Database Query Results : , , GDH

GDH, Glutamate dehydrogenase: Click to Expand ⟱
Source:
Type:
Glutamate dehydrogenase (GDH) is an enzyme that plays a central role in amino acid metabolism. It catalyzes the reversible oxidative deamination of glutamate to α-ketoglutarate and ammonia, linking amino acid metabolism with the tricarboxylic acid (TCA) cycle.

Role of GDH in Metabolism
• GDH converts glutamate, a key amino acid, into α-ketoglutarate, which is an essential intermediate in the TCA cycle.
• By doing so, GDH contributes to energy production and anaplerosis (replenishment of TCA cycle intermediates).
•GDH activity can support cell survival when cancer cells rely not only on glycolysis (the Warburg effect) but also on glutaminolysis—using glutamine as a key nutrient for energy and biosynthesis.

GDH Expression in Cancer
• Many cancers exhibit metabolic reprogramming to support rapid growth and proliferation. Some tumors have been found to upregulate GDH expression, allowing them to better use glutamine and glutamate as alternative energy sources.
• Elevated GDH expression can facilitate increased flux of glutamate into the TCA cycle, thereby supporting bioenergetic and biosynthetic demands of cancer cells.
• The increase in GDH activity may also help cancer cells adapt to nutrient-depleted or hypoxic microenvironments by offering metabolic flexibility.
Scientific Papers found: Click to Expand⟱
1071- EGCG,    Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase
- in-vitro, Nor, NA
*GDH↓,
2310- EGCG,    Epigallocatechin-3-gallate downregulates PDHA1 interfering the metabolic pathways in human herpesvirus 8 harboring primary effusion lymphoma cells
- in-vitro, lymphoma, PEL
GLUT3↑, PDHA1↓, GDH↓, ROS↑, Glycolysis↓, OXPHOS↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

OXPHOS↓, 1,   ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

GDH↓, 1,   Glycolysis↓, 1,   PDHA1↓, 1,  

Barriers & Transport ⓘ

GLUT3↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

GDH↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: GDH, Glutamate dehydrogenase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:989  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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