Database Query Results : , , STEAP3

STEAP3, Six Transmembrane Epithelial Antigen of the Prostate 3: Click to Expand ⟱
Source:
Type:
The STEAP3 gene (Six Transmembrane Epithelial Antigen of the Prostate 3) is a metalloreductase that plays a crucial role in the regulation of iron and copper metabolism. The STEAP3 gene is overexpressed in various types of cancer.

STEAP3 gene is a key regulator of iron and copper metabolism and is overexpressed in various types of cancer. Its expression is associated with poor prognosis and increased risk of metastasis and recurrence.
Scientific Papers found: Click to Expand⟱
1009- And,  5-FU,    Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer
- in-vivo, CRC, HCT116 - in-vitro, CRC, SW480
ChemoSen↑, Casp9↑, Ferroptosis↑, Wnt/(β-catenin)↓, FTL↑, TP53↑, ACSL5↑, GCLC↑, GCLM↑, SAT1↑, STEAP3↑, ACSL5↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   GCLC↑, 1,   GCLM↑, 1,  

Metal & Cofactor Biology ⓘ

FTL↑, 1,   STEAP3↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACSL5↑, 2,   SAT1↑, 1,  

Cell Death ⓘ

Casp9↑, 1,   Ferroptosis↑, 1,  

DNA Damage & Repair ⓘ

TP53↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Wnt/(β-catenin)↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  

Clinical Biomarkers ⓘ

TP53↑, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: STEAP3, Six Transmembrane Epithelial Antigen of the Prostate 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:963  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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