 1, PPARγ↓, 2, PPARγ↑, 3, p‑PPARγ↓, 1, SCD1↓, 1, SIRT1↓, 1, SIRT1↑, 9, SIRT2↑, 1,

Cell Death ⓘ

Akt↓, 5, Akt↑, 5, e-Akt↑, 1, Apoptosis↓, 11, Apoptosis∅, 2, ASK1↓, 1, BAX↓, 5, BAX↑, 3, Bax:Bcl2↓, 3, Bcl-2↓, 2, Bcl-2↑, 1, Bcl-2∅, 1, Bcl-xL↓, 1, BMP2↑, 1, Casp12↓, 1, Casp3?, 1, Casp3↓, 9, Casp3↑, 2, Casp3∅, 1, cl‑Casp3↓, 2, cl‑Casp8↑, 1, Casp9↓, 3, Casp9↑, 1, Cyt‑c↓, 3, Cyt‑c↑, 3, Cyt‑c∅, 3, Ferroptosis↓, 4, HEY1↑, 1, iNOS↓, 11, iNOS↑, 1, JNK↓, 3, JNK↑, 1, MAPK↓, 7, MAPK↑, 6, necrosis↓, 1, p38↑, 2,

Kinase & Signal Transduction ⓘ

AMPKα↑, 1, SOX9↑, 1,

Transcription & Epigenetics ⓘ

Ach?, 1, Ach↑, 4, AntiThr↑, 1, other?, 2, other↓, 8, other↑, 27, other↝, 21, other∅, 1, tumCV∅, 1,

Protein Folding & ER Stress ⓘ

CHOP↓, 1, CHOP↑, 1, cl‑eIF2α↑, 1, ER Stress↓, 6, GRP78/BiP↓, 2, GRP78/BiP↑, 2, HSF1↑, 2, HSP70/HSPA5↑, 1, HSP70/HSPA5↝, 1, HSPs↑, 2, IRE1↓, 1, p‑PERK↑, 1, UPR↓, 1, UPR↑, 1,

Autophagy & Lysosomes ⓘ

LC3II↑, 1, MitoP↓, 1, MitoP↑, 2, p62↓, 1, p62↑, 2,

DNA Damage & Repair ⓘ

DNAdam↓, 7, DNAdam↑, 2, DNArepair↑, 2, GADD45A↑, 1, p‑γH2AX↓, 1,

Cell Cycle & Senescence ⓘ

E2Fs↑, 1,

Proliferation, Differentiation & Cell State ⓘ

Choline↑, 1, Diff↑, 4, EMT↑, 1, ERK↓, 1, ERK↑, 6, e-ERK↑, 1, FGF↑, 1, FOXO↑, 1, GSK‐3β↓, 4, p‑GSK‐3β↑, 1, HDAC↓, 2, IGF-1↓, 2, IGF-1↑, 2, IGFBP1↑, 1, IGFBP3↑, 1, Mst1↓, 1, mTOR↓, 3, mTOR↑, 2, mTOR↝, 1, p‑mTOR↑, 1, neuroG↑, 1, NOTCH↑, 1, PI3K↓, 5, PI3K↑, 3, PTEN↓, 2, PTEN↑, 1, RAS↓, 1, Src↓, 1, STAT↓, 1, STAT3↓, 1, TumCG∅, 1, VGCC↑, 1, Wnt↑, 2,

Migration ⓘ

5LO↓, 2, AntiAg↑, 8, AP-1↓, 3, APP↓, 2, ARG↑, 1, Ca+2?, 1, Ca+2↓, 3, Ca+2↑, 5, Ca+2↝, 4, cal2↓, 1, Cartilage↑, 3, CLDN1↝, 1, COL2A1↑, 1, F-actin↑, 1, FAK↑, 2, MMP2↓, 3, MMP2↑, 2, MMP9↓, 7, MMP9↑, 2, MMPs↓, 4, PKA↑, 2, PKCδ?, 1, PKCδ↓, 3, PKCδ↑, 2, RAGE↓, 1, serineP↓, 1, SMAD3↓, 1, TGF-β↓, 3, TGF-β↑, 3, TIMP1↓, 1, TIMP1↑, 1, TumCP↓, 1, VCAM-1↓, 3, ZO-1↝, 1, α-SMA↝, 1, β-catenin/ZEB1↑, 2, β-Endo↑, 1,

Angiogenesis & Vasculature ⓘ

angioG↓, 3, angioG↑, 3, eNOS↓, 1, eNOS↑, 1, Hif1a↓, 2, Hif1a↑, 1, Hif1a∅, 1, NO↓, 9, NO↑, 5, VEGF↓, 1, VEGF↑, 6,

Barriers & Transport ⓘ

BBB↓, 2, BBB↑, 23, GLUT1↑, 2, GLUT3↑, 1, GLUT4↑, 2,

Immune & Inflammatory Signaling ⓘ

COX1↓, 1, COX2↓, 21, CRP↓, 8, CTSZ↓, 1, HMGB1↓, 1, ICAM-1↓, 2, IFN-γ↓, 1, IFN-γ↑, 1, IL1↓, 3, IL10↓, 1, IL10↑, 5, IL12↓, 1, IL17↓, 2, IL18↓, 1, IL1α↓, 1, IL1β↓, 23, IL1β↑, 1, IL2↓, 4, IL33↓, 1, IL4↑, 1, IL5↑, 1, IL6↓, 31, IL6↑, 3, IL8↓, 5, Imm↑, 4, INF-γ↓, 1, Inflam?, 1, Inflam↓, 98, Inflam↑, 3, MCP1↓, 2, MCP1↑, 1, MIP‑1α↓, 1, MyD88↓, 1, NF-kB↓, 29, NF-kB↑, 1, NK cell↑, 1, p65↓, 1, PGE2↓, 8, TLR2↓, 2, TLR4↓, 3, TLR4↑, 1, TNF-α↓, 44, VitD↑, 2,

Cellular Microenvironment ⓘ

pH↝, 2,

Synaptic & Neurotransmission ⓘ

5HT↓, 1, 5HT↑, 2, AChE↓, 8, AChE∅, 1, ADAM10↑, 1, BChE↓, 3, BDNF↑, 14, BrainVol↑, 1, ChAT↑, 1, GABA↑, 3, GABA↝, 1, MAOA↓, 1, tau↓, 3, p‑tau↓, 8, TrkB↑, 2,

Protein Aggregation ⓘ

AGEs↓, 1, Aβ↓, 23, BACE↓, 5, IDE↑, 1, NLRP3↓, 4, PP2A↑, 1, β-Amyloid↓, 1,

Hormonal & Nuclear Receptors ⓘ

GR↑, 2, testos↑, 2,

Drug Metabolism & Resistance ⓘ

BioAv?, 1, BioAv↓, 32, BioAv↑, 48, BioAv↝, 16, BioEnh↑, 6, Dose↓, 2, Dose↑, 6, Dose↝, 38, Dose∅, 2, eff?, 1, eff↓, 26, eff↑, 196, eff↝, 18, Half-Life↓, 3, Half-Life↑, 5, Half-Life↝, 9, Half-Life∅, 3, P450↓, 2, selectivity↑, 3,

Clinical Biomarkers ⓘ

ALAT↓, 7, ALP↓, 3, ALP↑, 1, AST↓, 9, BG↓, 1, Bil↓, 1, BloodF↑, 1, BMD↑, 7, BMPs↑, 1, BP↓, 8, BP↝, 1, BP∅, 1, Calcium↑, 1, creat↓, 4, CRP↓, 8, GutMicro↑, 11, GutMicro↝, 1, hs-CRP↓, 1, IL6↓, 31, IL6↑, 3, LDH↓, 5, LDH↑, 1, LDH∅, 1, Mag↑, 1, NOS2↓, 1, RAGE↓, 1, VitD↑, 2,

Functional Outcomes ⓘ

AntiAge↑, 6, AntiCan↑, 6, AntiDiabetic↑, 3, AntiTum↑, 1, BOLD↑, 2, Bone Healing↑, 1, cachexia↓, 1, cardioP↓, 1, cardioP↑, 28, CardioT↓, 3, chemoP↑, 8, chemoPv↑, 2, ChemoSideEff↓, 1, cognitive?, 1, cognitive↑, 48, cognitive↝, 1, hepatoP↑, 20, memory↓, 1, memory↑, 37, Mood↑, 7, motorD↓, 1, motorD↑, 12, neuroP↓, 1, neuroP↑, 66, Obesity↓, 1, OS↓, 1, OS↑, 5, Pain↓, 3, QoL↑, 2, radioP↑, 6, RenoP↑, 14, Risk↓, 10, Risk↑, 1, Sleep↑, 1, Strength↑, 3, toxicity?, 2, toxicity↓, 47, toxicity↑, 4, toxicity↝, 9, toxicity∅, 32, Weight↓, 3, Weight∅, 1, Wound Healing↑, 4,

Infection & Microbiome ⓘ

AntiFungal↑, 1, AntiViral↑, 2, Bacteria↓, 13, CD8+↑, 1, Inf↓, 1, IRF3↓, 1, Sepsis↓, 5,
Total Targets: 455

Scientific Paper Hit Count for: eff, efficacy

65 Silver-NanoParticles
56 Magnetic Fields
43 Sulforaphane (mainly Broccoli)
38 Curcumin
35 Vitamin C (Ascorbic Acid)
32 Thymoquinone
28 Shikonin
27 Chemotherapy
25 Piperlongumine
24 Artemisinin
23 EGCG (Epigallocatechin Gallate)
23 Selenite (Sodium)
22 Baicalein
22 Quercetin
21 Resveratrol
20 Copper and Cu NanoParticles
20 Ashwagandha(Withaferin A)
20 Berberine
18 Radiotherapy/Radiation
18 Magnetic Field Rotating
17 Apigenin (mainly Parsley)
17 Phenylbutyrate
17 Selenium NanoParticles
16 immunotherapy
16 Dichloroacetate
16 diet FMD Fasting Mimicking Diet
16 Gambogic Acid
15 Selenium
15 Lycopene
14 Propolis -bee glue
14 Exercise
14 Phenethyl isothiocyanate
13 3-bromopyruvate
12 Citric Acid
12 Fisetin
11 Folic Acid, Vit B9
11 Auranofin
11 salinomycin
11 Rosmarinic acid
10 chitosan
10 Alpha-Lipoic-Acid
10 Melatonin
10 Luteolin
10 Metformin
10 Betulinic acid
10 Capsaicin
10 Vitamin K2
10 Silymarin (Milk Thistle) silibinin
10 diet Methionine-Restricted Diet
10 Honokiol
10 VitK3,menadione
9 SonoDynamic Therapy UltraSound
9 Atorvastatin
9 Boron
9 Ellagic acid
9 Disulfiram
9 doxorubicin
9 Hydrogen Gas
9 Urolithin
8 Gold NanoParticles
8 Hyperthermia
8 Vitamin D3
8 Chrysin
8 Plumbagin
8 Parthenolide
7 Cisplatin
7 Piperine
6 5-fluorouracil
6 Coenzyme Q10
6 Vitamin B12
6 Photodynamic Therapy
6 Fenbendazole
6 Allicin (mainly Garlic)
6 Caffeic acid
6 HydroxyCitric Acid
6 Juglone
5 Astragalus
5 Akkermansia
5 Ascorbyl Palmitate
5 Astaxanthin
5 Boswellia (frankincense)
5 diet Plant based
5 MCToil
5 Magnolol
5 Moringa oleifera
4 2-DeoxyGlucose
4 almonertinib
4 Andrographis
4 Aspirin -acetylsalicylic acid
4 Dipyridamole
4 diet Short Term Fasting
4 Propyl gallate
4 Pterostilbene
4 Sulfasalazine
4 Whole Body Vibration
3 Anthocyanins
3 Gemcitabine (Gemzar)
3 Anti-oxidants
3 Docetaxel
3 Aloe anthraquinones
3 Lutein
3 Zeaxanthin
3 Bortezomib
3 Chlorogenic acid
3 erastin
3 Ginseng
3 Lecithin
3 Naringin
3 Radio Frequency
3 Spermidine
3 Taurine
3 Vitamin B1/Thiamine
2 5-Aminolevulinic acid
2 Glucose
2 Zinc
2 Aromatherapy
2 Arsenic trioxide
2 Baicalin
2 Butyrate
2 beta-carotene(VitA)
2 Caffeine
2 Choline
2 Oxygen, Hyperbaric
2 Emodin
2 ferumoxytol
2 temozolomide
2 Kaempferol
2 hydroxychloroquine
2 Genistein (soy isoflavone)
2 γ-linolenic acid (Borage Oil)
2 Orlistat
2 Potassium
2 Methylene blue
2 metronomic chemo
2 Methylsulfonylmethane
2 Mushroom Lion’s Mane
2 nicotinamide adenine dinucleotide
2 Niclosamide (Niclocide)
2 Nimbolide
2 Phosphatidylserine
2 Aflavin-3,3′-digallate
1 cetuximab
1 Serotonin, 5-hydroxytryptamine
1 dietMediterranean
1 Trichostatin A
1 wortmannin
1 Resiquimod
1 Anzaroot, Astragalus fasciculifolius Bioss
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 Bevacizumab (brand Avastin)
1 Amodiaquine
1 Vitamin A, Retinoic Acid
1 Sorafenib (brand name Nexavar)
1 Trastuzumab
1 D-limonene
1 Huperzine A/Huperzia serrata
1 Biochanin A
1 Bacopa monnieri
1 Rutin
1 urea
1 Carnosine
1 Cinnamon
1 Black phosphorus
1 chemodynamic therapy
1 Dichloroacetophenone(2,2-)
1 Date Fruit Extract
1 diet Fermented Foods
1 diet Ketogenic
1 Calorie Restriction Mimetics
1 PXD, phenoxodiol
1 Ferulic acid
1 Vitamin E
1 flavonoids
1 Flickering Light Stimulation
1 verapamil
1 Garcinol
1 tamoxifen
1 Hydroxycinnamic-acid
1 HydroxyTyrosol
1 itraconazole
1 Laetrile B17 Amygdalin
1 lambertianic acid
1 Docosahexaenoic Acid
1 Matrine
1 Methyl Jasmonate
1 capecitabine
1 methotrexate
1 Magnesium
1 Methylglyoxal
1 Mushroom Reishi
1 Myricetin
1 Oleocanthal
1 sericin
1 Paclitaxel
1 borneol
1 Psoralidin
1 enzalutamide
1 Oxaliplatin
1 Scoulerine
1 polyethylene glycol
1 acetaminophen
1 Formononetin
1 acetazolamide
1 Iron
1 Squalene
1 Glutathione
1 statins
1 Sutherlandioside D
1 triptolide
1 Tumor Treating Fields
1 Ursolic acid
1 Vitamin B3,Niacin
1 Vitamin B5,Pantothenic Acid
1 Vitamin B6,pyridoxine
1 Wogonin

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:961  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Database Query Results : , , eff

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned ⓘ

Redox & Oxidative Stress ⓘ

Metal & Cofactor Biology ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Cellular Microenvironment ⓘ

Synaptic & Neurotransmission ⓘ

Protein Aggregation ⓘ

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Metal & Cofactor Biology ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Cellular Microenvironment ⓘ

Synaptic & Neurotransmission ⓘ

Protein Aggregation ⓘ

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

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