Database Query Results : , , MCP1

MCP1, CCL2,monocyte chemotactic protein-1: Click to Expand ⟱
Source:
Type:
MCP-1 (Monocyte Chemoattractant Protein-1, also known as CCL2)
MCP-1/CCL2 is a chemokine involved in recruiting monocytes, memory T cells, and dendritic cells to sites of inflammation.
– It plays a key role in mediating immune cell trafficking, inflammation, and tissue remodeling. MCP-1 is pivotal in inflammatory responses and can modulate immune cell infiltration into tissues.
– It also influences the polarization of macrophages, which may adopt pro-inflammatory (M1) or anti-inflammatory/pro-tumoral (M2) roles.

Many cancers (such as breast, prostate, ovarian, lung, and colon cancers) exhibit increased levels of MCP-1.
– Both tumor cells and associated stromal cells (e.g., cancer-associated fibroblasts, infiltrating immune cells) can produce MCP-1, contributing to an inflammatory milieu.

• Inducers of MCP-1:
– Hypoxia, oncogenic pathways, and cytokine-rich environments (e.g., IL-1β, TNF-α) can drive increased MCP-1 expression.
– This upregulation often correlates with an ongoing inflammatory response in the tumor microenvironment.
Scientific Papers found: Click to Expand⟱
3283- ALA,    Alpha-lipoic acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cells
- in-vitro, Nor, NA
*TNF-α↓, *NF-kB↓, *antiOx↑, *IronCh↑, *GSSG↓, *VCAM-1↓, *E-sel↓, *ICAM-1↓, *MCP1↓, *NF-kB↓, IKKα↓,
3667- ART/DHA,    Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia
- Review, Sepsis, NA
*cognitive↑, *neuroP↑, *TNF-α↓, *IL6↓, *NF-kB↓, *AMPK↑, *ROS↓, *Akt↑, *MCP1↓, *MIP2↓, *TGF-β↑, *Inflam↓,
1074- ART/DHA,    Artemisinin attenuates lipopolysaccharide-stimulated proinflammatory responses by inhibiting NF-κB pathway in microglia cells
- in-vitro, Nor, BV2
*TNF-α↓, *IL6↓, *MCP1↓, *NO↓, *iNOS↓, *IκB↑,
3689- Ash,    Ashwagandha attenuates TNF-α- and LPS-induced NF-κB activation and CCL2 and CCL5 gene expression in NRK-52E cells
- in-vitro, NA, NRK52E
*RenoP↑, *NF-kB↓, *MCP1↓, *RANTES↓,
4303- Ash,    Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
- Review, AD, NA
*neuroP↑, *Sleep↑, *Inflam↓, *cardioP↑, *cognitive↑, *Aβ↓, *TNF-α↓, *IL1β↓, *IL6↓, *MCP1↓, *lipid-P↓, *tau↓, *ROS↓, *BBB↑, *AChE↓, *GSH↑, *GSTs↑, *GSR↑, *GPx↑, *SOD↑, *Catalase↑, ChemoSen↑, *Strength↑,
3174- Ash,    Withaferin A Acts as a Novel Regulator of Liver X Receptor-α in HCC
- in-vitro, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
NF-kB↓, angioG↓, Inflam↓, TumCP↓, TumCMig↓, TumCI↓, Sp1/3/4↓, VEGF↓, angioG↓, uPA↓, PDGF↓, MCP1↓, ICAM-1↓, *NRF2↑, *hepatoP↑,
2614- Ba,    Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders
- Review, NA, NA
*toxicity↓, *antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *MCP1↓, *hepatoP↑, *neuroP↑,
2481- Ba,  Rad,    Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages
- in-vitro, ESCC, Eca109 - in-vitro, ESCC, KYSE150
12LOX↓, RadioS↑, Dose↝, RANTES↓, MCP1↓,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1↓, PGE2↓, COX2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1↓, COX2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, eff↑, EGFR↓, Glycolysis↓, Dose?, p27↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2↓, ChemoSen↑, eff↑, eff↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
2760- BetA,    A Review on Preparation of Betulinic Acid and Its Biological Activities
- Review, Var, NA - Review, Stroke, NA
AntiTum↑, Cyt‑c↑, Smad1↑, Sepsis↓, NF-kB↓, ICAM-1↓, MCP1↓, MMP9↓, COX2↓, PGE2↓, ERK↓, p‑Akt↓, *ROS↓, *LDH↓, *hepatoP↑, *SOD↑, *Catalase↑, *GSH↑, *AST↓, *ALAT↓, *RenoP↑, *ROS↓, *α-SMA↓,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
1418- CUR,    Potential complementary and/or synergistic effects of curcumin and boswellic acids for management of osteoarthritis
- Review, Arthritis, NA
*COX2↓, *Inflam↓, *5LO↓, *NO↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↑, *IL6↓, *IL8↓, *IL12↓, *MCP1↓, *PGE2↓, *MMP2↓, *MMP3↓, *MMP9↓, *NLRP3↓, *ROS↓,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2↓, *MCP1↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE↓, *AChE↓, *LDL↓,
2819- CUR,  Chemo,    Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury
- Review, Var, NA
*hepatoP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *ROS↓, *ALAT↓, *AST↓, *MDA↓, *NRF2↑, *COX2↑, *NF-kB↓, *ICAM-1↓, *MCP1↓, *HO-1↑, CXCc↓,
1976- EGCG,    Epigallocatechin-3-gallate exhibits anti-tumor effect by perturbing redox homeostasis, modulating the release of pro-inflammatory mediators and decreasing the invasiveness of glioblastoma cells
- in-vitro, GBM, U87MG
ROS↑, MMP↓, Casp3↑, Cyt‑c↑, Trx1↓, Ceru↓, IL6↓, IL8↓, MCP1↓, RANTES?, uPA↝, ROS↑,
3768- H2,    Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial
- Trial, AD, NA
*ROS↓, *NO↓, *BACE↓, *BDNF↑, *VEGF↑, *p‑tau↓, *MCP1↓, *IL6↓, *cognitive↑, *toxicity∅,
3468- MF,    An integrative review of pulsed electromagnetic field therapy (PEMF) and wound healing
- Review, NA, NA
*other↑, *necrosis↓, *IL6↑, *TGF-β↑, *iNOS↑, *MMP2↑, *MCP1↑, *HO-1↑, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *BioAv↑, eff⇅, DNAdam↑, Apoptosis↑, ROS↑, TumCP↓, *ROS↓, *FGF↑,
4105- MF,    Extremely low frequency electromagnetic fields stimulation modulates autoimmunity and immune responses: a possible immuno-modulatory therapeutic effect in neurodegenerative diseases
- Review, AD, NA
*Inflam↓, *neuroP↑, *NO↑, *ROS↓, *NO↓, *MCP1↑, *HSP70/HSPA5↑, *antiOx↑, *NRF2↑, *NF-kB↓,
228- MFrot,  MF,    Rotating magnetic field ameliorates experimental autoimmune encephalomyelitis by promoting T cell peripheral accumulation and regulating the balance of Treg and Th1/Th17
- NA, MS, NA
*CD4+↑, *MCP1↓, RANTES↓, *MIP‑1α↓, *Treg lymp↓, *IFN-γ↓, *IL17↓, *CXCc↓,
4036- NAD,  VitB3,    NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
- in-vivo, AD, NA
*Inflam↓, *p‑tau↓, *DNAdam↓, *memory↑, *motorD↑, *cognitive↑, *BBB↑, IL1β↓, *TNF-α↓, *MCP1↓, *RANTES↓, *ROS↓, *SIRT3↑, *SIRT6↑,
3249- PBG,    Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence
- Review, Var, NA
*Inflam↓, *ROS↓, *MDA↓, *TNF-α↓, *NO↓, *iNOS↓, *SOD↑, *GPx↑, *GSR↓, *GSH↑, *neuroP↑, *IL6↓, *MMP2↓, *MMP9↓, *MCP1↓, *HSP70/HSPA5↑, *motorD↑, *Pain↓, *VCAM-1↓, *NF-kB↓, *MAPK↓, *JNK↓, *IL1β↓, *AChE↓, *toxicity∅, cognitive↑,
3000- PL,    Biological and physical approaches on the role of piplartine (piperlongumine) in cancer
- in-vitro, Nor, HUVECs - in-vitro, Laryn, HEp2
Inflam↓, AntiTum↑, *α-tubulin↓, selectivity↑, HIF2a↓, MCP1↓,
3927- PTS,    Effects of Pterostilbene on Cardiovascular Health and Disease
- Review, AD, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *BioAv↑, *toxicity↓, *NADPH↓, *ROS↓, *Catalase↑, *GSH↑, *SOD↑, *TNF-α↓, *IL1β↓, *IL4↓, *MMPs↓, *COX2↓, *MAPK↝, *NF-kB↓, *IL8↓, *MCP1↓, *E-sel↓, *lipid-P↓, *NRF2↑, *PPARα↑, *LDL↓, other↓,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, eff↑, P-gp↓, eff↑, eff↑, eff↑, eff↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3068- RES,    Resveratrol decreases the expression of genes involved in inflammation through transcriptional regulation
- in-vitro, lymphoma, U937
p65↓, SOD2↓, Prx↓, Catalase↓, Trx↓, TNF-α↓, IL8↓, MCP1↓, SIRT1↑,
3012- RosA,  Rad,    Rosmarinic Acid Prevents Radiation-Induced Pulmonary Fibrosis Through Attenuation of ROSMYPT1TGFβ1 Signaling Via miR-19b-3p
- in-vitro, Nor, IMR90
*Inflam↓, *ROS↓, *p‑NF-kB↓, *Rho↓, *ROCK1↓, *radioP↑, *MCP1↓, *RANTES↓, *ICAM-1↓, *PGC1A↑, *NOX4↓, *Dose↝,
4498- Se,    Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
*Imm↑, *GutMicro↑, *BioAv↑, *Risk↓, *Dose↝, Risk↓, *CRP↓, *GPx↓, *Inflam↓, *selenoP↑, *Dose↝, *ROS↓, *MDA↓, *SOD↑, *GPx↑, *IL1↓, *MCP1↓, *IL6↓, *TNF-α↓, Risk↓, *neuroP↑, *memory↑,
1432- SFN,    Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients with multiple atypical nevi
- Human, Melanoma, NA
other↑, decorin↑, *toxicity↓, IP-10/CXCL-10↓, MCP1↓, CXCL9↓, MIP-1β↓, IFN-γ↓,
4598- SNP,    In vivo human time-exposure study of orally dosed commercial silver nanoparticles
- in-vivo, Nor, NA
*toxicity∅, *Dose↝, *Dose↝, *BioAv↝, *BioAv↝, *H2O2∅, *IL8∅, *IL1α∅, *IL1β∅, *MCP1∅, *NQO1∅, *BioAv↓,
3425- TQ,    Advances in research on the relationship between thymoquinone and pancreatic cancer
Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, ChemoSen↑, angioG↓, Inflam↓, NF-kB↓, PI3K↓, Akt↓, TGF-β↓, Jun↓, p38↑, MAPK↑, MMP9↓, PKM2↓, ROS↑, JNK↑, MUC4↓, TGF-β↑, Dose↝, FAK↓, NOTCH↓, PTEN↑, mTOR↓, Warburg↓, XIAP↓, COX2↓, Casp9↑, Ki-67↓, CD34↓, VEGF↓, MCP1↓, survivin↓, Cyt‑c↑, Casp3↑, H4↑, HDAC↓,
3404- TQ,    The Neuroprotective Effects of Thymoquinone: A Review
- Review, Var, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *TNF-α↓, *IL6↓, *IL1β↓, *NF-kB↓, *iNOS↓, *NRF2↑, *neuroP↑, *MMP↑, *ROS↓, *MDA↓, *GSH↑, *Catalase↑, *SOD↑, *IL12↓, *MCP1↓, *IP-10/CXCL-10↓, *PGE2↓,
3410- TQ,    Anti-inflammatory effects of thymoquinone and its protective effects against several diseases
- Review, Arthritis, NA
*Inflam↓, *antiOx↑, *COX2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL6↓, *TNF-α↓, *IFN-γ↓, *PGE2↓, *cardioP↑, *Catalase↑, *SOD↑, *Thiols↑, *neuroP↑, *IL12↓, *MCP1↓, *CXCc↓, *ROS↓,
2103- TQ,    Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells
- in-vitro, PC, Hs766t - in-vitro, PC, MIA PaCa-2
MCP1↓, TNF-α↓, IL1β↓, COX2↓, NF-kB↓, HDAC↓, P21↑,
4861- Uro,    Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions
- in-vivo, AD, NA
*memory↑, *Aβ↓, *toxicity↓, *BBB↑, *p‑tau↓, *eff↓, *IL1α↓, *MCP1↓, *MIP‑1α↓, *TNF-α↓, *IL2↓, *SIRT1↓, *DNAdam↓, *Dose↝, *Strength↑, *motorD↑, *CTSZ↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 35

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

chemoPv↑, 1,  

Redox & Oxidative Stress ⓘ

Catalase↓, 1,   Ceru↓, 1,   lipid-P?, 1,   Prx↓, 1,   ROS↓, 1,   ROS↑, 6,   SOD2↓, 1,   Trx↓, 1,   Trx1↓, 1,  

Metal & Cofactor Biology ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   CDC25↓, 2,   MEK↓, 1,   MMP↓, 4,   Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   AMPK↑, 2,   cMyc↓, 1,   Glycolysis↓, 1,   PKM2↓, 1,   PPARα↓, 1,   p‑S6K↓, 1,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 2,   p‑Akt↓, 1,   Apoptosis↑, 4,   BAX↓, 1,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   Bcl-xL↓, 1,   Casp3↓, 1,   Casp3↑, 4,   Casp8↑, 2,   Casp9↑, 3,   Cyt‑c↑, 5,   DR4↑, 1,   DR5↑, 1,   Fas↑, 1,   FasL↑, 1,   IAP1↓, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   MDM2↓, 2,   p27↑, 1,   p38↑, 1,   survivin↓, 2,   Telomerase↓, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

H4↑, 1,   other↓, 2,   other↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5↓, 1,   HSP90↓, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

ATM↑, 1,   DNAdam↑, 2,   P53↑, 1,   cl‑PARP↑, 2,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 3,   CDK4↓, 3,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 2,   P21↑, 1,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   CD34↓, 1,   CSCs↓, 1,   Diff↓, 1,   EMT↓, 1,   EMT↑, 1,   ERK↓, 4,   p‑ERK↓, 1,   HDAC↓, 2,   Jun↓, 1,   Let-7↑, 1,   mTOR↓, 2,   p‑mTORC1↓, 1,   n-MYC↓, 1,   Nestin↓, 1,   NOTCH↓, 2,   PI3K↓, 2,   PTEN↑, 2,   RAS↓, 2,   SOX2↓, 1,   STAT3↓, 2,   TOP1↓, 1,   TOP2↓, 1,   TOP2↑, 1,   Wnt↓, 1,  

Migration ⓘ

decorin↑, 1,   FAK↓, 2,   Ki-67↓, 1,   KRAS↓, 1,   miR-200b↑, 1,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 3,   MMP3↓, 1,   MMP9↓, 5,   MUC4↓, 1,   PDGF↓, 2,   PKCδ↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Smad1↑, 1,   TGF-β↓, 2,   TGF-β↑, 1,   TumCI↓, 4,   TumCMig↓, 1,   TumCP↓, 4,   TumMeta↓, 2,   uPA↓, 3,   uPA↝, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   EGFR↓, 1,   Hif1a↓, 1,   HIF2a↓, 1,   p‑PDGFR-BB↓, 1,   VEGF↓, 5,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

CCR7↓, 1,   CD4+↓, 1,   COX2↓, 7,   CXCc↓, 1,   CXCL9↓, 1,   CXCR4↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 1,   IKKα↓, 2,   IL1↓, 1,   IL1α↓, 1,   IL1β↓, 2,   IL6↓, 3,   IL8↓, 2,   Inflam↓, 5,   IP-10/CXCL-10↓, 1,   JAK2↓, 1,   MCP1↓, 12,   MIP-1β↓, 1,   MIP2↓, 1,   NF-kB↓, 7,   p65↓, 1,   PGE2↓, 4,   RANTES?, 1,   RANTES↓, 2,   TNF-α↓, 3,  

Synaptic & Neurotransmission ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 2,   ChemoSen↑, 5,   Dose?, 1,   Dose↓, 1,   Dose↑, 2,   Dose↝, 2,   eff↑, 15,   eff⇅, 1,   eff↝, 1,   Half-Life↓, 1,   RadioS↑, 2,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

AR↓, 1,   ascitic↓, 1,   EGFR↓, 1,   IL6↓, 3,   Ki-67↓, 1,   KRAS↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   AntiTum↑, 3,   cognitive↑, 1,   RenoP↑, 1,   Risk↓, 2,   toxicity↓, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 187

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 9,   Catalase↑, 8,   GPx↓, 1,   GPx↑, 5,   GSH↑, 7,   GSR↓, 1,   GSR↑, 1,   GSSG↓, 1,   GSTs↑, 2,   H2O2∅, 1,   HO-1↑, 5,   lipid-P↓, 4,   MDA↓, 4,   MPO↓, 1,   NOX4↓, 1,   NQO1↑, 1,   NQO1∅, 1,   Nrf1↑, 1,   NRF2↑, 8,   ROS↓, 20,   selenoP↑, 1,   SIRT3↑, 1,   SOD↑, 10,   Thiols↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 2,   AMPK↑, 2,   LDH↓, 1,   LDL↓, 2,   NADPH↓, 2,   PGC1A↑, 1,   PPARα↑, 1,   SIRT1↓, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↑, 1,   iNOS↓, 3,   iNOS↑, 1,   JNK↓, 1,   MAPK↓, 1,   MAPK↑, 1,   MAPK↝, 1,   necrosis↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↓, 2,   SIRT6↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

FGF↑, 1,   GSK‐3β↓, 2,   mTOR↓, 1,  

Migration ⓘ

5LO↓, 1,   Ca+2↝, 1,   CDK5↓, 1,   E-sel↓, 2,   MMP2↓, 2,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 2,   MMPs↓, 1,   Rho↓, 1,   ROCK1↓, 1,   TGF-β↑, 2,   Treg lymp↓, 1,   TXNIP↓, 1,   VCAM-1↓, 2,   α-SMA↓, 1,   α-tubulin↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   NO↓, 5,   NO↑, 1,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↑, 3,  

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1,   COX2↓, 5,   COX2↑, 1,   CRP↓, 1,   CTSZ↓, 1,   CXCc↓, 2,   ICAM-1↓, 3,   IFN-γ↓, 2,   IL1↓, 2,   IL10↓, 1,   IL10↑, 1,   IL12↓, 3,   IL17↓, 3,   IL1α↓, 1,   IL1α∅, 1,   IL1β↓, 8,   IL1β∅, 1,   IL2↓, 1,   IL2↑, 1,   IL23↓, 1,   IL4↓, 1,   IL6↓, 10,   IL6↑, 1,   IL8↓, 2,   IL8∅, 1,   Imm↑, 1,   Inflam↓, 17,   IP-10/CXCL-10↓, 1,   IκB↑, 1,   MCP1↓, 20,   MCP1↑, 2,   MCP1∅, 1,   MIP‑1α↓, 2,   MIP2↓, 1,   NF-kB↓, 13,   p‑NF-kB↓, 1,   PGE2↓, 3,   RANTES↓, 3,   TNF-α↓, 16,  

Synaptic & Neurotransmission ⓘ

AChE↓, 3,   BDNF↑, 2,   tau↓, 2,   p‑tau↓, 4,  

Protein Aggregation ⓘ

Aβ↓, 4,   BACE↓, 2,   NLRP3↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 2,   Dose↝, 6,   eff↓, 1,   Half-Life↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   AST↓, 2,   BP↓, 1,   CRP↓, 1,   GutMicro↑, 1,   IL6↓, 10,   IL6↑, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   cardioP↑, 3,   cognitive↑, 4,   hepatoP↑, 4,   memory↑, 4,   motorD↑, 3,   neuroP↑, 10,   OS↑, 1,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 1,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 4,   toxicity∅, 3,  
Total Targets: 148

Scientific Paper Hit Count for: MCP1, CCL2,monocyte chemotactic protein-1
4 Thymoquinone
3 Ashwagandha(Withaferin A)
3 Curcumin
3 Magnetic Fields
2 Artemisinin
2 Baicalein
2 Radiotherapy/Radiation
2 Berberine
1 Alpha-Lipoic-Acid
1 Betulinic acid
1 Boswellia (frankincense)
1 Chemotherapy
1 EGCG (Epigallocatechin Gallate)
1 Hydrogen Gas
1 Magnetic Field Rotating
1 nicotinamide adenine dinucleotide
1 Vitamin B3,Niacin
1 Propolis -bee glue
1 Piperlongumine
1 Pterostilbene
1 Quercetin
1 Resveratrol
1 Rosmarinic acid
1 Selenium
1 Sulforaphane (mainly Broccoli)
1 Silver-NanoParticles
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:990  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page