Database Query Results : , , CREB2

CREB2, cAMP response element‐binding protein 2: Click to Expand ⟱
Source:
Type:
CREB2 (cAMP response element‐binding protein 2) is a member of the CREB/ATF family of transcription factors.
– CREB2 is involved in stress-related signaling pathways and has been implicated in processes like memory consolidation and synaptic plasticity in neuronal cells.
– It helps in the cellular response to environmental and intracellular stresses by modulating the expression of target genes.
– Through regulation of gene expression, CREB2 can influence proliferation, differentiation, and apoptosis in various cell types.
– The balance of CREB2 activity is critical in maintaining normal cellular homeostasis.

– Some studies have reported increased CREB2 expression in certain cancers (e.g., brain tumors, leukemia), while others have noted reduced expression in different tumor types.
Scientific Papers found: Click to Expand⟱
1078- And,    Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HUVECs - in-vivo, BC, MCF-7 - in-vitro, BC, T47D - in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-361
TumCP↓, COX2↓, *angioG↓, Cyt‑c↑, CREB2↓, cFos↓, NF-kB↓, HATs↓, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, Apoptosis↑, *toxicity↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   Bax:Bcl2↑, 1,   cl‑Casp3↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,  

Transcription & Epigenetics ⓘ

HATs↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

cFos↓, 1,   CREB2↓, 1,  

Migration ⓘ

TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   NF-kB↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Angiogenesis & Vasculature ⓘ

angioG↓, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: CREB2, cAMP response element‐binding protein 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:991  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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