Database Query Results : , , Bfl-1

Bfl-1, Bfl-1 (A1): Click to Expand ⟱
Source:
Type:
Bfl-1 (also known as A1 in some contexts) in the context of cancer biology, its role in apoptosis regulation, and its relevance to immunotherapy.
• Bfl-1 is a member of the BCL2 protein family, which comprises both pro- and anti-apoptotic regulators.
• Also known as A1 in several species, Bfl-1 is an anti-apoptotic protein that contributes to cell survival by binding and sequestering pro-apoptotic factors.
• This interaction helps prevent the initiation of the mitochondrial (intrinsic) pathway of apoptosis.


– Several studies have found that Bfl-1 can be overexpressed in various malignancies.
– Its increased expression allows cancer cells to resist apoptosis induced by both intrinsic cellular stress and extrinsic signals, contributing to tumor development and progression.
Scientific Papers found: Click to Expand⟱
1057- EDM,    Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion
NF-kB↓, TNF-α↓, COX2↓, cycD1/CCND1↓, cMyc↓, MMP9↓, ICAM-1↓, MDR1↓, XIAP↓, Bcl-2↓, Bcl-xL↓, IAP1↓, IAP2↓, cFLIP↓, Bfl-1↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

Bfl-1↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,  

Cell Death ⓘ

Bcl-2↓, 1,   Bcl-xL↓, 1,   cFLIP↓, 1,   IAP1↓, 1,   IAP2↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Migration ⓘ

MMP9↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   ICAM-1↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

MDR1↓, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Bfl-1, Bfl-1 (A1)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:981  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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