Database Query Results : , , EP4

EP4, Prostaglandin E2 receptor 4: Click to Expand ⟱
Source:
Type:
Also known as PTGER4
EP4 (Prostaglandin E2 receptor 4) - Inflammation-Driven Growth, Immune Suppression, and Metastasis
-is a receptor that plays a role in various cellular processes, including inflammation and cell growth. In cancer, EP4 has been implicated in tumor development and progression.

Overexpressed in: Colorectal, Breast, Lung, Prostate, Ovarian, GBM cancers(with poor prognosis).
Underexpressed in: Some types of renal cell carcinoma (correlated with improved overall survival).

EP4 appears to play a tumorigenic role in various types of cancer, and its expression levels can be used as a prognostic marker to predict patient outcomes.
Core Pro-Tumor Mechanisms
a. Proliferation and Survival
EP4 activation:
-Elevates cAMP/PKA and PI3K–AKT signaling
-Promotes cell survival and resistance to stress
-Cooperates with growth-factor pathways
b. Invasion and Metastasis
-EP4 enhances:
-EMT programs
-Cell migration and invasion
-Matrix remodeling and metastatic seeding
c. Angiogenesis
EP4 signaling increases:
-VEGF expression
-Endothelial migration and vessel formation
-Tumor perfusion


Scientific Papers found: Click to Expand⟱
3054- RES,    Resveratrol induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis, and cell cycle arrest in the A375SM malignant melanoma cell line
- in-vitro, Melanoma, A375
TumCG↓, P21↑, p27↑, CycB/CCNB1↓, ROS↑, ER Stress↑, p‑p38↑, P53↑, p‑eIF2α↑, EP4↑, CHOP↑, Bcl-2↓, BAX↓, TumCCA↑, NRF2↓, ChemoSen↑, GSH↓,
1019- TQ,    Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation
- vitro+vivo, CRC, LoVo
TumCP↓, p‑PI3K↓, p‑Akt↓, p‑GSK‐3β↓, β-catenin/ZEB1↓, COX2↓, PGE2↓, EP2↓, EP4↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   NRF2↓, 1,   ROS↑, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   BAX↓, 1,   Bcl-2↓, 1,   p27↑, 1,   p‑p38↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Cell Cycle & Senescence ⓘ

CycB/CCNB1↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EP2↓, 1,   EP4↓, 1,   EP4↑, 1,   p‑GSK‐3β↓, 1,   p‑PI3K↓, 1,   TumCG↓, 1,  

Migration ⓘ

TumCP↓, 1,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   PGE2↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  
Total Targets: 26

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: EP4, Prostaglandin E2 receptor 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:970  State#:%  Dir#:%
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