Database Query Results : , , Axin2

Axin2, Axis Inhibition Protein 2: Click to Expand ⟱
Source:
Type:
Axin2 is a key component of the Wnt/β-catenin signaling pathway, acting primarily as a negative feedback regulator. Its expression is often used as a readout for active Wnt signaling, which in many cancers is involved in tumor initiation, progression, and cancer stem cell maintenance.

Axin2 is frequently upregulated, reflecting high Wnt/β-catenin activity.
This feedback loop is critical for tight control of cell proliferation and differentiation.
Scientific Papers found: Click to Expand⟱
1047- RES,    Resveratrol induces PD-L1 expression through snail-driven activation of Wnt pathway in lung cancer cells
- in-vitro, Lung, H1299 - in-vitro, Lung, A549 - in-vitro, Lung, H460
PD-L1↑, Snail↑, E-cadherin↓, N-cadherin↑, Fibronectin↑, Vim↑, Axin2↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

Axin2↓, 1,  

Migration ⓘ

E-cadherin↓, 1,   Fibronectin↑, 1,   N-cadherin↑, 1,   Snail↑, 1,   Vim↑, 1,  

Immune & Inflammatory Signaling ⓘ

PD-L1↑, 1,  

Clinical Biomarkers ⓘ

PD-L1↑, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Axin2, Axis Inhibition Protein 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:976  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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