Database Query Results : , , SHARP

SHARP, SHARP1/BHLHE41: Click to Expand ⟱
Source:
Type:
SHARP1/BHLHE41 is a basic helix-loop-helix (bHLH) transcription factor that regulates gene expression by binding to E-box elements in target gene promoters.
– A suppressor of breast cancer metastasis
– It generally functions as a transcriptional repressor, controlling the expression of genes involved in circadian rhythm, differentiation, and metabolism.
• Circadian Rhythm and Metabolism:
– SHARP1 plays a role in maintaining circadian rhythm by modulating the oscillatory expression of clock genes.
– Through these regulatory networks, it also influences energy metabolism and cell-cycle control.

– Some studies report downregulation of SHARP1 in certain cancers, which may correlate with loss of its differentiation and growth-suppressive functions.
– In other contexts, SHARP1 may be upregulated, potentially reflecting an adaptive response to the altered microenvironment or a compromised circadian program in tumors.
Scientific Papers found: Click to Expand⟱
1081- CBDA,    Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells
- in-vitro, BC, MDA-MB-231
COX2↓, Id1↓, SHARP↑,
1243- LA,    Lactobacilli Modulate Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway in Triple Negative Breast Cancer Cell Line
- in-vitro, BC, MDA-MB-231
Hif1a↓, HSP90↓, GLUT1↓, VHL↓, SHARP↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

SHARP↑, 2,  

Protein Folding & ER Stress ⓘ

HSP90↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

Id1↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   VHL↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SHARP, SHARP1/BHLHE41
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:992  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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